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1. 发明公开

EP2519636A4 PRODUCTION OF HEMAGGLUTININ-NEURAMINIDASE PROTEIN IN MICROALGAE 有权转让
标题翻译：制造血凝素神经氨酸酶蛋白微藻
公开(公告)号：EP2519636A4
公开(公告)日：2013-07-03
申请号：EP10841650
申请日：2010-12-28
申请人： DSM IP ASSETS BV , MERIAL LTD
发明人： APT KIRK E , LIPMEIER JAMES CASEY , BAYNE ANNE-CECILE V , PRITCHARD JOYCE A , GUO XUAN
IPC分类号： C12N15/45 , A61K39/17
CPC分类号： C12Y302/01018 , C12N7/00 , C12N9/2402 , C12N15/8257 , C12N2760/18151 , C12N2760/18651

2. 发明授权

EP1773387B1 AVIPOX RECOMBINANTS EXPRESSING FOOT AND MOUTH DISEASE VIRUS GENES 有权转让
标题翻译：手足口病病毒基因表达的重组禽痘
公开(公告)号：EP1773387B1
公开(公告)日：2013-06-12
申请号：EP05856627.4
申请日：2005-04-20
申请人： Merial Ltd.
发明人： NORDGREN, Robert , LOOSMORE, Sheena, May , AUDONNETT, Jean-Christophe, Francis , GRUBMAN, Marvin, J.
IPC分类号： A61K39/135 , C12N7/00 , A61K39/12
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , C12N7/00 , C12N2710/24043 , C12N2770/32134

3. 发明授权

EP2358687B9 Thioamide compounds, method of making and method of using thereof 无效转让
标题翻译：硫代酰胺，方法及其AND METHOD FOR USE
公开(公告)号：EP2358687B9
公开(公告)日：2013-04-17
申请号：EP09744007.7
申请日：2009-10-20
申请人： Merial Ltd.
发明人： LE HIR DE FALLOIS, Loïc, Patrick , LEE, Hyoung, Ik , TIMMONS, Philip, Reid
IPC分类号： C07D249/18 , C07D471/04 , C07C327/00 , A01N43/707 , A61P33/00
CPC分类号： C07D249/18 , C07D471/04

4. 发明公开

EP2280752A4 VETERINARY SYRINGE FOR MULTIPLE INJECTIONS 审中-公开
标题翻译：兽医注射器注射几次
公开(公告)号：EP2280752A4
公开(公告)日：2013-03-06
申请号：EP09718945
申请日：2009-03-11
申请人： MERIAL LTD
发明人： HOLMES ROBERT WILLIAM LACHLAN , WALKER RODNEY GORDON , EBBETT TODD DONALD , STANDING COLIN ANTHONY , WILLIAMS PETER ROBERT , CIAMPA GIOVANNI , ROSSIGNUOLO MICHAEL , SMITH ROBERT JOHN
IPC分类号： A61M5/24 , A61M5/00 , A61M5/28
CPC分类号： A61M5/178 , A61D1/02 , A61D7/00 , A61D17/00 , A61M5/24 , A61M5/2425 , A61M5/2459 , A61M5/3129 , A61M5/31511 , A61M5/3158 , A61M5/3204 , A61M2005/005 , A61M2005/2414 , A61M2005/31516
摘要： A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

5. 发明授权

EP1877085B1 COCCIDIAL VACCINE AND METHODS OF MAKING AND USING SAME 有权转让
标题翻译： KOKZIDIOSEIMPFSTOFF和方法生产和使用
公开(公告)号：EP1877085B1
公开(公告)日：2012-12-05
申请号：EP06750404.3
申请日：2006-04-14
申请人： Merial Ltd. , UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
发明人： MCDOUGALD, Larry, R. , FULLER, Alberta, Lorraine , PRITCHARD, Joyce, Anita
IPC分类号： A61K39/012
CPC分类号： A61K39/012 , A61K2039/522 , A61K2039/542 , A61K2039/552

6. 发明公开

EP1713326A4 STABILIZED FORMULATION OF IVERMERCTIN FEED PREMIX 有权转让
标题翻译：稳定的静脉输液混合制剂
公开(公告)号：EP1713326A4
公开(公告)日：2012-08-22
申请号：EP04814670
申请日：2004-12-17
申请人： MERIAL LTD
发明人： FREEHAUF KEITH ALLAN
IPC分类号： A01N25/00 , A01N25/02 , A01N25/08 , A01N25/12 , A01N37/02 , A01N43/04 , A01N43/90 , A23K1/00 , A23K1/14 , A23K1/16 , A23K1/165 , A23K1/17 , A23K1/18 , A61K47/00
CPC分类号： A23K50/30 , A23K20/121 , A23K50/20
摘要： The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment or prophylaxis of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment or prophylaxis of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.
摘要翻译：本发明涉及一种稳定的预混饲料或饲料状制剂，由于通过控制制剂中已经存在的稳定剂的量，活性成分的降解降低了延长的保质期。饲料预混物用于治疗或预防哺乳动物，特别是猪和马的寄生虫。本发明还涉及一种延长稳定的预混饲料或饲料样制剂的保存期限的方法，用于治疗或预防猪和马中的寄生虫侵袭，包括控制制剂中已经存在的抗氧化剂或稳定剂的量减少或防止活性成分的酸/碱催化分解的形成。

7. 发明公开

EP1737294A4 METHOD AND APPARATUS FOR AUTOMATIC JET INJECTION OF BIRD EGGS 有权转让
标题翻译： VERFAHREN UND VORRICHTUNG ZUR AUTOMATISCHEN JET-INJEKTION VON VOGELEIERN
公开(公告)号：EP1737294A4
公开(公告)日：2012-06-06
申请号：EP05763828
申请日：2005-04-01
申请人： MERIAL LTD
发明人： KARACA KEMAL , HAYZER DAVID J , JOHNSTON JOSEPH H JR
IPC分类号： A01K45/00
CPC分类号： A01K45/007
摘要： An in ovo jet injection apparatus and related methods for treating live eggs. The jet injection apparatus includes one or more jet injection delivery devices configured to deliver one or more treatment substances to predetermined areas of eggs using a high pressure stream of the treatment substance(s). Multiple treatment substances can be delivered so that they are spatially and/or temporally separate. The devices and methods of the invention enable the effective use of a plurality of treatment substances, including those that are effective when used alone but can be noxious if mixed. The methods and apparatus for the jet injection of substances into embryonic chicks reduce the risk of mechanical injury to the developing birds that would be caused by injection needles. The methods and apparatus of the invention can also reduce the introduction of an infection into the chicks.
摘要翻译：一种用于处理活鸡蛋的卵喷射装置及相关方法。射流注射装置包括一个或多个喷射输送装置，其配置成使用高压流的处理物质将一种或多种处理物质输送到蛋的预定区域。可以交付多种处理物质，使其在空间和/或时间上分离。本发明的装置和方法能够有效地使用多种处理物质，包括单独使用时有效的处理物质，但如果混合则可能是有害的。用于将物质喷射入胚胎雏鸡的方法和装置降低了由注射针引起的对发育中的鸟类的机械损伤的风险。本发明的方法和装置还可以减少对雏鸡感染的引入。

8. 发明公开

EP1702056A4 NON-ANIMAL PRODUCT CONTAINING VETERINARY FORMULATIONS 审中-公开
标题翻译：与兽用制剂NICHTTIERISCHES产品
公开(公告)号：EP1702056A4
公开(公告)日：2012-05-02
申请号：EP04814549
申请日：2004-12-17
申请人： MERIAL LTD
发明人： CLEVERLY DOUGLAS , HAGENBUCH MICHELLE , CHEN JUN , AZAD ABUL , MUHITCH JAMES , CHEN WEN-HSIA , NACHED HASSAN
IPC分类号： A61K9/20 , A23K1/165 , A23K1/17 , A61K9/00 , A61K9/28 , A61K9/68 , A61K31/365 , A61K31/405 , A61K31/495 , A61K31/506 , A61K45/06
CPC分类号： A61K9/0056 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K31/365 , A61K31/405 , A61K31/495 , A61K31/506 , A61K45/06 , A61K2300/00

9. 发明公开

EP1694123A4 TOPICAL FORMULATIONS COMPRISING A 1-N-ARYLPYRAZOLE DERIVATIVE AND A FORMAMIDINE 有权转让
标题翻译：含有1-N-芳基吡唑衍生物和甲脒的局部用制剂
公开(公告)号：EP1694123A4
公开(公告)日：2012-04-25
申请号：EP04814548
申请日：2004-12-17
申请人： MERIAL LTD
发明人： BOECKH ALBERT , CRAMER LUIZ GUSTAVO , SOLL MARK D
IPC分类号： A01N43/56 , A01N37/52 , A01N47/02 , A01P7/02 , A01P7/04
CPC分类号： A01N43/56 , A01N47/02 , A01N2300/00 , A01N37/52
摘要： The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.
摘要翻译：本发明尤其提供了包含至少一种1-N-氨基吡唑衍生物和氨苄青霉素的新型局部制剂，以及用于治疗，控制或预防哺乳动物或鸟类寄生虫侵袭的方法。本发明的制剂包括点状，或喷雾制剂，并且可以包括另外的外寄生物杀虫剂，例如IGR化合物，除虫菌素或米尔倍霉素衍生物或拟除虫菊酯杀虫剂，以及驱肠虫剂如苯并咪唑和咪唑并噻唑。本发明的配方以更快的控制速率提供更大的寄生虫控制持续时间。本发明的公式从第一次申请至多三个月仍然有效。此外，本发明的制剂防止蜱附着于动物，从而提供防止蜱携带疾病的保护。本发明可以控制，治疗或预防的外寄生虫包括蜱，跳蚤，螨虫，虱子，虱子，蚊子，苍蝇和牛。。

10. 发明公开

EP2367566A2 RECOMBINANT AVIAN INFLUENZA VACCINE AND USES THEREOF 有权转让
标题翻译：重组禽流感疫苗及其应用
公开(公告)号：EP2367566A2
公开(公告)日：2011-09-28
申请号：EP09760072.0
申请日：2009-11-30
申请人： Merial Ltd. , Biolex Therapeutics, Inc.
发明人： GUO, Xuan , BUBLOT, Michel , PRITCHARD, Joyce, A. , DICKEY, Lynn, F.
IPC分类号： A61K39/00
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines.

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