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    • 2. 发明授权
    • Therapeutic agents containing bacteriophages against P. aeruginosa
    • Bakteriophagen gegen P. aeruginosa enhaltende therapeutische Wirkstoffe
    • EP2570130B1
    • 2014-11-26
    • EP12195158.6
    • 2004-07-23
    • Biocontrol Limited
    • Soothill, JamesHawkins, CatherineHarper, David
    • A61K35/76A61P31/00
    • A61K35/76A61K31/424A61K31/43A61K38/00A61K38/51A61K45/06C07K14/21C07K16/1214C12N2795/00031C12N2795/00032A61K2300/00
    • The present invention relates in its broadest aspect to combined phage/antibiotic therapy. More particularly, it relates to use of (i) one or more bacteriophages and (ii) one or more antibiotics in the manufacture of a combined product for simultaneous, separate or sequential administration of (i) and (ii) to treat a bacterial infection characterized by biofilm formation, for example an infection comprising or consisting of P. aeruginosa. Treatment in this context may be either therapeutic or prophylactic treatment. Also provided are deposited bacteriophages each exhibiting different strain specificity against P. aeruginosa and combinations of such bacteriophages, e.g. a panel of six deposited bacteriophages which was found to be effective against a high percentage of clinical isolates of P. aeruginosa from canine ear infections.
    • 本发明最广泛地涉及联合噬菌体/抗生素治疗。 更具体地说,本发明涉及(i)一种或多种噬菌体的用途和(ii)一种或多种抗生素在制造用于同时,分开或依次施用(i)和(ii)的组合产品中以治疗细菌感染 其特征在于生物膜形成,例如包含铜绿假单胞菌或由铜绿假单胞菌组成的感染。 在这种情况下的治疗可以是治疗性或预防性治疗。 还提供了各自对铜绿假单胞菌显示不同的菌株特异性的沉积噬菌体和这种噬菌体的组合,例如 一组六个沉积的噬菌体被发现对来自犬耳感染的高百分比的铜绿假单胞菌的临床分离株有效。