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71. 发明公开

EP2357472A1 METHOD FOR EVALUATING STATE OF CELLS 有权
标题翻译： VERFAHREN ZUR BEURTEILUNG DES ZUSTANDES VON ZELLEN
公开(公告)号：EP2357472A1
公开(公告)日：2011-08-17
申请号：EP09827386.5
申请日：2009-11-20
申请人： National University Corporation Hokkaido University
发明人： NISHIMURA, Shin-Ichiro , TAKEGAWA, Yasuhiro
IPC分类号： G01N33/48 , G01N27/62 , G01N33/00
CPC分类号： G01N33/5023 , G01N2400/00
摘要： Provided are a novel marker of the state of cells and the differentiation level of the same which is usable as a substitute for a gene or a protein; a means for quantitatively understanding this marker; and a means for understanding the state of specific cells and the differentiation level of the same using this marker. A method for determining a sugar chain category to be used for evaluating the state of cells. The quantitative profile of N-linked sugar chains of cells before a change in the state thereof is obtained. Next, the quantitative profile of N-linked sugar chains contained in the cells after the change in the state thereof is obtained. Sugar chains showing variations in the contents thereof between these two quantitative profiles are extracted and the individual sugar chains contained in the extracted sugar chains are classified into the following categories based on sugar chain type: either the high-mannose type or the non-high-mannose type; (1) the presence/absence of a bisect; (2) the number fucose residues(0, 1, or 2 or more); (3) the presence/absence of sialic acid; and (4) the degree of branching (2 or 3 or more). From these five categories, a sugar chain category appropriate for evaluating the state of cells is determined. A method for evaluating the state of cells and the differentiation of cells using the thus determined sugar chain category.
摘要翻译：提供可用作基因或蛋白质的替代物的细胞状态和分化水平的新型标记物; 一种用于定量了解该标记的方法; 以及用于使用该标记物来理解特定细胞的状态和其分化水平的手段。用于确定用于评估细胞状态的糖链类别的方法。获得其状态改变前的细胞的N-连接糖链的定量分布。接下来，获得其状态变化后的细胞中含有的N-连接糖链的定量分布。提取显示这两种定量分布之间的含量变化的糖链，并且基于糖链类型将提取的糖链中包含的各糖链分为以下几类：高甘露糖型或非高糖型，甘露糖型; （1）二等分的存在/不存在; （2）数字岩藻糖残基（0,1或2以上）; （3）唾液酸的存在/不存在; 和（4）支化度（2或3以上）。从这五个类别中，确定适合于评估细胞状态的糖链类别。使用如此确定的糖链类别来评估细胞状态和细胞分化的方法。

72. 发明公开

EP2336813A1 COUPLED SYSTEM MULTI-CORE FIBER, COUPLING MODE MULTIPLEXER AND DEMULTIPLEXER, SYSTEM FOR TRANMISSION USING MULTI-CORE FIBER AND METHOD FOR TRANSMISSION USING MULTI-CORE FIBER 有权
标题翻译： ÜBERTRAGUNGSVERFAHRENMIT GEKOPPELTEN MEHRKERNFASERN UND KOPPLUNGSMODUS-（DE）MULTIPLEXER
公开(公告)号：EP2336813A1
公开(公告)日：2011-06-22
申请号：EP09817893.2
申请日：2009-10-02
申请人： National University Corporation Yokohama National University , National University Corporation Hokkaido University , National Institute of Information and Communication Technology
发明人： KOKUBUN, Yasuo , KOSHIBA, Masanori , MORIOKA, Toshio
IPC分类号： G02B6/04 , G02B6/122 , G02B6/30
CPC分类号： G02B6/02042 , G02B6/2804 , H04B10/2581 , H04J14/04
摘要： The multi-core fiber of the present invention uses a multi-core fiber configuration, compatible with the "coupled" operation mode in which coupling between cores is positively utilized, to carry out mode division multiplexing transmission via a multi-core fiber that contains multiple single-mode cores in one optical fiber. The multi-core fiber of the present invention uses a configuration in which mode multiplexing transmission is carried out using a multi-core fiber that contains multiple single-mode cores in one optical fiber, wherein multiple cores are strongly coupled intentionally to form a coupled multi-core fiber that makes the coupled modes correspond, one to one, to the transmission channels.
摘要翻译：本发明的多核心光纤采用与核心之间的耦合被积极利用的“耦合”操作模式兼容的多核心光纤配置，通过包含多个核心的多芯光纤进行模式分割复用传输一个光纤中的单模核心。本发明的多核光纤使用在一个光纤中使用包含多个单模核的多芯光纤进行模式复用传输的结构，其中多个核被有意地强耦合以形成耦合多核心光纤使得耦合模式一一对应于传输信道。

73. 发明公开

EP2335744A1 BONE-FILLING TYPE AGENT FOR INDUCING CARTILAGE REGENERATION 审中-公开
标题翻译： KNOCHENFÜLLENDESMITTEL ZUR EINLEITUNG VON KNORPELREGENERATION
公开(公告)号：EP2335744A1
公开(公告)日：2011-06-22
申请号：EP09809951.8
申请日：2009-08-26
申请人： National University Corporation Hokkaido University
发明人： YASUDA, Kazunori , OSADA, Yoshihito , GONG, Jian Ping , KITAMURA, Nobuto
IPC分类号： A61L27/00
CPC分类号： A61L27/52 , A61L2430/06
摘要： Provided is a medical material which enables a novel treatment method for cartilage regeneration being different from a treatment method through transplantation of autologous cartilage, a cartilage alternative or undifferentiated cells. Provided is a bone-filling type agent for inducing cartilage regeneration comprising a hydrogel which contains, as a monomer unit, an acid having an acidic group and/or a salt obtained by adding a metal to an acidic group and does not contain an interpenetrating network structure or a semi-interpenetrating network structure composed of two or more polymers. The bone-filling type agent for inducing cartilage regeneration can induce natural cartilage regeneration in the body by filling it in a hole or a groove provided in subchondral bone beneath cartilage defect.
摘要翻译：本发明提供一种能够使软骨再生的新型治疗方法与通过移植自体软骨，软骨替代或未分化细胞的治疗方法不同的医疗材料。提供一种用于诱导软骨再生的骨填充剂，其包含水凝胶，所述水凝胶含有作为单体单元的具有酸性基团的酸和/或通过在酸性基团中添加金属而不含互穿网络而获得的盐结构或由两种或多种聚合物组成的半互穿网络结构。用于诱导软骨再生的骨填充剂可以通过将其填充在软骨缺损的软骨下骨中提供的孔或槽中来诱导体内的天然软骨再生。

74. 发明公开

EP2306569A1 FUEL CELL AND ELECTRICITY GENERATION METHOD USING THE SAME 有权
标题翻译：燃料电池和使用该燃料电池的发电方法
公开(公告)号：EP2306569A1
公开(公告)日：2011-04-06
申请号：EP09797874.6
申请日：2009-07-10
申请人： National University Corporation Hokkaido University
发明人： UEDA Wataru , TAKEGUCHI Tatsuya
IPC分类号： H01M8/02 , H01B1/08 , H01M4/90 , H01M4/92
CPC分类号： H01M8/1246 , H01B1/08 , H01M8/1016 , H01M8/124 , H01M2008/1095 , H01M2300/0065 , H01M2300/0071 , H01M2300/0074 , H01M2300/0094 , Y02E60/521 , Y02E60/525 , Y02P70/56
摘要： Provided is a fuel cell which can obtain a sufficiently high electromotive force even under a low-temperature condition such as room temperature without using a deleterious substance or platinum. This fuel cell uses an electrolyte layer containing a layer - shaped metal oxide which has been subjected to the steam treatment.
摘要翻译：本发明提供一种燃料电池，即使在室温等低温条件下也可以得到充分高的电动势，而不使用有害物质或铂。该燃料电池使用包含经过蒸汽处理的层状金属氧化物的电解质层。

75. 发明授权

EP2060594B1 Method for producing polymer 有权
标题翻译：一种聚合物的制造方法
公开(公告)号：EP2060594B1
公开(公告)日：2011-03-09
申请号：EP08019258.6
申请日：2008-11-04
申请人： National University Corporation Hokkaido University , AgriBioIndustry Inc.
发明人： Tajima, Kenji c/o Graduate School of Engineering , Satou, Yasuharu c/o Graduate School of Engineering , Munekata, Masanobu c/o Graduate School of Engineering , Matsushima, Tokuo , Taguchi, Seiichi, c/o Graduate School of Engineering,
IPC分类号： C08G63/82 , C12P7/62
CPC分类号： C08G63/823 , C12P7/625

76. 发明公开

EP2281628A2 Method for producing noble metal-supported photocatalyst particles 审中-公开
标题翻译： Verfahren zur Herstellung nobler metall-unterstützterPhotokatalysatorpartikel
公开(公告)号：EP2281628A2
公开(公告)日：2011-02-09
申请号：EP10251392.6
申请日：2010-08-04
申请人： Sumitomo Chemical Company, Limited , National University Corporation Hokkaido University
发明人： Abe, Ryu , Kanome, Naoko , Sogabe, Kohei , Sakatani, Yoshiaki
IPC分类号： B01J23/42 , B01J23/44 , B01J23/46 , B01J23/50 , B01J23/52 , B01J23/648 , B01J23/652 , B01J23/847 , B01J23/888 , B01J35/00 , B01J37/02 , B01J37/34
CPC分类号： B01J35/004 , B01J23/42 , B01J23/44 , B01J23/46 , B01J23/462 , B01J23/464 , B01J23/468 , B01J23/50 , B01J23/52 , B01J23/6484 , B01J23/6527 , B01J23/8474 , B01J23/888 , B01J37/0201 , B01J37/34
摘要： A method for producing a photocatalytic, which can produce a photocatalyst showing high photocatalytic activity, is provided.
The present invention relates to a method for producing noble metal-supported photocatalyst particles wherein a noble metal is supported on the surface of the photocatalyst particles, and a method for producing a dispersion of the noble metal-supported photocatalyst particles, the methods comprising steps of: blowing an inert gas into a raw dispersion in which the photocatalyst particles are dispersed and a precursor of the noble metal is dissolved in a dispersion medium; and irradiating the raw dispersion with light having energy larger than that of a bandgap of the photocatalyst particles, thereby supporting the noble metal on the surface of the photocatalyst particles.
摘要翻译：本发明提供了能够制造光催化活性高的光催化剂的光催化剂的制造方法。本发明涉及贵金属负载型光催化剂粒子的制造方法，其中贵金属负载在光催化剂粒子的表面上，贵金属负载型光催化剂粒子的分散体的制造方法，将惰性气体吹入其中分散有光催化剂颗粒的原料分散体和贵金属的前体溶解在分散介质中; 并用能量大于光催化剂颗粒的带隙的光照射原料分散体，从而将贵金属负载在光催化剂颗粒的表面上。

77. 发明公开

EP2272886A1 Copolymer resin composition, molded product, and method of manufacturing a copolymer resin composition 有权
标题翻译：共聚物树脂组合物模制产品和制造方法的共聚物树脂组合物
公开(公告)号：EP2272886A1
公开(公告)日：2011-01-12
申请号：EP10168590.7
申请日：2010-07-06
申请人： Ricoh Company, Ltd. , Agri Bio Industry Incorporated , National University Corporation Hokkaido University
发明人： Yamanaka, Yasuo , Harada, Tadakatsu , Yaginuma, Hidekazu , Munekata, Masanobu , Tajima, Kenji , Satoh, Yasuharu , Matsushima, Tokuo
IPC分类号： C08G63/06
CPC分类号： C08G63/06
摘要： Disclosed is a copolymer resin composition including a lactic acid copolymer, the lactic acid copolymer containing monomer units represented by the following chemical formulas [1], [2], and [3],

, wherein a content of a monomer unit represented by the chemical formula [3] is 50 mol% or more and 95 mol% or less, a weight-average molecular weight of the lactic acid copolymer is 20,000 or more and 1,000,000 or less, and a deflection temperature of the lactic acid copolymer under load is 65 °C: or higher and 100 °C or lower at a bending stress of 1.80 MPa.
摘要翻译：公开了一种包括乳酸共聚物，含有由下述化学式所表示的单体单元的乳酸共聚物的共聚物树脂组合物[1]，[2]和[3]，worin由化学表示的单体单元的含量式[3]为50摩尔％以上且95摩尔％以下，所述乳酸共聚物的重均分子量为20,000以上和1,000,000以下，以及负载下的乳酸共聚物的变形温度为65 ℃或在1.80MPa的弯曲应力更高和100℃或更低。

78. 发明公开

EP2269646A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY 审中-公开
标题翻译： PROPHYLAKTISCHER ODER THERAPEUTISCHER WIRKSTOFF GEGEN DIABETES ODER ADIPOSITAS
公开(公告)号：EP2269646A1
公开(公告)日：2011-01-05
申请号：EP09715914.9
申请日：2009-02-25
申请人： Ajinomoto Co., Inc. , National University Corporation Hokkaido University
发明人： HARA, Hiroshi , HIRA, Tohru , ETO, Yuzuru
IPC分类号： A61K45/00 , A61K38/00 , A61P3/04 , A61P3/10 , A61P43/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/137 , A61K2300/00
摘要： Disclosed is a safe prophylactic or therapeutic agent for diabetes or obesity. The prophylactic or therapeutic agent for diabetes or obesity comprises, as an active ingredient, a calcium receptor activator such as γ-Glu-X-Gly [wherein X represents an amino acid or an amino acid derivative], γ-Glu-Val-Y [wherein Y represents an amino acid or an amino acid derivative], γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Om, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH 2 , γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), cinacalcet, a cinacalcet analogue compound and protamine.
摘要翻译：公开了用于糖尿病或肥胖的安全预防或治疗剂。用于糖尿病或肥胖症的预防或治疗剂包括作为活性成分的钙受体激活剂如3-Glu-X-Gly [其中X表示氨基酸或氨基酸衍生物]，3-Glu-Val-Y [其中Y表示氨基酸或氨基酸衍生物]，3-Glu-Ala，3-Glu-Gly，3-Glu-Cys，3-Glu-Met，3-Glu-Thr，3-Glu-Val， 3-Glu-Om，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，3-Glu-Met（O），3-Glu-3-Glu-Val， -Glu-Val-NH 2，3-Glu-Val-ol，3-Glu-Ser，3-Glu-Tau，3-Glu-Cys（S-Me）（O），3-Glu-Leu， Glu-Ile，3-Glu-t-Leu，3-Glu-Cys（S-Me），西那卡塞，西那卡塞类似物化合物和鱼精蛋白。

79. 发明公开

EP2268102A1 PLANAR HEATING ELEMENT OBTAINED USING DISPERSION OF FINE CARBON FIBERS IN WATER AND PROCESS FOR PRODUCING THE PLANAR HEATING ELEMENT 审中-公开
标题翻译：通过在水中集表面加热和处理分散微细碳纤维用于制造面板加热
公开(公告)号：EP2268102A1
公开(公告)日：2010-12-29
申请号：EP08865060.1
申请日：2008-12-25
申请人： Hodogaya Chemical Co., Ltd. , National University Corporation Hokkaido University
发明人： FUGETSU, Bunshi , TARUMOTO, Naohiro , YANO, Yasuhito , SUZUKI, Jun , TSUKADA, Takayuki , MUNEKANE, Fuminori
IPC分类号： H05B3/20 , H05B3/03 , H05B3/14
CPC分类号： H05B3/20 , H01C17/0652 , H01C17/06586 , H05B3/145 , H05B2203/01 , H05B2203/011 , H05B2203/013 , H05B2203/017 , H05B2203/026 , H05B2203/034 , H05B2214/04 , Y10T29/49083 , Y10T29/49099
摘要： [Problems]
To produce planar heating elements having high exothermic efficiency and provide energy-saving electric carpets, floor heating, wall surface heating appliances and heaters for thawing on roads and/or roofs or antifogging for mirrors.
[Means for solving]
To provide a planar heating element produced by applying, to an insulating substrate or the like, an electrically conductive fine carbon fiber film that is fabricated using an aqueous dispersion of fine carbon fibers in which the fine carbon fibers are evenly dispersed in an aqueous solution.
摘要翻译： [问题]为了制备平面加热元件具有高放热效率和解冻道路和/或屋顶或防雾镜用于提供节能电地毯，地板采暖，壁面加热器具和加热器。 [用于解决为了提供通过施加，以在绝缘基板或类似物，的导电性微细碳纤维膜并使用在微细碳纤维的wässrige分散体制造，其中微细碳纤维均匀地分散所产生的面状发热体在wässrige溶液。

80. 发明公开

EP2261947A1 DIFFRACTION IMAGE CAPTURING METHOD AND CHARGED PARTICLE BEAM DEVICE 审中-公开
标题翻译： DIFFRAKTIONSBILDERFASSUNGSVERFAHREN UND VORRICHTUNG ZUR ABSTRAHLUNG GELADENER TEILCHEN
公开(公告)号：EP2261947A1
公开(公告)日：2010-12-15
申请号：EP09728554.8
申请日：2009-04-03
申请人： Hitachi, Ltd. , National University Corporation Hokkaido University
发明人： DOBASHI, Takashi , KOGUCHI, Masanari , KAMIMURA, Osamu , OHTA, Hiroya , GOHARA, Kazutoshi
IPC分类号： H01J37/22 , H01J37/26 , H01J37/295
CPC分类号： H01J37/222 , H01J37/26 , H01J37/295 , H01J2237/24578
摘要： A charged particle beam microscope device of the present invention is configured such that in a diffraction pattern obtained by radiating a parallel charged particle beam onto a sample (22) having a known structure, a distance (r) between spots of a diffraction pattern, which reflects the structure of the sample, is measured, and the variation of a distance (L) between the sample and a detector, which depends on a diffraction angle (θ), is corrected. This enables the correction of distortion that varies with an off-axis distance from the optical axis in a diffraction pattern, and a high precision structural analysis by performing accurately analyzing the spot positions of the diffraction pattern.
摘要翻译：本发明的带电粒子束显微镜装置被构造为使得通过将平行带电粒子束照射到具有已知结构的样品（22）上获得的衍射图案中衍射图案的点之间的距离（r），其中反映样品的结构，被测量，取决于衍射角（¸）的样品和检测器之间的距离（L）的变化被校正。由此，能够通过对衍射图案的光斑位置进行精确分析，能够进行衍射图案中的偏离离开光轴的距离变化的畸变校正和高精度的结构分析。

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