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    • 73. 发明公开
    • ORAL HYGIENE COMPOSITIONS
    • 口服卫生组合物
    • EP3046632A1
    • 2016-07-27
    • EP14777917.7
    • 2014-09-18
    • Glymur B.V.
    • CRIELAARD, WillemBRUGMAN, MartijnBRUS, Ronald Hendrik PeterKLEIN, Bart
    • A61Q11/00A61Q11/02A61K8/19A61K8/22A61K8/42A61K8/96A61K33/06A61K33/02
    • A61K8/19A61K8/42A61K31/17A61K33/00A61K33/02A61K33/06A61K33/40A61K2800/74A61Q11/00A61K2300/00
    • Mouth hygiene compositions that reduce VSC by changing the growth conditions in the oral cavity in favor of bacteria capable of anaerobic respiration. Anaerobic respiration is a form of respiration that involves electron acceptors other than oxygen. Examples of such alternative electron acceptors are sulfates, nitrates, sulfur and fumarate. A shift towards anaerobic respirational growth of the microflora in the oral cavity is brought about using an oral hygiene composition that is rich in nitrates. Such a composition considerably reduces the production of VSC compounds, especially hydrogen sulfide. Moreover, it has been established that by using these oral hygiene compositions, the overall diversity of the mouth flora is not diminished, but rather shifted from an halitotic (strictly anaerobically growing) bacterial population to a less halitotic one. The compositions are suitably used to treat and/or prevent halitosis in mammals.
    • 本发明提供口腔卫生组合物,其通过改变口腔中的生长条件而有利于能够厌氧呼吸的细菌来减少VSC。 无氧呼吸是呼吸的一种形式,涉及氧以外的电子受体。 这种替代电子受体的例子是硫酸盐,硝酸盐,硫磺和富马酸盐。 根据本发明,使用富含硝酸盐的口腔卫生组合物使口腔中的微生物菌群厌氧呼吸生长发生转变。 这种组合物显着减少了VSC化合物的产生,特别是硫化氢。 此外,已经证实,通过使用根据本发明的口腔卫生组合物,口腔菌群的整体多样性不会减少,而是从嗜好(严格厌氧生长)的细菌群体转移到不太常见的细菌群体。 根据本发明的组合物适用于治疗和/或预防哺乳动物的口臭。