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71. 发明公开

EP2786657A2 A method of producing an antibody comprising a human variable region and a rodent constant region. 有权
标题翻译：其包含人可变区和来自啮齿动物的恒定区的抗体的制造方法。
公开(公告)号：EP2786657A2
公开(公告)日：2014-10-08
申请号：EP14172437.7
申请日：2002-02-15
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： Murphy, Andrew J. , Yancopoulos, George, D. , Economides, Aris , Karow, Margaret , MacDonald, Lynn , Stevens, Sean , Valenzuela, David
IPC分类号： A01K67/027 , C07K16/00
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译：一种用于工程和利用大DNA载体的方法为目标，通过同源重组，并修改，以任何期望的方式，内源基因和染色体位点中的真核细胞。靶向这些用于真核细胞的载体的大DNA，称为LTVECs，从克隆的组DNA比那些通常用于由拟进行同源真核细胞中靶向其他途径较大的片段衍生的。这样提供了一种检测真核细胞，其中LTVEC已经正确靶向和改性所需的内源基因（一个或多个）或染色体基因座（基因座），以及使用合成的细胞，以产生生物轴承遗传修饰的快速和方便的方法。

72. 发明公开

EP2773766A1 IN VIVO ADCC MODEL 审中-公开
标题翻译：体内ADCC模型
公开(公告)号：EP2773766A1
公开(公告)日：2014-09-10
申请号：EP12779061.6
申请日：2012-10-29
申请人： Roche Glycart AG
发明人： BREUSTEDT, Daniel , GERDES, Christian , IGLESIAS, Antonio , UMANA, Pablo
IPC分类号： C12N15/85 , A01K67/027 , C07K16/28 , C07K14/705
CPC分类号： A61K49/0008 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , C07K14/70535 , C12N15/8509 , C12N2800/204 , C12N2800/30 , G01N33/5011
摘要： The present invention relates to a non-human animal comprising a humanized low affinity FcgR locus. Also provided herein is the use of said non-human animal for determining in vivo efficacy of antibodies, and methods for determining in vivo efficacy of antibodies.

73. 发明授权

EP2245455B1 METHOD FOR DISTINGUISHING SECRETORY GRANULES OF DIFFERENT AGES 有权
标题翻译：方法DISTINCTION分泌颗粒剂不同年龄
公开(公告)号：EP2245455B1
公开(公告)日：2014-07-09
申请号：EP09702668.6
申请日：2009-01-16
申请人： Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus
发明人： SOLIMENA, Michele , IVANOVA, Anna
IPC分类号： G01N33/50 , A01K67/027
CPC分类号： G01N33/5076 , A01K67/0275 , A01K2217/07 , A01K2227/105 , A01K2267/0393 , C07K2319/036 , C12N15/8509 , G01N33/5005 , G01N33/74

74. 发明公开

EP2739740A1 HUMANIZED UNIVERSAL LIGHT CHAIN MICE 无效
标题翻译： UNIVERSELLE，LEICHTKETTIGE，HUMANISIERTEMÄUSE
公开(公告)号：EP2739740A1
公开(公告)日：2014-06-11
申请号：EP12746246.3
申请日：2012-08-03
申请人： Regeneron Pharmaceuticals, Inc.
发明人： MCWHIRTER, John , MACDONALD, Lynn , STEVENS, Sean , DAVIS, Samuel , BUCKLER, David, R. , HOSIAWA, Karolina, A. , MURPHY, Andrew, J.
IPC分类号： C12N15/85 , A01K67/027 , C12N9/64 , C07K16/46
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/2833 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/515 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N9/6489 , C12N15/8509 , C12N2800/204 , C12N2800/30
摘要： Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V/J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided.
摘要翻译：提供了包含人源化重链免疫球蛋白基因座，表达通用轻链的人源化轻链基因座和编码ADAM6或直系同源物或其同源物或功能片段的基因的小鼠，组织，细胞和遗传物质。提供了表达包含人可变结构域的人源化重链的小鼠，并且其表达包含人可变结构域的人源化轻链，其中轻链来自不超过一个或不超过两个轻链V和J或重排的V / J序列。提供表达具有通用轻链和人源化重链的抗体的肥沃雄性小鼠。提供了制备双特异性结合蛋白的方法和组合物。

75. 发明公开

EP2410032A3 Phosphorus-containing stabilizers for fluoroolefins 有权转让
标题翻译：含有稳定剂的氟代烯烃磷
公开(公告)号：EP2410032A3
公开(公告)日：2014-05-07
申请号：EP11007705.4
申请日：2007-08-31
申请人： E.I. Du Pont De Nemours and Company
发明人： Leck, Thomas J. , Mouli, Nandini , Minor, Barbara Haviland , Nappa, Mario Joseph
IPC分类号： C09K5/04
CPC分类号： C12N5/0635 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/054 , A01K2217/072 , A01K2227/107 , A01K2267/01 , A61K39/00 , C07H21/04 , C07K14/70503 , C09K5/045 , C09K2205/126 , C12N15/79 , C12N15/85 , C12N15/8509 , C12N2510/02 , C12N2510/04 , C12N2517/02
摘要： The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one phosphorus-containing compound selected from the group consisting of thiophosphates, butylated triphenylphosphorothionates, and organophosphates. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

76. 发明公开

EP2718440A1 PROTEIN HAVING NUCLEASE ACTIVITY, FUSION PROTEINS AND USES THEREOF 有权
标题翻译：蛋白质麻醉剂NUKLEASE-AKTIVITÄT，FUSIONSPROTEINE UND DEREN VERWENDUNGEN
公开(公告)号：EP2718440A1
公开(公告)日：2014-04-16
申请号：EP12725813.5
申请日：2012-06-06
申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
发明人： KÜHN, Ralf
IPC分类号： C12N15/62 , C12N15/82 , C12N15/85 , A01K67/027 , C07K14/415
CPC分类号： C12N15/907 , A01K67/0275 , A01K2207/05 , A01K2217/07 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/195 , C07K2319/80 , C12N9/16 , C12N9/22 , C12N15/62 , C12N15/8509 , C12N2800/80 , C12N2999/007 , C12Y301/21004
摘要： The present invention relates to a nucleic acid molecule encoding (I) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (c) a nucleic acid molecule encoding an endonuclease, the amino acid sequence of which is at least 70% identical to the amino acid sequence of SEQ ID NO: 1; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 50% identical to the nucleotide sequence of SEQ ID NO: 2; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein T is replaced by U; (II) a fragment of the polypeptide of (I) having the activity of an endonuclease. Also, the present invention relates to a vector comprising the nucleic acid molecule and a protein encoded by said nucleic acid molecule. Further, the invention relates to a method of modifying the genome of a eukaryotic cell and a method of producing a non-human vertebrate or mammal.
摘要翻译：本发明涉及编码（I）具有内切核酸酶活性的多肽的核酸分子，其是（a）编码包含或由SEQ ID NO：1的氨基酸序列组成的多肽的核酸分子; （b）包含SEQ ID NO：2的核苷酸序列或由其组成的核酸分子; （c）编码内切核酸酶的核酸分子，其氨基酸序列与SEQ ID NO：1的氨基酸序列至少70％相同; （d）包含与SEQ ID NO：2的核苷酸序列至少50％相同的核苷酸序列或由其组成的核酸分子; （e）相对于（d）的核酸分子简并的核酸分子; 或（f）对应于（a）〜（e）中任一项所述的核酸分子的核酸分子，其中T被U代替; （II）具有内切核酸酶活性的（I）多肽的片段。此外，本发明涉及包含核酸分子和由所述核酸分子编码的蛋白质的载体。此外，本发明涉及一种修饰真核细胞的基因组的方法和一种生产非人脊椎动物或哺乳动物的方法。

77. 发明授权

EP2118663B1 REGULATION OF EXPRESSION OF PI3KB PROTEIN IN TUMORS 有权
标题翻译：调控蛋白在肿瘤PI3KB-表达的
公开(公告)号：EP2118663B1
公开(公告)日：2014-04-02
申请号：EP08709845.5
申请日：2008-02-12
申请人： Universita' Degli Studi di Torino
发明人： HIRSCH, Emilio , FORNI, Guido , CURCIO, Claudia , CIRAOLO, Elisa
IPC分类号： A01K67/027 , A61K49/00 , C12N9/12 , C12N15/85 , C12Q1/48 , G01N33/574
CPC分类号： C12Q1/485 , A01K67/0278 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , C12N9/1205 , C12N15/8509 , C12N2800/30 , G01N33/57407 , G01N33/57415 , G01N2333/91215 , G01N2500/00

78. 发明授权

EP2037737B1 Cell membrane repair proteins, nucleic acids encoding the same and associated methods of use 有权
标题翻译：细胞膜修复蛋白质，核酸其编码和使用的相应方法。
公开(公告)号：EP2037737B1
公开(公告)日：2014-04-02
申请号：EP07867154.2
申请日：2007-07-11
申请人： University Of Medicine And Dentistry Of New Jersey
发明人： MA, Jianjie , WEISLEDER, Noah , CAI, Chuanxi
IPC分类号： C07K14/47 , A61K38/17 , C07K19/00
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K16/18 , C07K2319/10 , C12N15/8509 , C40B30/06 , C40B40/02

79. 发明公开

EP2626416A3 Reprogramming of somatic cells 审中-公开
标题翻译： Umprogrammierung von somatischen Zellen
公开(公告)号：EP2626416A3
公开(公告)日：2013-12-18
申请号：EP12003893.0
申请日：2008-04-07
申请人： The Whitehead Institute for Biomedical Research
发明人： Jaenisch, Rudolph , Hanna, Jacob , Wernig, Marius , Lenger, Christopher J. , Meissner, Alexander , Brambrink, Oliver Tobias , Welstead G, Grant , Foreman, Ruth
IPC分类号： C12N5/07
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g. partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g. a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
摘要翻译：本公开涉及重编程一种或多种体细胞的方法，例如，部分分化或完全/终末分化的体细胞，分化为较少分化的状态，例如。多能或多能的状态。在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。

80. 发明公开

EP2604111A3 Animal models and therapeutic molecules 审中-公开
标题翻译：动物模型和治疗性分子
公开(公告)号：EP2604111A3
公开(公告)日：2013-12-18
申请号：EP12195041.4
申请日：2010-07-07
申请人： Kymab Limited
发明人： Bradley, Allan , Lee, E-Chiang , Liang, Qi , Wang, Wei
IPC分类号： A01K67/027 , C07K16/00 , C07K16/46 , C12N15/85 , C12N15/90
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2217/052 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1239 , C07K16/18 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N15/8509
摘要： The invention discloses methods for the generation of chimaeric human - non human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.

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