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1. 发明公开

EP3216464A1 PROCESS FOR PREPARATION OF BEADS FOR IMAGING 审中-公开
标题翻译：制备用于成像的小珠的过程
公开(公告)号：EP3216464A1
公开(公告)日：2017-09-13
申请号：EP16159884.2
申请日：2016-03-11
申请人： Stichting Katholieke Universiteit Nijmegen
发明人： Srinivas, Mangala , Koshkina, Olga , Figdor, Carl Gustav , de Vries, Ingrid Jolanda Monique
IPC分类号： A61K49/00 , A61K49/18 , A61K49/22 , G01N29/04 , G01N29/24 , G01N24/08
CPC分类号： A61K49/223 , A61K49/0002 , A61K49/1818 , G01N29/2418 , G01N2291/02475 , G01R33/281
摘要： The invention relates to a process for the preparation of beads comprising a biocompatible hydrophobic polymer, a perfluorocarbon and optionally a metal compound, comprising the steps of:
a) adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture,
b) adding the first liquid mixture to an aqueous solution of a biocompatible surfactant under sonication to obtain a second liquid mixture,
c) maintaining the sonication of the second liquid mixture while cooling,
d) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads comprising the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound,
e) separating the beads from the suspension and preparing a water suspension of the beads and
f) freeze-drying the water suspension to obtain the beads,
wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most 10 seconds,
wherein the sonication in step b) and the sonication in step c) are performed by a probe at an amplitude of at least 240 µm for 1-10 minutes and
wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1.
摘要翻译：本发明涉及制备包含生物相容性疏水性聚合物，全氟化碳和任选的金属化合物的珠粒的方法，其包括以下步骤：a）将全氟化碳和任选的金属化合物加入生物相容性疏水性聚合物在 b）在超声处理下将第一液体混合物加入到生物相容表面活性剂的水溶液中以获得第二液体混合物，c）在冷却的同时维持第二液体混合物的超声处理，d）蒸发从第二液体混合物中分离极性溶剂以获得包含生物相容性疏水性聚合物，全氟化碳和任选的金属化合物的珠粒的悬浮液，e）从珠粒中分离珠粒并制备珠粒的水悬浮液，以及f）水悬浮液以获得珠子，其中将第一液体混合物添加至生物相容性物质步骤b）中的表面活性剂在至多10秒的时间内进行，其中步骤b）中的超声处理和步骤c）中的超声处理通过探针在至少240μm的幅度下进行1-10分钟，并且其中生物相容性表面活性剂与生物相容性疏水性聚合物的重量比至少为3：1。

2. 发明授权

EP3191823B1 SABRE NMR ANALYSIS METHOD 有权
公开(公告)号：EP3191823B1
公开(公告)日：2019-11-20
申请号：EP15760442.2
申请日：2015-09-08
申请人： Stichting Katholieke Universiteit Nijmegen
发明人： RUTJES, Floris Petrus Johannes Theodorus , FEITERS, Martinus Christiaan , VAN WEERDENBURG, Bram Johannes Arnoldus , ESHUIS, Nan , HERMKENS, Niels Koen Jan , TESSARI, Marco
IPC分类号： G01N24/08 , G01R33/46 , G01R33/465 , G01R33/28
摘要： The invention provides a method for the detection with SABRE magnetic resonance of an analyte at an unknown concentration Csub in a complex sample, the method comprising: (a) providing a series of mixtures M1, M2, …, Mn, wherein each mixture comprises a predefined part of the complex sample comprising the analyte, a SABRE catalyst at a concentration Cm, and especially also a co-substrate at a concentration Cco-sub, wherein Csub

3. 发明授权

EP3069347B1 MAGNETO-OPTICAL DEVICE 有权
公开(公告)号：EP3069347B1
公开(公告)日：2018-09-19
申请号：EP14800173.8
申请日：2014-11-14
申请人： Stichting Katholieke Universiteit Nijmegen
发明人： RASING, Theodorus Henricus Maricus Maria , SAVOINI, Matteo
IPC分类号： G11C13/06 , G11C13/04 , G11C11/16 , G11B11/10
CPC分类号： G11C11/02 , G11C11/16 , G11C13/04 , G11C13/06
摘要： A magneto-optical device comprising a magnetic unit and an optical unit, an electronic device comprising the magneto-optical device, a method of energy saving using the magneto-optical device, an array comprising the magneto-optical devices, and a method of changing magnetic orientation.

4. 发明公开

EP3069347A2 MAGNETO-OPTICAL DEVICE 有权
标题翻译：磁光学设备
公开(公告)号：EP3069347A2
公开(公告)日：2016-09-21
申请号：EP14800173.8
申请日：2014-11-14
申请人： Stichting Katholieke Universiteit Nijmegen
发明人： RASING, Theodorus Henricus Maricus Maria , SAVOINI, Matteo
IPC分类号： G11C13/06 , G11C13/04 , G11C11/16 , G11B11/10
CPC分类号： G11C11/02 , G11C11/16 , G11C13/04 , G11C13/06
摘要： A magneto-optical device comprising a magnetic unit and an optical unit, an electronic device comprising the magneto-optical device, a method of energy saving using the magneto-optical device, an array comprising the magneto-optical devices, and a method of changing magnetic orientation.

5. 发明公开

EP3191823A1 SABRE NMR ANALYSIS METHOD 有权
标题翻译： SABER核磁共振分析方法
公开(公告)号：EP3191823A1
公开(公告)日：2017-07-19
申请号：EP15760442.2
申请日：2015-09-08
申请人： Stichting Katholieke Universiteit Nijmegen
发明人： RUTJES, Floris Petrus Johannes Theodorus , FEITERS, Martinus Christiaan , VAN WEERDENBURG, Bram Johannes Arnoldus , ESHUIS, Nan , HERMKENS, Niels Koen Jan , TESSARI, Marco
IPC分类号： G01N24/08 , G01R33/46 , G01R33/465 , G01R33/28
摘要： The invention provides a method for the detection with SABRE magnetic resonance of an analyte at an unknown concentration Csub in a complex sample, the method comprising: (a) providing a series of mixtures M1, M2, …, Mn, wherein each mixture comprises a predefined part of the complex sample comprising the analyte, a SABRE catalyst at a concentration Cm, and especially also a co-substrate at a concentration Cco-sub, wherein Csub
摘要翻译：本发明提供了一种利用SABER磁共振检测复杂样品中未知浓度Csub的分析物的方法，所述方法包括：（a）提供一系列混合物M1，M2，...，Mn，其中每种混合物包含包含分析物的复合物样品的预定义部分，浓度为Cm的SABRE催化剂，特别是浓度为Cco-sub的共底物，其中Csub

6. 发明授权

EP0715714B1 A MEASURING DEVICE FOR MEASURING THE INTENSITY AND/OR POLARIZATION OF ELECTROMAGNETIC RADIATION, FOR DETERMINING PHYSICAL PROPERTIES OF A PREPARATION, AND FOR READING INFORMATION FROM A STORAGE MEDIUM 失效
标题翻译：测量装置用于确定所述强度和/或极化电磁辐射和制备例和装置的物理测定特性信息读取从存储设备
公开(公告)号：EP0715714B1
公开(公告)日：1997-05-07
申请号：EP95900322.9
申请日：1994-09-16
申请人： STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN
发明人： VAN KEMPEN, Herman , ABRAHAM, D. L., Stichting Kath. Univ. Nijmegen , PRINS, Menno, Willem, José , JANSEN, Ronald , VAN DER WIELEN, Maurice C. M. M.
IPC分类号： G01N27/00 , G02B21/00 , G11B9/00
CPC分类号： G01Q60/16 , G01Q30/02 , G01Q60/02 , G01Q60/12 , G01Q60/14 , G01Q60/22 , G01R33/032 , G11B9/14 , G11B9/1463 , G11B11/007 , G11B11/10515 , G11B11/10545 , G11B13/045 , Y10S977/834 , Y10S977/852 , Y10S977/868 , Y10S977/95 , Y10S977/954 , Y10S977/96
摘要： A measuring device for measuring the intensity and/or polarization of electromagnetic radiation, more in particular of light. The measuring device is provided with a tunnel tip arranged facing a body at some distance, which tunnel tip at least partly consists of a semiconductor material. The measuring device further comprises a control unit for obtaining information about the intensity and/or polarization of the radiation by means of a tunnel current, generated under the influence of the radiation in the tunnel tip, between the tunnel tip and the body and/or a surface photovoltage of the tunnel tip, generated under the influence of the radiation. The device can be used as near field microscope, polarization selective near field detector. In one special embodiment the body forms an information storage medium.

7. 发明公开

EP0715714A1 A MEASURING DEVICE FOR MEASURING THE INTENSITY AND/OR POLARIZATION OF ELECTROMAGNETIC RADIATION, FOR DETERMINING PHYSICAL PROPERTIES OF A PREPARATION, AND FOR READING INFORMATION FROM A STORAGE MEDIUM 失效
标题翻译：测量器具，用于确定强度和/或极化电磁辐射和物理特征测定...
公开(公告)号：EP0715714A1
公开(公告)日：1996-06-12
申请号：EP95900322.0
申请日：1994-09-16
申请人： STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN
发明人： VAN KEMPEN, Herman , ABRAHAM, D. L., Stichting Kath. Univ. Nijmegen , PRINS, Menno, Willem, José , JANSEN, Ronald , VAN DER WIELEN, Maurice C. M. M.
IPC分类号： G01N27 , G01Q30 , G01Q60 , G01R33 , G11B9 , G11B11 , G11B13
CPC分类号： G01Q60/16 , G01Q30/02 , G01Q60/02 , G01Q60/12 , G01Q60/14 , G01Q60/22 , G01R33/032 , G11B9/14 , G11B9/1463 , G11B11/007 , G11B11/10515 , G11B11/10545 , G11B13/045 , Y10S977/834 , Y10S977/852 , Y10S977/868 , Y10S977/95 , Y10S977/954 , Y10S977/96
摘要： A measuring device for measuring the intensity and/or polarization of electromagnetic radiation, more in particular of light. The measuring device is provided with a tunnel tip arranged facing a body at some distance, which tunnel tip at least partly consists of a semiconductor material. The measuring device further comprises a control unit for obtaining information about the intensity and/or polarization of the radiation by means of a tunnel current, generated under the influence of the radiation in the tunnel tip, between the tunnel tip and the body and/or a surface photovoltage of the tunnel tip, generated under the influence of the radiation. The device can be used as near field microscope, polarization selective near field detector. In one special embodiment the body forms an information storage medium.

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