专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

EP0597423B1 Azetidinone compound and process for preparation thereof 失效
标题翻译：氮杂环丁酮化合物和它们的制备方法
公开(公告)号：EP0597423B1
公开(公告)日：2002-03-06
申请号：EP93118085.5
申请日：1993-11-08
申请人： TANABE SEIYAKU CO., LTD.
发明人： Iwasaki, Tameo , Kondo, Kazuhiko
IPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D217/24 , C07D217/22 , C07D239/88 , C07D239/93 , C07D265/22 , C07D265/20 , C07D279/08 , C07D477/00 , C07D499/88 , C07D205/08
CPC分类号： C07D401/06 , C07D205/08 , C07D217/24 , C07D239/88 , C07D265/12 , C07D265/22 , C07D279/08 , C07D403/06 , C07D413/06 , C07D417/06 , C07D477/04

63. 发明公开

EP0860433A1 QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 失效
标题翻译：喹啉衍生物含有和喹唑啉衍生物的WHAT血小板衍生生长因子受体INHIBIREN的自磷酸化和YOU药物组合物
公开(公告)号：EP0860433A1
公开(公告)日：1998-08-26
申请号：EP96935541.1
申请日：1996-11-05
申请人： KIRIN BEER KABUSHIKI KAISHA
发明人： KUBO, Kazuo, Iyaku Tansaku Kenkyusho , OHYAMA, Shinichi, Iyaku Tansaku Kenkyusho , SHIMIZU, Toshiyuki, Iyaku Tansaku Kenkyusho , NISHITOBA, Tsuyoshi, Iyaku Tansaku Kenkyusho , KATO, Shinichiro, Iyaku Tansaku Kenkyusho , MUROOKA, Hideko, Iyaku Tansaku Kenkyusho , KOBAYASHI, Yoshiko, Iyaku Tansaku Kenkyusho
IPC分类号： C07D215/20 , C07D215/22 , C07D215/36 , C07D239/74 , C07D239/88 , C07D239/93 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/056 , A61K31/47
CPC分类号： C07D215/233 , C07D215/20 , C07D215/36 , C07D239/88 , C07D401/12 , C07D405/10 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel quinoline derivatives and quinazoline derivatives represented by the following formula (I):
[wherein R 1 and R 2 are each independently H or C 1 -C 4 -alkyl, or R 1 and R 2 together form C 1 -C 3 -alkylene, X is O, S or CH 2 , W is CH or N, and Q is a substituted aryl group or substituted heteroaryl group] and their pharmaceutically acceptable salts, having platelet-derived growth factor receptor autophosphorylation inhibitory activity, to pharmaceutical compositions containing these compounds, and to methods for the treatment of diseases associated with abnormal cell growth such as tumors.
摘要翻译：本发明涉及由下式（I）表示的新的喹啉衍生物和喹唑啉衍生物： a其中R1和R2各自unabhängigH或C1-C4烷基，或者R1和R2一起形成C1-C3亚烷基， X是O，S或CH 2，W为CH或N，且Q是被取代的芳基或取代的杂groupÜ和它们的药学上可接受的盐，具有血小板衍生的生长因子受体自磷酸化的抑制活性，含有这些化合物的药物组合物，和以用于治疗与异常细胞生长有关的疾病的治疗方法：如肿瘤。

64. 发明授权

EP0572782B1 1-Aryl-3-(3,4-dihydro-4-oxo-3-quinazolinyl)-urea fungicidal agents 失效
标题翻译： 1-芳基-3-（3,4-二氢-4-氧代-3-喹唑啉基）-ureas以及它们作为杀真菌剂的使用
公开(公告)号：EP0572782B1
公开(公告)日：1996-06-26
申请号：EP93106107.1
申请日：1993-04-15
申请人： AMERICAN CYANAMID COMPANY
发明人： Takasugi, James Jan , Neypes, Millord Victor Ty , Evans, Lynn Susan , Kohls, Clint Louis , Witucki, Laurie Ann
IPC分类号： C07D239/92 , C07D239/93 , C07D239/95 , C07D239/96 , A01N43/54
CPC分类号： C07D239/93 , A01N43/54 , C07D239/92 , C07D239/95 , C07D239/96

65. 发明公开

EP0665224A4 PYRIMIDINE DERIVATIVE. 失效
标题翻译： PYRIMIDINDERIVATE。
公开(公告)号：EP0665224A4
公开(公告)日：1995-06-13
申请号：EP93922632
申请日：1993-10-14
申请人： NIPPON SODA CO
发明人： YAMADA HIROKAZU ODAWARA RESEAR , TANAKA KATSUNORI TAKAOKA PLANT , ADACHI HIROYUKI ODAWARA RESEAR , YAMADA SHIGEO ODAWARA RESEARCH , SHIMODA SUSUMU ODAWARA RESEARC , HASHIMOTO SHO NIPPON SODA CO L , UMEDA NOBUHIRO ODAWARA RESEARC
IPC分类号： A01N43/54 , A01N43/90 , A01N47/24 , A01N57/24 , C07D239/28 , C07D239/30 , C07D239/34 , C07D239/36 , C07D239/38 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/86 , C07D239/90 , C07D239/91 , C07D239/93 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D495/04 , C07F7/08 , C07F9/6512 , C07F9/6561 , C07D239/26 , C07D401/04
CPC分类号： C07D239/28 , A01N43/54 , A01N43/90 , A01N47/24 , A01N57/24 , C07D239/34 , C07D239/36 , C07D239/38 , C07D239/40 , C07D239/42 , C07D239/47 , C07D239/86 , C07D239/90 , C07D239/91 , C07D239/93 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07F7/0812 , C07F9/65122 , C07F9/65126 , C07F9/65127 , C07F9/6561
摘要： A compound represented by general formula (I) and excellent in herbicidal and agrohorticultural antibacterial activities, wherein R?1 and R2¿ represent each hydrogen, alkyl, etc., or alternatively they may be combined together to represent oxo, thioxo, etc., or a spiro ring selected from among (a), (b), etc.; R?3 and R5¿ represent each hydrogen, halogen, alkyl, etc., and R4 represents hydrogen, halogen, amino, etc., provided that R?3 and R5¿ are different from each other when R4 is hydrogen and that R4 may be combined with R3 or R5 and the pyrimidine ring to represent a condensed ring represented by (c) or (d); R?6 and R7¿ represent each hydrogen, halogen, alkyl, etc., provided that the case wherein both R?6 and R7¿ represent hydrogen is excluded; R8 represents halogen, alkyl, etc.; and n represents 0, 1, 2 or 3; provided that when both R?1 and R2¿ represent hydrogen, then R4 is combined with R3 or R5 and the pyrimidine group to represent the above condensed ring.

66. 发明公开

EP0597423A3 Azetidinone compound and process for preparation thereof 失效
标题翻译： Azetidinonverbindung und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0597423A3
公开(公告)日：1995-04-12
申请号：EP93118085.5
申请日：1993-11-08
申请人： TANABE SEIYAKU CO., LTD.
发明人： Iwasaki, Tameo , Kondo, Kazuhiko
IPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D217/24 , C07D217/22 , C07D239/88 , C07D239/93 , C07D265/22 , C07D265/20 , C07D279/08 , C07D477/00 , C07D499/88 , C07D205/08
CPC分类号： C07D401/06 , C07D205/08 , C07D217/24 , C07D239/88 , C07D265/12 , C07D265/22 , C07D279/08 , C07D403/06 , C07D413/06 , C07D417/06 , C07D477/04
摘要： There is disclosed an azetidinone compound of the formula [I]:

wherein Ring B is a benzene ring which may have substituent(s), R¹ is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1β-methylcarbapenem-type antibacterial agent.
摘要翻译：公开了式[I]的氮杂环丁酮化合物：其中环B为可具有取代基的苯环，R 1为可具有取代基的羟基取代的低级烷基， X为氧原子等，Y为氧原子等，Z为可具有取代基的亚甲基，可用作1β-甲基碳青霉烯型抗菌剂的合成中间体。

67. 发明公开

EP0597423A2 Azetidinone compound and process for preparation thereof 失效
标题翻译：氮杂环丁酮化合物和它们的制备方法。
公开(公告)号：EP0597423A2
公开(公告)日：1994-05-18
申请号：EP93118085.5
申请日：1993-11-08
申请人： TANABE SEIYAKU CO., LTD.
发明人： Iwasaki, Tameo , Kondo, Kazuhiko
IPC分类号： C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D217/24 , C07D217/22 , C07D239/88 , C07D239/93 , C07D265/22 , C07D265/20 , C07D279/08 , C07D477/00 , C07D499/88 , C07D205/08
CPC分类号： C07D401/06 , C07D205/08 , C07D217/24 , C07D239/88 , C07D265/12 , C07D265/22 , C07D279/08 , C07D403/06 , C07D413/06 , C07D417/06 , C07D477/04
摘要： There is disclosed an azetidinone compound of the formula [I]:

wherein Ring B is a benzene ring which may have substituent(s), R¹ is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1β-methylcarbapenem-type antibacterial agent.

68. 发明公开

EP0326330A3 QUINOLINE, QUINAZOLINE, AND CINNOLINE FUNGICIDES QUINOLINE, QUINAZOLINE, AND CINNOLINE FUNGICIDES 失效
标题翻译：喹啉，喹唑啉和喹啉酮类喹喔啉，喹唑啉和喹啉类杀菌剂
公开(公告)号：EP0326330A3
公开(公告)日：1990-08-22
申请号：EP89300658
申请日：1989-01-25
申请人： ELI LILLY AND COMPANY
发明人： ARNOLD, WENDELL RAY , COGHLAN, MICHAEL JOSEPH , KRUMKALNS, ERIKS VICTOR , JOURDAN, GLEN PHIL , SUHR, ROBERT GEORGE
IPC分类号： A01N43/42 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/713 , C07D215/04 , C07D215/12 , C07D215/18 , C07D215/22 , C07D215/233 , C07D215/36 , C07D215/42 , C07D215/44 , C07D215/60 , C07D221/16 , C07D237/28 , C07D239/74 , C07D239/88 , C07D239/93 , C07D239/94 , C07D401/12 , C07D405/12
CPC分类号： C07D215/233 , A01N43/42 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/713 , C07D215/12 , C07D215/18 , C07D215/36 , C07D215/44 , C07D215/60 , C07D221/16 , C07D237/28 , C07D239/88 , C07D401/12 , C07D405/12
摘要： Compounds of the formula (1) wherein
X is CR⁵ or N, where R⁵ is H, Cl, or CH₃;
Y is CR⁵′ if X is N, and Y is CR⁵′ or N if X is CR⁵, where R⁵′ is H, Cl, or Br;
Z is O, S, SO, SO₂, NR⁶, where R⁶ is H, (C₁-C₄) alkyl, or (C₁-C₄) acyl, or CR⁷R⁸, where R⁷ and R⁸ are in dependently H, (C₁-C₄) acyl, (C₁-C₄) alkyl, (C₁-C₄) alkenyl, (C₂-C₄) alkynyl, CN, or OH, or R⁷ and R⁸ combine to form a carbocyclic rirg containing four to six carbon atoms;
R¹ to R⁴ are independently H, OH, NO₂, halo, I, (C₁-C₄) alkyl, (C₃-C₄) branched alkyl, (C₁-C₄) alkoxy, halo (C₁-C₄) alkyl, halo (C₁-C₄) alkoxy, or halo (C₁-C₄) alkylthio; or R¹ and R² or R² and R³ combine to form a carbocyclic ring containing 4 to 6 carbon atoms;
A is

(a) a C₁-C₁₈ saturated or unsaturated hydro carbon chain, straight chain or branched, optionally in cluding a hetero atom selected from O, S, SO, SO₂, or Si, and optionally substituted with halo, halo (C₁-C₄) alkoxy, hydroxy, or (C₁-C₄) acyl;
(b) (C₃-C₈) cycloalkyl or cycloalkenyl;
(c) a phenyl group of the formula (2) wherein R⁹ to R¹³ are independently H, CN, NO₂, OH, halo, I, (C₁-C₄) alkyl, (C₃-C₄) branched alkyl, (C₂-C₄ ) acyl, halo (C₁-C₄) alkyl, hydroxy (C₁-C₄) alkyl, (C₁-C₄) alkoxy, halo (C₁-C₄) alkoxy, (C₁-C₄) alkylthio, halo (C₁-C₄) alkylthio, phenyl, substituted phenyl, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl (C₁-C₄) alkyl, substituted phenyl (C₁-C₄) alkyl, benzoyl, substituted benzoyl, SiR²⁰R²¹R²² or OSiR²⁰R²¹R²², where R²⁰, R²¹, and R²² are H, a C₁-C₆ alkyl group, straight chain or branched, phenyl, or substituted phenyl, provided that at least one of R²⁰, R²¹, and R²² is other than H, or R¹¹ and R¹² or R¹² and R¹³ combine to form a carbo cyclic ring, provided that unless all of R⁹ to R¹³ are H or F, then at least two of R⁹ to R¹³ are H;
(d) a furyl group of formula (3) wherein R¹⁴ is H, halo, halomethyl, CN, NO₂, (C₁-C₄) alkyl, (C₃-C₄) branched alkyl, phenyl, or (C₁-C₄) alkoxy,
(e) a thienyl group of formula (4) wherein R¹⁵ is H, halo, halomethyl, CN, NO₂, (C₁-C₄) alkyl, (C₃-C₄) branched alkyl, phenyl, or (C₁-C₄) alkoxy;
(f) a group of formula (5) or (5a) wherein R¹⁶ is H, halo, halomethyl, CN, NO₂, (C₁-C₄) alkyl, (C₃-C₄) branched alkyl, phenyl, substituted phenyl, or (C₁-C₄) alkoxy, and F is N or CH and G is O, NR¹⁹ or CH, provided that either F is N or G is NR¹⁹, where R¹⁹ is H, (C₁-C₄) alkyl, (C₁-C₄) acyl, phenylsulfonyl, or substituted phenylsulfonyl;
(g) a group selected from 1-naphthyl, substituted 1-naphthyl, 4-pyrazolyl, 3-methyl-4-pyrazolyl, 1,3-benzodioxolyl, tricyclo[3.3.1.1(3,7)]dec-2-yl, 1-(3-chlorophenyl)-1H-tetrazol-5-yl, pyridyl, pyridazinyl, or an acid addition salt of a compound of formula (1), or an N-oxide of a compound of formula (1) where Y is CH; provided Z is CR⁷R⁸ if A is a group des cribed in paragraph (d), (e), or (f); and provided that Z is S, SO, or SO₂ if A is a group described in paragraph (a), are plant fungicides.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式