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1. 发明公开

EP3075451A1 DISPOSABLE FLOW CHIP DEVICE 有权
标题翻译： EINWEG-Fluss女士-CHIP-VORRICHTUNG
公开(公告)号：EP3075451A1
公开(公告)日：2016-10-05
申请号：EP15162040.8
申请日：2015-03-31
申请人： Coris Bioconcept SPRL
发明人： Mertens, Pascal , Ote, Isabelle , Leclipteux, Thierry , Aussems, Eric
IPC分类号： B01L3/00
摘要： The present invention is related to a disposable flow chip device (1) comprising a microfluidic chip (2) comprising two reservoirs (13, 14) being in fluidic communication with a micro-channel (18), with one or more detection zone(s) (23) and with connectors (12), a pump cartridge (3) comprising a pipe (9) being in contact, in use, with one or more roller(s) (27) of an external peristaltic pump (4), and hermetic connectors (10) complementary to the microfluidic chip connectors (12), wherein the pipe (9) is in fluid communication with the reservoirs (13, 14) of the microfluidic chip (2). The invention relates also to a method and an apparatus for detecting and/or quantifying one or more analyte(s) possibly present in a biological sample using the disposable flow chip device (1) according to the invention.
摘要翻译：本发明涉及一种包括微流体芯片（2）的一次性流动芯片装置（1），其包括与微通道（18）流体连通的两个储存器（13,14），其中一个或多个检测区域（23）和连接器（12），包括在使用中与外部蠕动泵（4）的一个或多个辊（27）接触的管道（9）的泵筒（3）和与所述微流体芯片连接器（12）互补的密封连接器（10），其中所述管道（9）与所述微流体芯片（2）的储存器（13,14）流体连通。本发明还涉及使用根据本发明的一次性流芯片装置（1）来检测和/或定量可能存在于生物样品中的一种或多种分析物的方法和装置。

2. 发明公开

EP1657550A1 Double-sided device for multiplex dipstick immunodiagnostic 审中-公开
标题翻译：多普勒色谱仪Vorrichtung und Verfahren zu ihrer Verwendung
公开(公告)号：EP1657550A1
公开(公告)日：2006-05-17
申请号：EP04447250.4
申请日：2004-11-18
申请人： Coris Bioconcept SPRL
发明人： Leclipteux, Thierry , Degallaix, Stéphane , Denorme, Laurence , Mertens, Pascal , Olungu, Christine
IPC分类号： G01N33/558 , C12Q1/68
CPC分类号： G01N33/558
摘要： The present invention relates to methods and devices for detecting one or more analytes or analyte products in a biological sample. This invention in particular relates to improved rapid tests such as "dipsticks" and "lateral flow" devices. The invention in particular relates to chromatographic device made of two active sides, in order to allow multiplex detections, quantitative or semi-quantitative detections, use of multiple sizes and kinds of particles or microspheres, use of different nitrocellulose porosities, use of different kinds of membranes. The devices described in this invention allow to detect or identify various biologicals or chemicals with one manipulation.
摘要翻译：本发明涉及用于检测生物样品中一种或多种分析物或分析物产物的方法和装置。本发明特别涉及改进的快速测试，例如“骰子”和“横向流动”装置。本发明特别涉及由两个活性侧制成的色谱装置，以便允许多重检测，定量或半定量检测，使用多种尺寸和种类的颗粒或微球，使用不同的硝酸纤维素孔隙率，使用不同种类的膜。本发明中描述的装置允许通过一次操纵来检测或识别各种生物制品或化学品。

3. 发明公开

EP2870260A1 PROCEDE ET DISPOSITIF POUR LA DETECTION RAPIDE DE SEQUENCES NUCLEOTIDIQUES AMPLIFIEES 有权
标题翻译： VERFAHREN UND VORRICHTUNG ZUM SCHNELLEN NACHWEIS VON AMPLIFIZIERTEN NUKLEOTIDSEQUENZEN
公开(公告)号：EP2870260A1
公开(公告)日：2015-05-13
申请号：EP13734714.2
申请日：2013-07-01
申请人： Coris Bioconcept SPRL
发明人： LECLIPTEUX, Thierry , MERTENS, Pascal , AVRAIN, Laetitia , OTE, Isabelle , SMEKENS, Valérie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/50273 , B01L7/525 , B01L2200/10 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0825 , B01L2300/088 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0481 , G01N2021/6439 , C12Q2537/143 , C12Q2565/625 , C12Q2565/629
摘要： The present invention relates to a method and a device for amplification and rapid detection of target nucleotide sequences possibly present in a sample, combining continuous-flow PCR amplification with oligochromatography detection by capillary action on a test strip.
摘要翻译：用于快速扩增和检测样品中可能存在的靶核苷酸序列的方法和装置，优选将PCR扩增与通过测试条上的毛细作用的低色谱检测结合。

4. 发明授权

EP1957984B1 TEST DEVICE FOR RAPID DIAGNOSTICS 有权
标题翻译：试验装置进行快速诊断
公开(公告)号：EP1957984B1
公开(公告)日：2011-10-05
申请号：EP06829403.2
申请日：2006-12-08
申请人： Coris Bioconcept SPRL
发明人： MERTENS, Pascal , DENORME, Laurence , LECLIPTEUX, Thierry
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/558 , G01N33/54386 , G01N33/569
摘要： This invention relates to devices for detecting analytes or analogues thereof in a biological sample comprising: a solid support, whereon is provided several juxtaposed zones, whereby the sample is able to migrate from a sample receiving zone towards a detection zone, whereby the analyte if present is detected, whereby both zones comprises material allowing a capillary flow of the sample through said zones, characterized in that in between said zones an intermediate zone of transport of the sample is provided which is free from any capillary material, allowing the sample to migrate by gravitational forces on the support laid in a vertical position. This invention also relates to methods for detecting analytes or analogues thereof in a biological sample.

5. 发明授权

EP2786019B1 MICROFLUIDIC DEVICE WITH DEFORMABLE VALVE 有权
公开(公告)号：EP2786019B1
公开(公告)日：2018-07-25
申请号：EP12849108.1
申请日：2012-10-17
申请人： International Business Machines Corporation , Coris Bioconcept SPRL
发明人： AVRAIN, Laetitia , DELAMARCHE, Emmanuel , HITZBLECK, Martina , LAURENT, Thierry , MERTENS, Pascal , SMEKENS, Valérie
IPC分类号： F04B53/10 , B81B3/00 , F16K7/16 , G01N37/00 , F16K99/00 , B01L7/00 , B01L3/00
CPC分类号： B01L3/00 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0688 , B01L2400/082 , B01L2400/086 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0026 , F16K2099/008 , F16K2099/0084
摘要： A microfluidic device includes a first microchannel, a second microchannel, and a valve comprising at least an input port and an output port, the ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid along a flow direction (z) defined by the ports; wherein the valve further comprises one or more walls joining the ports and defining a hollow chamber that is wider than each of the microchannels in a direction perpendicular to the flow direction, the walls at least partly deformable along a deformation direction (−y) intersecting the flow direction, such that the walls can be given at least a first deformation state and a second deformation state, such that the liquid can be pulled along the flow direction substantially more in the second deformation state than in the first deformation state.

6. 发明公开

EP3280815A1 METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE 有权
标题翻译：用于检测产生卡巴肽酶的肠杆菌科的方法和装置
公开(公告)号：EP3280815A1
公开(公告)日：2018-02-14
申请号：EP16717589.2
申请日：2016-04-11
申请人： Coris Bioconcept SPRL
发明人： BOGAERTS, Pierre , GLUPCZYNSKI, Gerald , HUANG, Te-Din , MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry
IPC分类号： C12Q1/04 , G01N33/573 , C07K16/40 , C07K16/12
CPC分类号： G01N33/573 , C12Q1/04 , G01N2333/986 , Y02A50/451
摘要： The present invention is related to a method for the detection of one or several carbapenemases from a Carbapenemase-producing Enterobacteriaceae (CPE) possibly present in a biological sample, the method comprising the steps of providing a support, immobilizing on the support one or several capture reagents interacting with one or several epitope regions of one or several carbapenemases, providing one or several detection reagents interacting with one or several epitope regions of the one or several carbapenemases, the detection reagent or reagents being linked, directly or indirectly, to a label to form one or several detection conjugates, providing a sample to be tested comprising, or not, one or several carbapenemases to detect, bringing the sample into contact with the capture reagent or reagents, revealing a specific binding between one or several carbapenemases present in the sample using the detection reagent or reagents. The invention relates also to an immunochromatographic detection device to implement the method according to the invention.

7. 发明授权

EP3280815B1 METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE 有权
公开(公告)号：EP3280815B1
公开(公告)日：2020-10-28
申请号：EP16717589.2
申请日：2016-04-11
申请人： Coris Bioconcept SPRL
发明人： BOGAERTS, Pierre , GLUPCZYNSKI, Gerald , HUANG, Te-Din , MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry
IPC分类号： C12Q1/04 , G01N33/573 , C07K16/40 , C07K16/12

8. 发明公开

EP2786019A1 MICROFLUIDIC DEVICE WITH DEFORMABLE VALVE 有权
标题翻译：与变形的阀微流体装置
公开(公告)号：EP2786019A1
公开(公告)日：2014-10-08
申请号：EP12849108.1
申请日：2012-10-17
申请人： International Business Machines Corporation , Coris Bioconcept SPRL
发明人： AVRAIN, Laetitia , DELAMARCHE, Emmanuel , HITZBLECK, Martina , LAURENT, Thierry , MERTENS, Pascal , SMEKENS, Valérie
IPC分类号： F04B53/10 , B81B3/00 , F16K7/16 , G01N37/00
CPC分类号： B01L3/00 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0688 , B01L2400/082 , B01L2400/086 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0026 , F16K2099/008 , F16K2099/0084
摘要： The invention is notably directed to a microfluidic device (100) comprising: a first microchannel (31), a second microchannel (32), and a valve (50) comprising at least an input port (51) and an output port (52), said ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid (L) along a flow direction (z) defined by the ports, wherein the valve further comprises one or more walls (54, 56, 58, 20) joining the ports and defining a hollow chamber (53) that is wider than each of the microchannels in a direction perpendicular to the flow direction, said walls at least partly deformable along a deformation direction (– y) intersecting the flow direction, such that the walls can be given at least a first deformation state (S1) and a second deformation state (S2), the liquid being pulled along the flow direction substantially more in the second deformation state than in the first deformation state, by capillarity.

9. 发明公开

EP1623042A1 ONE STEP OLIGOCHROMATOGRAPHIC DEVICE AND METHOD OF USE 有权
标题翻译：一步寡聚色谱装置和使用方法
公开(公告)号：EP1623042A1
公开(公告)日：2006-02-08
申请号：EP04730419.1
申请日：2004-04-30
申请人： Coris Bioconcept SPRL
发明人： RENUART, Ismaelle , MERTENS, Pascal , LECLIPTEUX, Thierry
IPC分类号： C12Q1/68 , G01N33/558
CPC分类号： G01N33/54386 , C12Q1/6834 , G01N30/90 , G01N30/92 , G01N33/558 , C12Q2565/625 , C12Q2565/137 , C12Q2545/101 , C12Q2563/131 , C12Q2537/125
摘要： The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved rapid tests such as 'dipsticks', 'lateral flow' devices and 'flow-through' devices. The invention in particular relates to oligochromatographic devices (1) that make use of a peptide- or hapten-coupled oligonucleotide and a reagent (5) specifically recognizing said hapten or peptide (8) and a conjugated probe (6) that hybridizes specifically to a target sequence (7). It allows to detect specifically the presence of a polynucleotides directly or after molecular amplification steps with the use of a specific genuine internal control and a chromatographic control.
摘要翻译：本发明涉及用于检测生物样品中优选清洁液体样品中的一种或多种分析物的方法和装置。本发明尤其涉及改进的快速测试，例如“测试棒”，“横流”装置和“流通”装置。本发明尤其涉及利用肽或半抗原偶联的寡核苷酸和特异性识别所述半抗原或肽（8）的试剂（5）和特异性杂交至特异性结合的探针（6）的寡聚色谱装置（1）目标序列（7）。它允许直接或在分子扩增步骤之后使用特定的真正内部对照和色谱对照来特异性检测多核苷酸的存在。

10. 发明授权

EP3075451B1 DISPOSABLE FLOW CHIP DEVICE 有权
公开(公告)号：EP3075451B1
公开(公告)日：2020-05-13
申请号：EP15162040.8
申请日：2015-03-31
申请人： Coris Bioconcept SPRL
发明人： MERTENS, Pascal , OTE, Isabelle , LECLIPTEUX, Thierry , AUSSEMS, Eric
IPC分类号： B01L3/00

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