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71. 发明公开

EP3553498A1 OPTICAL DETECTION AND MEASUREMENT OF HEMATOCRIT AND FREE HEMOGLOBIN CONCENTRATION 有权
公开(公告)号：EP3553498A1
公开(公告)日：2019-10-16
申请号：EP19168820.9
申请日：2019-04-12
申请人： Fenwal, Inc.
发明人： KUSTERS, Benjamin E. , MIN, Kyungyoon
IPC分类号： G01N21/25 , G01N21/49 , G01N21/31 , A61B5/157 , G01N33/72
摘要： A colorimetric optical sensor device includes a broadband light source configured to emit a light that is exposed to a fluid in a vessel. At least a portion of the light is reflected off of the fluid and received by an optical spectrometer. The optical spectrometer analyzes at least a portion of the received light to determine a main wavelength of the light. A controller correlates the main wavelength to a corresponding hematocrit or free hemoglobin concentration and generates an output indicative of the hematocrit or the free hemoglobin concentration of the fluid. The hematocrit or free hemoglobin concentration information may be used by a separation assembly in which the colorimetric optical sensor device may be incorporated to modify a separation procedure in which the monitored fluid is to be separated or is a component or constituent of a previously separated biological fluid.

72. 发明授权

EP2683457B1 MEMBRANE SEPARATION DEVICES, SYSTEMS AND METHODS EMPLOYING SAME, AND DATA MANAGEMENT SYSTEMS AND METHODS 有权
公开(公告)号：EP2683457B1
公开(公告)日：2018-06-20
申请号：EP12757597.5
申请日：2012-03-09
申请人： Fenwal, Inc.
发明人： KUSTERS, Benjamin, E. , WEGENER, Christopher, J. , MIN, Kyungyoon
IPC分类号： B01D17/12 , B01D61/00 , B01D24/28 , B01D33/15
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

73. 发明公开

EP3329948A1 BLOOD COMPONENT POOLING DEVICE, SYSTEM AND METHOD 有权
公开(公告)号：EP3329948A1
公开(公告)日：2018-06-06
申请号：EP17204644.3
申请日：2017-11-30
申请人： Fenwal, Inc.
发明人： SALOMON, Alexandra , GRIEP, Julie , MIN, Kyungyoon , WEGENER, Christopher J. , RAJU, Anand
IPC分类号： A61M1/02
CPC分类号： A61M1/029 , A61J1/05 , A61M1/0209 , A61M1/0281 , A61M1/3692 , A61M2202/0427 , A61M2205/3393 , A61M2209/082 , A61M2209/084
摘要： A device for pooling a blood component stored in source containers includes a pump or pumps configured to pump a fluid in a first direction and a second direction and receive a pump line having a first end connected to the source containers. A pool clamp is configured to receive a pool line having a first end connected to a second end of the pump line and a second end connected to a pool container. A wash clamp is configured to receive a wash line having a first end connected to the second end of the pump line and a second end connected to a wash media container. A controller is configured to open the pool clamp, close the wash clamp and operate the pump in the first direction and to alternatively close the pool clamp, open the wash clamp and operate the pump in the second direction.

74. 发明公开

EP3326666A1 SYSTEMS AND METHODS FOR CONTROLLING AN IRRADIATION DEVICE 有权
公开(公告)号：EP3326666A1
公开(公告)日：2018-05-30
申请号：EP17203683.2
申请日：2017-11-27
申请人： Fenwal, Inc.
发明人： CRAWLEY, Brett T. , MIN, Kyungyoon
IPC分类号： A61M1/02
CPC分类号： A61L2/0047 , A61L2/24 , A61L2202/14 , A61L2202/22 , A61M1/025 , A61M2205/051 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393
摘要： A method and system for treating a biological fluid within a container by subjecting the container to light is provided. The system includes a fluid treatment chamber for receiving the container of biological fluid; an agitation assembly for oscillating the container of biological fluid within the fluid treatment chamber including a variable speed motor; one or more light sources in proximity to the fluid treatment chamber; at least one sensor for sensing a condition of the biological fluid in the container; and a programmable controller. The programmable controller is further configured to operate the variable speed motor to oscillate the container of biological fluid within the fluid treatment chamber at an initial oscillation rate; activate the one or more light sources; receive a signal indicative of one or more sensed conditions of the fluid in the container; and vary the speed of the motor to adjust the oscillation rate of the container of biological fluid within the fluid treatment chamber based on the sensed conditions.

75. 发明公开

EP3254713A1 SYSTEMS FOR THERAPEUTIC PLATELET DEPLETION 有权
标题翻译：用于治疗性血小板减少的系统
公开(公告)号：EP3254713A1
公开(公告)日：2017-12-13
申请号：EP17174699.3
申请日：2017-06-07
申请人： Fenwal, Inc.
发明人： RADWANSKI, Katherine N. , MIN, Kyungyoon , ALI, Zahra R.
IPC分类号： A61M1/38 , A61M1/36 , A61M1/02
摘要： Systems are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma. The platelet-rich plasma is conveyed from a first stage of the chamber to a second stage, where it is separated into platelets and platelet-poor plasma. The platelet-poor plasma is conveyed out of the chamber while the platelets are allowed to accumulate in the second stage of the chamber. When a controller of the system has determined that the maximum chamber capacity of platelets has been accumulated in the second stage of the chamber, the platelets are conveyed out of the chamber to a waste container. The cycle of separating blood into its components, accumulating platelets in the chamber, and then flushing the platelets from the chamber is repeated until a target platelet concentration of the blood is achieved.
摘要翻译：提供了用于从血液中消除血小板的系统。该系统包括多级血液分离室，其中血液被分离成红血细胞和富血小板血浆。富含血小板的血浆从腔室的第一阶段输送到第二阶段，在那里它被分离成血小板和贫血小板血浆。贫血小板血浆被输送出腔室，同时使血小板在腔室的第二阶段积聚。当系统的控制器已经确定血小板的最大室容量已经积聚在室的第二阶段时，血小板从室被输送到废物容器。重复将血液分离成其组分，在血小板中积聚血小板，然后从血小板冲洗血小板的循环，直到达到血液的目标血小板浓度。

76. 发明公开

EP3219462A1 APPARATUS AND METHOD FOR CONNECTING AND EVALUATING A CONNECTION SITE 有权
标题翻译：用于连接和评估连接站点的装置和方法
公开(公告)号：EP3219462A1
公开(公告)日：2017-09-20
申请号：EP17164830.6
申请日：2015-06-11
申请人： Fenwal, Inc.
发明人： KUSTERS, Benjamin E. , MIN, Kyungyoon
IPC分类号： B29C65/02 , B29C65/82 , A61M39/08 , A61M39/14 , A61M39/18 , G01M3/28 , B26F1/26 , B26F3/00 , B29C65/04 , B29C65/74 , B29C65/78 , F16L13/00
摘要： System, apparatus and method for opening a heat-bonded connection (32) formed between two hollow, flexible thermoplastic conduits (20, 22). A pressure difference is created by a pump (46) between the inside of at least one of the conduits and the ambient atmosphere sufficient to cause expansion of a wall of the tubing conduit in the vicinity of a frangible portion (32) at least partially blocking the connection to disrupt the frangible portion and reduce the blocking. The integrity of the heat-bonded connection is tested by sensing an internal pressure in an occlusion between the pump (46) and an occluder (40).
摘要翻译：用于打开在两个中空的柔性热塑性导管（20,22）之间形成的热结合连接（32）的系统，装置和方法。在至少一个导管的内部与周围大气之间的泵（46）产生的压力差足以导致管道导管壁在易碎部分（32）附近至少部分阻塞连接破坏易碎部分并减少阻塞。通过感测泵（46）和封堵器（40）之间的闭塞中的内部压力来测试热粘合连接的完整性。

77. 发明公开

EP3200109A1 HEAD-MOUNTED DISPLAY DEVICE FOR USE IN A MEDICAL FACILITY 有权
标题翻译：头戴式显示设备用于医疗机构
公开(公告)号：EP3200109A1
公开(公告)日：2017-08-02
申请号：EP17158920.3
申请日：2015-05-13
申请人： Fenwal, Inc.
发明人： CORK, William H. , CASE, Brian , KRAUSE, Kevin , MIN, Kyungyoon , MOSKAL, Witold
IPC分类号： G06F19/00 , G02B27/01
CPC分类号： G02B27/017 , A61B3/113 , A61B5/002 , A61B5/02 , A61B5/6803 , A61B5/742 , A61B2017/00221 , A61B2090/0807 , A61B2090/502 , G02B2027/014 , G02B2027/0178 , G06F19/00 , G16H40/63
摘要： A head-mounted display device for interface with a medical device configured to perform an invasive procedure on a patient, such as a blood component collection, an infusion, a feeding operation, etc.
摘要翻译：一种头戴式显示装置，用于与配置成对患者进行侵入性手术的医疗装置（例如血液成分采集，输注，供给操作等）接口。

78. 发明公开

EP3184131A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译：离心分离系统与红血球细胞壁
公开(公告)号：EP3184131A1
公开(公告)日：2017-06-28
申请号：EP17156439.6
申请日：2012-03-28
申请人： Fenwal, Inc.
发明人： MIN, Kyungyoon , BROWN, Richard I. , FOLEY, John T. , CASE, Brian C.
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝另一壁延伸的突起。分离室被容纳在壁之间的离心机中，该室包括用于使血液流入室的入口，用于使血浆流出室的血浆出口和用于使红血球流出的红细胞出口的房间。当腔室容纳在壁之间的离心机中时，第一突出部延伸到分离的血液成分的路径中，其朝向血浆出口端口流动并且防止细胞血液成分流入血浆出口端口。第二突出部延伸到分离的血液成分流向红细胞出口端口的路径中，并防止血浆流入红细胞出口端口。

79. 发明授权

EP1555927B1 BLOOD PROCESSING SYSTEMS AND METHODS FOR COLLECTING PLASMA FREE OR ESSENTIALLY FREE OF CELLULAR BLOOD COMPONENTS 有权转让
标题翻译：血液处理系统以及用于去除血浆中游离的或基本上血浆游离血细胞成分方法
公开(公告)号：EP1555927B1
公开(公告)日：2015-12-23
申请号：EP03774903.3
申请日：2003-10-21
申请人： Fenwal, Inc.
发明人： MIN, Kyungyoon , BROWN, Richard, I. , MORIARITY, Julie
IPC分类号： B04B5/04 , A61M1/36 , A61M1/38
CPC分类号： A61M1/3693 , A61M1/3633 , A61M1/3696 , A61M1/38 , A61M2202/0429 , A61M2205/128 , B04B5/0442 , B04B2005/045

80. 发明公开

EP2731667A1 FLUID FLOW CONDUITS AND APPARATUS AND METHODS FOR MAKING AND JOINING FLUID CONDUITS 有权
标题翻译：流体流线和设备及其制造方法和流体管路连接
公开(公告)号：EP2731667A1
公开(公告)日：2014-05-21
申请号：EP12810482.5
申请日：2012-12-12
申请人： Fenwal, Inc.
发明人： WEGENER, Christopher , MIN, Kyungyoon , BRIERTON, Mark , KUSTERS, Benjamin , MADSEN, James , CORK, William H.
IPC分类号： A61M39/14 , B29C65/02 , B29C65/20 , B29C65/32 , B29C65/30
CPC分类号： A61M39/143 , A61M39/14 , B29C65/022 , B29C65/2015 , B29C65/203 , B29C65/30 , B29C65/32 , B29C65/3444 , B29C65/3456 , B29C65/36 , B29C65/3644 , B29C65/3656 , B29C65/4855 , B29C65/5021 , B29C65/5057 , B29C65/7841 , B29C66/0342 , B29C66/1142 , B29C66/3494 , B29C66/5221 , B29C66/5223 , B29C66/52298 , B29C66/5346 , B29C66/5414 , B29C66/543 , B29C66/71 , B29C66/72321 , B29C66/73115 , B29C66/73141 , B29C66/857 , B29C66/91231 , B29C66/91421 , B29C66/91651 , B29C66/919 , B29C66/91933 , B29C66/949 , B29C66/954 , B29K2027/06 , B29K2023/12 , B29K2067/003
摘要： Fluid flow conduits (14, 14a, 14b, 82, 110, 128, 138) are disclosed. Each conduit (14, 14a, 14b, 82, 110, 128, 138) has a polymeric open end that is sealed by a sealing member (26, 26a, 26b, 84, 102, 130, 140) that includes a heating element (28, 68). The polymeric end material is melted, the sealing members (26, 26a, 26b, 84, 102, 130, 140) are moved to expose the melted open ends of the conduits (14, 14a, 14b, 82, 110, 128, 138) and the ends are brought together to form a fused or welded connection between the conduits (14, 14a, 14b, 82, 110, 128, 138) .
摘要翻译：流体流动管道（14，14A，14B，82，110，128，138）是游离缺失盘。每个导管（14，14A，14B，82，110，128，138）（具有由密封构件（26，26A，26B，84，102，130，140密封的聚合物开口端）没有包括加热元件 28，68）。聚合物端材料被熔化，密封件（26，26A，26B，84，102，130，140）被移动以露出导管的（熔化的开口端14，14A，14B，82，110，128，138 ）和端部合在一起以形成管道（14，14A，14B，82，110，128，138）之间的熔合或焊接连接。

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