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81. 发明公开

EP1363636A1 A METHOD FOR THE TREATMENT OF HEART FAILURE 有权
标题翻译：左西孟旦组合和钙源心力衰竭的治疗
公开(公告)号：EP1363636A1
公开(公告)日：2003-11-26
申请号：EP02711903.1
申请日：2002-02-08
申请人： ORION CORPORATION
发明人： LEVIJOKI, Jouko
IPC分类号： A61K31/501 , A61K33/06 , A61P9/04 , A61P9/10
CPC分类号： A61K33/06 , A61K33/42 , A61K31/50 , A61K2300/00
摘要： A combination therapy for the treatment of heart failure, particularly acute heart failure, comprises administering a combination of levosimendan or a pharmaceutically acceptable salt thereof and a calcium ion source and/or an intracellular calcium increasing agent to a patient. The combination shows a synergistic effect even at doses having no effect if administered alone.

82. 发明公开

EP1353656A2 METHOD FOR TREATING STRESS OR TENSION 审中-公开
标题翻译：方法压力和紧张的治疗
公开(公告)号：EP1353656A2
公开(公告)日：2003-10-22
申请号：EP02710903.2
申请日：2002-01-22
申请人： ORION CORPORATION
发明人： MÄKI-IKOLA, Outi
IPC分类号： A61K31/00
CPC分类号： A61K31/13
摘要： A method of treating stress and/or tension in a mammal by administering to the mammal an effective amount of 1,7,7-trimethylbicyclo[2.2.1]heptane derivative of Formula I wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.

83. 发明公开

EP1322300A1 INHALATION PARTICLES INCORPORATING A COMBINATION OF TWO OR MORE ACTIVE INGREDIENTS 无效
标题翻译：吸入颗粒，其包含至少两个活性物质
公开(公告)号：EP1322300A1
公开(公告)日：2003-07-02
申请号：EP01974367.3
申请日：2001-10-05
申请人： ORION CORPORATION
发明人： WATANABE, Wiwik , KAUPPINEN, Esko , AHONEN, Petri , BROWN, David , MUTTONEN, Esa
IPC分类号： A61K9/72 , A61K9/14 , A61K31/57 , A61K31/165 , A61P11/06
CPC分类号： A61K9/0075 , A61K31/165 , A61K31/167 , A61K31/57 , A61K31/573 , A61K45/06 , Y10S514/826 , A61K2300/00
摘要： Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof are disclosed. The particles have narrow particle size distribution, rough surfaces and improved stability. The inhalation particles of the invention are particularly useful in the administration of a combination medicament, e.g. a combination of an anti-inflammatory agent and a bronchodilator, by inhalation in the treatment of asthma and other respiratory disorders.

84. 发明授权

EP0910354B1 ANTIOXIDANT COMPOUNDS 失效
标题翻译：抗氧化剂
公开(公告)号：EP0910354B1
公开(公告)日：2002-10-16
申请号：EP97920759.4
申请日：1997-05-02
申请人： ORION CORPORATION
发明人： AHOTUPA, Markku , KANGAS, Lauri
IPC分类号： A61K31/135
CPC分类号： A61K31/138
摘要： A new use of halogenated triphenylethylene derivatives for lowering levels of serum lipid peroxides and for the prevention or treatment of oxidative tissue damage induced by lipid peroxidation is disclosed. The new use includes the prevention or treatment of atherosclerosis, ischemic injury, psoriasis, inflammatory diseases, such as inflammatory bowel disease, or cardiovascular disorders, such as coronary heart disease, cardiac ischemic injury and post-ischemic cardiac arrhythmias, or the treatment of AIDS.

85. 发明公开

EP1235605A1 MULTIDOSE POWDER INHALER 有权
标题翻译：多剂量粉剂吸入器
公开(公告)号：EP1235605A1
公开(公告)日：2002-09-04
申请号：EP00987498.3
申请日：2000-12-07
申请人： ORION CORPORATION
发明人： SEPPÄLÄ, Kari
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0068 , A61M2202/064
摘要： A powder inhaler comprises a medicament container (1), a rotatable metering disc (7) extending into the interior of the medicament container (1) and an air channel through which air is drawn via a mouthpiece (2). The metering disc (7) has one or more peripherally located dosing grooves (9) extending axially through the metering disc (7). The dosing grooves (9) are filled with a metered dose of the medicament while being inside the medicament container (1) and are transferred to the air channel wherein the stream of inhaled air discharges the dose of the medicament directly from the dosing groove (9).
摘要翻译：粉末吸入器包括药物容器（1），延伸到药物容器（1）内部的可旋转计量盘（7）以及空气通道，空气通过该空气通道经由吹口（2）抽出。计量盘（7）具有一个或多个沿周向设置的剂量槽（9），其沿轴向延伸穿过计量盘（7）。剂量槽（9）在处于药物容器（1）内部时被计量剂量的药物填充，并被传送到空气通道，其中吸入的空气流直接从剂量槽（9）排出药物剂量）。

86. 发明公开

EP1191935A1 A METHOD FOR THE TREATMENT OR PREVENTION OF CORONARY GRAFT VASOSPASM 有权
标题翻译：治疗或抑制血管痉挛KORONARIMPLANTAT
公开(公告)号：EP1191935A1
公开(公告)日：2002-04-03
申请号：EP00942162.9
申请日：2000-06-29
申请人： ORION CORPORATION
发明人： LEHTONEN, Lasse , PAPP, Julius , SZECSI, Janos
IPC分类号： A61K31/50 , A61P9/00
CPC分类号： A61K31/50
摘要： Levosimendan, or (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]-propanedinitrile, which has been previously suggested for the treatment of congestive heart failure is useful in the treatment or prevention of coronary graft vasospasm after coronary artery by-pass surgery.

87. 发明授权

EP0726772B1 A METHOD FOR SENSITIZATION OF CANCER CELLS FOR KILLER CELL MEDIATED LYSIS 失效
标题翻译：用于使癌细胞提高认识的一种方法由杀伤细胞介导的溶解
公开(公告)号：EP0726772B1
公开(公告)日：2001-11-07
申请号：EP94922877.9
申请日：1994-08-02
申请人： Baral, Edward , Berczi, Istvan , Nagy, Eva , ORION CORPORATION
发明人： Baral, Edward , Berczi, Istvan , Nagy, Eva , Kangas, Lauri
IPC分类号： A61K38/22 , A61K35/78 , A61K35/55 , A61K35/14 , A61K31/01
CPC分类号： A61K35/17 , A61K31/138 , A61K38/2013 , A61K2300/00
摘要： PCT No. PCT/FI94/00333 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Aug. 2, 1994 PCT Pub. No. WO95/04544 PCT Pub. Date Feb. 16, 1995The invention relates to a method of sensitizing cancer cells for a killer cell mediated lysis which involves administering to a patient an effective amount of antiestrogen and killer cells either jointly or sequentially, wherein the killer cells are selected from the group of NK cells, LAK cells and CTL cells and the antiestrogen is selected from the group of triphenylethylene class antiestrogens, such as tamoxifen or toremifene or their pharmaceutically acceptable salt.

88. 发明公开

EP1140197A1 SOLUBLE COMPOSITIONS OF TOREMIFENE 有权
标题翻译：托瑞米芬可溶性化合物
公开(公告)号：EP1140197A1
公开(公告)日：2001-10-10
申请号：EP99963615.2
申请日：1999-12-16
申请人： ORION CORPORATION
发明人： AF URSIN, Kaija , SALMIA, Jukka , NISKANEN, Heikki , KORTESUO, Pirjo , KANANEN, Mikko , KIESVAARA, Juha , OTSOMAA, Leena
IPC分类号： A61K47/12 , A61K47/20 , A61K31/138
CPC分类号： A61K47/12 , A61K31/138 , A61K47/20
摘要： The invention relates to aqueous composition of toremifene or a pharmaceutically acceptable salt thereof comprises lactic acid, acetic acid, formic acid, methanesulfonic acid or the corresponding anion (lactate, acetate, formate or mesylate) as a solubility enhancing agent. The invention also relates to novel salts of toremifene with an acid selected from the group consisting of lactic acid, acetic acid, formic acid or methanesulfonic acid.

89. 发明公开

EP1137408A1 AGENT FOR LOWERING ENDOTHELIN LEVELS 有权
标题翻译：内皮素水平降低药
公开(公告)号：EP1137408A1
公开(公告)日：2001-10-04
申请号：EP99959457.5
申请日：1999-12-08
申请人： ORION CORPORATION
发明人： YLIKORKALA, Olavi , METSÄ-HEIKKILÄ, Merja , HIETANEN, Päivi , ELLMEN, Juha
IPC分类号： A61K31/138 , A61P9/10 , A61P7/02 , A61P9/14 , A61P43/00
CPC分类号： A61K31/00
摘要： The present invention relates to a new medical use of triphenylethylene antiestrogen toremifene or a pharmaceutically acceptable thereof for lowering endothelin-1 levels in mammals, and for the prevention or treatment of endothelin mediated diseases.

90. 发明公开

EP1133986A1 Use of deramciclane for the treatment of anxiety and depression 审中-公开
标题翻译： Verwendung von Deramciclane zur Behandlung von Depression and Angst
公开(公告)号：EP1133986A1
公开(公告)日：2001-09-19
申请号：EP00302207.6
申请日：2000-03-17
申请人： ORION CORPORATION
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K31/135
CPC分类号： A61K31/138
摘要： The present invention relates to deramciclane, (1R,2S,4R)-(-)-2-[N,N-(dimethylaminoethoxy)]-2-phenyl-1,7,7-trimethyl-bicyclo[2.2.1]heptane, and its use in the treatment of disorders relating to serotonergic systemin humans, specifically depression and anxiety.
摘要翻译：本发明涉及衍生物，（1R，2S，4R） - （ - ） - 2-N，N-（二甲基氨基乙氧基）-2-苯基-1,7,7-三甲基 - 双环-22.1庚烷，及其用途治疗与人类血清素能系统相关的疾病，特别是抑郁和焦虑。

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