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71. 发明公开

EP0975370A2 COMPOSITION AND METHOD FOR ENHANCING TRANSPORT ACROSS BIOLOGICAL MEMBRANES 失效
标题翻译：成分和方法延迟运输生物膜的
公开(公告)号：EP0975370A2
公开(公告)日：2000-02-02
申请号：EP98923711.0
申请日：1998-05-21
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： ROTHBARD, Jonathan, B. , WENDER, Paul, A.
IPC分类号： A61K47/48
CPC分类号： C07D305/14 , A61K31/785 , A61K47/62 , A61K47/645 , A61K48/00 , C07B2200/11 , C40B40/00
摘要： Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In one embodiment, the polymer consists of from 6 to 25 subunits, at 50 % of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form. The transport-enhancing polymers are exemplified, in a preferred embodiment, by peptides in which arginine residues constitute the subunits. Such a polyarginine peptide may be composed of either all D-, all L- or mixed D- and L-arginines, any may include additional amino acids. More preferably, at least one, and preferably all of the subunits are D-arginine residues, to enhance biological stability of the polymer during transit of the conjugate of its biological target.

72. 发明公开

EP1501532A2 PEPTIDE INHIBITORS OF PROTEIN KINASE C 审中-公开
标题翻译：肽抑制剂蛋白激酶C
公开(公告)号：EP1501532A2
公开(公告)日：2005-02-02
申请号：EP03728494.0
申请日：2003-04-22
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： MOCHLY-ROSEN, Daria
IPC分类号： A61K38/00
CPC分类号： C12N9/1205 , A61K38/45 , C07K7/06 , C07K7/08
摘要： PKC V5 isozyme-specific peptides are described. The sequences and compositions comprising the sequences are useful for treating diseases states associated with the PKC isozyme from which they are respectively derived. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides are also described.

73. 发明公开

EP1401473A2 TRANSPORTERS COMPRISING SPACED ARGININE MOIETIES 有权
标题翻译： TRANSPORTER具有间隔精氨酸粒子
公开(公告)号：EP1401473A2
公开(公告)日：2004-03-31
申请号：EP02742477.9
申请日：2002-02-14
申请人： Cellgate Inc. , THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： WENDER, Paul, A. , ROTHBARD, Jonathan, B. , WRIGHT, Lee , KREIDER, Erik, L. , VANDEUSEN, Christopher, L.
IPC分类号： A61K38/00
CPC分类号： A61K47/64
摘要： The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit 'Z' is L-arginine or D-arginine, and subunit 'Y' is an amino acid that does not comprise an amidino or guanidino moiety. Subscript 'n' is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.

74. 发明公开

EP1381839A2 METHOD OF IMAGING CELL DEATH IN VIVO 审中-公开
标题翻译：方法形像，细胞死亡的体内表征
公开(公告)号：EP1381839A2
公开(公告)日：2004-01-21
申请号：EP02763924.4
申请日：2002-04-03
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY , Theseus Imaging Corporation
发明人： STRAUSS, H., W. , BLANKENBERG, Francis, G. , GREEN, Allan, M. , STEINMETZ, Neil
IPC分类号： G01N1/00
CPC分类号： A61K41/00 , A61K51/087 , A61K51/088
摘要： A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. Methods for tumor radiotherapy are also provided.

75. 发明公开

EP1381672A1 BIOSYNTHESIS OF POLYKETIDE SYNTHASE SUBSTRATES 审中-公开
标题翻译：多肽合成酶底物的生物合成
公开(公告)号：EP1381672A1
公开(公告)日：2004-01-21
申请号：EP02725059.6
申请日：2002-02-28
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： KHOSLA, Chaitan , PFEIFER, Blaine
IPC分类号： C12N1/21 , C12N9/00 , C12N15/63 , C12N15/54 , C12N15/81
CPC分类号： C12N9/1288 , C12N9/16 , C12N15/52 , C12P1/00 , C12P17/189
摘要： The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.
摘要翻译：描述了催化生产聚酮化合物的起始剂和增量剂单元的酶的使用。另外，描述了修改的装载模块，其可以接受多种起始单元，例如取代的苯甲酸酯，并且可以用于生成天然产物的取代衍生物。这些酶可用于提高天然产生的聚酮化合物或合理设计的聚酮化合物的产量。通过使用这些技术，已经在大肠杆菌中完成了合成完整的聚酮化合物。在聚酮化合物和其他次级代谢产物的微生物中通过延迟生产直到指数期后和通过保持培养基中相对恒定的营养水平可以提高产量。另外，通过提供硫酯酶II的表达系统可以增强聚酮化合物的生产。因此，通过改变宿主生物体并改变培养条件，可以增强次级代谢产物的合成。本发明还导致具有所需特征的宿主生物体用于生产这种聚酮化合物并评估基因改组的结果。

76. 发明公开

EP1322224A1 ASSESSING CONDITION OF A JOINT AND CARTILAGE LOSS 有权
标题翻译：端的铰链状况评估和软骨损失
公开(公告)号：EP1322224A1
公开(公告)日：2003-07-02
申请号：EP01970941.9
申请日：2001-09-14
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： LANG, Philipp , STEINES, Daniel
IPC分类号： A61B5/055 , A61B5/103
CPC分类号： G06T7/0081 , A61B5/055 , A61B5/1038 , A61B5/107 , A61B5/1075 , A61B5/4514 , A61B5/4528 , A61B5/7257 , A61B6/03 , A61B8/0875 , G01R33/50 , G01R33/56 , G01R33/5608 , G06T7/0012 , G06T7/11 , G06T7/187 , G06T2207/10088 , G06T2207/30008
摘要： Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. The amount of cartilage tissue that has been lost, for example as a result of arthritis, can be estimated.

77. 发明公开

EP1311878A1 AMORPHOUS COMPOUNDS FOR WIDEBAND OPTICAL AMPLIFIERS 有权
标题翻译：非晶组合物技术的光纤宽带放大器
公开(公告)号：EP1311878A1
公开(公告)日：2003-05-21
申请号：EP00955265.4
申请日：2000-07-28
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： FEILLENS, Yannick G. , DIGONNET, Michel, J., F. , FEJER, Martin, M.
IPC分类号： G02B1/11 , G02B6/134 , H01S3/10 , H01S3/067 , H01S3/17 , C03C3/00
CPC分类号： H01S3/17 , C03C3/095 , C03C3/12 , H01S3/06716 , H01S3/06754 , H01S3/1603 , H01S3/1661
摘要： In a method of amplifying optical input signals over a wide bandwidth, the optical input signals are applied to an optical waveguide (810) made from a rare-earth-doped amorphous material (e.g., erbium-doped yttrium aluminum oxide material). The optical input signals include optical signals having wavelengths over a range of at least 80 nanometers, and, preferably, over a range of at least 160 nanometers. Pump light (830) is applied to the optical waveguide (810) to cause the waveguide (810) to provide optical gain to the optical input signals. The optical gain causes the optical signals to be amplified within the waveguide (810) to provide amplified optical signals over the extended 80-160-nanometer range, including, in particular, optical signals having wavelengths at one end of the range and optical signals having wavelengths at a second end of the range.

78. 发明公开

EP1284051A2 TIME-REVERSAL BLOCK TRANSMIT DIVERSITY SYSTEM FOR CHANNELS WITH INTERSYMBOL INTERFERENCE AND METHOD 审中-公开
标题翻译： SYSTEM AND METHOD FOR时间反演块传输多样性与符号间干扰的信道
公开(公告)号：EP1284051A2
公开(公告)日：2003-02-19
申请号：EP01926912.5
申请日：2001-04-13
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： LINDSKOG, Erik, D. , PAULRAJ, Arogyaswami, J.
IPC分类号： H04B7/00 , H04L25/03
CPC分类号： H04B7/0669 , H04L1/0618
摘要： A method for diversity transmission and reception for channels with intersymbol interference is created. With this method one can transmit from two or more antennas in such a way that a receiver with one or more antennas can benefit from the diversity offered by the difference in channels from the transmit antennas to the receiver antenna(s). The way the transmission and reception is organized makes it relatively simple to in the receiver detect the transmitted symbols despite intersymbol interference in the channel. Due to the increased diversity experienced by the receiver the average power level required at the receiver is reduced which can be used to increase the capacity or coverage of a wireless network and/or reduce the required transmitted power.

79. 发明公开

EP1260116A1 FOLDED SAGNAC SENSOR ARRAY 有权
标题翻译： FOLDED萨格奈克传感器组
公开(公告)号：EP1260116A1
公开(公告)日：2002-11-27
申请号：EP01926350.8
申请日：2001-03-02
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： VAKOC, Benjamin, A.
IPC分类号： H04R1/44 , G01B9/02
CPC分类号： G01S3/80 , G01H9/004
摘要： A folded Sagnac fiber optic acoustic sensor array (1200) operates in a manner similar to a Sagnac Interferometer but uses a common delay path to reduce distributed pickup in downlead fibers. The fiber optic acoustic sensor (716) is used to detect acoustic waves in water. By basing the folded Sagnac sensor array on the operating principles similar to the Sagnac interferometer rather than basing the array on a Mach-Zehnder interferometer, the sensor array has a stable bias point, has reduced phase noise, and allows a broadband signal source to be used rather than requiring a more expensive narrowline laser. A large number of acoustic sensors (718(N)) can be multiplexed into the architecture of the folded Sagnac fiber optic acoustic array.

80. 发明公开

EP1248519A1 EXPANSION OF STEM AND PROGENITOR CELLS BY BETA-CATENIN 审中-公开
标题翻译： STEM膨胀和细胞PREβ-连环蛋白
公开(公告)号：EP1248519A1
公开(公告)日：2002-10-16
申请号：EP01903087.3
申请日：2001-01-17
申请人： THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY
发明人： REYA, Tannishtha , NUSSE, Roeland , WEISSMAN, Irving, L.
IPC分类号： A01N1/02 , C12N5/00 , C12N5/02 , C12N7/00 , C12N15/63 , C12N15/86 , C12P21/04 , C12P21/06
CPC分类号： C12N5/0647 , C12N2501/125 , C12N2501/415 , C12N2501/998
摘要： Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of β-catenin in the cell. The expanded cells substantially maintain their original phenotype including the ability to give rise to multiple types of differentiated cells. The intracellular levels of β-catenin may be manipulated by providing exogenous β-catenin protein to the cell, or by introduction into the cell of a genetic construct encoding β-catenin. The β-catenin may be a wild-type or stabilized mutant form of the protein. Preferably the long term cell culture medium substantially lacks stromal cells and cytokines.

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