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    • 85. 发明公开
    • NOVEL SYNTHESIS-REGULATING SRNA AND METHOD FOR PREPARING SAME
    • 合成新法规斯尔纳和方法及其生产
    • EP2803727A2
    • 2014-11-19
    • EP13735942.8
    • 2013-01-11
    • Korea Advanced Institute Of Science And Technology
    • LEE, Sang YupNA, DokyunYOO, Seung Min
    • C12N15/113C12N15/63C12N1/21
    • C12N15/1138C12N15/111C12N15/63C12N15/67C12N15/70C12N2310/11C12N2310/13C12N2310/18C12N2310/3519C12N2310/531C12P7/22C12P13/001C12P13/225
    • The present invention relates to a novel customized sRNA that reduces gene expression in prokaryotic cells, a preparation method thereof, and the use thereof, and more particularly to a synthetic sRNA comprising an Hfq binding site, derived from the sRNA of any one of MicC, SgrS and MicF, and a region that base-pairs with the target gene mRNA, and to a preparation method thereof and the use thereof. The synthetic sRNA according to the invention has an advantage in that the degree of inhibition of the target gene can be controlled by regulating the ability of the synthetic sRNA to bind to the mRNA of the target gene. The use of the synthetic sRNA that regulates the expression of the target gene makes it possible to effectively construct a recombinant microorganism without using a conventional gene deletion method and to reduce the expression of the target gene, and thus the synthetic sRNA is useful for the production of recombinant microorganisms. Also, the synthetic sRNA can be quickly applied to various strains, and thus is very suitable for the measurement of metabolic capabilities of strains and the selection of the most suitable strain. In addition, recombinant microorganisms, which are obtained by metabolic flux manipulation using the synthetic sRNA and produce tyrosine or cadaverine with high efficiency, are useful in the drug and industrial fields. In other words, the use of the sRNA according to the present invention can make it easy to select target genes whose expression is to be inhibited for the highly efficient production of metabolites. Accordingly, the synthetic sRNA can be used to construct recombinant strains for efficient production of various metabolites and to establish efficient methods for production of various metabolites, and thus is highly useful.
    • 86. 发明公开
    • CONTENT TRANSMITTING SYSTEM, METHOD FOR OPTIMIZING NETWORK TRAFFIC IN THE SYSTEM, CENTRAL CONTROL DEVICE AND LOCAL CACHING DEVICE
    • 内容的传输系统,用于优化网络流量此系统,中央控制设备和local cache存储设备
    • EP2800310A1
    • 2014-11-05
    • EP12863260.1
    • 2012-12-26
    • SK Telecom Co., LtdKorea Advanced Institute of Science and Technology
    • LEE, JongminLEE, KyungjunSHIM, YoungjaeWOO, ShinaePARK, Kyoungsoo
    • H04L12/26H04L12/70
    • H04L67/2842H04L43/028H04L43/04H04L45/02
    • The present invention relates to a method for optimizing duplicated transmission traffic for reducing traffic on a network caused by a duplicated content transmission in a content transmission system, and to a central control device and to a local caching device. A content transmission system comprising a central control device connected to a content server and comprising a local caching device connected to a client on a content transmission network so as to monitor duplicated content transmission, can enable the local caching device or the central control device to check a duplication of a content packet chunk, enable the central control device to transmit only a chunk identifier and flow information to the local caching device since the content packet chunk provided from/by the content server to the client is checked for duplication, enable the local caching device to check the received chunk identifier and, if there is a matched chunk identifier, transmit the content packet stored in the local caching device to the client. Thus, the load of the network traffic transmitted in a duplicate manner between the Internet and a toll center can be reduced, thereby achieving the effects of network operation convenience and cost-effectiveness.
    • 本发明涉及一种方法,用于优化重复发送业务量用于减少通过在内容发送系统中的重复的内容传输中导致网络上的业务,以及在中央控制装置和到本地缓存装置。 一种内容传送系统,包括连接到内容服务器的中央控制装置,并包括连接到客户端的内容传输网络上,以便监测重复的内容传输的本地缓存装置,可以使本地缓存装置或中央控制装置,以检查 内容分组块的重复,使中央控制装置只发送的块标识符,并且自由内容服务器向客户机从/提供的内容分组块流信息到本地缓存装置被选中用于复制,使本地 高速缓存设备,以检查所接收到的块标识符,并且如果存在匹配的块标识符,发送存储在本地缓存装置到客户端的内容分组。 因此,网络流量反式在互联网和收费中心之间的重复的方式mitted的负荷可以被减少,由此实现的网络操作的便利性和成本效益的影响。