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1. 发明公开

EP2310055A2 NOUVEAU PROCEDE DE MESURE DE LA RESISTANCE A L'INSULINE 审中-公开
标题翻译： VERFAHREN ZUR MESSUNG VON INSULINRESSTENZ
公开(公告)号：EP2310055A2
公开(公告)日：2011-04-20
申请号：EP09737082.9
申请日：2009-07-17
申请人： Université Joseph Fourier , INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： GHEZZI, Catherine , FAGRET, Daniel , DEMONGEOT, Jacques , PERRET, Pascale, Marie-Pierre
IPC分类号： A61K49/00 , A61K51/04 , G06F19/00
CPC分类号： A61K51/0491 , A61K49/0004
摘要： The present invention relates to the use of at least one glucose derivative, halogenated in the 6-position, for implementing a method for determining the insulin resistance in a mammal, in particular a human, by measuring - the variation in the amount (as a function of time) of the abovementioned derivative, in muscle cells, for a given period Δt, after administration of the abovementioned derivative, and - the variation in the amount (as a function of time) of the abovementioned derivative, in the abovementioned muscle cells, for a period substantially equal to the abovementioned period Δt, after administration of the abovementioned derivative, preceded by an administration of insulin.
摘要翻译：使用至少一种在6位卤化的葡萄糖衍生物的方法，用于通过测量哺乳动物，特别是人中的胰岛素抵抗的测定方法，通过测量量（作为时间的函数）的变化给药期间肌肉细胞中的衍生物，在施用衍生物之后，在施用本发明的时间段之后，在肌肉细胞中的衍生物在基本上等于期间t的时间内（作为时间的函数）的变化（作为时间的函数）衍生物，之前是胰岛素的给药。

2. 发明公开

EP2253316A1 serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of vestibular deficits 有权
标题翻译：用于与Vestibularisdefiziten内耳病理的治疗或预防5-羟色胺5-HT3受体拮抗剂
公开(公告)号：EP2253316A1
公开(公告)日：2010-11-24
申请号：EP09305464.1
申请日：2009-05-20
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K31/4178 , A61P1/08 , A61K31/00 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/46 , A61K31/4747 , A61K31/496 , A61K31/538 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00
CPC分类号： A61K31/4178 , A61K31/00 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/46 , A61K31/4747 , A61K31/496 , A61K31/538 , A61K31/7088
摘要： The invention relates to serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a vestibular deficit.
摘要翻译：本发明涉及对血清素5-HT 3受体拮抗剂用于在前庭赤字的治疗或预防的用途。

3. 发明授权

EP1704249B1 PROCEDE D'EVALUATION QUANTITATIVE D'UN REARRANGEMENT OU D'UNE RECOMBINAISON GENETIQUE CIBLEE D'UN INDIVIDU ET SES APPLICATIONS 有权
标题翻译：定量评价重排或有针对性的基因重组在一个独立的方法及其用途
公开(公告)号：EP1704249B1
公开(公告)日：2010-11-17
申请号：EP04805634.5
申请日：2004-12-03
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives , INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： MARCHE, Patrice , JOUVIN-MARCHE, Evelyne , PASQUAL, Nicolas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q1/6886 , C12Q2600/16
摘要： A method for quantitative evaluation of a rearrangement or targeted genetic recombination of an individual and the immunity repertoire of an individual and the uses thereof, particularly in the case of follow-up to a treatment or in the diagnosis and/or prognosis of certain pathologies. Said method comprises at least: (a) extraction of human genomic DNA from a biological sample, (b) amplification of a segment of said genomic DNA, the size thereof ranging from a few hundreds of base pairs and several quantities of ten kb by multiplex PCR in the presence of: one or several couples of primers, and polymerase DNA or a polymerase DNA mixture enabling the amplification of segments of genomic DNA, the size thereof ranging from several hundreds of base pairs and several quantities of ten kb, having a corrective effect enabling elongation to be substantially improved, said amplification also comprising a stage of initial denaturation, cycles of denaturation, hybridation and elongation and wherein the elongation stages are carried out at least during a period of 10 minutes at 68 °C-72 °C; (c) separation of the amplified DNAg fragments and (d) detection of the rearranged or recombined segments.

4. 发明公开

EP2115169A1 METHODS AND KITS FOR DETERMINING DRUG SENSITIVITY IN PATIENTS INFECTED WITH HCV 有权
标题翻译：方法来确定药物的敏感性HCV感染患者
公开(公告)号：EP2115169A1
公开(公告)日：2009-11-11
申请号：EP08708666.6
申请日：2008-02-04
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale) , Assistance Publique - Hôpitaux de Paris , Universite Rene Descartes (Paris V) , Université Paris 7 - Denis Diderot
发明人： VIDAUD, Michel , BIECHE, Ivan , ASSELAH, Tarik , MARCELLIN, Patrick
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： G01N33/5767 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The present invention relates to an in vitro method for determining whether a patient infected with HCV is a responder or non-responder to the treatment with interferon-alpha and ribavirin. More specifically, the method of the invention comprises a step of determining the expression level of the IFI27, CXCL9 and G1 P2 genes in a biological sample.

5. 发明公开

EP2091521A1 ANTICONVULSIVE PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：抗惊厥药物组合物
公开(公告)号：EP2091521A1
公开(公告)日：2009-08-26
申请号：EP07822818.6
申请日：2007-11-22
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： PICAUD, Serge , SAHEL, José , WANG, Qinping , DUBOC, Agnès , SIMONUTTI, Manuel
IPC分类号： A61K31/00 , A61K31/195 , A61K45/06 , A61P25/08 , A61P27/02
CPC分类号： A61K45/06 , A61K31/19
摘要： The present invention pertains to pharmaceutical compositions comprising, as the active ingredients, a combination of vigabatrin and of at least one glutamate receptor activating substance.

6. 发明公开

EP2069398A2 NUCLEIC ACIDS FOR EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN MAMMALIAN CANCER CELLS 有权
标题翻译： NUCLEIC FOR哺乳动物癌细胞利益核苷酸表达
公开(公告)号：EP2069398A2
公开(公告)日：2009-06-17
申请号：EP07803443.6
申请日：2007-09-12
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： FAIVRE, Jamila , HERVE, Julie , CLERC, Jérôme , BRECHOT, Christian
IPC分类号： C07K14/47 , C12N15/79 , C12N15/63 , C12N15/861 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/85 , A61K48/00 , C12N15/113 , C12N2310/111 , C12N2800/107 , C12N2800/108
摘要： The invention relates to regulatory polynucleotides derived (i) from rat and human AFP promoter sequences and (ii) from rat and human HIP/PAPI promoter sequences, which regulatory polynucleotides are useful for expressing nucleic acids of interest specifically in mammalian cancer cells, including mammalian cancer liver cells.

7. 发明公开

EP2046320A2 ANTICONVULSIVE PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：抗真菌药物组合物
公开(公告)号：EP2046320A2
公开(公告)日：2009-04-15
申请号：EP07788056.5
申请日：2007-07-31
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： PICAUD, Serge , DUBOC, Agnès , PAQUES, Michel , SAHEL, José , SIMONUTTI, Manuel
IPC分类号： A61K31/197 , A61P25/08
CPC分类号： A61K31/197 , A61K45/06 , A61K2300/00
摘要： The present invention pertains to pharmaceutical compositions comprising, as the active ingredients, a combination of vigabatrin and of at least one substance having anti-ischemic effect.
摘要翻译：本发明涉及药物组合物，其包含作为活性成分的氨己烯酸与至少一种具有抗局部缺血作用的物质的组合。

8. 发明公开

EP1985230A1 Method for filtering out artefacts of deep brain stimulation 审中-公开
标题翻译：韦尔法罕zur Ausfilterung von Artefakten aus einer tiefen Hirnstimulation
公开(公告)号：EP1985230A1
公开(公告)日：2008-10-29
申请号：EP07300991.2
申请日：2007-04-26
申请人： INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61B5/04 , A61N1/36
CPC分类号： A61B5/04001 , A61B5/0478 , A61B5/7239 , A61N1/36082
摘要： The present invention relates to a method for filtering the signal of neuronal activity during a high frequency deep brain stimulation (DBS) to remove the stimulus artefact in the observed signal, comprising the step of approximating the observed signal trajectories in phase space the observed signal being considered as a sum of the stimulation artefacts induced by the signal of stimulation, wherein the signal of stimulation is assumed to be a solution of an ordinary differential equation including a self-oscillating system with stable limit cycle; slicing the observed signal and its derivative into segments, each segment corresponding to a period of stimulation ; collecting N selected periods of stimulation to a training set ; estimating the limit cycle of the self-oscillating system ; synchronizing each artefact of the observed signal with the estimated limit cycle ; subtracting the estimated limit cycle from each artefact in phase space according to the synchronization ; collecting all segments in order to obtain whole filtered signal and finally presenting the results in time domain.
摘要翻译：本发明涉及一种在高频深部脑刺激（DBS）过滤神经元活动信号以去除观察信号中的刺激伪影的方法，包括以下步骤：将观测信号的观测信号近似为观察信号，被认为是由刺激信号引起的刺激伪影的总和，其中刺激信号被假设为包括具有稳定极限循环的自振荡系统的普通微分方程的解; 将观察到的信号及其导数切片成段，每段对应一段刺激; 将N个选定的刺激时段收集到训练集; 估计自振系统的极限循环; 将观测信号的每个假象与估计的极限周期同步; 根据同步从相位空间中的每个伪像减去估计极限周期; 收集所有段以获得整个过滤的信号，并最终在时域显示结果。

9. 发明公开

EP1895000A1 Identification d'une mutation de JAK2 impliquée dans la polyglobulie de Vaquez 审中-公开
标题翻译：识别鳗鱼突变von JAK2 im Zusammenhang mit Polyglobulie beim Osler-Vaquez-Syndrom
公开(公告)号：EP1895000A1
公开(公告)日：2008-03-05
申请号：EP07118874.2
申请日：2005-10-26
申请人： Assistance Publique - Hôpitaux de Paris , INSERM (Institut National de la Santé et de la Recherche Medicale) , Institut Gustave Roussy , Université de Versailles Saint-Quentin-en-Yvelines , Université Paris Sud
发明人： Vainchenker, William , Ugo, Valérie , James, Chloé , Le Couedic, Jean-Pierre , Casadevall, Nicole
IPC分类号： C12N9/12 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6813 , C12N9/1205 , C12N15/113 , C12Q1/6883 , C12Q2600/156 , G01N33/57426 , G01N33/57496 , G01N2333/91215 , G01N2500/04
摘要： La présente invention concerne le variant V617F de la protéine tyrosine kinase JAK2, ledit variant étant responsable de la Polyglobulie de Vaquez. L'invention se rapporte également à une méthode de diagnostic en première intention de l'érythrocytose et de la thrombocytose permettant de les rattacher à des syndromes myéloprolifératifs ou à la détéction dans les syndromes myéloprolifératifs du variant JAK2 V617F permettant de les reclasser dans un nouveau groupe nosologique et à l'identification d'inhibiteurs spécifiques et de siRNA.
摘要翻译：分离的JAK2（Janus激酶2）蛋白是氨基酸617的突变，特别是SEQ ID No.1中存在的序列的突变V617F或其它哺乳动物中的相似序列是新的。编码变体JAK2 V617F的核苷酸序列尤其是SEQ ID No 2，其具有来自标记转录开始的ATG的位置1849的t / g突变。

10. 发明公开

EP1846574A1 PROCEDE DE DETERMINATION DE LA DIVERSITE DES LYMPHOCYTES T DANS UN ECHANTILLON BIOLOGIQUE 审中-公开
标题翻译：方法用于确定T淋巴细胞的多样性的生物样品
公开(公告)号：EP1846574A1
公开(公告)日：2007-10-24
申请号：EP06709239.5
申请日：2006-02-03
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , INSERM (Institut National de la Santé et de la Recherche Medicale)
发明人： CANDEIAS, Serge , TOUVREY, Cédric , JOUVIN-MARCHE, Evelyne , MARCHE, Patrice
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2600/156
摘要： The invention relates to the field comprising the diagnosis of possible immune system disorders and the analysis of immune responses. In particular, the invention relates to a method of determining the diversity of T lymphocytes in a biological sample, based on the molecular analysis of the structure of the junctions resulting from the recombination rearrangement V(D)J of element δRec-1 with an AJ gene. More specifically, the invention relates to a method of analysing the combinatorial diversity and/or the junctional diversity of the excision circles (TREC) resulting from the rearrangement of δRec-1, in order to determine the heterogeneity of a given population of T lymphocytes.

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