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71. 发明公开

EP1946774A1 CEREBRAL INFARCTION-PREVENTIVE AGENT 失效转让
标题翻译： MITTEL ZUR VERHINDERUNG VON GEHIRNINFARKT
公开(公告)号：EP1946774A1
公开(公告)日：2008-07-23
申请号：EP06811724.1
申请日：2006-10-13
申请人： National University Corporation Okayama University , Ehime University
发明人： NISHIBORI, Masahiro , MORI, Shuji , TAKAHASHI, Hideo , TOMONO, Yasuko , ADACHI, Naoto , LIU, Keyue
IPC分类号： A61K39/395 , A61P9/10 , A61P25/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/76
摘要： An objective of the present invention is to provide a suppressant for cerebral infarction occurred after long-term ischemia associated with actual cerebral infarction, and has fewer side effects. The cerebral infarction suppressant of the present invention is characterized in comprising an anti-HMGB1 monoclonal antibody as an active ingredient.
摘要翻译：本发明的目的是提供与实际脑梗死相关的长期缺血后发生的脑梗塞抑制剂，副作用较少。本发明的脑梗死抑制剂的特征在于，含有抗HMGB1单克隆抗体作为有效成分。

72. 发明公开

EP1859849A1 DEAERATOR AND DEAERATING METHOD 审中-公开
标题翻译： ENTLÜFTERUNDENTLÜFTUNGSVERFAHREN
公开(公告)号：EP1859849A1
公开(公告)日：2007-11-28
申请号：EP06728692.2
申请日：2006-03-07
申请人： National University Corporation Okayama University
发明人： WASHIO, S., c/o Graduate Sch. Natural Sci. & Tech.
IPC分类号： B01D19/00
CPC分类号： B01D19/0036 , B01D19/0094
摘要： The present invention provides a deaerator and a deaerating method which enable the continuous deaeration of a liquid at a low cost. That is, with respect to a pipe which supplies a fluid by a supply means, a rip-out portion which rips out a fluid from an innerperipheral surface of the pipe is provided at a predetermined position in the inside of the pipe, and the fluid is supplied at a predetermined flow rate by a flow control means which adjusts the flow rate of the liquid which is supplied through the pipe so as to form a cavity on a downstream side of the rip-out portion. A through hole which communicates with the cavity is formed in the pipe, and deaeration of the liquid is performed by exhausting gases in the inside of the cavity by suction means such as a vacuum pump via the through hole.
摘要翻译：本发明提供了一种能够以低成本连续脱气液体的除气器和脱气方法。也就是说，对于通过供给装置供给流体的管道，在管的内部的规定位置设置有从管的内周表面流出的流体的剥离部，流体通过流量控制装置供给流量控制装置，流量控制装置调节通过管道供应的液体的流量，以便在裂开部分的下游侧形成空腔。在管中形成与空腔连通的通孔，通过通孔等真空泵等抽吸机构排出空腔内的气体，进行液体的脱气。

73. 发明公开

EP1835286A1 METHOD OF EXAMINING PREGNANCY TOXEMIA 审中-公开
标题翻译：检测妊娠毒血症的方法
公开(公告)号：EP1835286A1
公开(公告)日：2007-09-19
申请号：EP05819438.2
申请日：2005-12-26
申请人： National University Corporation Okayama University
发明人： MAESHIMA, Yohei Graduate School of Medicine , HIROKOSHI, Kumiko c/o Graduate School of Medicine , MAKINO, Hirofumi c/o Graduate School of Medicine , MASUYAMA, Hisashi c/o Okayama University Hospital , HIRAMATSU, Yuji c/o Graduate School of Medicine
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6893 , G01N2333/515 , G01N2800/368
摘要： It is intended to provide a method of detecting the onset of pregnancy toxemia whereby the onset risk of pregnancy toxemia can be adequately evaluated. Namely, a method of detecting the onset of pregnancy toxemia in a pregnant mammal which comprises the measurement step of measuring the concentration of angiopoietin-2 in a body fluid, the comparison step of comparing the angiopoietin-2 concentration obtained in the above measurement step with a normal level, and the judgment step of judging the presence or absence of the onset risk of pregnancy toxemia based on the results of the above comparison step. In the judgment step, it may be considered that the patient has a risk of the onset of pregnancy toxemia in the case where the angiopoietin-2 concentration obtained in the measurement step is lower than the normal level.
摘要翻译：它旨在提供一种检测妊娠毒血症发病的方法，从而可以充分评估妊娠毒血症的发病风险。即，在怀孕哺乳动物中检测妊娠毒血症的发病的方法，其包括测量体液中血管生成素-2浓度的测量步骤，比较步骤，将在上述测量步骤中获得的血管生成素-2浓度与正常水平，以及基于上述比较步骤的结果判断妊娠毒血症的发病风险的存在或不存在的判断步骤。在判断步骤中，可以认为在测量步骤中获得的血管生成素-2浓度低于正常水平的情况下，患者有发生妊娠毒血症的风险。

74. 发明公开

EP1380542A2 Method of manufacturing aluminium-substituted hematite 审中-公开
标题翻译：制造铝取代赤铁矿的方法
公开(公告)号：EP1380542A2
公开(公告)日：2004-01-14
申请号：EP03015197.1
申请日：2003-07-04
申请人： President of Okayama University
发明人： Takada, Jun , Fujii, Tatsuo , Nakanishi, Makoto
IPC分类号： C01G49/00
CPC分类号： C01G49/0045 , C01P2002/72 , C01P2002/77 , C09C1/24
摘要： A method of manufacturing aluminum-substituted hematite represented by α-(Fe 1-x Al x ) 2 O 3 where x=0.01 to 0.15, by mixing an iron compound and an aluminum compound such that an atomic ratio of Fe to Al falls within the range of 99:1 to 85:15, adding citric acid and ethylene glycol to the mixture of the iron compound and aluminum compound to produce a gel, and pyrolyzing the gel, followed by calcining the pyrolyzed product.
摘要翻译：通过混合铁化合物和铝化合物以使Fe与Al的原子比落入99:1的范围内，制备由α-（Fe1-xAlx）2O3（其中x = 0.01-0.15）表示的由铝取代的赤铁矿的方法。 1至85:15，向铁化合物和铝化合物的混合物中加入柠檬酸和乙二醇以产生凝胶，并热解凝胶，接着煅烧热解产物。

75. 发明公开

EP4177339A1 METHOD FOR PRODUCING CARTILAGE TISSUE 审中-实审
公开(公告)号：EP4177339A1
公开(公告)日：2023-05-10
申请号：EP21833040.5
申请日：2021-07-01
申请人： National University Corporation Okayama University , Kake Educational Institution , Nissan Chemical Corporation
发明人： TAKARADA Takeshi , IWAI Ryosuke , SUZUKI Kohei , FUKASAWA Natsuki
IPC分类号： C12N5/077 , C08F220/04 , C08F220/34 , C12M3/00 , C12N5/0735 , C12N5/10
摘要： The present invention is to provide a method for producing a cartilage tissue which comprises a step of providing a substrate for producing cell aggregates provided with a plurality of spots comprising a copolymer containing recurring units derived from monomers represented by the following formulae (I) and (II):

[wherein U a1 , U a , R a1 , R a2 and R b are as described in the specification and claims] on a substrate having an ability to suppress adhesion of cells; a step of seeding human cartilage progenitor cells which are positive for PRRX1 protein and derived from pluripotent stem cells on the substrate; a step of producing cell aggregates by culturing the cells; and a step of culturing the aggregates to produce a cartilage tissue.

76. 发明公开

EP4008349A1 METHOD FOR TREATING LIVER CANCER WITH COMBINED USE OF REIC/DKK-3 GENE AND ANTI-TUMOR AGENT 审中-实审
公开(公告)号：EP4008349A1
公开(公告)日：2022-06-08
申请号：EP20847959.2
申请日：2020-07-31
申请人： Momotaro-Gene Inc. , National University Corporation Okayama University
发明人： KUMON Hiromi , SHIRAHA Hidenori , OYAMA Atsushi , UCHIDA Daisuke , IWAMURO Masaya , OKADA Hiroyuki
IPC分类号： A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N15/12 , C12N15/861 , A61K33/24 , A61K38/17 , A61K31/282 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/555 , A61K31/7088 , A61K35/761
摘要： This invention provides a method for treatment of hepatic cancer with the use of an anti-tumor agent in combination with the REIC/Dkk-3 gene. This invention also provides a therapeutic agent for treatment of hepatic cancer used in combination with an anti-tumor agent, which comprises, as an active ingredient, the REIC/Dkk-3 gene.

77. 发明公开

EP3913366A1 METHOD AND KIT FOR DETERMINING POSSIBILITY OF ONSET OF IGA NEPHROPATHY 审中-公开
公开(公告)号：EP3913366A1
公开(公告)日：2021-11-24
申请号：EP19910385.4
申请日：2019-12-23
申请人： National University Corporation Okayama University
发明人： WADA, Jun , MISE, Koki
IPC分类号： G01N33/53
摘要： Provided is a more accurate method for determining the possibility that a subject has developed IgA nephropathy. A method of determining the possibility that a subject has developed IgA nephropathy, in accordance with an aspect of the present invention, includes the step of determining the level of at least one glycan in a sample taken from the subject, the at least one glycan being at least one glycan that binds to at least one lectin selected from the group consisting of ACA, MAH, ABA, STL, LEL, WGA, MPA, Jacalin, MAL_I, PNA, ACG, GSL_I_A4, ConA, SSA, AOL, and GSL_II.

78. 发明公开

EP3882630A1 METHOD FOR DETECTING OXIDIZED LDL/BETA2GPI COMPLEX, AND DETECTION KIT 无效
公开(公告)号：EP3882630A1
公开(公告)日：2021-09-22
申请号：EP21712937.8
申请日：2021-02-02
申请人： National University Corporation Okayama University
发明人： MATSUURA, Eiji , TAKENAKA, Fumiaki , TAN, Xian Wen
IPC分类号： G01N33/53 , G01N33/543
摘要： The object of the present invention is to provide an easy and quick detection method for detecting an oxLDL/β 2 GPI complex in biological samples, and a detection kit therefor. The present invention attains this object by providing a detection method for detecting an oxLDL/β 2 GPI complex, which uses a test strip for lateral flow assay, comprising a step of capturing the oxLDL/β 2 GPI complex in the test sample in a predetermined position on the test strip by a first binding component that binds to the oxLDL/β 2 GPI complex; and a step of labeling the oxLDL/β 2 GPI complex captured in the predetermined position on the test strip by making a second binding component comprising a labeling agent be bound to the captured oxLDL/β 2 GPI complex, and a detection kit therefor.

79. 发明公开

EP3808362A1 REACTIVE OXYGEN PRODUCTION INHIBITOR AND/OR SCAVENGING PROMOTER 审中-公开
公开(公告)号：EP3808362A1
公开(公告)日：2021-04-21
申请号：EP19810753.4
申请日：2019-05-21
申请人： National University Corporation Okayama University
发明人： NISHIBORI, Masahiro , MORI, Shuji , WAKE, Hidenori
IPC分类号： A61K38/08 , A61K38/10 , A61K38/16 , A61P17/18 , A61P39/06 , C07K7/06
摘要： The present invention provides a production inhibitor and/or scavenging promoter for reactive oxygen, and relates to a production inhibitor and/or scavenging promoter for reactive oxygen containing as an active ingredient a peptide having histidine-rich sequence. The histidine-rich sequence is the amino acid sequence identified by any one or a plurality of the following SEQ ID NOs: 2 to 8; (SEQ ID NO: 2) DLHPH; (SEQ ID NO: 3) KHHSH; (SEQ ID NO: 4) EQHPH; (SEQ ID NO: 5) GHHPH; (SEQ ID NO: 6) AHHPH; (SEQ ID NO: 7) EHDTH; and (SEQ ID NO: 8) RQHPH.

80. 发明公开

EP3791894A1 ANTI-S100A8/A9 ANTIBODY AND USE THEREOF 审中-实审转让
公开(公告)号：EP3791894A1
公开(公告)日：2021-03-17
申请号：EP19792052.3
申请日：2019-04-15
申请人： National University Corporation Okayama University , Niigata University , National University Corporation Gunma University , Kawasaki Gakuen Educational Foundation
发明人： SAKAGUCHI, Masakiyo , TOYOOKA, Shinichi , TOMIDA, Shuta , SHIEN, Kazuhiko , SATO, Hiroki , KINOSHITA, Rie , FUTAMI, Junichiro , ARAKI, Kota , OKAZAKI, Mikio , KONDO, Eisaku , INOUE, Yusuke , YAMAUCHI, Akira
IPC分类号： A61K39/395 , A61P29/00 , A61P35/00 , A61P35/04 , C07K16/32 , C12N15/13
摘要： Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.

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