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    • 79. 发明公开
    • Poly-beta-1,4-N-Acetyglucosamine
    • 聚-β-1,4--N-Acetyglucosamine
    • EP1452546A3
    • 2004-10-13
    • EP04007828.9
    • 1994-12-01
    • MARINE POLYMER TECHNOLOGIES, INC.
    • Vournakis, John N.Finkielsztein, SergioPariser, Ernest R.Helston, Mike
    • C08B37/08C12P19/26
    • C12R1/89A61K9/205A61K47/69A61L31/042C08B37/003C12P19/26C08L5/08
    • The present invention relates, first, to a purified, easily produced poly-β-1→4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a β-1→4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
    • 首先,本发明涉及纯化的,容易产生的聚-β-1→4-N-乙酰葡糖胺(p-GlcNAc)多糖物质。 本发明的p-GlcNAc是高分子量的聚合物,其组成单糖以β-1→4构象连接,并且其不含蛋白质且基本上不含单氨基酸,以及其他有机和无机污染物 。 另外,描述了p-GlcNAc的衍生物和重新配制。 本发明进一步涉及从微藻(优选硅藻)起始来源纯化本发明的p-GlcNAc的方法。 更进一步地,本发明涉及用于p-GlcNAc的衍生化和再形成的方法。 此外,本发明涉及纯p-GlcNAc,其衍生物和/或其重构物的用途。