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81. 发明授权

EP0687283B1 FILM D'ELASTOMERE COMPRENANT DES GOUTTELETTES, SON PROCEDE DE PREPARATION ET SES APPLICATIONS 有权
标题翻译：熔滴含弹性体膜您处理和使用
公开(公告)号：EP0687283B1
公开(公告)日：2000-05-17
申请号：EP95904590.7
申请日：1994-12-22
申请人： HUTCHINSON
发明人： BUSNEL, René, Guy , CHEYMOL, André , RIESS, Gérard
IPC分类号： C08J5/18 , C08K5/00 , C08J3/09 , C08J3/215 , C08L21/00 , A61F6/00 , A61B19/04 , A01N25/34
CPC分类号： C08J3/215 , A61B42/00 , A61F6/04 , C08J5/18 , C08J2321/00 , C08K5/0058 , C08L51/00 , C08L53/00 , C08L21/00
摘要： Elastomeric films containing uniformly dispersed liquid droplets of active chemical ingredients such as anti-corrosive agents, lubricants or drugs such as biocides, a preparation method therefor, and uses thereof, are disclosed. Stable emulsions comprising a continuous phase consisting of a solution of an elastomer in an organic solvent, and a dispersed phase including at least one active chemical ingredient in a solvent which is non-miscible with the elastomer solution, said emulsions being convertible into elastomeric films, and a preparation method therefor are also disclosed. Said elastomeric film includes dispersed droplets of a solvent (b) which is non-miscible with the elastomer and loaded with at least one active chemical ingredient, the resulting dispersion being stabilised by means of a block or graft copolymer comprising poly B sequences which are miscible with said droplets, and poly A sequences which are not miscible therewith.

82. 发明授权

EP0717847B1 USE OF ANTIBODIES AGAINST BETA-2 MICROGLOBULIN-FREE, CLASS I HLA MOLECULES TO PROVIDE HIV DIAGNOSTIC TESTS AS WELL AS COMPOSITIONS HAVING A PROTECTIVE ACTION AGAINST HIV INFECTIONS 失效转让
标题翻译：抗体BETA-2微球蛋白-FREE CLASS-I HLA分子使用它来获取诊断艾滋病毒检测和组合物保护作用的抗HIV感染
公开(公告)号：EP0717847B1
公开(公告)日：2000-04-19
申请号：EP94927036.7
申请日：1994-09-06
申请人： FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR , Fondation Mondiale Recherche et Prevention SIDA
发明人： BERETTA, Alberto
IPC分类号： G01N33/569 , G01N33/543 , G01N33/554
CPC分类号： G01N33/56988
摘要： Use of an antibody able to detect both epitopes of HIV gp160 protein and of beta 2-microglobulin free Class I HLA FHC, to provide a diagnostic test to detect the HIV infection in an analyte which is negative for the presence of specific anti-HIV antibodies, and for the preparation of a composition which is able to provide a passive immunity against HIV infections.

83. 发明公开

EP0833895A1 LIGNEES IMMORTALISEES DE CELLULES RETINIENNES ET LEURS APPLICATIONS 失效
标题翻译： LIGNEES IMMORTALISEES DE CELLULES RETINIENNES ET LEURS应用
公开(公告)号：EP0833895A1
公开(公告)日：1998-04-08
申请号：EP97920791.0
申请日：1997-04-18
申请人： Neurotech S.A.
发明人： GREENWOOD, John , ADAMSON, Peter , LUND, Raymond
IPC分类号： C12N15 , C12N5 , C12P21 , C12R1
CPC分类号： C12N5/0621 , C12N2503/00 , C12N2510/04
摘要： The invention features immortalized retina-derived (retinal endothelial or retinal epithelial pigmentary) cell lines capable of being implanted in the retina and of carrying a therapeutic substance to the eye and to the central nervous system. Such lines can also be used as a model for studying blood central nervous system interfaces. These lines are derived from primary retinal cultures selected from the group consisting of primary retinal endothelial cells and primary retinal epithelial cells, comprise a nucleic acid fragment containing at least one immortalizing fragment of a heat-sensitive viral oncogene, which nucleic fragment is optionally associated with at least one selection gene, and have the morphological characteristics and at least the expression characteristics of the surface antigens of corresponding primary cultures.
摘要翻译：本发明的特征是永生化的视网膜衍生的（视网膜内皮或视网膜上皮色素）细胞系，其能够植入视网膜并将治疗物质携带到眼睛和中枢神经系统。这样的线也可以用作研究血液中枢神经系统界面的模型。这些系源自选自初级视网膜内皮细胞和初级视网膜上皮细胞的初级视网膜培养物，包含含有至少一个热敏病毒癌基因的永生化片段的核酸片段，所述核酸片段任选地与至少一个选择基因，并且具有相应原代培养物的表面抗原的形态特征和至少表达特征。

84. 发明授权

EP0438332B1 Peptides dérivant de la glycoprotéine d'enveloppe de virus HIV, leurs applications à la détection d'une infection due à ces virus et à la vaccination contre le SIDA 失效
标题翻译：从病毒HIV-包膜糖蛋白，其用于检测这些病毒的感染和防治艾滋病疫苗接种的肽
公开(公告)号：EP0438332B1
公开(公告)日：1998-04-08
申请号：EP91400049.2
申请日：1991-01-11
申请人： ORGENICS LTD.
发明人： Martin, Jacques , Somme, Gérard
IPC分类号： C07K14/16 , A61K39/21 , G01N33/569
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , Y10S435/975 , Y10S530/806

85. 发明公开

EP0812359A1 VIH-1 DE GROUPE O, FRAGMENTS DESDITS VIRUS, AINSI QUE LEURS APPLICATIONS 失效
标题翻译： HIV-1组0，该病毒适当的片段和它们应用
公开(公告)号：EP0812359A1
公开(公告)日：1997-12-17
申请号：EP96904904.0
申请日：1996-02-26
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS
发明人： SIMON, François , SARAGOSTI, Sentob , LOUSSERT-AJAKA, Ibtissam , LY, Thoai-Duong , CHAIX-BAUDIER, Marie-Laure
IPC分类号： G01N33 , A61K39 , C07K14 , C07K16 , C12N7 , C12N15 , C12Q1 , C12R1
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/16021 , C12N2740/16122
摘要： Group O HIV-1 retrovirus strains, particularly the strains known as BCF02, BCF01, BCF06, BCF07, BCF08, BCF11, BCF03, BCF09, BCF12, BCF13 and BCF14, fragments of said retroviruses, and the uses thereof as a diagnostic reagent and as an immunogen, are disclosed.

86. 发明公开

EP0787197A1 LIGNEES IMMORTALISEES DE CELLULES ENDOTHELIALES CEREBRALES ET LEURS APPLICATIONS THERAPEUTIQUES 失效
标题翻译：固定化HIRNENDOTHELIAZELLINIEN及其治疗用途
公开(公告)号：EP0787197A1
公开(公告)日：1997-08-06
申请号：EP95934188.0
申请日：1995-10-09
申请人： ASSOCIATION POUR LE DEVELOPPEMENT DE L'IMMUNOLOGIE MOLECULAIRE-ADIM
发明人： CHAVEROT, Nathalie , COURAUD, Pierre-Olivier , LATERRA, John , QUINONERO, Jérôme , ROUX, Françoise , STROSBERG, Arthur, Donny , TCHELINGERIAN, Jean-Léon , VIGNAIS, Lionel
IPC分类号： C12N15 , A61K35 , A61K38 , A61K45 , A61K48 , A61P25 , A61P35 , C07K14 , C12N5
CPC分类号： C07K14/005 , A61K35/12 , A61K38/185 , A61K48/00 , C07K14/48 , C07K14/82 , C12N5/069 , C12N2510/04 , C12N2710/10322 , C12N2740/13043
摘要： The invention relates to optionally modified immortalized lines of endothelial brain cells of mammalians, as well as applications as preventive or curative drug and particularly for the treatment of primary and secondary, neurologic or psychiatric diseases, including brain tumors, and for stimulating the growth and reproduction of breeding animals. The invention also relates to the method for preparing said cell lines. The endothelial cell lines of mammalians disclosed are comprised of immortalized endothelial brain cells presenting at least one of the following characteristics of differentiated endothelial brain cells, in a stable way: the expression of endothelial markers, the secretion of vasoactive substances, the expression of molecules of the major histocompatilility complex (MHC), the expression of hormonal receptors, and the existence of tight junctions; said cell lines comprise a nucleic acid fragment having at least one immortalizing fragment of a viral or cellular oncogene, optionally associated with at least one selection gene, and an expression vector comprising a sequence coding for a polypeptide, a protein or a viral vector, optionally associated with at least one selection gene and optionally at least one marker gene, and they are capable in vivo to integrate brain vessels of a host mammalian and produce said polypeptide, said protein or said viral vector.

87. 发明授权

EP0565402B1 Tendeur automatique pour courroie, notamment pour courroie de transmission synchrone, comme une courroie de distribution de moteur thermique 失效
标题翻译：自动皮带张紧器，特别是用于同步驱动带，用于内燃发动机的气门控制这种带
公开(公告)号：EP0565402B1
公开(公告)日：1997-05-14
申请号：EP93400797.2
申请日：1993-03-29
申请人： HUTCHINSON
发明人： Varin, Hervé
IPC分类号： F16H7/12 , F16H7/08
CPC分类号： F16H7/129 , F16H7/0829 , F16H7/0848 , F16H2007/0806 , F16H2007/0812 , F16H2007/0859 , F16H2007/0891 , F16H2007/0893

88. 发明授权

EP0651815B1 BACULOVIRUS MODIFIE, SON PROCEDE D'OBTENTION, ET VECTEURS D'EXPRESSION OBTENUS A PARTIR DUDIT BACULOVIRUS 失效
标题翻译：改进的杆状病毒，用于生产自己及其表达载体
公开(公告)号：EP0651815B1
公开(公告)日：1997-04-09
申请号：EP91913605.1
申请日：1991-07-17
申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： DEVAUCHELLE, Gérard , CERUTTI, Martine , CAHOREAU, Claire , MARTIN, Marianne 15 bis, chemin de l'Escalette
IPC分类号： C12N15/86 , C12N15/33 , C12N15/52 , C12N7/01
CPC分类号： C12N15/86 , C12N2710/14143
摘要： The invention relates to a modified baculovirus wherein one of the two strong late promoters of the wild baculovirus is inactive, as well as to a method for obtaining such a modified baculovirus and to its application for obtaining vectors for the expression of exogenous genes. Said modified baculovirus is particularly deprived of the polyhedrin gene promoter and contains the protein P10 gene promoter.

89. 发明授权

EP0573348B1 Procédé de dépôt de cuivre sur un substrat et dispositif pour sa mise en oeuvre 失效
标题翻译：一种用于铜的用于执行该方法的基板和装置上的沉积过程
公开(公告)号：EP0573348B1
公开(公告)日：1997-03-26
申请号：EP93401398.8
申请日：1993-06-02
申请人： FRANCE TELECOM , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Torres, Joaquim , Palleau, Jean , Madar, Roland , Bernard, Claude
IPC分类号： C23C16/14 , C23C16/44
CPC分类号： C23C16/14 , C23C16/4488

90. 发明授权

EP0663967B1 COMPOSITE NONWOVEN FABRICS AND METHOD OF MAKING SAME 失效
标题翻译：一种复合织物及其制造方法
公开(公告)号：EP0663967B1
公开(公告)日：1996-07-10
申请号：EP92925188.2
申请日：1992-11-19
申请人： FIBERWEB NORTH AMERICA, INC.
发明人： AUSTIN, Jared, A.
IPC分类号： D04H13/00
CPC分类号： D04H3/14 , D04H1/559 , D04H1/56 , Y10T428/24826 , Y10T442/621 , Y10T442/66
摘要： The invention is directed to composite nonwoven fabrics comprising a hydrophobic nonwoven web, a nonwoven web of thermoplastic meltblown microfibers and a hydrophilic nonwoven web comprising staple fibers. The nonwoven web of thermoplastic meltblown fibers is sandwiched between the hydrophobic nonwoven web and the hydrophilic nonwoven web and all of the layers are thermally bonded together via discontinuous thermal bonds distributed substantially throughout the composite nonwoven fabric.

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