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1. 发明授权

EP2840379B1 An automated test method for testing risk and integrity of pharmaceutical filtration membranes 有权
公开(公告)号：EP2840379B1
公开(公告)日：2019-05-08
申请号：EP13180167.2
申请日：2013-08-13
申请人： Institute of Nuclear Energy Research, Atomic
发明人： Chiu, Shu-Pei , Li, Ming-Hsin , Chang, Chih-Hsien , Lee, Te-Wei
IPC分类号： G01N15/08

2. 发明公开

EP3476296A1 TOMOGRAPHY SYSTEM AND METHOD THEREOF 有权
公开(公告)号：EP3476296A1
公开(公告)日：2019-05-01
申请号：EP18162275.4
申请日：2018-03-16
申请人： Institute of Nuclear Energy Research Atomic Energy Council Executive Yuan, R.O.C
发明人： CHANG, CHIA-HAO , CHANG, SHU-CHUN , TSENG, FAN-PIN , NI, YU-CHING
IPC分类号： A61B6/03 , A61B6/00 , G01V5/00
摘要： A tomography method includes: a step of having a photon counting detector to undergo a relative motion with respect to an X-Ray source, and capturing 2×N projected energy spectral data at 2×N individual discrete projection angles that divide the relative motion, the N being a positive integer; a step of reforming the 2×N projected energy spectral data at the 2×N individual discrete projection angles and establishing corresponding projection intensity data; and, a step of basing on the projection intensity data and the 2×N projected energy spectral data at the 2×N individual discrete projection angles to calculate the material decomposition images. In addition, a tomography system is also provided.

3. 发明授权

EP2562825B1 Lift-off structure for substrate of a photoelectric device and method thereof 有权
公开(公告)号：EP2562825B1
公开(公告)日：2019-01-16
申请号：EP11401601.7
申请日：2011-09-27
申请人： Institute of Nuclear Energy Research Atomic Energy Council
发明人： Tsai, Yu-Li , Wu, Chih-Hung , Ho, Jei-Li
IPC分类号： H01L21/78 , H01L31/18 , H01L31/0693 , H01L31/0224 , H01L31/0687

4. 发明公开

EP3220462A1 MANUFACTURING METHODS OF A METAL-SUPPORTED SOLID OXIDE FUEL CELL 有权
标题翻译：一种金属支撑的固体氧化物燃料电池的制造方法
公开(公告)号：EP3220462A1
公开(公告)日：2017-09-20
申请号：EP17159021.9
申请日：2016-07-25
申请人： Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan
发明人： HWANG, Chang-Sing , TSAI, Chun-Huang , CHANG, Chun-Liang , CHUANG SHIE, Zong-Yang , YANG, Sheng-Fu , HUANG, Te-Jung , WU, Ming-Hsiu , LIN, Jing-Kai
IPC分类号： H01M4/86 , H01M4/88 , H01M4/90 , H01M8/0232 , H01M8/0245 , H01M8/0258 , H01M8/0271 , H01M8/1226 , H01M8/126 , H01M8/1213 , H01M8/1253 , H01M8/124 , H01M8/00
CPC分类号： H01M8/1226 , H01M4/8657 , H01M4/8807 , H01M4/8857 , H01M4/886 , H01M4/9066 , H01M8/006 , H01M8/0232 , H01M8/0236 , H01M8/0245 , H01M8/0258 , H01M8/0271 , H01M8/1213 , H01M8/1253 , H01M8/126 , H01M8/1286 , H01M2008/1293 , Y02E60/525 , Y02P70/56
摘要： The invention provides a manufacturing method of a metal-supported solid oxide fuel cell (50) comprising a permeable substrate (200). The method comprises the steps of:
providing a substrate body (S20);
forming a plurality of gas channels (112) on the substrate body by using a drilling process (S21);
forming a permeable powder layer (260) on the substrate body (S22) by using further steps of:
forming a green layer (of permeable powder layer (260) by a tape caster, sintering the green layer into a permeable powder layer (260) by using a high temperature sintering process, disposing the sintered permeable powder layer (260) onto the substrate body and making them laminated and connected together by using high temperature pressing process;
reducing the surface pore sizes of the permeable powder layer (260) to be smaller than 30 μm (S24) ;
using a high temperature pressing process (S25) to flatten a permeable metal substrate (200);
and using an atmospheric plasma spraying process (S26) to sequentially form a porous anode layer (52), a dense anode isolation layer (53), a dense electrolyte layer (54), a dense cathode isolation layer (55) and a porous cathode layer (56) on the permeable metal substrate (100, 200).
摘要翻译：本发明提供了一种包括可渗透基底（200）的金属支撑固体氧化物燃料电池（50）的制造方法。该方法包括以下步骤：提供基板主体（S20）; 通过钻孔工艺在基体上形成多个气体通道（S21）; 通过进一步的步骤在基体上形成可渗透粉末层（260）（步骤S22）：通过带式连铸机形成可渗透粉末层（260）的生坯层，将生坯层烧结成可渗透粉末层（260）通过高温烧结工艺，将烧结而成的可渗透粉末层（260）设置在基体上并通过高温压制工艺将它们层压连接在一起;将可渗透粉末层（260）的表面孔径减小为（S24）;使用高温压制工艺（S25）使渗透性金属基底（200）变平;以及使用大气等离子喷涂工艺（S26）依次形成多孔阳极层（52），致密层阳极隔离层（53），致密电解质层（54），致密阴极隔离层（55）和可渗透金属基底（100,200）上的多孔阴极层（56）。

5. 发明公开

EP3184535A1 METHOD FOR PREPARING 6-AMINOHEXYL LACTOSIDE-NOTA CONJUGATE 有权
标题翻译：制备6-氨基己酸半乳糖苷 - 诺他共轭物的方法
公开(公告)号：EP3184535A1
公开(公告)日：2017-06-28
申请号：EP16180099.0
申请日：2016-07-19
申请人： Institute of Nuclear Energy Research Atomic Engery Council, Executive Yuan, R.O.C.
发明人： CHEN, Rui-Yu , JIANG, Yan-Feng , WANG, Mei-Hui , WANG, Jen-Tsung , LIN, Wuu-Jyh
IPC分类号： C07H1/00 , C07H15/26 , A61K49/00
CPC分类号： C07H15/26 , A61K49/0002 , C07H1/00
摘要： The present invention provides a method for preparing a 6-aminohexyl lactoside-NOTA conjugate. The preparation method comprises brominating perbenzoylated lactose with hydrobromic acid; glycosylating 6-azidohexanol to obtain 6-azidohexyl perbenzoyl lactoside; and deprotecting this precursor in two steps to obtain 6-aminohexyl lactoside and conjugating 6-aminohexyl lactoside to NCS-benzyl-NODA GA (i.e. 2,2'-(7-(1-carboxy-4-((4-isothiocyanate benzyl) amino)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl) diacetic acid) in triethyl amine as an alkaline solvent, to obtain a 6-aminohexyl lactoside-NCS-benzyl-NODA GA conjugate. In this novel preparation method, no deglycosylated side product is produced, such that the yield is considerably increased to 46%. Therefore, the method is suitable for future massive production since the requirement for repeated preparations for massive production is reduced, and the impurities produced in the previously scaled-up preparation process are not present.
摘要翻译：本发明提供了制备6-氨基己基乳糖苷-NOTA缀合物的方法。该制备方法包括用氢溴酸溴化过苯甲酰化乳糖，将6-叠氮基己醇进行糖基化以获得6-叠氮基己基过苯甲酰基乳糖苷; （即2,2' - （7-（1-羧基-4 - （（4-异硫氰酸苯甲基）苄基）-NDA-甘氨酸（NCS-苄基-NODA GA）偶联6-氨基己基乳糖苷并将6-氨基己基乳糖苷偶联到NCS- 氨基）-4-氧代丁基）-1,4,7-三氮杂壬烷-1,4-二基）二乙酸）在碱性溶剂三乙胺中反应，得到6-氨基己基乳糖苷-NCS-苄基-NODA GA缀合物。在这种新型制备方法中，不产生去糖基化的副产物，使得产率显着增加至46％。因此，该方法适用于未来的大规模生产，因为减少了大量生产的重复准备的要求，并且不存在先前放大的制备过程中产生的杂质。

6. 发明授权

EP3040310B1 Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 失效
标题翻译：一种制备用于纳米粒子和照射化疗剂的涂层对辐射敏感的共聚物支援处理
公开(公告)号：EP3040310B1
公开(公告)日：2017-03-01
申请号：EP15150057.6
申请日：2015-01-05
申请人： Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan
发明人： Lin, Wuu-Jyh , Duh, Ting-Shien , Li, Wei-Ming , Li, Ming-Hsin
IPC分类号： C01G43/00 , A61K49/04 , C08J3/07 , C01B19/00 , A61K51/12 , A61K41/00
CPC分类号： A61K41/0028 , A61K9/5146 , A61K51/1244 , C01B19/00 , C08J3/07

7. 发明授权

EP2621006B1 An anode on a pretreated substrate for improving redox-stablility of solid oxide fuel cell and the fabrication method thereof 有权
标题翻译：阳极预处理过的基片上，以提高固体氧化物燃料电池及其制造方法的氧化还原稳定性或其
公开(公告)号：EP2621006B1
公开(公告)日：2016-10-26
申请号：EP12152766.7
申请日：2012-01-26
申请人： Institute of Nuclear Energy Research Atomic Energy Council
发明人： Hwang, Chang-Sing , Tsai, Chun-Huang , Yu, Jen-Feng , Chang, Chun-Liang , Lin, Jun-Meng , Cheng, Shih-Wei
IPC分类号： H01M8/1226 , H01M4/88 , H01M4/86 , H01M4/90 , H01M8/124
CPC分类号： H01M4/8817 , H01M4/8652 , H01M4/8657 , H01M4/886 , H01M4/9016 , H01M8/1226 , H01M2008/1293

8. 发明公开

EP3040310A1 Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 失效
标题翻译：一种制备用于纳米粒子和照射化疗剂的涂层对辐射敏感的共聚物支援处理
公开(公告)号：EP3040310A1
公开(公告)日：2016-07-06
申请号：EP15150057.6
申请日：2015-01-05
申请人： Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan
发明人： Lin, Wuu-Jyh , Duh, Ting-Shien , Li, Wei-Ming , Li, Ming-Hsin
IPC分类号： C01G43/00 , A61K49/04 , C08J3/07 , C01B19/00 , A61K51/12 , A61K41/00
CPC分类号： A61K41/0028 , A61K9/5146 , A61K51/1244 , C01B19/00 , C08J3/07
摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.
摘要翻译：用于涂覆辐射敏感共聚物载体的制备方法辐射纳米颗粒和/或化疗药包括通过二硒化物的嵌段共聚物和DSPE-PEG-生物标志物涂覆化疗药物纳米球和/或辐射的纳米颗粒也可以从打开的纳米球通过释放质子质子治疗期间穿透组织。质子疗法的治疗效果是通过使用从在打开纳米球释放的辐射的纳米颗粒，以产生与质子核裂变用于释放电子以破坏肿瘤的癌细胞和从打开的纳米球释放组织之间分配化疗药物的两种方式增强杀死肿瘤的癌细胞。

9. 发明公开

EP3016191A1 A fabrication process for production of SOFC-MEA with a pore array anode structure for improving output power density 有权转让
标题翻译：用于与孔排列阳极结构制造SOFC-MEA的制造方法，以提高输出密度
公开(公告)号：EP3016191A1
公开(公告)日：2016-05-04
申请号：EP14190594.3
申请日：2014-10-28
申请人： Institute of Nuclear Energy Research Atomic Energy Council, Executive Yuan
发明人： Lin, Tai-Nan , Kuo, Jen-Yuan , Kuo, Hong-Yi , Kao, Wei-Xin , Yeh, Chun-Yen
IPC分类号： H01M8/12 , H01M4/86 , H01M4/88 , H01M4/90
CPC分类号： H01M8/1213 , H01M4/8621 , H01M4/8857 , H01M4/8889 , H01M4/9033 , H01M8/1253 , Y02E60/525 , Y02P70/56
摘要： A fabrication process for production of planar type solid oxide fuel cell with high electrical conductivity and low fuel gas impedance is disclosed. It is a tape casting to produce an anode substrate furnished with a pore array structure on one or plurality of layers of the anode green tape on the utmost outside of the anode. It is to implement the process of solid oxide fuel cell membrane electrode assembly (SOFC-MEA) with precision abrasion to remove nickel depleted layer on the anode surface to complete the production of a unit cell. The fabrication of anode with pore array structure provides a good conduction effect for fuel gas and the solid oxide fuel cell with this treatment has features of high electrical conductivity and low fuel gas impedance to improve the performance of SOFC unit cell.
摘要翻译：生产平面型固体氧化物燃料电池的具有高导电性和低的燃料气体阻抗的制造工艺游离缺失盘。它是一种流延成型，以产生在配有一个孔阵列结构上的阳极极为外阳极生带材层的一个或多个阳极的衬底。它是与精密磨损实现固体氧化物燃料电池的膜电极组件（MEA SOFC）的过程中在阳极表面上除去镍层耗尽，完成生产单元电池的。与孔阵列结构的阳极的制造提供用于燃料气体和这种治疗的固体氧化物燃料电池的良好传导效应具有高导电性和低的燃料气体的阻抗特性来提高SOFC单元电池的性能。

10. 发明公开

EP3011977A1 KIT FOR PREPARATION OF 186/188-RHENIUM LABELED LIPOSOMES AND THEIR THERAPEUTIC USES 审中-公开
标题翻译：工具包ZER HERSTELLUNG VON 186/188-RHENIUM MARKIERTEN LIPOSOMEN UND IHRE THERAPEUTISCHE ANWENDUNGEN
公开(公告)号：EP3011977A1
公开(公告)日：2016-04-27
申请号：EP14191188.3
申请日：2014-10-30
申请人： Institute of Nuclear Energy Research Atomic Energy Council
发明人： Chiu, Shu-Pei , Lin, Bo-Sian , Lin, Liang-Ting , Lee, Yi-Jang , Lee, Te-Wei , Huang, Feng-Yun , Lo, Jen-Mau
IPC分类号： A61K51/12 , A61P35/00 , A61P35/04 , A61K103/10
CPC分类号： A61K51/065 , A61J1/05 , A61K51/1234 , A61K51/1237
摘要： The invention relates to a kit for preparation of target radiopharmaceuticals, a method of using the kit to prepare target radiopharmaceuticals and use of the target radiopharmaceuticals. The target radiopharmaceuticals comprise a radio-nuclear loading on liposome and inhibit the tumor growth and metastatic progression of head and neck cancer, lung cancer and brain cancer. The radiopharmaceuticals may be used for treating the mentioned cancers.
摘要翻译：本发明涉及用于制备靶放射性药物的试剂盒，使用该试剂盒制备靶放射性药物的方法和靶放射性药物的使用。靶向放射性药物包括在脂质体上的放射性核载荷并抑制头颈癌，肺癌和脑癌的肿瘤生长和转移进展。放射性药物可用于治疗所述癌症。

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