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1. 发明授权

EP0476018B2 INTRODUCTION OF BACTERIA IN OVO 有权
标题翻译：细菌在OVO简介
公开(公告)号：EP0476018B2
公开(公告)日：2005-06-29
申请号：EP90909317.1
申请日：1990-05-31
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： BAILEY, Joseph, Stanley , COX, Nelson, Anthony
IPC分类号： A01N63/00 , A01K37/00 , A01K45/00 , A23L1/32
CPC分类号： A61K35/741 , Y10S435/853
摘要： A method and apparatus for introducing probiotic bacteria into the digestive tract of a bird in order to exclude undesirable bacteria therefrom, and inoculated eggs produced thereby, are disclosed. In a preferred embodiment of the invention, a fertile bird egg is administered a Salmonella competitive exclusion culture. The culture is preferably administered into the air cell of the egg in an amount effective to colonize the digestive tract of the embryonic bird contained within the egg, and the culture preferably comprises at least one anaerobic bacteria of intestinal origin.

2. 发明授权

EP0415999B1 COMPOSITIONS HAVING USE AS TREATMENT OF PSORIASIS AND NEUROPSYCHIATRIC DEFICITS 有权
标题翻译：使用准备在银屑病和神经精神疾病的治疗
公开(公告)号：EP0415999B1
公开(公告)日：1998-07-22
申请号：EP89906251.7
申请日：1989-05-25
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
发明人： BRIDGE, Peter , GOODWIN, Frederick, K.
IPC分类号： C07K14/16 , C07K14/73 , A61K38/16
CPC分类号： C07K14/005 , A61K38/162 , C12N2740/16122

3. 发明授权

EP0587555B1 A BIFUNCTIONAL DTPA-TYPE LIGAND 有权转让
标题翻译： EIN BIFUNKTIONELLER LIGAND DES DTPA TYPE
公开(公告)号：EP0587555B1
公开(公告)日：1998-06-10
申请号：EP91908519.1
申请日：1991-03-22
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： GANSOW, Otto A. , BRECHBIEL, Martin W.
IPC分类号： A61K51/04 , C07C229/16 , G01N33/534
CPC分类号： G01N33/534 , A61K47/54 , A61K47/547 , A61K47/56 , A61K51/048 , A61K2123/00 , C07C229/16 , C07C331/28 , C07C2601/14

4. 发明授权

EP0394277B1 SECOND GENERATION MONOCLONAL ANTIBODIES HAVING BINDING SPECIFICITY TO TAG-72 AND HUMAN CARCINOMAS AND METHODS FOR EMPLOYING THE SAME 有权转让
标题翻译：单克隆抗体第二代具有用于TAG-72和人癌及其使用的结合特异性方法
公开(公告)号：EP0394277B1
公开(公告)日：1998-01-14
申请号：EP88907519.8
申请日：1988-06-07
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
发明人： SCHLOM, Jeffrey , COLCHER, David
IPC分类号： G01N33/53
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6851 , A61K51/1045 , A61K2123/00 , C07K2319/00 , Y10S436/813
摘要： The present invention relates to second generation monoclonal antibodies having binding specificity to a tumor associated glycoprotein having an approximate molecular weight of >10 d (''TAG-72'') and human carcinomas and methods for employing the same. Hybridomas producing such antibodies have been prepared.

5. 发明公开

EP0773294A3 Efficient directional genetic cloning system 失效
标题翻译：用于定向克隆的遗传功能强大的系统
公开(公告)号：EP0773294A3
公开(公告)日：1997-09-17
申请号：EP96115534.8
申请日：1990-07-30
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： Miki, Toru , Aaronson, Stuart A. , Fleming, Timothy
IPC分类号： C12N15/16 , C07K14/71 , C12N15/10 , C12N15/85
CPC分类号： C07K14/71 , C07K14/82 , C12N15/1096 , C12N15/64 , C12N15/66
摘要： A highly efficient genetic cloning system is disclosed which is particularly useful for cloning cDNA copies of eukaryotic mRNAS and can direct the orientation of inserts in plasmid composite vectors with large cloning capacities. Cleavage of such vector DNA, by the restriction enzyme SfiI, for example, creates two different non-symmetrical 3' extensions at the ends of vector DNA. Using a linker-primer and an adaptor, cDNA is prepared to have two different sticky ends which can be ligated to those of the vector. When the cDNA fragments and the vector DNAs are mixed, both the molecules can assemble without self-circularization due to base-pairing specificity. This system provides (1) high cloning efficiency (10 7 -10 8 clones/g poly (A) + RNA), (2) low background (more than 90% of the clones contain inserts), (3) directional insertion of cDNA fragments into the vectors, (4) presence of a single insert in each clone, (5) accommodation of long inserts (up to 10kb), (6) a mechanism for rescue of the plasmid part from a λ genome, and (7) a straightforward protocol for library preparation.

6. 发明授权

EP0484374B1 RAPID, VERSATILE AND SIMPLE SYSTEM FOR EXPRESSING GENES IN EUKARYOTIC CELLS 有权
标题翻译：快速，灵活，易于方式来表达在真核细胞中的基因
公开(公告)号：EP0484374B1
公开(公告)日：1997-09-03
申请号：EP90910982.9
申请日：1990-07-03
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
发明人： MOSS, Bernard , FUERST, Thomas , ELROY-STEIN, Orna
IPC分类号： C12N15/10 , C12N15/85
CPC分类号： C12N15/86 , C12N9/1033 , C12N9/1247 , C12N15/10 , C12N15/67 , C12N15/85 , C12N2710/24143 , C12N2770/32243
摘要： An efficient, versatile and simple expression system which confers cap-independent translation to prokaryotic RNAs in eukaryotic cells has been described. The utility of recombinant vaccinia virus for this purpose has been illustrated.

7. 发明授权

EP0520005B1 NITROXIDES FOR WEIGHT REDUCTION 失效
标题翻译：氮氧化物减肥
公开(公告)号：EP0520005B1
公开(公告)日：1997-08-27
申请号：EP91906494.9
申请日：1991-03-18
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： MITCHELL, James, B. , DeGRAFF, William, G. , HAHN, Stephen , SAMUNI, Amram
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/42 , A61K31/421
摘要： The instant invention is directed to the use of a biologically compatible composition, containing an effective amount of a metal independent nitroxide compound which is preferably represented by formula (I), wherein R1 is -CH3; R2 is -C2H5, -C3H7, -C4H9, -C5H11, -C6H13, -CH2-CH(CH3)2, -CHCH3C2H5, or -(CH2)7-CH3, or wherein R1 and R2 together form spirocyclopentane, spirocyclohexane, spirocycloheptane, spirocyclooctane, 5-cholestane, or norbornane, R3 is -Oo or -OH, or a physiologically acceptable salt thereof, and a pharmaceutically acceptable carrier, as antioxidants capable of protecting cells, tissues, organs, and whole organisms against the deleterious effects of harmful oxygen-derived species generated during oxidative stress.

8. 发明公开

EP0787492A1 Use of nitroxides and oxazolidines for protection against ionising radiation and oxidative stress 失效
标题翻译： on on on en en en Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress Stress
公开(公告)号：EP0787492A1
公开(公告)日：1997-08-06
申请号：EP97100145.8
申请日：1991-03-18
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： DeGraff, William G. , Mitchell, James B. , Hahn, Stephen , Samuni, Amram
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/42 , A61K31/421
摘要： Metal-independent nitroxides and oxazolidine compounds capable of forming oxazolidine-oxyls are useful in protecting patients from the effects of ionising radiation and oxidative stress.
摘要翻译：能够形成恶唑烷氧基的金属不依赖的氮氧化物和恶唑烷化合物可用于保护患者免受电离辐射和氧化应激的影响。

9. 发明公开

EP0773294A2 Efficient directional genetic cloning system 失效
标题翻译： Leistungsfähiges系统zur gerichteten genetischen Klonierung
公开(公告)号：EP0773294A2
公开(公告)日：1997-05-14
申请号：EP96115534.8
申请日：1990-07-30
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE
发明人： Miki, Toru , Aaronson, Stuart A. , Fleming, Timothy
IPC分类号： C12N15/16 , C07K14/71 , C12N15/10 , C12N15/85
CPC分类号： C07K14/71 , C07K14/82 , C12N15/1096 , C12N15/64 , C12N15/66
摘要： A highly efficient genetic cloning system is disclosed which is particularly useful for cloning cDNA copies of eukaryotic mRNAS and can direct the orientation of inserts in plasmid composite vectors with large cloning capacities. Cleavage of such vector DNA, by the restriction enzyme SfiI, for example, creates two different non-symmetrical 3' extensions at the ends of vector DNA. Using a linker-primer and an adaptor, cDNA is prepared to have two different sticky ends which can be ligated to those of the vector. When the cDNA fragments and the vector DNAs are mixed, both the molecules can assemble without self-circularization due to base-pairing specificity. This system provides (1) high cloning efficiency (10 7 -10 8 clones/g poly (A) + RNA), (2) low background (more than 90% of the clones contain inserts), (3) directional insertion of cDNA fragments into the vectors, (4) presence of a single insert in each clone, (5) accommodation of long inserts (up to 10kb), (6) a mechanism for rescue of the plasmid part from a λ genome, and (7) a straightforward protocol for library preparation.
摘要翻译：公开了一种高效的遗传克隆系统，其特别可用于克隆真核mRNA的cDNA拷贝，并且可以以大克隆能力指导插入片段在质粒复合载体中的取向。例如，通过限制性酶SfiI切割这种载体DNA，在载体DNA的末端产生两个不同的非对称3'延伸。使用接头引物和衔接子，制备cDNA具有可以与载体连接的两个不同的粘性末端。当cDNA片段和载体DNA混合时，由于碱基配对特异性，两个分子都可以组装而不进行自身循环。该系统提供（1）高克隆效率（10 -7 -10 -10克隆/克聚（A）+ RNA），（2）低背景（超过90％的克隆含有插入片段），（ 3）将cDNA片段定向插入到载体中，（4）每个克隆中存在单个插入片段，（5）长插入片段（最多10kb）的适应性，（6）从λ的拯救质粒部分的机制基因组，和（7）图书馆准备的直接协议。

10. 发明授权

EP0485431B1 PARTIAL AGONISTS OF THE STRYCHNINE INSENSITIVE GLYCINE MODULATORY SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX AS NEUROPSYCHOPHARMACOLOGICAL AGENTS 失效
标题翻译： N-甲基-D-天冬氨酸受体复合AS NEURO心理药理学物质士的宁不敏感的GLYCINMODULIERENDEN点的部分激动剂
公开(公告)号：EP0485431B1
公开(公告)日：1997-02-19
申请号：EP90911501.6
申请日：1990-08-02
申请人： THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce
发明人： SKOLNICK, Phil , LEWIN, Anita , MARVIZON, Juan-Carlos , MONN, James , RICE, Kenner
IPC分类号： A61K31/195 , A61K31/215
CPC分类号： A61K31/195 , A61K31/215
摘要： A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which method comprises administering an effective neuropsychopharmacological disorder-treating amount of a compound possessing partial agonist properties for the strychnine insensitive glycine modulatory sites of N-methyl-D-aspartate receptors. Exemplary of partial agonists which are useful in the method of the invention are 1-aminocyclopropanecarboxylic acid, and associated derivates thereof. Novel injectable pharmaceutical compositions are also disclosed.

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