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71. 发明公开

EP1491144A1 Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein 审中-公开
标题翻译：装置，系统和用于体液的提取和监测的分析物的方法
公开(公告)号：EP1491144A1
公开(公告)日：2004-12-29
申请号：EP04253352.1
申请日：2004-06-04
申请人： LIFESCAN, INC.
发明人： Racchini, Joel , Hilgers, Michael , Stout, Phil , Rademacher, Thomas , Mechelke, Joel , Hanson, Cass A.
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/022 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150175 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150824 , A61B5/15087 , A61B5/15117 , A61B5/15144 , A61B5/157 , A61B5/6824 , A61B2560/0431 , A61B2562/0295
摘要： A system for extracting a bodily fluid sample (e.g., an interstitial fluid [ISF] sample) and monitoring an analyte therein includes a disposable cartridge and a local controller module. The disposable cartridge includes a sampling module adapted to extract a bodily fluid sample and an analysis module adapted to measure an analyte (e.g., glucose) in the bodily fluid sample. The local controller module is in electronic communication with the disposable cartridge and is adapted to receive and store measurement data from the analysis module. An ISF extraction device includes a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting an ISF sample therefrom. The device also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site. The device is configured such that the pressure ring(s) is capable of applying pressure in an oscillating manner whereby an ISF glucose lag of the ISF sample extracted by the penetration member is mitigated. A method for extracting ISF includes providing an ISF fluid extraction device with a penetration member and a pressure ring(s). Next, a user's skin layer is contacted by the pressure ring(s) and penetrated by the penetration member. An ISF sample is then extracted from the user's skin layer while pressure is being applied in an oscillating manner by the pressure ring(s). The oscillating pressure mitigates an ISF glucose lag of the extracted ISF sample extracted.

72. 发明授权

EP1031319B1 Lancing device having a releasable connector 有权
标题翻译：刺血针具有可移除连接器
公开(公告)号：EP1031319B1
公开(公告)日：2004-11-10
申请号：EP00301395.0
申请日：2000-02-22
申请人： LIFESCAN, INC.
发明人： Levaughn, Richard Wayne , Purlee, John M. , Ruf, Christopher John , Taylor, William C.
IPC分类号： A61B5/15
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150259 , A61B5/150412 , A61B5/15113 , A61B5/15117 , A61B5/1519

73. 发明公开

EP1466633A1 Composite scaffolds seeded with mammalian cells 审中-公开
标题翻译：与哺乳动物细胞接种的复合支架
公开(公告)号：EP1466633A1
公开(公告)日：2004-10-13
申请号：EP04252019.7
申请日：2004-04-02
申请人： Lifescan, Inc.
发明人： Rezania, Alireza , Zimmerman, Mark
IPC分类号： A61L27/56 , A61L27/58 , A61L27/44 , A61L27/38
CPC分类号： A61L27/3852 , A61L27/3847 , A61L27/48 , A61L27/56 , C08L67/04
摘要： Implantable, biocompatible scaffolds containing a biocompatible, porous, polymeric matrix, a biocompatible, porous, fibrous mat encapsulated by and disposed within said polymeric matrix, and a plurality of mammalian cells seeded within said tissue scaffold. The invention also is directed to methods of treating disease or structural defects in a mammal utilizing the scaffolds of the invention.
摘要翻译：包含生物相容性多孔聚合物基质的可植入生物相容性支架，被所述聚合物基质包封和设置在所述聚合物基质内的生物相容性多孔纤维垫以及接种在所述组织支架内的多个哺乳动物细胞。本发明还涉及利用本发明的支架治疗哺乳动物的疾病或结构缺陷的方法。

74. 发明公开

EP1266608A3 Biological fluid sampling and analyte measurement devices and methods 有权
标题翻译：生物流体和分析物测量设备和方法的集合
公开(公告)号：EP1266608A3
公开(公告)日：2004-08-04
申请号：EP02254050.4
申请日：2002-06-11
申请人： Lifescan, Inc.
发明人： Leong, Koon-wah , Shartle, Robert
IPC分类号： A61B5/15 , A61B5/00
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532
摘要： A device for sampling a biological fluid and measuring a target analyte within the biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and access biological fluid, a sampling means and a measuring means. The sampling means comprises a fluid transfer medium, such as a hydrophilic porous material, by which sampled biological fluid is transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode and, typically, a reagent material, where the electrochemical cell is configured so as to make an electrochemical measurement of a target analyte in accessed biological fluid present therein. Methods of sampling biological fluids within the skin and measuring the sampled fluids are also provided, as well as kits comprising one or more of the inventive devices.

75. 发明公开

EP1413883A1 Method of reducing analysis time of endpoint-type reaction profiles 审中-公开
标题翻译： Methode zur Verringerung der Analysezeit bei Reaktionen mit Endpunktsbestimmung
公开(公告)号：EP1413883A1
公开(公告)日：2004-04-28
申请号：EP03256597.0
申请日：2003-10-20
申请人： Lifescan, Inc.
发明人： Matzinger, David
IPC分类号： G01N33/487 , G01N21/75 , G01N21/79 , G01N31/16
CPC分类号： C12Q1/00 , G01N21/79 , G01N33/557 , G06F19/702 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/12 , Y10T436/144444 , Y10T436/147777 , Y10T436/171538
摘要： Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.
摘要翻译：反应终点的特征在于引发化学反应，在与可反应的反应进展指标相关联的值的三个不同时间点获得至少三次测量，以及根据测量结果确定指示剂的终点值。还包括用于表征反应终点的系统的独立权利要求，其包括存储的程序，其能够在三个不同的时间点输入与可观察到的指示化学反应进程相关联的值的至少三个测量值，并存储能够从测量中确定可观测值的终点值的编程。

76. 发明公开

EP1402255A2 ELECTROCHEMICAL COAGULATION ASSAY AND DEVICE 审中-公开
标题翻译：电化学KOAGULIERUNGSTEST及相关设备
公开(公告)号：EP1402255A2
公开(公告)日：2004-03-31
申请号：EP01987292.8
申请日：2001-12-06
申请人： Lifescan, Inc.
发明人： OHARA, Timothy, J. , TEODORCZYK, Maria , SHARTLE, Robert, Justice
IPC分类号： G01N33/49 , G01N11/00 , G01N27/403 , G01N27/49
CPC分类号： B01L3/5027 , A61B5/150022 , A61B5/150358 , A61B10/0045 , B01L2300/0672 , B01L2300/0825 , B01L2400/0406 , G01N11/00 , G01N27/307 , G01N33/4905 , G01N33/491 , G01N33/5438
摘要： Methods and devices for electrochemically detecting a change in the viscosity of a fluid are provided. In the subject methods, a fluid sample is introduced into an electrochemical cell having oppositely spaced apart working and reference electrodes. An electric potential is applied to the cell to first achieve a steady state cell current. A decrease in the steady state cell current is then detected and related to a change in viscosity of the sample. In many embodiments, the sample is blood and the change in viscosity is related to the onset of coagulation in the blood sample, and often the PT of the blood sample. Also provided are test strips, kits thereof and meters for use in practicing the subject methods.

77. 发明公开

EP1291653A3 Devices for analyte concentration determination and methods of manufacturing and using the same 有权
标题翻译：用于确定分析物的浓度和它们的制备和使用的设备
公开(公告)号：EP1291653A3
公开(公告)日：2004-03-17
申请号：EP02255891.0
申请日：2002-08-23
申请人： Lifescan, Inc.
发明人： Matzinger, David , Quraishi, Khalid R. , Yu, Yeung Siu
IPC分类号： G01N33/52 , G01N33/558 , G01N33/543
CPC分类号： G01N33/558 , Y10S435/97 , Y10S436/808 , Y10S436/81
摘要： Test strips for determining the concentration of at least one analyte, e.g. , glucose, in a physiological sample and methods for their manufacture and use and are provided. The subject test strips include a transfer element for facilitating the transfer of sample to a reaction area of the test strip. In certain embodiments, the transfer element, typically porous, has a first area and a second area, and in certain embodiments the two areas have different thicknesses. In other embodiments, the transfer element is non-porous and is configured to transfer sample by wicking it between the transfer element and the reaction area of the test strip. In the subject methods, the transport element facilitates transfers of a sample to a reaction area of the test strip. The subject test strips and methods find use in a variety of different applications, particularly in the determination of glucose concentrations.

78. 发明公开

EP1394546A1 Method and system for determining the acceptability of signal data collected from a prothrombin time test strip 有权
标题翻译：方法和系统，用于确定从凝血酶原时间测试条收集的信号数据的可接受性
公开(公告)号：EP1394546A1
公开(公告)日：2004-03-03
申请号：EP03255396.8
申请日：2003-08-29
申请人： LIFESCAN, INC.
发明人： Kermani, Mahyar Z.
IPC分类号： G01N33/52 , G01N33/48 , G01N33/49 , G01N33/86
CPC分类号： G01N33/86 , G01N33/523
摘要： A method for determining the acceptability of signal data collected from a prothrombin time (PT) test strip includes collecting PT signal data from an assay area and control areas of the PT test strip. Relationships between PT signal data collected from the assay area and PT signal data collected from each of the control areas (e.g., a ratio of post-peak pseudo-slopes) are then ascertained. A determination is subsequently made, based on the relationships, as to whether the PT signal data collected from the assay area is acceptable or not for use in calculating a PT and/or an International Normalization Ratio (INR). This determination can include, for example, comparing the relationships to at least one predetermined threshold limit. A prothrombin time (PT) monitoring system includes a PT test strip and a device. The PT test strip includes an assay area and a control area. The device (e.g., a portable hand-held meter) includes an optical measurement means (e.g., an LED/photo-detector pair) for measuring an optical property (e.g., absorption) of the assay area and control areas, an analog-to-digital converter module, a microprocessor module and a memory module. The optical measurement means, analog-to-digital converter module, microprocessor module and memory module are adapted to (i) collect PT signal data from the assay area and control areas; (ii) ascertain at least one relationship between PT signal data collected from the assay and control areas and (iii) determine, based on the at least one relationship, whether the PT signal data collected from the assay area is acceptable.
摘要翻译：一种用于确定性采矿方法从凝血酶原时间（PT）测试条收集的信号数据的可接受性，包括从在化验区和PT测试条的控制区收集PT信号数据。然后从来自各控制区（E. G.，峰值后伪斜率的比值）的收集到的化验区和PT信号数据收集PT信号数据之间的关系被确定。的确定随后作出，基于所述关系，至于是否从测定区域中收集PT信号数据是可以接受的或不用于计算一个PT和/或国际标准化比率（INR）。该确定可以包括，例如，关系与至少一个预定阈值极限。凝血酶原时间（PT）监测系统包括PT测试条及装置。的PT测试条包括在测定区域和控制区域。的装置（例如，便携式手持米）包括光学测量装置（例如，以LED /光电检测器对），用于光学性质的测量（例如，吸收）测定区域和控制区域，到模拟 - 数字转换器模块，微处理器模块和存储器模块。光学测量装置，模拟 - 数字转换器模块，微处理器模块和存储器模块angepasst于（i）收集来自化验区和控制区PT信号数据; （二）确定来自测定和控制领域以及（iii）确定的矿山收集PT信号数据，基于所述至少一个关系之间的至少一个关系，无论从化验区所收集的PT信号数据是可接受的。

79. 发明公开

EP1167540A3 Dye couple for spectrophotometric determination of analytes 失效
标题翻译：耦合染料光度法测定分析物的
公开(公告)号：EP1167540A3
公开(公告)日：2004-01-21
申请号：EP01203297.5
申请日：1995-09-07
申请人： LIFESCAN, INC.
发明人： Yu, Yeung Siu
IPC分类号： C12Q1/26 , C07D277/82
CPC分类号： C12Q1/26 , Y10T436/143333
摘要： A dye coupled compound is provided for use in a test device containing a reagent system for detecting the presence or quantity of an analyte in a sample. The reagent system comprises one or more enzymes which, in the presence of the analyte, produce an oxidising agent in quantities indicative of the quantity of analyte in the sample. The compound of choice is meta[3-methyl 2-benzothiazolinonehydrozone]N-sulfonyl benzenesulfonate monosodium.

80. 发明公开

EP1347302A3 Direct immunosensor assay 有权
标题翻译：直接免疫传感器测定
公开(公告)号：EP1347302A3
公开(公告)日：2003-12-17
申请号：EP03251762.5
申请日：2003-03-20
申请人： LIFESCAN, INC.
发明人： Hodges, Alastair , Chatelier, Ronald
IPC分类号： G01N33/543 , C12Q1/00
CPC分类号： C12Q1/001 , G01N33/5438
摘要： This invention describes a quantitative, inexpensive, disposable immunosensor that requires no wash steps and thus generates no liquid waste. Moreover, in preferred embodiments of the sensor no timing steps are required of the user, and the sensor can be readily adapted to antigen-antibody interactions over a wide kinetic range.
摘要翻译：本发明描述了一种定量的，便宜的一次性免疫传感器，其不需要洗涤步骤并因此不产生液体废物。而且，在传感器的优选实施例中，用户不需要定时步骤，并且传感器可以容易地适应宽动力学范围内的抗原 - 抗体相互作用。

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