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1. 发明授权

EP1131631B1 IN SITU METHOD OF ANALYZING CELLS 有权
标题翻译：原位方法分析细胞
公开(公告)号：EP1131631B1
公开(公告)日：2009-01-07
申请号：EP99963904.0
申请日：1999-11-16
申请人： Applied Spectral Imaging Ltd.
发明人： GARINI, Yuval , MCNAMARA, George , SOENKSEN, Dirk, G. , CABIB, Dario , BUCKWALD, Robert, A.
IPC分类号： G01N33/53 , C12Q1/54 , C12Q1/28 , C12Q1/00 , C12Q1/42 , G01N33/569
CPC分类号： C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N1/30 , G01N21/6428 , G01N21/6456 , G01N33/5005 , G01N33/53 , G01N33/56966 , G01N33/582 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76 , Y10S435/968
摘要： A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected so that a spectral component associated with each of the N stains is collectible. Figure (1) shows a block diagram illustrating the main components of an imaging spectrometer.

2. 发明授权

EP0957345B1 Methods and apparati for spectral imaging using interferometers of the Fabry-Perot type 失效
标题翻译：方法和装置用于光谱成像由法布里 - 珀罗干涉仪的装置
公开(公告)号：EP0957345B1
公开(公告)日：2002-11-13
申请号：EP99111903.3
申请日：1993-07-22
申请人： Applied Spectral Imaging Ltd.
发明人： Cabib, Dario , Friedman, Zvi , Lipson, Stephen G. , Buckwald Robert A.
IPC分类号： G01J3/28
CPC分类号： G01J3/2823 , G01J3/26 , G01J2003/2866

3. 发明公开

EP1131631A4 IN SITU METHOD OF ANALYZING CELLS 有权
标题翻译：原位方法分析细胞
公开(公告)号：EP1131631A4
公开(公告)日：2002-11-04
申请号：EP99963904
申请日：1999-11-16
申请人： APPLIED SPECTRAL IMAGING LTD
发明人： GARINI YUVAL , MCNAMARA GEORGE , SOENKSEN DIRK G , CABIB DARIO , BUCKWALD ROBERT A
IPC分类号： C12Q1/68 , G01J3/02 , G01J3/12 , G01J3/26 , G01J3/28 , G01J3/44 , G01J3/453 , G01N1/30 , G01N21/64 , G01N21/78 , G01N33/50 , G01N33/53 , G01N33/533 , G01N33/535 , G01N33/569 , G01N33/58 , G06K9/00 , G06K9/76 , C12Q1/00 , C12Q1/28 , C12Q1/42 , C12Q1/54
CPC分类号： C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J2003/2866 , G01N1/30 , G01N21/6428 , G01N21/6456 , G01N33/5005 , G01N33/53 , G01N33/56966 , G01N33/582 , G01N2021/6423 , G01N2021/6441 , G06K9/00127 , G06K9/76 , Y10S435/968
摘要： A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collection device for collecting spectral data from the biological sample, the spectral data collection device and the N stains are selected so that a spectral component associated with each of the N stains is collectible. Figure (1) shows a block diagram illustrating the main components of an imaging spectrometer.

4. 发明公开

EP1114393A1 SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE 审中-公开
标题翻译：生物SPEKTRALBILDUNGSDATEN与内部参考分类
公开(公告)号：EP1114393A1
公开(公告)日：2001-07-11
申请号：EP99946816.8
申请日：1999-09-10
申请人： Applied Spectral Imaging Ltd.
发明人： CABIB, Dario , BUCKWALD, Robert, A. , BEN-YOSEF, Nissim
IPC分类号： G06K9/00
CPC分类号： G01B11/0675 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J5/10 , G01J2003/2866 , G01N1/30 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N33/582 , G01N2021/6417 , G06K9/00127 , G06K9/76
摘要： A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by the following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using said spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of said other constant components are modified to substantially resemble said spectral vector; (d) operating said correcting function on spectral associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying said corrected spectral vectors into classification groups.

5. 发明公开

EP1107688A1 SPECTRAL IMAGING USING ILLUMINATION OF PRESELECTED SPECTRAL CONTENT 审中-公开
标题翻译：选择性光谱目录光谱成像利用光
公开(公告)号：EP1107688A1
公开(公告)日：2001-06-20
申请号：EP99940981.6
申请日：1999-08-16
申请人： Applied Spectral Imaging Ltd.
发明人： ADEL, Michael, E. , CABIB, Dario , WINE, David
IPC分类号： A61B3/10
CPC分类号： A61B3/10 , G01J3/10 , G01J3/2823 , G01J2003/1282
摘要： This invention is a device, and method for spectral imaging of an object. A plurality of sets of narrow-band light sources (12) such as LEDs are provided. Each set emits illumination radiation in a different narrow spectral band. Each set is activated sequentially to illuminate the object (16). Light reflected from the object or transmitted by the object is focused (26) on a detector array (20) to image the object. Narrower illumination bands are provided by dispersing the emitted light using a dispersive optical element such as a diffraction grating. Alternatively, selected sets or subsets are activated simultaneously with duty cycles that emulate a preselected spectral distribution. For imaging ocular fundus tissue, the illumination light is shaped into an annular beam by an appropriately shaped wave-guide.

6. 发明公开

EP1100965A1 METHOD OF AND COMPOSITE FOR FLUORESCENT IN SITU HYBRIDIZATION 审中-公开
标题翻译：荧光原位杂交法和混合材料THEREFOR
公开(公告)号：EP1100965A1
公开(公告)日：2001-05-23
申请号：EP99935850.0
申请日：1999-07-23
申请人： Applied Spectral Imaging Ltd.
发明人： BAR-AM, Irit , JANISH, Cathy , GARINI, Yuval , CABIB, Dario , BUCKWALD, Robert, A.
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6841 , C12Q2527/125 , C12Q2563/107 , C12Q2527/101 , C12Q2525/151
摘要： A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (f) analyzing and presenting images of the now hybridized chromosome spread.

7. 发明公开

EP0957346A2 Methods and apparati for spectral imaging using an interferometer of the translating type in which a finite number of coherent beams interfere mutually 失效
标题翻译：方法和装置用于光谱成像通过具有有限数量的相干光束的相互叠加的干涉仪的装置
公开(公告)号：EP0957346A2
公开(公告)日：1999-11-17
申请号：EP99111904.1
申请日：1993-07-22
申请人： Applied Spectral Imaging Ltd.
发明人： Cabib, Dario , Friedman, Zvi , Lipson, Stephen G. , Buckwald Robert A.
IPC分类号： G01J3/28
CPC分类号： G01J3/2823 , G01J3/26 , G01J2003/2866
摘要： A method and an apparatus for analyzing an optical image of a scene to determine the spectral intensity of each pixel thereof, comprising: collecting and collimating incident light from the scene; passing the light through an interferometer wherein the light is first split into a finite plurality of coherent beams which travel along different optical paths inside the interferometer and then recombine to interfere with each other, the interferometer thereby outputting modulated light corresponding to a predetermined set of linear combinations of the spectral intensity of the light emitted from each pixel; focusing the light outputted from the interferometer on a two dimensional detector array; and processing the output of the detector array to determine the spectral intensity of each pixel thereof; the interferometer being of the translating type in which the optical path difference is varied to modulate the light by translating an element of the interferometer, such that at each instant each detector sees a different point of the scene and its signal is a linear combination of the spectral content of the light coming from each pixel, and that when the scanner completes one interferometer scan, the scene will have been scanned at all relevant linear combinations of the spectral content.
摘要翻译：一种用于在景物的光学影像分析确定性矿每个像素的光谱强度，其包括的方法和装置：从场景收集和准直入射光; 通过使光到干涉仪worin光首先被分为沿着干涉仪内不同的光路行进，然后再结合相干光束的有限多个具有海誓山盟干涉，所述干涉仪从而输出婷调制光对应于预定组线性的从每个像素发射的光的光谱强度的组合; 聚焦从二维检测器阵列上的干涉仪的输出的光; 和处理检测器阵列，以确定性矿其输出的每个像素的光谱强度; 该干涉仪是其中的光程差而改变通过在干涉仪的元件转换到调制光平移类型的，谋求确实在每个时刻的每个检测器看到不同点的场景和其信号是的线性组合从每个像素发出的光的光谱内容，并没有当扫描仪完成一个干涉仪扫描，现场将已经在频谱内容的所有相关的线性组合扫描。

8. 发明公开

EP0899558A2 Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardware therefor 无效
标题翻译：用于通过多个宽带滤光器的装置的图像元素分类为根据它们的光谱组的方法和装置
公开(公告)号：EP0899558A2
公开(公告)日：1999-03-03
申请号：EP98306743.0
申请日：1998-08-24
申请人： Applied Spectral Imaging Ltd.
发明人： Katzir, Nir , Garini, Yuval , Wine, David , Cabib, Dario
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N15/1475 , G01N21/6458 , G01N2021/6441 , G02B21/06
摘要： A method of classification of pixels into groups of pixels according to their association with a single fluorophore or a combination of fluorophores selected from a plurality of fluorophores, each of the fluorophores having characterizing excitation and emission spectra and specifying excitation and emission peaks, the method comprising the steps of (a) providing a plurality of pairs of wide-band excitation filters (114) and wide-band emission filters (116); (b) exciting fluorophores of each of the pixels with light filtered through one of the wide-band excitation filters, and recording emitted light intensity (122) as retrieved after passing through its paired emission filter; (c) repeating step (b) for all of the plurality of pairs of filters, such that each of the pixels is representable by a vector of a plurality of dimensions, the number of dimensions being equal to the number of the plurality of pairs of filters; (d) using an algorithm for evaluating the presence of each of the plurality of fluorophores in each of the pixels, thereby classifying each of the pixels into a group of pixels according to its association with a single fluorophore or combination of fluorophores.
摘要翻译：像素分类成像素gemäß的基团及其具有单个荧光团或荧光团的组合关联，包括：（a）提供许多宽带发射滤光片; （B）对于每个像素，记录发射的穿过发射滤波器中的每一个之后作为检索光强度，搜索并每个像素是通过等于宽带发射的数量的维数的矢量表示的过滤器; 和（c）使用在算法评定每个与每个像素相关联的荧光团的存在，因此，每个像素分类成一组像素gemäß的其与荧光团缔合。每个荧光团具有一个字符伊辛发射光谱和一个指定发射峰。

9. 发明授权

EP0935679B1 METHOD FOR CHROMOSOME CLASSIFICATION BY DECORRELATION STATISTICAL ANALYSIS AND HARDWARE THEREFORE 失效
标题翻译：如通过用于解相关统计分析和硬件的装置，用于染色体分类的方法
公开(公告)号：EP0935679B1
公开(公告)日：2004-11-24
申请号：EP97945247.1
申请日：1997-09-19
申请人： Applied Spectral Imaging Ltd.
发明人： CABIB, Dario , BUCKWALD, Robert, A. , BEN-YOSEF, Nissim
IPC分类号： C12Q1/68 , G02B21/00 , G06T5/00
CPC分类号： C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/457 , G01J2003/2866 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N33/56966 , G01N2021/6423 , G01N2021/6441 , G01N2021/6471 , G06K9/00127 , G06K9/76

10. 发明授权

EP0832417B1 METHOD FOR SIMULTANEOUS DETECTION OF MULTIPLE FLUOROPHORES FOR IN SITU HYBRIDIZATION AND CHROMOSOME PAINTING 失效
标题翻译：程序对在多个荧光基团同时检测和染色体原位杂交染色
公开(公告)号：EP0832417B1
公开(公告)日：2003-08-06
申请号：EP96944834.9
申请日：1996-12-10
申请人： Applied Spectral Imaging Ltd.
发明人： GARINI, Yuval , CABIB, Dario , BUCKWALD, Robert, A. , SOENKSEN, Dirk, G. , KATZIR, Nir , WINE, David , LAVI, Moshe
IPC分类号： G01J3/28 , C12Q1/68
CPC分类号： G01N21/6458 , A61B3/12 , A61B3/1241 , C12Q1/6816 , C12Q1/6841 , C12Q1/6883 , C12Q2600/156 , G01B11/0675 , G01J3/02 , G01J3/12 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/4406 , G01J3/453 , G01J3/4535 , G01J2003/2866 , G01N21/6428 , G01N33/5005 , G01N33/56966 , G01N33/582 , G01N2021/6417 , G01N2021/6441 , G06K9/00127 , G06K9/76

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