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1. 发明公开

EP2359883A1 Ultraviolet-sterilizer for tubing connector 有权
标题翻译：紫外线杀菌剂
公开(公告)号：EP2359883A1
公开(公告)日：2011-08-24
申请号：EP11165801.9
申请日：2009-07-28
申请人： Mallinckrodt Inc.
发明人： Neer, Charles S.
IPC分类号： A61M5/145 , A61M39/16 , A61M39/18 , A61L2/00
CPC分类号： A61L2/10 , A61M5/14546 , A61M39/16 , A61M39/165 , A61M39/18 , A61M2005/14553 , A61M2205/14
摘要： An injection system (108) includes a sterilization port (130) operable to sterilize a tube set connector (116) inserted therein. The sterilization port (130) may include a single sterilization port opening (132) through which the tube set connector (116), in an unconnected state, may be inserted. The sterilization port (130) may include an ultraviolet light source (158) capable of irradiating the tube set connector (116) with ultraviolet radiation when the tube set connector (116) is disposed within the sterilization port (130). The sterilization port (130) may include a movable member or door (136) capable of closing around the inserted tube set connector (116) and/or a tubing (118) connected to the tube set connector (116) to reduce the amount of ultraviolet light that may escape from the sterilization port (130). A sensor (194) may be included to determine if the tube set connector (116) has been inserted into the sterilization port (130).
摘要翻译：注射系统（108）包括可操作以对插入其中的管组连接器（116）进行消毒的灭菌口（130）。灭菌口（130）可以包括单个灭菌口开口（132），未连接状态的管组连接器（116）可通过该单个灭菌口开口插入。灭菌口（130）可以包括当管组连接器（116）设置在消毒口（130）内时能够用紫外线照射管组连接器（116）的紫外光源（158）。灭菌口（130）可以包括能够围绕插入的管组连接器（116）和/或连接到管组连接器（116）的管道（118）关闭的可移动构件或门（136），以减少可从灭菌口（130）逸出的紫外线。可以包括传感器（194）以确定管组连接器（116）是否已插入消毒端口（130）。

2. 发明公开

EP2350205A2 DITHIENOFURAN DYES FOR IMAGING AND THERAPY 审中-公开
标题翻译： DITHIENOFURANFARBSTOFFE用于成像和治疗
公开(公告)号：EP2350205A2
公开(公告)日：2011-08-03
申请号：EP09793085.3
申请日：2009-09-29
申请人： Mallinckrodt Inc.
发明人： RAJAGOPALAN, Raghavan , NEUMANN, William, L. , POREDDY, Amruta , FRESKOS, John, N. , DORSHOW, Richard, B.
IPC分类号： C09B57/00
CPC分类号： C07D497/14 , A61K41/0057 , A61K49/0021 , A61K49/005 , A61K49/0054 , A61K49/0056 , C09B57/00
摘要： The invention provides optical agents, including compositions, preparations and formulations, and methods of using and making optical agents. Optical agents of the present invention include dyes, and derivatives thereof, having a fused ring backbone structure having dithienofuran core. In some embodiments, dyes of the present invention are dithienofuran dyes having a dithienofuran core optionally functionalized to provide useful optical, biological, pharmacokinetic and/or physical properties.

3. 发明授权

EP2099764B1 PREPARATION OF SUBSTITUTED MORPHINAN-6-ONES AND SALTS AND INTERMEDIATES THEREOF 有权
标题翻译：制备取代吗啡-6-ONE和盐及其中间体
公开(公告)号：EP2099764B1
公开(公告)日：2011-07-27
申请号：EP07837847.8
申请日：2007-09-06
申请人： Mallinckrodt Inc.
发明人： WANG, Peter Xianqi , MOSER, Frank W. , CANTRELL, Gary L. , GROTE, Christopher W.
IPC分类号： C07D217/20
CPC分类号： C07D217/20
摘要： The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.

4. 发明公开

EP2344508A1 PROCESSES FOR THE SYNTHESIS OF OPIATE ALKALOIDS WITH REDUCED IMPURITY FORMATION 有权转让
标题翻译：方法OPIATALKALOIDEN与污染的形成减少合成
公开(公告)号：EP2344508A1
公开(公告)日：2011-07-20
申请号：EP09744220.6
申请日：2009-09-29
申请人： Mallinckrodt Inc.
发明人： ORR, Brian , STEELE, Miranda
IPC分类号： C07D489/12
CPC分类号： C07D489/12
摘要： The invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for the formation of opiate alkaloids that minimizes the formation of impurities.

5. 发明公开

EP2344507A1 PROCESSES FOR INCREASING THE YIELD OF THE HYDROLYSIS OF THE 3-0-METHYL AND 17-N-NITRILE GROUP IN THE PREPARATION OF OPIATE ALKALOID DERIVATIVES 有权转让
标题翻译：方法用于增加3-O-甲基和17-N-腈水解收IN OPIATALKALOIDDERIVATEN的制造
公开(公告)号：EP2344507A1
公开(公告)日：2011-07-20
申请号：EP09789378.8
申请日：2009-09-29
申请人： Mallinckrodt Inc.
发明人： ALLEN, Brenda, E.
IPC分类号： C07D489/12
CPC分类号： C07D489/12
摘要： The present invention provides processes for the production of opiate alkaloids. In particular, the present invention provides processes for recycling impurities into useful intermediates during the synthesis of opiate alkaloids.

6. 发明公开

EP2342208A1 RECYCLING PROCESS FOR INCREASING THE YIELD OF A GRIGNARD REACTION IN THE PREPARATION OF OPIATE ALKALOID DERIVATIVES 有权转让
标题翻译：回收过程增加收益OPIATALKALOIDDERIVATEN的制造Grignard反应
公开(公告)号：EP2342208A1
公开(公告)日：2011-07-13
申请号：EP09789383.8
申请日：2009-09-29
申请人： Mallinckrodt Inc.
发明人： KALOTA, Dennis, J.
IPC分类号： C07D489/12
CPC分类号： C07D489/12 , Y02P20/582
摘要： An improved opiate synthesis scheme is provided. An improvement to the oxidation of oripavine and oripavine derivatives comprises the in-situ formation of the peroxacids required to oxidize the oripavine and oripavine derivatives to form an intermediate. An improvement to the reduction of the intermediate to form oxycodone and oxycodone derivatives comprises reduction utilizing a hydrogen transfer reagent. These improvements allow the production of oxycodone and oxycodone derivatives without isolation of the intermediate, providing a one-pot synthesis method.

7. 发明公开

EP2337594A2 ULTRAVIOLET-STERILIZER FOR TUBING CONNECTOR 有权
标题翻译：紫外线消毒软管接头
公开(公告)号：EP2337594A2
公开(公告)日：2011-06-29
申请号：EP09790877.6
申请日：2009-07-28
申请人： Mallinckrodt Inc.
发明人： NEER, Charles, S.
IPC分类号： A61M5/145 , A61M39/16 , A61M39/18 , A61L2/00
CPC分类号： A61L2/10 , A61M5/14546 , A61M39/16 , A61M39/165 , A61M39/18 , A61M2005/14553 , A61M2205/14
摘要： An injection system (108) includes a sterilization port (130) operable to sterilize a tube set connector (116) inserted therein. The sterilization port (130) may include a single sterilization port opening (132) through which the tube set connector (116), in an unconnected state, may be inserted. The sterilization port (130) may include an ultraviolet light source (158) capable of irradiating the tube set connector (116) with ultraviolet radiation when the tube set connector (116) is disposed within the sterilization port (130). The sterilization port (130) may include a movable member or door (136) capable of closing around the inserted tube set connector (116) and/or a tubing (118) connected to the tube set connector (116) to reduce the amount of ultraviolet light that may escape from the sterilization port (130). A sensor (194) may be included to determine if the tube set connector (116) has been inserted into the sterilization port (130).

8. 发明公开

EP2331540A1 BERBERINE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF BERBERINE COMPOUNDS 审中-公开
标题翻译：小檗碱化合物和用于制备小檗碱化合物的方法
公开(公告)号：EP2331540A1
公开(公告)日：2011-06-15
申请号：EP09789379.6
申请日：2009-09-29
申请人： Mallinckrodt Inc.
发明人： GROTE, Christopher, W. , MOSER, Frank, W. , JOHNSON, JR., John, E.
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention is directed to berberine compounds and processes for the preparation of berberine compounds through an intramolecular Bischler-Napieralski cyclization.
摘要翻译：本发明涉及小檗碱化合物和通过分子内Bischler-Napieralski环化制备小檗碱化合物的方法。

9. 发明公开

EP2315148A1 Power injector with help functionality 审中-公开
标题翻译：电力供应商Hilfsfunktionalität
公开(公告)号：EP2315148A1
公开(公告)日：2011-04-27
申请号：EP10013743.9
申请日：2009-02-27
申请人： Mallinckrodt Inc.
发明人： Humeniuk, David P.
IPC分类号： G06F19/00
CPC分类号： G06F19/3406 , A61B6/548 , A61M5/14546 , A61M2005/14553 , A61M2205/502 , G06F19/00 , G06F19/321 , G06F19/3468 , G16H40/63
摘要： A power injector (10) with help functionality is disclosed. What may be characterized as a "help output" may be displayed on a graphical user interface (11) in response to a request for help. This help output may be based upon a current state of the power injector (10), may be accompanied by a cross-reference to an operator's manual for the power injector (10), may be expanded to provide additional detail, or any combination thereof. At least one system screen that relates to the help output may be displayed (e.g., simultaneously, sequentially). The help functionality may be in the form of having the power injector (10) incorporate help mode logic (256) that is configured to allow a user to view and obtain information on the various system screens that would be presented when using the power injector (10) to deliver a fluid, but without actually operating the power injector (10) to deliver fluid.
摘要翻译：公开了具有帮助功能的动力注射器（10）。可以被描述为“帮助输出”的内容可以响应于帮助请求在图形用户界面（11）上显示。这种帮助输出可以基于动力注射器（10）的当前状态，可以伴随着对于动力注射器（10）的操作者手册的交叉引用，可以被扩展以提供额外的细节或其任何组合。可以显示与帮助输出相关的至少一个系统屏幕（例如，同时，顺序地）。帮助功能可以是使动力注射器（10）包括帮助模式逻辑（256）的形式，其被配置为允许用户在使用动力注射器时在各种系统屏幕上观看和获取信息 10）以输送流体，但是没有实际操作动力注射器（10）以输送流体。

10. 发明公开

EP2298386A2 Improvements to powerhead of a power injection system 审中-公开
公开(公告)号：EP2298386A2
公开(公告)日：2011-03-23
申请号：EP10005399.0
申请日：2005-10-12
申请人： Mallinckrodt Inc.
发明人： Neer, Charles S. , Gibbs, Jonathan D. , Bruce, John Kevin , Ziemba, Robert J. , Brooks, David M. , Small, James R. , Wagner, Gary S.
IPC分类号： A61M5/145
CPC分类号： A61M5/007 , A61B6/548 , A61M5/14546 , A61M5/14566 , A61M5/16827 , A61M5/1785 , A61M2205/3306 , A61M2205/3317 , A61M2205/3389 , A61M2205/502 , A61M2205/52 , A61M2205/587 , A61M2205/6054 , A61M2205/6063
摘要： A contrast media injection system includes detects the absolute position of the syringe ram using a non-contact sensor. A series of magnets and Hall-Effect sensors may be used or an opto-reflective system. Illuminated knobs that are connected to the drive mechanism for the syringe ram rotate with the drive and provide visual feedback on operation through the illumination. Analog Hall-Effect sensors are used to determine the presence or absence of magnets that identify the type of faceplate being used. The faceplates include control electronics, connected to the powerhead through connectors, which may be interchangeably used by the two faceplates. The faceplate electronics include detectors for automatically detecting the capacity of pre-filled syringes. Additional features include using historical data to provide optimum pressure limit values during an injection protocol, a removable memory device for storing and transferring information such as injection protocols and injector statistics, and password protection of such protocols.

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