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81. 发明公开

EP2618139A4 BIOSENSOR AND PRODUCTION METHOD THEREFOR 无效
标题翻译：生物传感器及其制造方法
公开(公告)号：EP2618139A4
公开(公告)日：2016-12-28
申请号：EP11825053
申请日：2011-09-07
申请人： DAINIPPON PRINTING CO LTD
发明人： WATANABE MASANAO , ITO KENICHI , ISHII MAKOTO , YOSHIDAM HIROSHI , BABA TOSHIAKI
IPC分类号： G01N27/327 , G01N27/416
CPC分类号： G01N27/3271 , G01N27/3272
摘要： Provided is a biosensor which measures a concentration or the like of a particular component in a sample with a high level of sensitivity and can be produced at low cost, and a method for producing such a biosensor. A biosensor according to the present invention includes a first base material having an insulating surface; an adhesive layer located on the insulating surface of the first base material; and an electrode system and wiring sections fixed to the first base material via the adhesive layer. The electrode system includes top electrode layers and bottom electrode layers, and the bottom electrode layers are formed of a material having a higher conductivity than that of the top electrode layers; the electrode system includes a working electrode and a counter electrode, and also includes an enzyme reaction section located on the working electrode, the enzyme reaction section containing an enzyme and an electron acceptor; and the bottom electrode layers and the wiring sections are integral with each other.

82. 发明公开

EP3105572A1 CAPACITIVE BUBBLE DETECTION 有权
标题翻译： KAPAZITIVE BLASENDETEKTION
公开(公告)号：EP3105572A1
公开(公告)日：2016-12-21
申请号：EP15703094.1
申请日：2015-02-09
申请人： Robert Bosch GmbH
发明人： FUNK, Tobias , KAVUSI, Sam
IPC分类号： G01N27/22
CPC分类号： G01N27/3274 , G01N27/226 , G01N27/228 , G01N27/3271 , G01N27/3272 , G01N27/3276
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：用于生物传感器的装置和方法，包括测试部位的多位阵列，所述装置和方法可用于通过调节pH或离子来调节生物分子（生物分子）探针或检测试剂和目标分析物之间的结合相互作用在这种生物传感器中电极附近的梯度。适用于生物缓冲液中用于改变生物缓冲液pH值的电化学活性剂。使用电化学活性剂改变生物缓冲液的pH的方法。调节生物传感器中提供的结合相互作用的方法，用于更精确地控制和测量这些生物传感器中电极附近的pH或离子梯度的分析方法，以及用于更准确地测量生物样品中感兴趣的分析物的分析方法。

83. 发明公开

EP2980215A4 MODIFIED GLYCINE OXIDASE 有权
标题翻译：修饰的甘氨酸氧化酶
公开(公告)号：EP2980215A4
公开(公告)日：2016-11-30
申请号：EP14773823
申请日：2014-03-28
申请人： AJINOMOTO KK
发明人： KODAMA YUYA , HOSHINO WATARU , TAKAHASHI KAZUTOSHI , ITO MOEMI
IPC分类号： C12N15/09 , C12M1/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12P7/42 , C12Q1/26 , G01N27/327 , G01N27/416
CPC分类号： C12N9/0022 , C12P7/40 , C12P7/42 , C12Q1/005 , C12Q1/26 , C12Y104/03019 , G01N27/3271 , G01N2333/90638
摘要： The present invention provides a means and method useful for measurement of a glycine concentration. Specifically, the present invention provides a modified enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, comprising measuring glycine contained in a test sample using the modified enzyme; and the like.

84. 发明授权

EP1544596B1 Verfahren und Vorrichtung zur Bestimmung der Viskosität 有权
标题翻译：用于确定的粘度的方法和装置
公开(公告)号：EP1544596B1
公开(公告)日：2016-11-23
申请号：EP04028644.5
申请日：2004-12-03
申请人： Boehringer Ingelheim microParts GmbH
发明人： Kurowski, Dirk, Dr. , Schön, Christian , Peters, Ralf-Peter, Dr. , Bartos, Holger, Dr. , Yu, Ying, Dr.
IPC分类号： G01N11/10 , G01N11/16 , G01N33/49
CPC分类号： G01N11/162 , A61B5/14532 , C12Q1/56 , G01N11/10 , G01N27/3271 , G01N33/4905 , G01N33/66 , G01N2011/0086

85. 发明公开

EP3078750A1 BIO-ENZYME SENSOR CAPABLE OF SUPER HYDROPHOBIC SOLID-LIQUID-GAS THREE-PHASE COEXISTENCE AND METHOD FOR PREPARING SAME 有权
标题翻译： BIOENZYMSENSOR超疏水三相共存及其制造固体，液体和气体和工艺
公开(公告)号：EP3078750A1
公开(公告)日：2016-10-12
申请号：EP14867289.2
申请日：2014-03-07
申请人： Suzhou Institute of Nano-tech and Nano-bionics (SINANO) Chinese Academy of Sciences
发明人： JIANG, Lei , ZHANG, Xiangcheng , LEI, Yongjiu , SUN, Ruize , FENG, Xinjian
IPC分类号： C12Q1/00 , G01N27/327
CPC分类号： C12Q1/006 , C12Q1/004 , C12Q1/005 , G01N27/3271
摘要： A bio-enzyme sensor capable of super-hydrophobic solid-liquid-gas three-phase coexistence and a method for preparing the same. The bio-enzyme sensor comprises, from bottom to top, a base material with super-hydrophobic surface, a catalytic material having the function of catalyzing hydrogen peroxide, and bio-enzyme capable of reacting with a substance to be tested to generate hydrogen peroxide. A sufficient amount of oxygen can be provided for enzymatic reaction by forming a state of solid-liquid-gas three-phase coexistence on the surface of the super-hydrophobic material.
摘要翻译：阿能够超疏水固体 - 液体 - 气体三相共存和用于制备其的方法的生物酶传感器。生物酶传感器包括，从下到上，具有超疏水性表面的基体材料，将待测试具有催化过氧化氢，和能够与物质反应的生物酶的功能的催化材料，以产生过氧化氢。可以通过超疏水性材料的表面上形成固体 - 液体 - 气体三相共存的状态下被提供用于酶反应的氧的足够量。

86. 发明公开

EP2951568A4 STANDBY BIASING OF ELECTROCHEMICAL SENSOR TO REDUCE SENSOR STABILIZATION TIME DURING MEASUREMENT 有权转让
标题翻译： WITH A电化学传感器准备操作减少传感器测量的稳定化的周期
公开(公告)号：EP2951568A4
公开(公告)日：2016-09-14
申请号：EP14742842
申请日：2014-01-08
申请人： VERILY LIFE SCIENCES LLC
发明人： PLETCHER NATHAN , OTIS BRIAN
IPC分类号： A61B5/145 , G01N27/30 , G01N27/416 , G01N33/483
CPC分类号： A61B5/0004 , A61B5/0031 , A61B5/14507 , A61B5/14532 , A61B5/1459 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/6821 , A61B5/686 , A61B5/7264 , A61B5/742 , A61B2560/0209 , A61B2560/0214 , A61B2560/0219 , G01N27/3271
摘要： An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.
摘要翻译：眼上的装置包括嵌入在配置成安装到眼睛的表面的聚合物材料的电化学传感器。所述电化学传感器应用一个工作电极和一个参比电极，以允许安培电流以配置成测量安培电流和通信所测量的安培电流测量电子设备供电之前稳定之间的稳定电压。该电化学传感器消耗更少的功率，而不是在测量期间施加稳定电压。测量在响应发起内式眼安装的设备上接收在天线的测量信号。

87. 发明公开

EP2980215A1 MODIFIED GLYCINE OXIDASE 有权
标题翻译：修饰的甘氨酸氧化酶
公开(公告)号：EP2980215A1
公开(公告)日：2016-02-03
申请号：EP14773823.1
申请日：2014-03-28
申请人： Ajinomoto Co., Inc.
发明人： KODAMA, Yuya , HOSHINO, Wataru , TAKAHASHI, Kazutoshi , ITO, Moemi
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12P7/42 , C12Q1/26 , G01N27/327 , G01N27/416 , C12M1/34
CPC分类号： C12N9/0022 , C12P7/40 , C12P7/42 , C12Q1/005 , C12Q1/26 , C12Y104/03019 , G01N27/3271 , G01N2333/90638
摘要： The present invention provides a means and method useful for measurement of a glycine concentration. Specifically, the present invention provides a modified enzyme in which at least one amino acid residue is mutated so as to improve a property of a glycine oxidase which is associated with the measurement of glycine (e.g., activity of glycine oxidase for glycine, thermal stability of glycine oxidase, and substrate specificity of glycine oxidase for glycine,); and a method of analyzing glycine, comprising measuring glycine contained in a test sample using the modified enzyme; and the like.
摘要翻译：本发明提供了用于测量甘氨酸浓度的手段和方法。具体而言，本发明提供了一种修饰的酶，其中至少一个氨基酸残基被突变以改进与甘氨酸测量相关的甘氨酸氧化酶的性质（例如，甘氨酸氧化酶对甘氨酸的活性，甘氨酸氧化酶和甘氨酸氧化酶对甘氨酸的底物特异性）; 和分析甘氨酸的方法，包括使用修饰的酶测量测试样品中所含的甘氨酸; 等等。

88. 发明公开

EP2972275A1 WHOLE BLOOD HEMOLYSIS SENSOR 有权
标题翻译：全血溶血传感器
公开(公告)号：EP2972275A1
公开(公告)日：2016-01-20
申请号：EP14712547.0
申请日：2014-03-10
申请人： Instrumentation Laboratory Company
发明人： BALASUBRAMANIAN, Shankar , D'ORAZIO, Paul
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/005 , C12Q1/26 , G01N27/327 , G01N27/3271 , G01N27/3277
摘要： The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
摘要翻译：本发明涉及溶血传感器，溶血传感器系统以及利用溶血传感器或溶血传感器系统来监测或检测样本（例如全血样本，血浆样本，血清样本或溶血血液）中的溶血的方法。溶血传感器响应细胞外血红蛋白水平，例如全血样品中的细胞外血红蛋白作为检测全血中溶血的方法。

89. 发明公开

EP2972264A2 ON-BODY MICROSENSOR FOR BIOMONITORING 审中-公开
标题翻译： AMKÖRPERGETRAGENER MIKROSENSORFÜRBIOÜBERWACHUNG
公开(公告)号：EP2972264A2
公开(公告)日：2016-01-20
申请号：EP14770855.6
申请日：2014-03-14
申请人： Sano Intelligence, Inc.
发明人： PUSHPALA, Ashwin , SZMODIS, Alan , CHAPMAN, Matthew , HALL, Weldon , MILLER, Scott , HAFEZI, Hooman
IPC分类号： G01N27/26
CPC分类号： A61M37/0015 , A61B5/14503 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/4839 , A61B5/685 , A61B2562/028 , A61B2562/12 , A61B2562/125 , A61M25/00 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , C12Q1/006 , G01N27/3271 , Y10T29/49117
摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.
摘要翻译：一种用于微传感器的微传感器和制造方法，其包括长丝阵列，其中所述细丝阵列的每个细丝包括基底和连接到所述基底的导电层，并且被配置为促进分析物检测。所述长丝阵列的每个细丝还可以包括绝缘层，所述绝缘层被配置为隔离由所述导电层限定的用于分析物检测的区域，耦合到所述导电层的感测层，其被配置为能够将离子浓度转换成电子电压，以及选择性涂层耦合到感测层，被配置为便于检测特定的目标分析物/离子。微传感器便于检测存在于与微传感器接口的用户的体液中的至少一种分析物。

90. 发明公开

EP2943784A2 SALIVA GLUCOSE MONITORING SYSTEM 审中-公开
标题翻译：唾液血糖监测系统
公开(公告)号：EP2943784A2
公开(公告)日：2015-11-18
申请号：EP14737861.6
申请日：2014-01-13
申请人： Northeastern University
发明人： ZHANG, Wenjun , WANG, Ming, L.
IPC分类号： G01N27/327 , C23C28/00
CPC分类号： G01N27/3273 , G01N27/3271
摘要： A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting.

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