专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明公开

EP0421921A1 Doppelt beschichtete Granulate 有权转让
标题翻译：双涂颗粒。
公开(公告)号：EP0421921A1
公开(公告)日：1991-04-10
申请号：EP90810661.0
申请日：1990-08-30
申请人： CIBA-GEIGY AG
发明人： Wirth, Dagmar, Dr. , Bucher, Christian
IPC分类号： A61K31/66 , A61K9/54
CPC分类号： A61K31/66 , A61K9/5073
摘要： Die Erfindung betrifft eine vorteilhafte orale Darreichungsform für Dinatriumpamidronat in Kapseln. Diese Kapseln sind mit doppelt beschichteten Granulaten gefüllt. Die innere Beschichtung ist hydrophil und elastisch, die äussere Beschichtung ist magensaftresistent und darmsaftlöslich. Die Granulate zeichnen sich durch gute Magenverträglichkeit aus.
摘要翻译：本发明涉及一种用于在胶囊帕米膦酸二钠有利的口服剂型。这些胶囊填充有双涂颗粒。内涂层是亲水性的和弹性的，该外涂层是耐胃液和溶于肠液。该颗粒是通过良好的耐受性胃肠特点。

82. 发明公开

EP0386967A3 A drug-release controlling coating material for long acting formulations 失效
标题翻译：用于长期配制的药物释放控制涂料
公开(公告)号：EP0386967A3
公开(公告)日：1991-04-03
申请号：EP90302287.9
申请日：1990-03-05
申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
发明人： Ohmura, Tadayoshi , Fukui, Muneo , Sugiura, Hiroshi , Hosono, Toshiharu , Kajiyama, Atsushi , Yoneya, Satoru,
IPC分类号： A61K9/52 , A61K9/54
CPC分类号： A61K9/5078 , A61K9/5026
摘要： A coating material for controlling drug release, useful for long acting formulations (e.g. for once-a-day administration), and a long acting granular composition comprising a drug (especially one conventionally difficult to prepar in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material may comprise, in a specific ratio, specific water-insoluble and low water-permeability polymer and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer materials).

83. 发明公开

EP0377518A3 Sustained release pharmaceutical composition 有权转让
标题翻译：持续释放药物组合物
公开(公告)号：EP0377518A3
公开(公告)日：1990-10-24
申请号：EP90300130.3
申请日：1990-01-05
申请人： F.H. FAULDING & CO. LIMITED
发明人： Morella, Angel Mario , Fisher, Mark Christopher
IPC分类号： A61K31/485 , A61K9/52 , A61K9/54
CPC分类号： A61K31/485 , A61K9/5026 , A61K9/5031 , A61K9/5047 , A61K9/5078
摘要： A sustained release pharmaceutical pellet composition suitable for treating pain-associated conditions in patients comprises a core element including at least one active ingredient of high solubility; and a core coating for the core element which is partially soluble at a highly acidic pH to provide a slow rate of release of active ingredient e.g a morphine compound, and wherein the active ingredient is available for absorption at a relatively constant faster rate in the intestine over an extended period of time, such that blood levels of active ingredient are maintained with the therapeutic range over an extended period of time.

84. 发明公开

EP0366621A1 Orally pharmaceutical preparations with colon selective delivery 失效
标题翻译：具有结肠选择性递送的口服药物制剂
公开(公告)号：EP0366621A1
公开(公告)日：1990-05-02
申请号：EP89830455.5
申请日：1989-10-19
申请人： BOEHRINGER INGELHEIM ITALIA S.p.A.
发明人： Iamartino, Piero , Maffione, Grazia , Pontello, Lino
IPC分类号： A61K9/54 , A61K9/24
CPC分类号： A61K9/5073 , A61K9/2886
摘要： Orally administrable pharmaceutical preparation containing an active ingredient to be released in the lower part of the gastrointestinal tract, i.e. in the large intestine, and especially colon, consisting of a core containing a therapeutically active substance and coated with three protection layers at different solubility. The manufacturing and the use of these preparations are also described.
摘要翻译：口服给药的药物制剂，其含有待释放于胃肠道下部，即大肠中的活性成分，特别是结肠，由含有治疗活性物质的核心组成，并且用不同溶解度的三层保护层包衣。还描述了这些制剂的制造和使用。

85. 发明公开

EP0265457A4 VACCINE AND IMPLANT. 失效
标题翻译：疫苗和植入。
公开(公告)号：EP0265457A4
公开(公告)日：1989-07-26
申请号：EP87902324
申请日：1987-04-08
申请人： DARATECH PTY LTD
发明人： STELMASIAK TEODOR
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/26 , A61K9/54 , A61K9/58 , A61K39/00 , A61K47/00 , A61K47/32 , A61K9/52 , A61K37/24
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/2077 , A61K39/0006

86. 发明公开

EP0315414A1 Controlled release dosage form 有权转让
标题翻译： Darreichungsform mit kontrollierter Freigabe。
公开(公告)号：EP0315414A1
公开(公告)日：1989-05-10
申请号：EP88310271.7
申请日：1988-11-01
申请人： TANABE SEIYAKU CO., LTD.
发明人： Samejima, Masayoshi , Noda, Kazuo , Kobayashi, Masao , Ishikawa, Shigeyuki
IPC分类号： A61K9/54 , A61K9/24 , A61K31/55
CPC分类号： A61K9/5078
摘要： A controlled release dosage form which consists essentially of a core containing a medicament; an inner coating layer composed of ethylcellulose and a hydrophobic substance; and an outer coating layer containing a medicament are disclosed. Said dosage form shows rapid increase in blood concentration of the medicament and at the same time maintains the high level of the blood concentration over a prolonged period time.
摘要翻译：控制释放剂型，其主要由含有药物的核心组成; 由乙基纤维素和疏水性物质组成的内层; 并且公开了含有药物的外涂层。所述剂型显示药物血液浓度的快速增加，并且同时在长时间内保持高浓度的血液浓度。

87. 发明公开

EP0305918A1 Controlled release delivery coating formulation for bioactive substances 失效转让
标题翻译： Die zur Freisetzung bioaktiver Substanzen kontrollierendeUmhüllungszubereitung。
公开(公告)号：EP0305918A1
公开(公告)日：1989-03-08
申请号：EP88113933.1
申请日：1988-08-26
申请人： AIR PRODUCTS AND CHEMICALS, INC.
发明人： Ambegoankar, Anil S. , Howells, Roger Alan
IPC分类号： A61K9/54
CPC分类号： A01N25/26 , A61K9/2886 , A61K9/5073
摘要： The present invention relates to a bioactive composition having a controlled, sustained release delivery pattern when contacted with a suitable surrounding media. The composition comprises a pharmaceutically, insecticidally, herbicidally or fertilizing bioactive material core, soluble in a given surrounding media, the core present in an amount at least sufficient for a total dosage during a specified treatment period; a first coating enveloping the bioactive material core comprising a polymer or a blend of polymers, said polymer or blend of polymers being swellable upon penetration by the surrounding media; and a second coating enveloping the first coating, the second coating comprising a polymer or a blend of polymers being water-insoluble and forming a semi-permeable barrier to the inward diffusion of the surrounding media and the outward diffusion of the bioactive material dissolved in the surrounding media.
摘要翻译：本发明涉及当与合适的周围介质接触时具有受控的持续释放递送模式的生物活性组合物。组合物包含可溶于给定周围培养基的药学，杀虫，除草或施肥的生物活性物质核心，核心以至少足以在指定治疗期间的总剂量存在的量存在; 包围生物活性材料芯的第一涂层包括聚合物或聚合物的共混物，所述聚合物或聚合物的共混物在被周围介质穿透时可溶胀; 以及包封第一涂层的第二涂层，所述第二涂层包含聚合物或聚合物的共混物，其是不溶于水的并且形成对周围介质的向内扩散的半透性屏障和溶解在所述第二涂层中的生物活性材料的向外扩散周边媒体。

88. 发明公开

EP0256933A1 Procédé de préparation d'un médicament à base de fénofibrate, médicament obtenu par ce procédé 有权
标题翻译：一种用于制造药物的，从而和药物获得的非诺贝特碱处理。
公开(公告)号：EP0256933A1
公开(公告)日：1988-02-24
申请号：EP87401824.5
申请日：1987-08-06
申请人： ETHYPHARM
发明人： Boyer, Jean-François
IPC分类号： A61K31/235 , A61K9/54
CPC分类号： A61K31/22 , A61K9/5078
摘要： Médicament sous forme de granules à base de fénofibrate, chaque granule comportant un noyau neutre, une couche à base de fénofibrate et une couche de protection, caractérisé en ce que, dans la couche à base de fénofibrate, celui-ci est présent sous forme de microparticules cristallines de dimension inférieure ou égale à 50 microns, et de préférence de l'ordre de 10 microns.

89. 发明公开

EP0225085A1 Controlled absorption pharmaceutical formulation 失效
标题翻译：药物制剂具有受控的吸收。
公开(公告)号：EP0225085A1
公开(公告)日：1987-06-10
申请号：EP86308810.0
申请日：1986-11-12
申请人： ELAN CORPORATION P.L.C.
发明人： Panoz, Donald Eugene , Geogeghan, Edward James
IPC分类号： A61K31/49 , A61K9/52 , A61K9/54
CPC分类号： A61K31/49 , A61K9/5078
摘要： A controlled absorption quinidine formulation for oral administration comprises a pellet having a core of quinidine or a pharmaceutically acceptable salt thereof in association with an organic acid and optionally other excipients, and an outer membrane which permits release of quinidine in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XXI at 37°C and 75 r.p.m. is not more than 15% after one hour of measurement. Not more than 50% of the total quinidine is release after a total of 4 hours of measurement, not more than 80% is released after a total of 8 hours of measurement and not less than 90% release is achieved after a total of 24 hours.

90. 发明公开

EP0207405A2 Method for making pharmaceutical combination composition in granularly heterogenous solid unit dosage form with enhanced bioavailability 有权
标题翻译：一种用于在具有增强的生物利用度的粒状多相剂型制备组合的药物组合物的方法。
公开(公告)号：EP0207405A2
公开(公告)日：1987-01-07
申请号：EP86108447.3
申请日：1983-07-20
申请人： Mylan Pharmaceuticals, Inc.
发明人： Blume, Cheryl D., Dr. , Bonner, Paul Hamilton
IPC分类号： A61K9/54
CPC分类号： A61K9/5084 , A61K9/2077 , A61K31/54 , A61K2300/00
摘要： A novel comblnation pharmaceutical composition is de. acribed, together with a method for making the same, wherein the pharmaceutically active ingredients are separately milled and then formed Into separate granules, and only thereafter blended together to form the combination composition. The method for achieving this novel combination composition is also described.
摘要翻译：一种新的组合的药物组合物进行了说明，与制造相同，worin的药物活性成分被分别研磨，然后形成为单独的颗粒，并且仅在其后混合在一起以形成组合的组合物的方法一起。因此描述了用于实现这种新颖的组合组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式