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1. 发明授权

EP3075840B1 DEVICE FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTIMICROBIAL DRUGS 有权转让
公开(公告)号：EP3075840B1
公开(公告)日：2018-10-17
申请号：EP14866121.8
申请日：2014-10-27
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12M1/26 , C12Q1/06 , C12Q1/18
CPC分类号： C12Q1/18 , C12M23/12 , C12M41/34
摘要： The invention relates to the field of microbiology. A device for determining the sensitivity of microorganisms to antimicrobial drugs is configured in the form of a sterile plate made from a plastic material with indentations and is provided with a hermetically sealing element which covers the sterile plate. The indentations are filled with a solid culture medium containing agar. In different indentations, the culture medium contains antimicrobial drugs or combinations thereof or serves as a control. Between the plate and the hermetically sealing element, the device contains a moisture-absorbing material with a rigid mesh situated therebelow. The device is provided with a transparent protective lid made from a rigid durable plastic.

2. 发明公开

EP3384918A1 DRUGS (VARIANTS) AND METHODS FOR RESTORING MICROFLORA 有权
公开(公告)号：EP3384918A1
公开(公告)日：2018-10-10
申请号：EP16871132.3
申请日：2016-12-02
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： A61K35/66 , C12N1/20
CPC分类号： A61K35/66 , C12N1/20
摘要： The invention relates to microbiology and medicine and can be used to prevent and treat diseases and conditions associated with disruption of normal (autochthonous) microflora (microbiota) in humans or animals. In particular, a solution for recovery or creation of the subject's microflora comprising an active component containing microorganisms isolated from the microflora of the subject or the donor, wherein the active component can be enriched with bacteriophages of said microflora and/or additional microorganisms of the microflora cultivated on a nutrient medium, while the additional microorganisms of the microflora include microorganisms of the microflora that are yet nonculturable in the absence of the host organism, is proposed. Also provided are a pharmaceutical dosage form comprising the above solution and methods for prevention or treatment of diseases and/or conditions associated with and/or accompanied by a disorder or lack of the subject's own microflora, comprising administering the solution or pharmaceutical dosage form.

3. 发明公开

EP3315597A1 NUTRIENT MEDIUM FOR CULTIVATING BACTERIA 有权
标题翻译：培养细菌的营养培养基
公开(公告)号：EP3315597A1
公开(公告)日：2018-05-02
申请号：EP16814798.1
申请日：2016-06-23
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12N1/20 , C12R1/01
CPC分类号： C12N1/20 , C12R1/01
摘要： The invention relates to microbiology, and more particularly to nutrient media used for cultivating bacteria for the subsequent study thereof. A nutrient medium comprising a pancreatic digest of casein, a peptic digest of meat, a heart pancreatic digest, yeast extract, starch and water is characterized in that it additionally contains violuric acid and beef infusion, wherein the ratio of ingredients is (wt%): 0.3-1.0 pancreatic digest of casein; 0.1-1.5 peptic digest of meat; 0.1-0.9 heart pancreatic digest; 0.1-2.0 yeast extract, 0.3-0.8 starch; 0.001-0.05 violuric acid; 2.0-15 beef infusion; the remainder water. The nutrient medium can additionally contain 0.3-2.5 wt% agar-agar and/or 1-20 wt% whole or hemolyzed sheep red blood cells and/or 1-20 wt% whole or hemolyzed human red blood cells and/or 1-15 wt% horse blood serum. This provides for the simultaneous growth of the maximum possible number of bacteria present in an inoculate.
摘要翻译：本发明涉及微生物学，并且更具体地涉及用于培养细菌的营养培养基以用于随后的研究。包含胰酪氨酸消化液，肉消化液消化液，心脏胰脏消化液，酵母提取物，淀粉和水的营养培养基，其特征在于它还含有紫苏酸和牛肉浸液，其中成分比例为（wt％）：0.3-1.0胰酪氨酸消化物; 0.1-1.5消化肉消化; 0.1-0.9心脏胰腺消化; 0.1-2.0酵母提取物，0.3-0.8淀粉; 0.001-0.05三聚乙酸; 2.0-15牛肉输液; 剩下的水。营养培养基可另外含有0.3-2.5重量％琼脂琼脂和/或1-20重量％全血或溶血羊红细胞和/或1-20重量％全血或溶血的人红细胞和/或1-15 wt％马血清。这提供了接种物中存在的最大可能数量的细菌的同时增长。

4. 发明公开

EP3162800A4 FUNGICIDAL AGENT 审中-实审
公开(公告)号：EP3162800A4
公开(公告)日：2018-01-10
申请号：EP14896241
申请日：2014-06-24
申请人： TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
发明人： KRUTIKOV VIKTOR IOSIFOVICH
IPC分类号： A01N43/54 , A01N25/12 , A01P3/00 , A61K31/513 , A61P31/10 , C07D239/10
CPC分类号： A61K31/513 , A01N33/08 , A01N43/54 , A61K31/133 , C07C215/10 , C07D239/10 , C07D239/545 , A01N25/12
摘要： The invention relates to a novel fungicidal agent in the form of a salt associate having the structural formula shown. The agent can be used for treating diseases caused by fungi, and also for preventing fungal damage to various materials and agricultural products. The present fungicidal agent is an associate of 5-[3,5-dichloro-2-hydroxy benzylidene)amino]-4-hydroxy-1H-pyrimidine-2-on with 1,2,3,4,5-pentahydroxy-6-methylaminohexane and has the formula (I). This fungicidal agent exhibits a broad range of activity and high solubility, which increases the effectiveness of the use thereof in the form of solutions. Compounds were obtained in a crystalline form, and the structure thereof was established by means of magnetic resonance spectra in dimethyl sulfoxide.

5. 发明公开

EP3006020A1 METHOD FOR TREATING RECURRING SKIN AND MUCOUS MEMBRANE DISEASES CAUSED BY HSV-1 AND HSV-2 有权
标题翻译：方法用于治疗由HSV-1和HSV-2引起RECURRING皮肤和粘膜疾病
公开(公告)号：EP3006020A1
公开(公告)日：2016-04-13
申请号：EP14806838.0
申请日：2014-06-06
申请人： Tets, Viktor Veniaminovich , TETS, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , TETS, Georgy Viktorovich
IPC分类号： A61K9/02 , A61K9/06 , A61K31/63 , A61P31/22
摘要： The invention relates to medicine and specifically to methods for treating recurring forms of diseases related to the family of herpes viruses. A method for treating recurring diseases of the skin and mucous membranes caused by HSV-1 and HSV-2 involves applying a preparation to an affected area, said preparation including a base containing 0.5% or 1% of an active substance, namely a (2,6-dichlorophenyl)amide salt of carbopentoxysulfanilic acid of general formula (I): where X is Na, K, NH 4 ; the preparation is applied twice daily for 3-5 days and, should prodromes appear, a second course of treatment is carried out, in which the preparation is applied 1-2 times daily for 2-3 days; the base containing the active substance can be in the form of a cream, an ointment, a gel, a suspension, suppositories, a patch or a film. Carrying out the second course of treatment provides a sharp increase in therapeutic efficacy, even to the extent of preventing relapse over a prolonged period of observation as a result of the effect of the preparation, upon reuse, on the viruses persisting in nerve cells.

6. 发明公开

EP1661579A4 METHOD FOR TREATING DISEASES ASSOCIATED WITH CHANGES OF QUALITATIVE AND/ QUANTITATIVE COMPOSITION OF BLOOD EXTRACELLULAR DNA 失效转让
标题翻译： METHOD FOR疾病治疗用的质量和/或额外的细胞DNA定量组成变化相关
公开(公告)号：EP1661579A4
公开(公告)日：2009-11-25
申请号：EP04775224
申请日：2004-07-01
申请人： GENKIN DMITRY DMITRIEVICH , TETS VIKTOR VENIAMINOVICH
发明人： GENKIN DMITRY DMITRIEVICH , TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
IPC分类号： A61K38/43 , A61K38/47 , A61K20060101 , A61K38/46 , A61K38/50 , A61P3/10 , A61P9/10 , A61P31/00
CPC分类号： A61K38/465 , C12Y301/21001

7. 发明公开

EP1669357A1 SUBSTANCE WHICH EXHIBITS ANTIVIRAL AND ANTIBACTERIAL ACTIVITY AND IS BASED ON DERIVATIVES OF 2,8-DITHIOXO-1H-PYRANO 2,3D&cedi l;6,5-D DIPYRIMIDYNE AND 10-AZA-ANALOGUE THEREOF 审中-公开
标题翻译： SUBSTANZ MIT ANTIVIRALER UND ANTIBAKTERIELLER WIRKUNG AUF DER B
公开(公告)号：EP1669357A1
公开(公告)日：2006-06-14
申请号：EP03810030.1
申请日：2003-11-05
申请人： Tets, Viktor Veniaminovich , Krasnov, Konstantin Andreevich , Ashkinazi, Rimma Iliinichna
发明人： TETS, Viktor Veniaminovich , KRASNOV, Konstantin Andreevich , ASHKINAZI, Rimma Iliinichna
IPC分类号： C07D491/147 , C07D471/14 , A61K31/519 , A61P31/00
CPC分类号： C07D471/14 , C07D491/14
摘要： The inventive substance which exibits antiviral and antibacterial activity is based on derivatives of 2,8-dithioxo-1H-pyrano[2,3-d; 6,5-d']dipyrimidine and 10-aza-analogue, differs in that comprises the derivative of said group of general formula A1 * M:

where: X is selected from a group of O, NH, N-Alkyl;
R1 is selected from the group of H, OH, Cl, O-Alkyl, NH 2 , NH-Alkyl, NH-Ar, N(Alkyl) 2 , SH, S-Alkyl, S-Ar, S-Hetaryl;
R2 is selected from the group of C6H5, Aryl;
R3 is selected from the group of H, Cl, O-Alkyl, NH2, NH-Alkyl, NH-Ar, S-Hetaryl;
M-is absent or is selected from a group: cation Na, K, Li, ammonium or any other pharmacologically acceptable cation or complex of pharmacologically acceptable cation (see above) with anion of one of derivatives of A1 (variants R1-R3 are given above).
摘要翻译：发挥抗病毒和抗菌活性的本发明物质是基于2,8-二硫代-1H-吡喃并[2,3-d 6,5-d']二嘧啶和10-氮杂 - 类似物的不同之处在于包含通式A1 * M的所述基团的衍生物：其中：X选自O，NH，N-烷基; R 1选自H，OH，Cl，O-烷基，NH 2，NH-烷基，NH-Ar，N（烷基）2，SH，S-烷基，S-Ar，S-杂芳基; R2选自C6H5，Aryl; R 3选自H，Cl，O-烷基，NH 2，NH-烷基，NH-Ar，S-杂芳基; M不存在或选自阳离子Na，K，Li，铵或药理学上可接受的阳离子（见上文）与A1衍生物之一的阴离子的任何其他药学上可接受的阳离子或络合物（变体R1-R3）以上）。

8. 发明公开

EP1655036A1 METHOD FOR TREATING ONCOLOGICAL DISEASES 失效转让
标题翻译： VERFAHREN ZUR BEHANDLUNG VON ONKOLOGISCHEN ERKRANKUNGEN
公开(公告)号：EP1655036A1
公开(公告)日：2006-05-10
申请号：EP04748955.4
申请日：2004-07-01
申请人： GENKIN, Dmitry Dmitrievich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , TETS, Viktor Veniaminovich , TETS, Georgy Viktorovich
IPC分类号： A61K38/43 , A61K39/395 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/465 , A61K38/48 , A61K2039/505 , A61K2039/53 , C07K16/44 , C12Y301/21001 , A61K2300/00
摘要： The invention relates to medicine and veterinary science and can be used for treating mainly solid tumors. The inventive method for treating oncological diseases consisting in injecting a blood extracellular DNA destroying agent into a systemic blood circulation. Said blood extracellular DNA destroying agent can be embodied in the form of a DNAse enzyme, in particular a bovine pancreatic DNAse which is parenterally injected in doses ranging from of 50 000 Kunz units to 250 000 000 Kunz units a day every day during 5-360 days or in the form of a recombinant human DNAse. In addition, a blood extracellular DNA binding agent embodied in the form of anti-DNA antibodies can be injected into a systemic blood circulation. In addition a modified agent which modifies the chemical composition and/or conformation and/or polymery and/or an association with proteins and/or lipids and/or ribonucleic acids of the blood extracellular DNA. Said modifying agent can be embodied in the form of a enzyme-ribonuclease. An extracellular ribonuclease of a Serratia Mercenses bacterium can be used in the form of said agents.
摘要翻译：本发明涉及医学和兽医学，可用于主要治疗实体瘤。用于治疗肿瘤疾病的本发明的方法，其包括将血液细胞外DNA破坏剂注入全身血液循环中。所述血液细胞外DNA破坏剂可以以DNA酶，特别是牛胰腺DNAse的形式体现，其中每天在5-360之间每天以5万盎司单位至2.5万盎司单位的肠胃外注射天或重组人DNAse的形式。此外，以抗DNA抗体形式体现的血液细胞外DNA结合剂可以注射到全身血液循环中。另外还可以改变与细胞外DNA的蛋白质和/或脂质和/或核糖核酸的化学组成和/或构象和/或聚合和/或结合的修饰剂。所述改性剂可以以酶 - 核糖核酸酶的形式实施。沙雷氏菌属细菌的细胞外核糖核酸酶可以以所述药剂的形式使用。

9. 发明公开

EP1033369A4 5H-PYRANO [2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY 失效
标题翻译： -5H-吡喃并[2,3-D：6,5-D“] dipyrimidine衍生物具有抗菌，抗病毒和免疫调节效应
公开(公告)号：EP1033369A4
公开(公告)日：2001-07-18
申请号：EP97954962
申请日：1997-11-19
申请人： TETS VIKTOR VENIAMINOVICH
发明人： ASHKINAZI RIMMA ILIINICHNA
IPC分类号： A61K31/519 , A61P31/04 , A61P31/12 , A61P31/22 , A61P35/00 , A61P37/02 , C07D491/14 , C07D491/147 , A61K31/505
CPC分类号： C07D491/14
摘要： The present invention relates to the production of new substances having an antibacterial, antiviral, immuno-modulating and anti-tumoral activity. This invention more precisely relates to the synthesis of 5H-pyrano[2,3-d:6,5-d']dipyrimidine derivatives of general formula (I) where R1 represents a hydroxy group, a mercapto group or halogen, R2 represents a hydroxy group, an alkoxy group or halogen and R3 is hydrogen or aryl. In the preferred embodiments of the above-mentioned substances, the following conditions are observed: when R?1=R2=OH, R3=4-O¿2NC6H4 (I); when R?1=R2=Cl, R3=C¿6H5 (II); when R?1=R2=OH, R3=4-IC¿6H4 (III); when R?1=R2=OH, R3¿=H (IV); when R?1=OH, R2=OCH¿3 and R3=4-O2NC6H4 (V); when R?1=R2=OH, R3¿=4-ClC¿6?H4 (VI); when R?1=R2=OH, R3¿=4-BrC¿6?H4 (VII); when R?1=SH, R2¿=OH and R3=4-ClC¿6?H4 (VIII); and when R?1=SH, R2¿=OH and R3=4-O2NC6H4 (IX).

10. 发明公开

EP3634442A1 METHODS FOR TREATING AND PREVENTING DISEASES 审中-实审
公开(公告)号：EP3634442A1
公开(公告)日：2020-04-15
申请号：EP18805942.2
申请日：2018-04-20
申请人： Tets, Viktor, Veniaminovich , Tets, Georgy, Viktorovich
发明人： Tets, Viktor, Veniaminovich , Tets, Georgy, Viktorovich
IPC分类号： A61K35/741 , A61K35/745 , A61K35/747 , C12Q1/70

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