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    • 81. 发明公开
    • Gradient vacuum for high-flux x-ray source
    • GradientenvakuumfürRöntgenquellemit hohem Fluss
    • EP2690646A1
    • 2014-01-29
    • EP12178137.1
    • 2012-07-26
    • Agilent Technologies, Inc.
    • Kucharczyk, Damian
    • H01J35/10H01J35/20
    • H01J35/106H01J35/20
    • An X-ray tube (100) for generating an X-ray beam (102), the X-ray tube (100) comprising a rotatably mounted anode (104) arranged and configured to generate X-rays upon exposure to an electron beam (106), a hollow space (108) within the anode (104), a cooling unit (110) configured for cooling the anode (104) by fluid circulation within the hollow space (108), and a vacuum pump arrangement (114, 136, 150) configured for generating a first vacuum (116) within the hollow space (108) and a second vacuum (118) in a space (112) surrounding the anode (104), wherein the second vacuum (118) relates to a pressure value being lower than a pressure value relating to the first vacuum (116), wherein the vacuum pump arrangement (114, 136, 150) comprises a pump (114) arranged for forming a continuous pressure gradient between the first vacuum (116) and the second vacuum (118).
    • 一种用于产生X射线束(102)的X射线管(100),所述X射线管(100)包括可旋转地安装的阳极(104),其被布置和构造成在暴露于电子束时产生X射线 106),阳极(104)内的中空空间(108),冷却单元(110),被配置为通过中空空间(108)内的流体循环来冷却阳极(104),以及真空泵装置 ,150),其被配置为在所述中空空间(108)内产生第一真空(116),并且在围绕所述阳极(104)的空间(112)中产生第二真空(118),其中所述第二真空(118) 值小于与第一真空(116)相关的压力值,其中真空泵装置(114,136,150)包括泵(114),泵被设置成在第一真空(116)和 第二真空(118)。
    • 84. 发明公开
    • LIGATION METHOD EMPLOYING EUKARYOTIC tRNA LIGASE
    • LIGATIONSVERFAHREN MIT EUKARYOTISCHER TTRNA-LIGASE
    • EP2652133A2
    • 2013-10-23
    • EP11849675.1
    • 2011-12-15
    • Agilent Technologies, Inc.
    • ZEINER, GustiACH, Robert A.
    • C12N15/10C12Q1/68C12Q1/25
    • C12P19/34C12N15/10C12N15/1096C12Q2521/501C12Q2525/191
    • Provided herein is a method of preparing an RNA sample comprising: a) obtaining an RNA sample comprising: i. long RNA molecules that may be unfragmented or fragmented to contain 5′-OH group and a 2′-3′-cyclic phosphate group; and ii. short RNA molecules that comprise a 5′ phosphate group and a 3′ OH group; and b) contacting the RNA sample with an adaptor comprising either a 2′-PO group and 3′-OH group or a 2′,3′-cyclic phosphate group in the presence of a eukaryotic tRNA ligase, thereby producing a ligated RNA sample in which a) the short RNA molecules are selectively ligated to the adaptor or b) the short RNA molecules and long RNA fragments are selectively ligated to the adaptor.
    • 本文提供了制备RNA样品的方法,其包括:a)获得RNA样品,其包含:i。 可能未分裂或片段化的含有5'-OH基团和2'- 3'-环磷酸酯基团的长RNA分子; 和ii。 包含5'磷酸基团和3'OH基团的短RNA分子; 和b)在真核tRNA连接酶的存在下,将RNA样品与包含2'-PO基团和3'-OH基团或2',3'-环磷酸酯基团的衔接子接触,从而产生连接的RNA样品 其中a)短RNA分子选择性地连接到衔接子上,或b)短RNA分子和长RNA片段选择性地连接到衔接子上。
    • 89. 发明公开
    • Identification of aberrant microarray features
    • 识别onㄧten Mikroarray-Eigenschaften
    • EP2530616A2
    • 2012-12-05
    • EP12166664.8
    • 2012-05-03
    • Agilent Technologies, Inc.
    • Wolber, Paul KennethPage, Robert
    • G06F19/20
    • G06F19/20G06F19/24
    • Described herein is a method for identifying an aberrant feature on a nucleic acid array. In general terms, the method comprises: a) obtaining a log transformed normalized value indicating the amount of hybridization of a test sample to a first feature on the nucleic acid array; b) calculating a z-score for the first feature using: the log transformed normalized value; and the distribution of reference log transformed normalized values that indicate the amount of hybridization of control samples to the same feature on a plurality of reference arrays; and c) identifying said test feature as aberrant if it has a z-score that is above or below a defined threshold.
    • 本文描述了用于鉴定核酸阵列上的异常特征的方法。 一般来说,该方法包括:a)获得指示测试样品与核酸阵列上的第一特征的杂交量的对数转换的归一化值; b)使用:对数转换的归一化值来计算第一特征的z分数; 以及参考对数转换的归一化值的分布,其指示对照样本与多个参考阵列上相同特征的杂交量; 以及c)如果所述测试特征具有高于或低于定义的阈值的z分数,则将所述测试特征识别为异常。