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81. 发明公开

EP2888300A2 NOVEL AMPHIPHILIC GRAFT COPOLYMERS 有权转让
标题翻译：中性粒细胞磷脂酰胆碱酯酶
公开(公告)号：EP2888300A2
公开(公告)日：2015-07-01
申请号：EP13762625.5
申请日：2013-08-22
申请人： Becton Dickinson and Company , The University of Massachusetts
发明人： HERMEL-DAVIDOCK, Theresa , COUGHLIN, Edward Bryan
IPC分类号： C08F255/02 , C08F263/04 , C08L71/02
摘要： A novel amphiphilic graft copolymer is described. A process to make amphiphilic graft copolymers via grafting either poly(ethylene oxide) or polylactide side chains onto an EVA platform using oxo-anion ring-opening polymerization chemistry is also described. Polyethylene or polypropylene based graft copolymers are prepared starting from poly(ethylene-co-vinyl acetate) or maleic anhydride grafted isotactic polypropylene respectively. The amphiphilic character will result from the incorporation of hydrophilic poly(ethylene oxide) (PEO) side-chains. Various applications of the novel amphiphilic graft copolymer are also described including, but not limited to, thermoplastic elastomer, films, fibers, fabrics, gels, breathable packaging materials, additive for biodegradable system, surfactant, antistatic additives, polymer compatibilizers, phase transfer catalysts, solid polymer electrolytes, biocompatible polymers, or incorporation into the materials listed above.
摘要翻译：描述了一种新型的两亲接枝共聚物。还描述了通过使用氧代 - 阴离子开环聚合化学将聚（环氧乙烷）或聚丙交酯侧链接枝到EVA平台上来制备两亲性接枝共聚物的方法。分别从聚（乙烯 - 共 - 乙酸乙烯酯）或马来酸酐接枝的全同立构聚丙烯开始制备聚乙烯或聚丙烯基接枝共聚物。亲水性将由引入亲水性聚（环氧乙烷）（PEO）侧链产生。还描述了新型两亲性接枝共聚物的各种应用，包括但不限于热塑性弹性体，膜，纤维，织物，凝胶，透气包装材料，用于可生物降解的体系的添加剂，表面活性剂，抗静电添加剂，聚合物增容剂，相转移催化剂，固体聚合物电解质，生物相容性聚合物，或掺入上述材料中。

82. 发明公开

EP2877103A1 NEGATIVE PRESSURE WOUND CLOSURE DEVICE 有权转让
标题翻译：压力下的伤口闭合装置
公开(公告)号：EP2877103A1
公开(公告)日：2015-06-03
申请号：EP13820093.6
申请日：2013-07-15
申请人： The University of Massachusetts
发明人： DUNN, Raymond
IPC分类号： A61B17/03
摘要： The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue grasping elements to apply a wound closing force to the tissue.

83. 发明公开

EP2872493A2 COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY 有权转让
标题翻译：化合物治疗脊髓肌萎缩症
公开(公告)号：EP2872493A2
公开(公告)日：2015-05-20
申请号：EP13817021.2
申请日：2013-07-12
申请人： Indiana University Research and Technology Corporation , The Brigham and Women's Hospital, Inc. , The University of Massachusetts
发明人： ANDROPHY, Elliot J. , CHERRY, Jonathon J. , CUNY, Gregory D. , GLICKSMAN, Marcie A.
IPC分类号： C07D261/06 , C07D413/12 , A61K31/42 , A61P21/00
CPC分类号： C07D493/04 , C07C311/37 , C07C2601/08 , C07C2603/20 , C07D213/75 , C07D215/227 , C07D215/44 , C07D221/10 , C07D231/14 , C07D233/88 , C07D239/47 , C07D239/82 , C07D261/06 , C07D261/14 , C07D261/18 , C07D263/48 , C07D267/14 , C07D277/46 , C07D285/135 , C07D401/04 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07K14/47
摘要： Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
摘要翻译：本文公开了用于治疗脊髓性肌萎缩（SMA）的组合物和方法。在某些实施方案中，提供了增加SMN2基因产生的运动神经元（SMN）蛋白质生产的全长存活的化合物。

84. 发明公开

EP2632952A2 ANTI-SOD1 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗体及其用途SOD1
公开(公告)号：EP2632952A2
公开(公告)日：2013-09-04
申请号：EP11836951.1
申请日：2011-10-25
申请人： The University of Massachusetts
发明人： AMBROSINO, Donna , BABCOCK, Gregory , BROERING, Teresa , XU, Zuoshang
IPC分类号： C07K16/18 , C07K14/435 , C12N15/13 , A61K39/395 , A61K38/17 , A61P21/00
CPC分类号： C07K16/40 , A61K31/428 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention features anti-SODl antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.

85. 发明公开

EP2625543A1 SYSTEM AND METHOD FOR GENERATING DERIVED PRODUCTS IN A RADAR NETWORK 有权转让
标题翻译：系统在维也纳ZE ERZEUGUNG VON DERIVATEN在EINEM RADARNETZ
公开(公告)号：EP2625543A1
公开(公告)日：2013-08-14
申请号：EP11774141.3
申请日：2011-10-07
申请人： The University of Massachusetts
发明人： INSANIC, Edin , SIQUEIRA, Paul
IPC分类号： G01S13/95
摘要： The present invention relates to systems and methods of measuring atmospheric conditions using networked radar systems. A processor receives sensed data from the radar nodes of the network to determine weather conditions within the atmospheric region measured by network. Preferred embodiments use a velocity processor to determine the velocity of the atmosphere in real time for display.
摘要翻译：本发明涉及使用联网雷达系统测量大气条件的系统和方法。处理器从网络的雷达节点接收感测数据，以确定由网络测量的大气区域内的天气状况。优选实施例使用速度处理器来实时确定大气的速度进行显示。

86. 发明公开

EP2604635A1 Polymerization initiating system and method to produce highly reactive olefin functional polymers 有权
标题翻译： VURFAHREN ZUR HERSTELLUNG HOCHREAKTIVER FUNKTIONALER OLEFINPOLYMERE系统ZUR POLYMERISIERUNGSEINLEITUNG
公开(公告)号：EP2604635A1
公开(公告)日：2013-06-19
申请号：EP11194680.2
申请日：2011-12-20
申请人： The University of Massachusetts , Infineum International Limited
发明人： Faust, Rudolf , Dimitrov, Philip , Kumar, Rajeev , Emert, Jacob , Hua, Jun
IPC分类号： C08F110/10 , C08F4/14 , C08F4/16 , C08F4/22
CPC分类号： C08F110/10 , C08F4/14 , C08F4/16 , C08F4/22 , C08F2500/02 , C08F2500/03 , C08F2500/04
摘要： A method for producing highly reactive olefin polymers wherein at least 50 mol. % of the polymer chains have terminal double bonds, and a novel polymerization initiating system for accomplishing same.
摘要翻译：一种生产高反应性烯烃聚合物的方法，其中至少50mol。聚合物链的％具有末端双键，以及用于实现其的新型聚合引发体系。

87. 发明公开

EP2453931A2 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING 审中-公开
标题翻译：用电动丝编织而成的材料的，卷绕的治疗体系
公开(公告)号：EP2453931A2
公开(公告)日：2012-05-23
申请号：EP10800470.6
申请日：2010-07-14
申请人： Trustees Of Tufts College , The University Of Massachusetts Foundation, Inc.
发明人： ZHANG, Xiaohui , KAPLAN, David, L. , WHARRAM, Scott, E. , MCCARTHY, Stephen
IPC分类号： A61L15/22 , A61L15/32 , D01D5/00 , A61L15/36 , A61L15/44
CPC分类号： A61L15/40 , A61L15/225 , A61L15/44 , A61L2300/406 , A61L2300/62 , A61L2300/64 , D01D5/003 , D01F4/02 , D04H1/09 , D04H1/4266 , D04H1/728 , C08L71/02
摘要： The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.

88. 发明公开

EP2267131A1 Genetic inhibition by double-stranded RNA 有权
标题翻译： GENETISCHE HEMMUNG DURCH DOPPEL-STRÄNGIGEMRNA
公开(公告)号：EP2267131A1
公开(公告)日：2010-12-29
申请号：EP10177654.0
申请日：1998-12-21
申请人： Carnegie Institution Of Washington , The University of Massachusetts
发明人： Fire, Andrew , Xu, Siqun , Montgomery, Mary K. , Kostas, Stephen A. , Timmons, Lisa , Tabara, Hiroaki , Driver, Samuel E. , Mello, Crag C.
IPC分类号： C12N15/11 , C12N15/63 , C12N15/82
CPC分类号： C12N15/8285 , A01K2217/05 , A01K2227/703 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/8218 , C12N15/85 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/50 , C12N2310/53
摘要： A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo . The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
摘要翻译：提供了将RNA引入活细胞以抑制该细胞中靶基因的基因表达的方法。该方法可以离体或体内实施。 RNA具有双链结构的区域。抑制是序列特异性的，因为RNA的双链体区域和靶基因的一部分的核苷酸序列是相同的。本发明不同于现有技术通过反义或三链方法的基因表达干扰。

89. 发明公开

EP1663469A1 AMPHIPHILIC POLYMER CAPSULES AND RELATED METHODS OF INTERFACIAL ASSEMBLY 审中-公开
标题翻译：囊和两亲聚合物及相关方法用于表面ADD
公开(公告)号：EP1663469A1
公开(公告)日：2006-06-07
申请号：EP04783043.5
申请日：2004-09-03
申请人： The University of Massachusetts
发明人： Emrick, Todd S. , Breitenkamp, Kurt
IPC分类号： B01J13/00
CPC分类号： C08G61/08 , A61K9/5089 , B01J13/14 , C08L65/00
摘要： Polymer capsules from amphiphilic graft copolymers comprising reactive, hydrophobic polyolefin backbones, and hydrophilic poly(ethylene glycol) (PEG) grafts are produced by self-assembly of the polymers at the oilwater interface, and crosslinking the assembly with bis-cyclooctene PEG derivatives in conjunction with ring-open metathesis polymerization catalysts. The use of the graft copolymer architecture in capsule synthesis provides significant opportunities to tune both the surface properties, in terms of recognition, and the membrane properties, in terms of mechanical strength, encapsulation, and release.

90. 发明公开

EP0593592A1 THERMOTROPIC LIQUID CRYSTAL SEGMENTED BLOCK COPOLYMER 失效
标题翻译：热致液晶段嵌段共聚物。
公开(公告)号：EP0593592A1
公开(公告)日：1994-04-27
申请号：EP92914623.0
申请日：1992-07-07
申请人： THE UNIVERSITY OF MASSACHUSETTS AT AMHERST
发明人： KANTOR, Simon, W. , LENZ, Robert, W. , LU, Caixia
IPC分类号： C08G63 , C08G81 , C08L67 , C09K19
CPC分类号： C09K19/3809 , C08G63/181 , C08G63/60 , C08G81/00 , C08L67/02 , C08L2666/18
摘要： L'invention décrit des nouveaux copolymères en masse segmentée comprenant des blocs mésogéniques (ou ''tiges''), ainsi que des blocs en polymère en pelotte souple, pouvant se mélanger avec une matrice en polymère en pelotte souple sensiblement similaire, afin d'améliorer les propriétés mécaniques de ladite matrice. Par exemple, on a préparé des mélanges de téréphtalate de polybutylène (PBT) avec un copolymère en masse cristalline liquide contenant un téréphtalate de polytétramétylène 4,4'-téréphtaloyldioxydibenzoate-b-polybutylène (LCP-b-PBT), au moyen de leur précipitation provoquée par un solvant commun, de leur séchage et de leur filature à chaud à travers une filière capillaire, afin de produire un monofilament. Dans tous les mélanges, les régions de LCP-b-PBT ont présenté une dimension inférieure à 0,1 mum et une dispersion ultrafine et uniforme. Même si les mélanges ne présentaient qu'un allongement modéré en fibrilles, le contact d'adhésion entre le LCP-b-PBT et le PBT pur s'est avéré excellent. Les fibres ont généralement démontré que la résistance à la traction et l'elasticité augmentent avec la croissance du rapport d'étirement, de la teneur en LCP-b-PBT et de la température de traitement.

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