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1. 发明公开

EP1718660A1 OLIGONUCLEOTIDES RELATED TO LIPID MEMBRANE ATTACHMENTS 有权
标题翻译：寡核苷酸与脂质膜附着有关
公开(公告)号：EP1718660A1
公开(公告)日：2006-11-08
申请号：EP05711148.6
申请日：2005-02-28
申请人： Layerlab Aktiebolag
发明人： PFEIFFER, Indriati , HÖÖK, Fredrik
IPC分类号： C07H21/00 , C12Q1/68 , G01N33/543 , G01N33/68
CPC分类号： B01J19/0046 , A61K47/549 , A61K47/554 , C07H21/00
摘要： Oligonucleotide structures are provided that are capable of forming more stable bonds to a lipid membrane and thereby generate an improved control of the process whereby oliogonucleotide linkers are introduced to lipid membranes. Methods of forming lipid membrane oligonucleotide attachments are provided including lipid vesicles. The oligonucleotides typically comprise at least two hydrophobic anchoring moieties capable of being attached to a lipid membrane. Said moieties may be attached at the terminalends of an oligonucleotide or, in the case of a first and second strand forming a duplex, at the same terminal end one of the strands other end not being part of the duplex leaving it free to hybridize to additional strands. The lipid vesicles attached with the oligonucleotide can be used in biosensors and may contain membrane proteins.
摘要翻译：提供的寡核苷酸结构能够与脂质膜形成更稳定的键，从而产生改进的对寡核苷酸接头引入脂质膜的过程的控制。提供了形成脂质膜寡核苷酸附着物的方法，包括脂质囊泡。寡核苷酸通常包含至少两个能够附着于脂质膜的疏水性锚定部分。所述部分可以连接在寡核苷酸的末端，或者在第一和第二链形成双链体的情况下，在相同的末端，一个链另一端不是双链体的一部分，使其自由地与另外的杂交体杂交链。与寡核苷酸连接的脂质囊泡可用于生物传感器并可含有膜蛋白。

2. 发明公开

EP2396647A1 PROBING ELECTRODE/SOLUTION INTERFACES 无效
标题翻译：电极的初步探讨/溶液界面
公开(公告)号：EP2396647A1
公开(公告)日：2011-12-21
申请号：EP10741488.0
申请日：2010-02-11
申请人： Layerlab Aktiebolag
发明人： HANSSON, Niklas , OLOFSSON, Niklas , LUNDGREN, Anders , LUNDGREN, Björn , NORDBERG, Patrik
IPC分类号： G01N27/02 , G01N33/543
CPC分类号： G01N27/028
摘要： Systems and techniques for probing interfaces between electrodes and conductive solutions. In one aspect, devices can include a time variable source of power configured to output power that varies in time over a pair of output conductors, an electrode connected to a first of the conductors, an extrinsic inductive impedance connected between the pair of output conductors, and an impedance sensor connected to one or both of the output conductors and configured to measure net impedance between the pair of output conductors based on a known current or voltage output by the time variable power output. The measured net impedance includes the extrinsic inductive impedance and an impedance of the interface. The electrode is configured to be submersed in a conducting solution and form an interface with the conducting solution.

3. 发明公开

EP2250502A4 METHOD AND DEVICE FOR STUDYING TRANSPORT OF AN AGENT ACROSS A BILAYER MEMBRANE IN BIOANALYTICAL SENSOR APPLICATIONS 有权
标题翻译：方法和装置在BIOANALYSESENSOR应用程序通过双簧输送的试剂的研究
公开(公告)号：EP2250502A4
公开(公告)日：2011-04-27
申请号：EP09709128
申请日：2009-02-06
申请人： LAYERLAB AKTIEBOLAG
发明人： HOEOEK FREDRIK , BRAENDEN MAGNUS , TABAEI SEYED
IPC分类号： G01N33/543 , G01N21/55
CPC分类号： G01N33/68 , G01N21/211 , G01N21/41 , G01N21/553 , G01N33/50 , G01N33/5432 , G01N33/54353 , G01N33/54373 , G01N33/6872 , G01N33/92 , G01N2021/258 , G01N2333/43565 , G01N2500/00

4. 发明授权

EP1718660B1 OLIGONUCLEOTIDES RELATED TO LIPID MEMBRANE ATTACHMENTS 有权
标题翻译：与脂质膜ATTACHMENTS相关OLIGONUCLEOTIDES
公开(公告)号：EP1718660B1
公开(公告)日：2010-12-01
申请号：EP05711148.6
申请日：2005-02-28
申请人： Layerlab Aktiebolag
发明人： PFEIFFER, Indriati , HÖÖK, Fredrik
IPC分类号： C07H21/00 , C12Q1/68 , G01N33/543 , G01N33/68
CPC分类号： B01J19/0046 , A61K47/549 , A61K47/554 , C07H21/00
摘要： Oligonucleotide structures are provided that are capable of forming more stable bonds to a lipid membrane and thereby generate an improved control of the process whereby oliogonucleotide linkers are introduced to lipid membranes. Methods of forming lipid membrane oligonucleotide attachments are provided including lipid vesicles. The oligonucleotides typically comprise at least two hydrophobic anchoring moieties capable of being attached to a lipid membrane. Said moieties may be attached at the terminalends of an oligonucleotide or, in the case of a first and second strand forming a duplex, at the same terminal end one of the strands other end not being part of the duplex leaving it free to hybridize to additional strands. The lipid vesicles attached with the oligonucleotide can be used in biosensors and may contain membrane proteins.

5. 发明公开

EP2250502A1 METHOD AND DEVICE FOR STUDYING TRANSPORT OF AN AGENT ACROSS A BILAYER MEMBRANE IN BIOANALYTICAL SENSOR APPLICATIONS 有权
标题翻译：程序为代理通过一双簧AT BIOANALYSESENSOR应用的运输
公开(公告)号：EP2250502A1
公开(公告)日：2010-11-17
申请号：EP09709128.4
申请日：2009-02-06
申请人： Layerlab Aktiebolag
发明人： HÖÖK, Fredrik , BRÄNDÉN, Magnus , TABAEI, Seyed
IPC分类号： G01N33/543 , G01N21/55
CPC分类号： G01N33/68 , G01N21/211 , G01N21/41 , G01N21/553 , G01N33/50 , G01N33/5432 , G01N33/54353 , G01N33/54373 , G01N33/6872 , G01N33/92 , G01N2021/258 , G01N2333/43565 , G01N2500/00
摘要： The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analysed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.

6. 发明公开

EP1611256A1 SURFACE IMMOBILISED MULTILAYER STRUCTURE OF VESICLES 有权
标题翻译：表面固定多层结构的微生物
公开(公告)号：EP1611256A1
公开(公告)日：2006-01-04
申请号：EP04726345.4
申请日：2004-04-07
申请人： Layerlab Aktiebolag
发明人： GRANELI, Annette , REIMHULT, Erik , SVEDHEM, Sofia , PFEIFFER, Indriati , HÖÖK, Fredrik
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： G01N33/54373
摘要： A surface-immobilised multilayer structure of a plurality of vesicles (2), said structure comprising at least one linker (4) immobilised onto said surface, said at least one linker (4) being bound to at least one other linker, which is attached to a vesicle, which optionally may have another linker (5) bound to another linker (5) attached to another vesicle (2), wherein the structure either comprises at least two vesicles (2) bound via linkers (5) to each other or at least two vesicles (2) bound via linkers (5) attached to the vesicles to one linker (4) immobilised onto said surface (1).
摘要翻译：多个囊泡（2）的表面固定多层结构，所述结构包含至少一个固定在所述表面上的连接体（4），所述至少一个连接体（4）与至少一个其他连接体结合，（5）结合到另一个连接体（5）上，所述连接体（5）与另一个囊泡（2）连接，其中所述结构包含至少两个经由连接体（5）彼此结合的囊泡（2）至少两个囊泡（2）经由连接至囊泡的连接体（5）结合至固定于所述表面（1）上的一个连接体（4）。

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