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71. 发明公开

EP0191788A1 NOVEL RADIOPHARMACEUTICALS AND CHELATING AGENTS USEFUL IN THEIR PREPARATION 失效
标题翻译：新的无线电和药物化合物螯合有用其制备方法。
公开(公告)号：EP0191788A1
公开(公告)日：1986-08-27
申请号：EP85903750.0
申请日：1985-07-15
申请人： UNIVERSITY OF FLORIDA
发明人： BODOR, Nicholas, S.
IPC分类号： C07D211 , A61K51 , C07B59 , C07D213 , C07D215 , C07D217 , C07D277 , C07D285 , C07D417 , C07F13 , C07K5 , C09K3
CPC分类号： C07D213/53 , C07C323/00 , C07D213/82 , C07D277/04 , C07D285/00 , C07F13/005 , C07K5/06026
摘要： On propose un type de système de distribution du rédox ou de produits chimiques, du type à sel dihydropyridine$(1,7)$pyridinium pour l'envoi au cerveau et à d'autres organes d'un radionucléide, spécifique au site et/ou à site préférentiel. Un agent de chélation, capable d'effectuer la chélation avec un radionucléide et possédant une fonction amino primaire, secondaire ou tertiaire, peut être transformé dans un agent analogue correspondant dans lequel ladite fonction est remplacée par un système rédox à sel dihydropyridine$(1,7)$pyridinium et ensuite complexée avec un radionucléide pour créer un nouveau produit radiopharmaceutique qui sous sa forme dihydropyridine lipoïdale pénètre la barrière BBB (barrière sang-cerveau) et autorise des concentrations de radionucléides plus élevées dans le cerveau, en particulier étant donné que l'oxydation de la moitié dihydropyridine in vivo en sel pyridinium ionique ralentit son élimination du cerveu, tout en accélérant son élimination de la circulation générale. Ce système d'envoi de radionucléides est bien adapté à des utilisations en scintigraphie et dans des techniques radiographiques semblables.

72. 发明公开

EP0711463A1 APPARATUS AND METHOD FOR REPLENISHING LASER DYE SOLUTION 失效
标题翻译：设备和方法，用于将激光染料
公开(公告)号：EP0711463A1
公开(公告)日：1996-05-15
申请号：EP94924534.0
申请日：1994-07-27
申请人： CYNOSURE, INC.
发明人： FURUMOTO, Horace, W. , CECCON, Harry, L. , CHO, George, E., S. , HACKER, Mark, P.
IPC分类号： H01S3
CPC分类号： H01S3/022 , H01S3/213
摘要： In a dye laser system, a porous bed filter (40) is loaded with dye prior to operation of the system. With repeated firings, the dye solution is filtered by the porous bed filter (40) to remove by-products of the laser process. Solute concentration is monitored (52) and dye and additives removed by the filter (40) are replenished by a metering pump (42). Precise temperature control (56) assures consistent filtering of dye by the filter (40) for more consistent color and energy output. To control (48) the metering pump (42), the differential output of a two-channel absorption detector (68, 70) is digitized (76). The digitized signal is loaded into a counter (78) which drives the metering pump (42). The useful lifetime of the dye solution is enhanced by incorporating pH buffers in the solution.

73. 发明公开

EP0705296A1 TELOMER COMPOSITION 失效
标题翻译：客户组成
公开(公告)号：EP0705296A1
公开(公告)日：1996-04-10
申请号：EP94916838.0
申请日：1994-05-30
申请人： SOLA INTERNATIONAL HOLDINGS, LTD.
发明人： TOH, Huan, Kiak , KOK, Chong, Meng , MATISONS, Jani, Gunars , WILLIAMS, Michael
IPC分类号： G02C7 , C08F30 , C08F212 , C08F290 , C08G77 , G02B1
CPC分类号： G02B1/04 , C08F290/068 , C08G77/52 , C08L51/085 , C08L85/00 , C08L83/14
摘要： The present invention relates to the manufacture of plastic optical articles, such as video discs and ophthalmic lenses. The plastic is a telomer formed by reacting an aromatic olefin monomer with a partially substituted di- or polysiloxane, optionally with a catalyst and/or a crosslinking agent.
摘要翻译：本发明涉及制造塑料光学制品，例如视频光盘和眼镜片。该塑料是通过使芳族烯烃单体与部分取代的二硅氧烷或聚硅氧烷，任选地与催化剂和/或交联剂反应而形成的调聚物。

74. 发明公开

EP0690965A1 SINGLE SLIDING KEY TYPE COUNTERSHAFT AUTOMATIC TRANSMISSION 失效
标题翻译：与副滑动KEIL自动变速箱
公开(公告)号：EP0690965A1
公开(公告)日：1996-01-10
申请号：EP95910359.0
申请日：1995-01-19
申请人： EQUIPAMENTOS CLARK LTDA
发明人： MACHADO, Aryoldo
IPC分类号： F16D28 , F16D48 , F16H3
CPC分类号： F16H3/083 , F16H2063/3096 , Y10T74/19251 , Y10T74/19284 , Y10T74/19465
摘要： A single sliding key type automatic transmission having an input (2) with a sliding locating tube (1), plural rotary gears (201, 202, 203, 204, 205, 206) rotatable on the input shaft (2). An actuating tip (5) rotating with the input shaft (2) moves axially to cause the engagement pins (4) to engage the selected gear (201) to the input shaft (2) so as to transmit rotation to the countershaft (34). The transmission having a motor (16) for synchronizing the rotation of the input shaft (2) to the counter shaft (34) during a gearshift and additional motors (15, 19) for actuation of the gear shift.

75. 发明公开

EP0678165A1 CRYOPUMP WITH DIFFERENTIAL PUMPING CAPABILITY 失效
标题翻译：低温泵的差分性能。
公开(公告)号：EP0678165A1
公开(公告)日：1995-10-25
申请号：EP92912536.0
申请日：1992-05-13
申请人： HELIX TECHNOLOGY CORPORATION
发明人： BARTLETT, Allen, J. , AITKEN, Douglas, F.
IPC分类号： F04B37
CPC分类号： F04B37/08 , Y10S417/901

76. 发明公开

EP0662250A1 MULTI-PLY BATTERY SEPARATOR AND PROCESS OF FORMING 失效
标题翻译：分离器MULTI-LAYER电池和方法。
公开(公告)号：EP0662250A1
公开(公告)日：1995-07-12
申请号：EP93901174.0
申请日：1992-12-18
申请人： W.R. Grace & Co.-Conn.
发明人： TROFFKIN, Howard, Julian , REIN, Burton, Maxwell , SPOTNITZ, Robert, Mark , GIOVANNONI, Richard, Thomas , GUO, Yihong
IPC分类号： C08J9 , H01M2
CPC分类号： H01M2/1686 , C08J9/26 , C08J9/28 , C08J2201/0543 , C08J2201/0546 , H01M2/1653 , H01M2300/0025
摘要： A process of having a microporous multi-ply substantially unfilled sheet product which is capable of becoming non-porous at a predetermined elevated transformation temperature is formed by first forming a non-porous, multi-ply initial sheet product having at least one first ply and at least one second ply, each with its own viscosity profile. Porosity is then imparted to the initial sheet product, either by extracting extractable material contained within the first and second composition, or by stretching and annealing the initial sheet product.

77. 发明公开

EP0661986A1 BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM 失效
标题翻译：通过顺序代谢增强神经活性肽的脑部递送
公开(公告)号：EP0661986A1
公开(公告)日：1995-07-12
申请号：EP93922358.0
申请日：1993-09-17
申请人： UNIVERSITY OF FLORIDA
发明人： BODOR, Nicholas, S.
IPC分类号： C07K5 , C07K7 , C07K14 , A61K38
CPC分类号： C07K7/06 , A61K38/00 , A61K47/559 , C07K5/0806 , C07K5/0823 , C07K5/1008 , C07K5/1024 , C07K14/70
摘要： The invention provides novel peptide derivatives which are designed to deliver pharmacologically active peptides into the central nervous system by sequential metabolism. The peptide is placed in a molecular environment which disguises its peptide nature and provides biolabile, lipophilic functions to penetrate the blood-brain barrier by passive transport. The design incorporates a dihydropyridine-type redox targetor moiety, an amino acid or di- or tripeptide spacer inserted between the targetor and N-terminal amino acid unit of the peptide and a bulky, lipophilic substituent protecting the C-terminal amino acid unit of the peptide. The dihydropyridine-type targetor undergoes an enzymatically mediated oxidation to a hydrophilic, membrane-impermeable pyridinium salt. That polar targetor-peptide conjugate is trapped behind the lipoidal blood-brain barrier. Over time, cleavage of the lipophilic ester from the peptide by esterase and/or lipase enzymes and enzymatic cleavage of the targetor-spacer from the peptide results in release of the desired peptide in the brain.
摘要翻译：本发明提供了设计用于通过顺序代谢将药理活性肽递送至中枢神经系统的新型肽衍生物。将肽置于分子环境中，该环境伪装其肽性质并提供生物不稳定的亲脂性功能以通过被动转运穿透血脑屏障。该设计包含二氢吡啶型氧化还原靶向部分，插入到靶标和肽的N-末端氨基酸单元之间的氨基酸或二肽或三肽间隔物，以及保护肽的C-末端氨基酸单元的庞大的亲脂性取代基肽。二氢吡啶类型的靶向物经历酶促介导的氧化成亲水的，不透膜的吡啶鎓盐。该极性靶标 - 肽缀合物被捕获在类脂血脑屏障之后。随着时间的过去，通过酯酶和/或脂肪酶从肽上切割亲脂性酯并从肽上酶促切割靶或间隔子导致所需肽在脑中释放。

78. 发明公开

EP0651730A1 METHOD AND APPARATUS FOR CONTROLLING MICROORGANISMS 失效
标题翻译：方法和仪器监测微生物。
公开(公告)号：EP0651730A1
公开(公告)日：1995-05-10
申请号：EP93915606.0
申请日：1993-07-20
申请人： Diversey Corporation
发明人： CHRISTENSEN, Ronald, J. , BAKEP, Gary L. , STEIMEL, Lyle, H.
IPC分类号： C02F1 , C02F9
CPC分类号： C02F9/00 , C02F1/32 , C02F1/4674 , C02F1/722 , C02F1/76 , C02F1/766 , C02F2103/023 , C02F2103/28 , C02F2103/42 , C02F2301/043 , C02F2301/046
摘要： Water in a process water system, such as a cooling tower or pulp and paper processing plant, is treated to destroy biological microorganisms by diverting the portion of the water flowing through the system to a side stream. In the side stream, chemicals are added such as halide ions or sodium chlorite. The water is then passed through an electrolysis unit or a UV radiation unit to oxidize the precursor to form an active oxidant. Advantageously, the pH of the side stream can be lowered to significantly improve the oxidization of the halide ions. When a very small portion of the flow rate is passing through the side stream, the acid added does not significantly alter the pH of the entire system. In a preferred embodiment, the acid added is phosphonic acid which acts as an antiscalant. Also included in the present invention is a method to inject oxidant precursors into a process water system through an oxidant generation station.

79. 发明公开

EP0641238A1 CRYOGENIC WATERPUMP 失效
标题翻译：低温水泵
公开(公告)号：EP0641238A1
公开(公告)日：1995-03-08
申请号：EP93913978.0
申请日：1993-05-18
申请人： HELIX TECHNOLOGY CORPORATION
发明人： LESSARD, Philip, A. , AITKEN, Douglas, F. , BRADFORD, Robert, D. , GRAHAM, Roland, P. , MICHAUD, Steven, A. , MANNING, Karen, J.
IPC分类号： B01D8 , F04B37
CPC分类号： F04B37/08 , B01D8/00 , Y10S417/901

80. 发明公开

EP0627910A1 METHODS AND APPARATUS FOR DRUG DELIVERY USING SUPERCRITICAL SOLUTIONS 失效
标题翻译：方法和设备主动释放由超临界溶液。
公开(公告)号：EP0627910A1
公开(公告)日：1994-12-14
申请号：EP93906094.0
申请日：1993-02-19
申请人： Sievers, Robert, E. , HYBERTSON, Brooks, M. , HANSEN, Brian, N.
发明人： Sievers, Robert, E. , HYBERTSON, Brooks, M. , HANSEN, Brian, N.
IPC分类号： A61K9 , A61K49 , A61M15 , B01F3 , B01F5 , B01J3 , B05B7 , B05D1 , C09K3
CPC分类号： B01F3/068 , A61K9/0073 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J3/008 , B05B7/32 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： L'invention concerne des procédés et des appareils d'administration de composés physiologiquement actifs à un être humain ou à un animal cible, qui utilise une solution liquide supercritique contenant un solvant liquide supercritique et un soluté physiologiquement actif. On fait passer ladite solution supercritique dans une zone sous-critique afin d'entraîner l'évaporation du solvant et une dispersion des particules du soluté dans du gaz. La dispersion dans du gaz des particules du soluté est administrée directement à l'être humain ou à l'animal cible. Les appareils d'administration du composé physiologiquement actif tiennent dans la main.

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