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1. 发明授权

EP3329925B1 POLYION COMPLEX CAPABLE OF DELIVERING MRNA INTO LIVING BODY FOR TREATING ARTHROPATHY 有权转让
公开(公告)号：EP3329925B1
公开(公告)日：2021-01-13
申请号：EP16832944.9
申请日：2016-07-29
发明人： ITAKA, Keiji , OHBA, Shinsuke , TEI, Yuichi , KATAOKA, Kazunori
IPC分类号： A61K31/7105 , A61K47/34 , A61K47/42 , A61K48/00 , A61P19/02 , A61P29/00 , A61K9/107 , C12N15/09 , A61K47/60 , A61K47/64 , A61K47/69 , A61K9/00

2. 发明公开

EP3150194A1 PARTICLE COMPOSITION AND MEDICINAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：巴西马萨诸塞州民主共和国ZUSAMMENSETZUNG DAMIT
公开(公告)号：EP3150194A1
公开(公告)日：2017-04-05
申请号：EP16195540.6
申请日：2010-08-31
申请人： NanoCarrier Co., Ltd.
发明人： KATO, Yasuki , ISHII, Atsushi
IPC分类号： A61K9/10 , A61K9/16 , A61K31/7088 , A61K31/715 , A61K38/00 , A61K47/34 , A61K47/44
CPC分类号： A61K31/7088 , A61K9/107 , A61K9/1271 , A61K9/1272 , A61K31/715 , A61K38/38 , C12N15/88
摘要： The present invention provides a polymeric micelle comprising: block copolymer units being arranged radially with hydrophobic polymer-chain segments radially inside and hydrophilic polymer-chain segments radially outside; and a charged lipid which carries a charge opposite to the charge of a drug to be encapsulated, the charged lipid being attracted to the hydrophobic polymer-chain segment. In this polymeric micelle, the drug is retained within the micelle via electrostatic binding with the charged lipid, whereby the outer surface of the micelle is prevented from being charged to attract a substance which has a charge opposite to that of the charged lipid.
摘要翻译：本发明提供了一种聚合物胶束，其包括：嵌段共聚物单元径向排列有疏水性聚合物链段，并且在其外部具有亲水性聚合物链段; 和带电荷的脂质，其携带与要包封的药物的电荷相反的电荷，所述带电脂质被吸引到疏水性聚合物链段。在该聚合物胶束中，药物通过与带电脂质的静电结合而保留在胶束内，从而防止胶束的外表面被带电以吸引具有与带电脂质相反的电荷的物质。

3. 发明公开

EP2997979A1 POLYMERIC MICELLE PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药剂师ZUSAMMENSETZUNG MIT POLYMEREN MIZELLEN
公开(公告)号：EP2997979A1
公开(公告)日：2016-03-23
申请号：EP14797011.5
申请日：2014-05-16
申请人： NanoCarrier Co., Ltd.
发明人： KATO, Yasuki , HARADA, Mitsunori , TANAKA, Ryosuke
IPC分类号： A61K47/34 , A61K9/107
CPC分类号： A61K47/48692 , A61K9/107 , A61K9/1075 , A61K31/337 , A61K47/10 , A61K47/34 , A61K47/645 , A61K47/6883
摘要： A polymer micelle pharmaceutical composition is provided and includes: a block copolymer unit α having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; and a block copolymer unit β having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment, wherein: the block copolymer unit α and the block copolymer unit β are radially arranged in the state in which the hydrophilic polymer chain segments are directed outward and the hydrophobic polymer chain segments are directed inward; and the hydrophobic polymer chain segment of the block copolymer unit α is constituted of repeating units having side chains , at least one of the side chains having a hydrophilic group.
摘要翻译：提供聚合物胶束药物组合物，其包括：具有亲水性聚合物链段和疏水性聚合物链段的嵌段共聚物单元; 和具有亲水性聚合物链段和疏水性聚合物链段的嵌段共聚物单元，其中：嵌段共聚物单元和嵌段共聚物单元2在亲水性聚合物链段向外指向的状态下径向布置，疏水性聚合物链段向内指向; 并且嵌段共聚物单元的疏水性聚合物链段±由具有侧链的重复单元构成，至少一个侧链具有亲水性基团。

4. 发明公开

EP2781536A1 BLOCK COPOLYMER HAVING PHENYLBORONIC ACID GROUP INTRODUCED THEREIN, AND USE THEREOF 有权
标题翻译：封闭胶原蛋白整合剂PHENYLBORSÄUREGRUPPEUND VERWENDUNG
公开(公告)号：EP2781536A1
公开(公告)日：2014-09-24
申请号：EP12850688.8
申请日：2012-11-19
申请人： The University of Tokyo , National University Corporation Tokyo Medical and Dental University , NanoCarrier Co., Ltd.
发明人： KATAOKA, Kazunori , ISHII, Takehiko , NAITO, Mitsuru , MATSUMOTO, Akira , KATO, Yasuki
IPC分类号： C08G81/00
CPC分类号： A61K47/48323 , A61K31/713 , A61K47/48215 , A61K47/60 , A61K47/6455 , C08G69/40 , C08G69/42 , C08G81/00 , C08G2650/28
摘要： The present invention provides a block copolymer as a carrier that simultaneously achieves stability of a biotechnology-based drug in blood and drug-releasing property of the drug at an affected area. The block copolymer of the present invention is a block copolymer, including: a polyamino acid chain segment; and a hydrophilic polymer chain segment, wherein the polyamino acid chain segment includes an amino acid residue having a cationic group in a side chain and an amino acid residue having a substituted phenylboronic acid group in a side chain, the substituted phenylboronic acid group having a phenyl ring in which at least one hydrogen atom is substituted to have a pKa around a physiological pH.
摘要翻译：本发明提供了一种作为载体的嵌段共聚物，其同时使得生物技术型药物在血液中的稳定性和药物在患处的药物释放性质。本发明的嵌段共聚物是嵌段共聚物，包括：聚氨基酸链段; 和亲水性聚合物链段，其中所述聚氨基酸链段包含在侧链具有阳离子基团的氨基酸残基和在侧链中具有取代的苯基硼酸基团的氨基酸残基，所述取代的苯基硼酸基团具有苯基其中至少一个氢原子被取代以在生理pH附近具有pKa。

5. 发明公开

EP2666482A1 PARTICLE COMPOSITION AND PHARMACEUTICAL COMPOSITION USING PARTICLE COMPOSITION 审中-公开
标题翻译：巴西辣椒酱药用植物精油芝麻子酱巴西辣椒酱
公开(公告)号：EP2666482A1
公开(公告)日：2013-11-27
申请号：EP12733905.9
申请日：2012-01-16
申请人： The University of Tokyo , NanoCarrier Co., Ltd.
发明人： KATAOKA, Kazunori , CHRISTIE, Ronald James , NISHIYAMA, Nobuhiro , MIYATA, Kanjiro , FUKUSHIMA, Shigeto , MATSUMOTO, Yu , NOMOTO, Takahiro , KATO, Yasuki
IPC分类号： A61K47/34 , A61K9/10 , A61K31/7088 , A61K48/00 , C07K14/00 , C12N15/113
CPC分类号： A61K9/5031 , A61K9/107 , A61K31/711 , A61K31/713 , A61K38/193 , A61K47/60 , A61K47/6455
摘要： The present invention provides a block copolymer applicable as a drug carrier capable of forming a stable complex with a nucleic acid and releasing the nucleic acid in cells. The block copolymer is represented by the following formula (1) or (2)

where: R 1 and R 2 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 12 carbon atoms which may have a substituent; A represents a hydrophilic polymer chain; L 1 and L 3 each represent a linking group; B represents a cation-containing group; R 3 represents a side chain of any appropriate amino acid; z represents an integer of 5 to 500; x represents an integer of 40% or more of z; y represents an integer and may represent 0; z-x-y represents an integer and may represent 0; p represents an integer of 1 to 10; and q represents an integer of 1 to 10.
摘要翻译：本发明提供了可用作能够与核酸形成稳定的复合物并在细胞中释放核酸的药物载体的嵌段共聚物。嵌段共聚物由下式（1）或（2）表示，其中：R 1和R 2各自独立地表示氢原子或可具有取代基的碳原子数1〜12的直链或支链烷基; A表示亲水性聚合物链; L 1和L 3各自表示连接基团; B表示含阳离子基团; R 3表示任何合适的氨基酸的侧链; z表示5〜500的整数， x表示z的40％以上的整数。 y表示整数，可以表示0; z-x-y表示整数，可以表示0; p表示1〜10的整数， q表示1〜10的整数。

6. 发明公开

EP2042184A4 PHYSIOLOGICALLY ACTIVE POLYPEPTIDE, POLYMER MICELLE HAVING PROTEIN ENCLOSED THEREIN, AND PROCESS FOR PRODUCTION OF THE POLYMER MICELLE 审中-公开
标题翻译： PHYSIOLOGISH活性多肽，根据上述制造的高分子胶粒封闭于其中的蛋白质和PROCESS聚合物胶束
公开(公告)号：EP2042184A4
公开(公告)日：2013-10-30
申请号：EP07742839
申请日：2007-04-25
申请人： NANOCARRIER CO LTD
发明人： OHUCHI MIHO , HARADA MITSUNORI , AMANO YUKO , KATO YASUKI
IPC分类号： A61K47/32 , A61K9/00 , A61K9/10 , A61K9/107 , A61K31/337 , A61K31/4375 , A61K47/34 , A61K47/48 , A61P1/04 , A61P1/16 , A61P1/18 , A61P13/02 , A61P13/12 , A61P15/00 , A61P35/00
CPC分类号： A61K9/1075 , A61K9/0019 , A61K38/00 , A61K47/34
摘要： The invention provides a physiologically active polypeptide- or protein-encapsulating polymer micelle composition derived from a block copolymer comprising hydrophilic segments and hydrophobic segments.

7. 发明授权

EP2474310B1 Method for producing polymerized coordination compounds of platinum complex 失效
标题翻译：一种用于生产的铂络合物的聚合配位化合物处理
公开(公告)号：EP2474310B1
公开(公告)日：2013-08-21
申请号：EP12162996.8
申请日：2006-06-08
申请人： NanoCarrier Co., Ltd. , The University of Tokyo
发明人： Kobayashi, Katsutoshi , Nagasaki, Shoko , Kataoka, Kazunori , Tsuchiya, Chieko
IPC分类号： A61K31/282 , C07F15/00 , C08G69/10 , C08G69/42
CPC分类号： C07F15/0093 , C08G69/10 , C08G69/42 , Y02P20/55

8. 发明公开

EP2397487A4 SHORT-CHAIN CATIONIC POLYAMINO ACID AND USE THEREOF 有权
标题翻译：短链聚阳离子及其用途
公开(公告)号：EP2397487A4
公开(公告)日：2012-10-31
申请号：EP11740552
申请日：2011-02-23
申请人： NANOCARRIER CO LTD , UNIV TOKYO
发明人： KATO YASUKI , ISHII ATSUSHI , SHIBATA NAOYA , HAYASHI TATSUYUKI , KATAOKA KAZUNORI , MIYATA KANJIRO , NISHIYAMA NOBUHIRO
IPC分类号： C07K4/00 , A61K31/7105 , A61K31/713 , A61K47/42 , A61K47/48 , A61K48/00 , C08F212/00 , C08G69/10 , C08G69/48 , C12N15/11
CPC分类号： C08G69/10 , A61K47/60 , A61K47/6455 , C12N15/111 , C12N2310/14 , C12N2320/32

9. 发明授权

EP2287230B1 Docetaxel polymer derivative, method for producing same and use of same 有权
标题翻译： Docetaxelpolymerderivat，其制备和使用过程
公开(公告)号：EP2287230B1
公开(公告)日：2012-09-26
申请号：EP09750688.5
申请日：2009-05-20
申请人： NanoCarrier Co., Ltd.
发明人： HARADA, Mitsunori , SAITO, Hiroyuki , KATO, Yasuki
IPC分类号： C08G69/40 , A61K31/337 , A61K47/34 , A61K47/48 , A61P35/00 , C08G81/00 , A61K9/00 , C08G69/10
CPC分类号： A61K9/0019 , A61K31/337 , A61K47/60 , A61K47/64 , C08G69/10 , C08G69/40

10. 发明公开

EP2415463A1 PARTICULATE MEDICINAL COMPOSITION 有权
标题翻译： MEDIZINISCHE PARTIKELZUSAMMENSETZUNG
公开(公告)号：EP2415463A1
公开(公告)日：2012-02-08
申请号：EP11711242.5
申请日：2011-02-14
申请人： NanoCarrier Co., Ltd.
发明人： ISHII, Atsushi , KATO, Yasuki
IPC分类号： A61K9/107 , A61K9/19 , A61K47/24 , A61K47/34
CPC分类号： A61K9/1075 , A61K9/16 , A61K9/19 , A61K31/7084 , A61K31/713 , A61K47/24 , A61K47/34
摘要： The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.
摘要翻译：本发明提供了具有改善的药物包封稳定性并且适合于药物递送系统的颗粒药物组合物。颗粒状药物组合物1含有多个径向配置的嵌段共聚物单元2，每个嵌段共聚物单元2具有位于径向内侧的疏水性聚合物链段2b和位于径向外侧的亲水性聚合物链段2a; 包括生物大分子的药物4; 和带电荷的脂质3，其具有与药物4相反的电荷; 其中带电脂质3被吸引到疏水聚合物链段2b，并且药物3位于疏水性聚合物链段2b的径向内部。药物组合物1可以有效地防止药物4与粒子分离。

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