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    • 9. 发明公开
    • Oral care composition comprising dissolved tin and fluoride
    • Mundpflegezusammensetzung mitaufgelöstemZinn und Fluorid
    • EP2111844A1
    • 2009-10-28
    • EP08155126.9
    • 2008-04-24
    • Gaba International AG
    • Moya Argilagos, DallyMatur, TuranScheffel, Cornelia
    • A61K8/19A61K8/41A61K8/69A61Q11/00A61K8/365
    • A61Q11/00A61K8/19A61K8/21A61K8/345A61K8/365A61K8/416
    • An oral care composition comprising a liquid phase containing dissolved tin, 200 to 2000 ppm fluoride ions, based on the oral composition, and 5 to 60 % by weight, based on the oral care composition, of a C (3-5) sugar alcohol; characterised in that the content of dissolved tin [Sn] in the liquid phase is at least 1000 ppm, based on the composition, and that the composition comprises an organic acid and ammonium cations of the formula (I):

               R-NH + R a -[(CH 2 ) u -NH + R b ] v -R c ·     (I)

      wherein R is a saturated or unsaturated straight-chain hydrocarbon residue of 10 to 20 carbon atoms, v is an integer from 0 to 1, u is an integer from 2 to 3 and R a , R b and R c are independently selected from hydrogen and -CH 2 CH 2 OH. The composition is preferably a mouthrinse. These compositions are tested in the treatment or prevention of erosive tooth demineralisation caused by food acids.
    • 一种口腔护理组合物,其包含基于所述口腔组合物含有溶解的锡,200至2000ppm氟离子的液相和基于口腔护理组合物的5-60重量%的C(3-5)糖醇 ; 其特征在于,基于组成,液相中溶解的锡[Sn]的含量为至少1000ppm,并且该组合物包含式(I)的有机酸和铵阳离子:€ƒ€ƒ €ƒ€ƒ€ƒ€ƒR-NH + R a - [(CH 2)u -NH + R b] v -R cƒ€ƒ€ƒ€ƒ(ƒ)其中R是 10至20个碳原子的饱和或不饱和直链烃残基,v为0至1的整数,u为2至3的整数,R a,R b和R c独立地选自氢和-CH 2 CH 2 OH。 组合物优选为漱口水。 在治疗或预防食物酸引起的侵蚀性牙齿脱矿质中测试这些组合物。