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1. 发明公开

EP4426337A1 IGA FC AND IGG FC TANDEM PROTEIN CONSTRUCTS 审中-实审
公开(公告)号：EP4426337A1
公开(公告)日：2024-09-11
申请号：EP22817120.3
申请日：2022-11-07
申请人： Oslo Universitetssykehus HF , Universitetet I Oslo
发明人： ANDERSEN, Jan Terje , FOSS, Stian , MESTER, Simone
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K2319/0020130101 , C07K2317/6420130101 , C07K2317/5220130101 , C07K2317/7220130101 , C07K2317/9420130101 , C07K2317/73420130101 , C07K16/32 , C07K16/2887

2. 发明授权

EP3052135B1 INHIBITORS OF METALLO-BETA-LACTAMASE (MBL) COMPRISING A ZINC CHELATING MOIETY 有权
公开(公告)号：EP3052135B1
公开(公告)日：2018-07-18
申请号：EP14789590.8
申请日：2014-10-06
申请人： Universitetet I Oslo
发明人： RONGVED, Pål , ÅSTRAND, Ove Alexander Høgmoen , BAYER, Annette , LEIROS, Hanna-Kirsti Schrøder , SAMUELSEN, Ørjan , EDVARDSEN, Kine Susann Waade , MUHAMMAD, Zeeshan
IPC分类号： A61K47/64 , C07D401/14 , C07D405/14 , A61K38/05 , A61K45/06 , A61K31/444 , C07K5/062 , A61P31/04
CPC分类号： C07D401/14 , A61K31/444 , A61K38/05 , A61K45/06 , A61K47/64 , C07D405/14 , C07K5/06026
摘要： Compounds according to formula I are provided: A-L-B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.

3. 发明公开

EP3052135A1 INHIBITORS OF METALLO-BETA-LACTAMASE (MBL) COMPRISING A ZINC CHELATING MOIETY 有权
标题翻译：金属-β-内酰胺酶（MBL）与一组ZINKCHELATBILDENDEN抑制剂
公开(公告)号：EP3052135A1
公开(公告)日：2016-08-10
申请号：EP14789590.8
申请日：2014-10-06
申请人： Universitetet I Oslo
发明人： RONGVED, Pål , ÅSTRAND, Ove Alexander Høgmoen , BAYER, Annette , LEIROS, Hanna-Kirsti Schrøder , SAMUELSEN, Ørjan , EDVARDSEN, Kine Susann Waade , MUHAMMAD, Zeeshan
IPC分类号： A61K47/48 , A61P31/04
CPC分类号： C07D401/14 , A61K31/444 , A61K38/05 , A61K45/06 , A61K47/64 , C07D405/14 , C07K5/06026
摘要： Compounds according to formula I are provided: A-L-B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.

4. 发明公开

EP2946640A1 LANGMUIR PROBE 有权
标题翻译：朗缪尔探空仪
公开(公告)号：EP2946640A1
公开(公告)日：2015-11-25
申请号：EP14700699.3
申请日：2014-01-16
申请人： Universitetet I Oslo
发明人： PEDERSEN, Arne , BEKKENG, Tore André , TRONDSEN, Espen , MOEN, Jøran
IPC分类号： H05H1/00 , B64G1/10 , B64G1/52
CPC分类号： G01R19/25 , B64G1/66 , H05H1/0075
摘要： A method of determining payload potential comprises: receiving data on a first bias voltage and a resulting first collected current of a first needle of a multi-needle Langmuir probe; receiving data on a second bias voltage and a resulting second collected current of a second needle of the multi-needle Langmuir probe; assigning a value for the electron temperature in which the multi-needle Langmuir probe was operating; and using the current and voltage data, the assigned electron temperature value and Langmuir probe theory to calculate the platform potential of the multi-needle Langmuir probe.
摘要翻译：确定有效负载电位的方法可以包括以下步骤：接收关于第一偏置电压的数据，以及多针Langmuir探针的第一针的最终的第一收集电流，接收第二偏置电压上的数据和得到的第二收集电流多针Langmuir探针的第二针，分配多针Langmuir探针的电子温度值，并使用电流和电压数据，指定的电子温度值和Langmuir探针理论来计算平台多针Langmuir探头的潜力。

5. 发明公开

EP2861568A2 TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS 有权
标题翻译： TERTIÄREAMINE ZUR VERWENDUNG BEI DER BEHANDLUNG VON HERZERKRANKUNGEN
公开(公告)号：EP2861568A2
公开(公告)日：2015-04-22
申请号：EP13723783.0
申请日：2013-05-17
申请人： Universitetet I Oslo
发明人： TASKEN, Kjetil , LYGREN, Birgitte , ØSTENSEN, Ellen , KLAVENESS, Jo
IPC分类号： C07D277/56 , C07C211/27 , C07C211/29 , C07D257/04 , C07D213/36 , C07D307/79 , C07C211/44 , A61P9/00 , A61K31/426 , A61K31/41 , A61K31/343 , A61K31/4409 , A61K31/135
CPC分类号： C07D307/81 , C07C211/27 , C07C211/29 , C07C211/43 , C07C211/49 , C07C217/58 , C07C229/38 , C07C275/40 , C07D213/36 , C07D257/04 , C07D277/28 , C07D277/56 , C07D307/79
摘要： The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
摘要翻译：本发明涉及用于治疗，特别是用于治疗心血管疾病的式（I）的叔胺。已经发现这些化合物通过干扰与PKA底物磷胆碱结合的A激酶锚蛋白18delta（AKAP18δ）来调节磷胆碱磷酸化。该化合物共享三（烷基芳基/烷基杂芳基）胺结构。

6. 发明公开

EP2346330A1 ANTIMICROBIAL COMPOSITIONS AND USES 审中-公开
标题翻译：抗菌组合物和用途
公开(公告)号：EP2346330A1
公开(公告)日：2011-07-27
申请号：EP09740872.8
申请日：2009-10-09
申请人： Universitetet I Oslo
发明人： SCHEIE, Anne, Aamdal , BENNECHE, Tore , LØNN-STENSRUD, Jessica , SKRAMSTAD, Jan
IPC分类号： A01N43/10 , A61K31/385 , C07D333/32 , A61P31/02 , C07F7/18 , C08F290/14
CPC分类号： C07D333/32 , A01N43/10 , A01N55/00 , A61K31/385 , C07F7/1836 , C08F290/148 , A01N25/34 , A01N2300/00
摘要： An agent comprising the compound according to general formula (I) wherein R
1 , R
2 , R
3 and R
4 are each independently H or a substituent, and wherein at least one of R
1 , R
3 and R
4 is halogen, cyano, cyanate, thiocyanate or C
1 -C
6 haloalkyl.

7. 发明公开

EP2291384A2 METAL ORGANIC FRAMEWORK COMPOUNDS 有权
标题翻译：有机金属骨架CONNECTIONS
公开(公告)号：EP2291384A2
公开(公告)日：2011-03-09
申请号：EP09738396.2
申请日：2009-04-29
申请人： Universitetet I Oslo
发明人： HAFIZOVIC, Jasmina , OLSBYE, Unni , LILLERUD, Karl, Petter , JACOBSEN, Soren , GUILLOU, Nathalie
IPC分类号： C07F7/00 , B01J31/16 , B01J31/22 , C07C51/41 , B01J31/02
CPC分类号： B01D53/02 , B01D2253/204 , B01J31/1691 , B01J2531/48 , C01B3/56 , C01B21/0455 , C01B32/50 , C07C7/12 , C07C63/14 , C07C63/15 , C07C63/307 , C07F7/006
摘要： The invention provides novel Zr MOFs, in particular compounds having a surface area of at least 1020 m2/g or if functionalized, having a surface area of at least 500 m2/g.

8. 发明公开

EP2240521A1 POLYMER ORGANOCATALYST AND PREPARATION PROCESS 审中-公开
标题翻译：聚合物有机催化剂和方法
公开(公告)号：EP2240521A1
公开(公告)日：2010-10-20
申请号：EP09701153.0
申请日：2009-01-07
申请人： Universitetet I Oslo
发明人： KRISTENSEN, Tor Erik , HANSEN, Tore , HANSEN, Finn Knut
IPC分类号： C08F26/06
CPC分类号： C08F26/06
摘要： A chiral polymer organocatalyst comprising a main chain and side chain organocatalytic groups covalently attached to the main chain, which organocatalytic groups comprise an amino acid or amino acid derivative of the following general formula (I), in which one stereoisomeric form predominates: formula (I) wherein the catalyst is bound to the polymer main chain via R1, R2, R4, R5 or R6 through a linker (L) or direct bond, and wherein R1 -R6 and Z are defined as follows: R1 is H, a naturally occurring alpha-amino acid side chain or a non-natural commercially available alpha-amino acid side chain that may contain L; R2 is H, O (doubly bonded to give a carbonyl), O-L (where L is a linker), NH-L or L; R3 is H or doubly bonded to give a carbonyl with R2 when R2 is O; R4 is H, C1-C6 alkyl or L R5 is H, CO2H, C1-C6 alkyl, benzyl, L, CONHR (in which R is alkyl, aryl, hetereoaryl, arylalkyl or, heteroarylalkyl), tetrazolyl, CH2 coupled to a triazole moiety, an esterified CH2OH or CO2R (in which R is alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl), formula (II) or formula (III) wherein z is formula (IV) or a directed bond, X4 is H, Me3Si or Et3Si, X3 comprises a naturally-occurring alpha-amino acid side chain, H, C1-C6 alkyl or phenyl, Ar1 and Ar2 are each independently aryl or heteroaryl, and Y denotes the position of attachment to the main chain or linker; and R6 is H, CO2H3 C1-C6 alkyl, benzyl or L; and wherein the polymer organocatalyst comprises a cross-linked polymer.

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