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61. 发明公开

EP2805167A4 BIOMARKERS FOR GASTRIC CANCER AND USES THEREOF 审中-公开
标题翻译： BIOMARKERFÜRMAGENKREBS UND VERWENDUNGEN DAVON
公开(公告)号：EP2805167A4
公开(公告)日：2015-12-09
申请号：EP13738133
申请日：2013-01-17
申请人： ADELAIDE RES & INNOVATION PTY
发明人： HOFFMANN PETER , PENNO MEGAN , ERNST MATTHIAS ROBERT WALTER
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5023 , G01N33/57488 , G01N33/92 , G01N2333/65 , G01N2333/76 , G01N2333/775 , G01N2333/811 , G01N2800/52 , G01N2800/60
摘要： The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison. On the basis of the identification of biological markers associated with gastric cancer, the present invention also provides a method of determining if a subject is susceptible to developing gastric cancer, a method of assessing progression of gastric cancer in a subject, a method for screening a candidate therapeutic agent useful for treating gastric cancer in a subject, and a kit for diagnosing gastric cancer in a subject.
摘要翻译：本发明提供与胃癌相关的生物标志物。特别地，本发明提供了一种诊断受试者胃癌（GC）的方法，所述方法包括：测量受试者中一种或多种蛋白质的表达水平，其中所述一种或多种蛋白质选自维生素D结合蛋白（VDBP），聚集蛋白，胰岛素样生长因子结合蛋白复合酸不稳定亚基（IGFALS）和微生物; 将受试者中的每种蛋白质的表达水平与该蛋白质或每种蛋白质的参考表达水平进行比较; 并根据比较诊断受试者的GC。本发明基于与胃癌相关的生物标志物的鉴定，还提供了确定受试者是否易于发生胃癌的方法，评估受试者胃癌进展的方法，筛选方法可用于治疗受试者胃癌的候选治疗剂和用于诊断受试者胃癌的试剂盒。

62. 发明公开

EP2837937A1 Method for the detection of the prozone effect of photometric assays 审中-公开
标题翻译： Verfahren zur Bestimmung der Prozonwirkung von photometrischen Assays
公开(公告)号：EP2837937A1
公开(公告)日：2015-02-18
申请号：EP13180560.8
申请日：2013-08-15
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： Garbulewska, Ewelina , Kurz, Georg , Lopez-Calle, Eloisa , Roedl, Josef
IPC分类号： G01N33/53
CPC分类号： G01N33/557 , G01N33/5306 , G01N2333/76
摘要： The invention provides a method for determination of the amount of a specific analyte in a sample which may show a prozone effect by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. The optical signal is measured simultaneously for the specific analyte in the sample to be determined at the wavelength used for the determination of the analyte and at least at an additional specific wavelength used for the detection of the prozone effect over the complete reaction time. The reaction rate ratio R is calculated by using the signals obtained at the wavelength used for the detection of the prozone effect. By comparison of the calculated ratio value R with predetermined limit values it is judged if a prozone effect is present in the sample.
摘要翻译：本发明提供了一种用于测定样品中特定分析物的量的方法，其可以通过光度测定显示前区效应，其中特异性分析物在分析物相互作用之后从反应混合物的光学信号的变化中量化与分析物特异性测定试剂。同时测量样品中用于测定分析物的波长确定的特定分析物的光学信号，并至少在用于在完整反应时间内检测前区效应的另外的特定波长。通过使用在用于检测前区效应的波长处获得的信号来计算反应速率比R. 通过将计算的比值R与预定极限值进行比较，判断样品中是否存在前区效应。

63. 发明公开

EP2715367A2 METHODS AND COMPOSITIONS FOR DETECTING ENDOMETRIAL OR OVARIAN CANCER 审中-公开
标题翻译：方法和组合物子宫内膜癌或卵巢癌的检测
公开(公告)号：EP2715367A2
公开(公告)日：2014-04-09
申请号：EP12792463.7
申请日：2012-06-01
申请人： University of South Alabama
发明人： PANNELL, Lewis, Kenneth , FINAN, Michael, Albert , ROCCONI, Rodney, P.
IPC分类号： G01N33/574 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/6893 , G01N33/57411 , G01N2333/76 , G01N2560/00 , G01N2800/56 , G01N2800/7028
摘要： Some embodiments of the present invention relate to methods and compositions for assessing the absence, presence, progression, or stage of cancer. In particular, methods and compositions for detecting endometrial cancer or ovarian cancer are provided.

64. 发明授权

EP2431741B1 Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权
标题翻译：一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741B1
公开(公告)日：2013-08-21
申请号：EP11009919.9
申请日：2009-10-20
申请人： Baxter International Inc , Baxter Healthcare SA , Nektar Therapeutics
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76

65. 发明公开

EP2357476A3 Detection and measurement of blood-feeding activity 审中-公开
标题翻译：检测和测量血液摄食活力的
公开(公告)号：EP2357476A3
公开(公告)日：2012-03-21
申请号：EP10163465.7
申请日：2006-07-27
申请人： Cytosignet, Inc.
发明人： Smith, Nathan L.
IPC分类号： G01N33/53 , G01N33/72 , G01N21/76 , G01N33/566 , C12Q1/28 , C07K16/00 , C12P21/08
CPC分类号： G01N33/68 , G01N21/76 , G01N33/5308 , G01N33/72 , G01N2333/43582 , G01N2333/43586 , G01N2333/43591 , G01N2333/76
摘要： There is provided a composition for detecting the presence of hematophagous ectoparasite, comprising a reagent reactive against hematophagous ectoparasitic antigens.

66. 发明公开

EP2418485A1 DETECTOR AND DETECTION METHOD 有权
标题翻译： DETEKTOR UND NACHWEISVERFAHREN
公开(公告)号：EP2418485A1
公开(公告)日：2012-02-15
申请号：EP09843017.6
申请日：2009-04-09
申请人： Hitachi Chemical Company, Ltd.
发明人： HIGUCHI, Masayuki , NAKANO, Yuuichi , SUZUKI, Nahoko , NAKAMURA, Miki , YAMASHITA, Kouhei
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , G01N33/6854 , G01N2333/76
摘要： Provided is a strip-shaped detector that detects an analyte in a liquid sample. The detector includes a collecting member that directly collects a liquid sample from a living organism, a holding member that holds a labeling reagent binding specifically to the analyte in a state where the labeling reagent can move along with the movement of the liquid sample, a detecting member to which a detection reagent is immobilized which captures a complex of the analyte and the labeling reagent by binding specifically to the analyte, an absorbing member that can absorb the liquid sample, and a liquid-impermeable supporting member, wherein the respective members are arranged on the supporting member in the longitudinal direction of the detector so that the liquid sample moves through the inside of these members, and the collecting member includes a protruding portion sticking out of the supporting member at the upstream side in the movement direction of the liquid sample.
摘要翻译：提供了一种检测液体样品中的分析物的条形检测器。检测器包括：收集构件，其从活体直接收集液体样品;保持构件，其保持在标记试剂可随着液体样品的移动而移动的状态下特异性结合分析物的标记试剂;检测固定有检测试剂的成员，其通过特异性结合分析物捕获分析物和标记试剂的复合物，可吸收液体样品的吸收构件和液体不可渗透的支撑构件，其中各构件布置在检测器的纵向方向上的支撑构件上，使得液体样品通过这些构件的内部移动，并且收集构件包括在液体样品的移动方向上游侧的支撑构件伸出的突出部分。

67. 发明公开

EP2276510A2 CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE 有权
标题翻译：化学和生物化学物质生物标志物有机磷酸盐
公开(公告)号：EP2276510A2
公开(公告)日：2011-01-26
申请号：EP09801832.8
申请日：2009-04-14
申请人： Human Biomolecular Research Institute
发明人： CASHMAN, John, R. , MACDONALD, Mary, T.
IPC分类号： A61K47/48
CPC分类号： C07K7/06 , A61K47/643 , A61K47/646 , C07K16/18 , C07K16/44 , C12P21/005 , G01N33/6842 , G01N33/6893 , G01N2333/76 , G01N2410/00 , G01N2430/00 , G01N2430/10 , G01N2800/42
摘要： Provided is a method to identify OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts.
摘要翻译：提供了用于鉴定OP-加合的OP暴露生物标志物的方法以及含有OP的化合物，其可以提供OP加合物和式1的化合物，用于引发特异性和选择性结合OP加合物的抗体，其中式1化合物具有 OP-肽 - 连接子-CP，其中CP是载体蛋白，OP表示对应于共价修饰式I的肽的酪氨酸残基羟基的反应性有机磷化合物的结构，其它可变基团如本文所述。

68. 发明公开

EP2035830A4 ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASE 有权
标题翻译：白蛋白结合的蛋白/肽复合物作为疾病生物标志
公开(公告)号：EP2035830A4
公开(公告)日：2010-07-21
申请号：EP07809552
申请日：2007-06-14
申请人： UNIV JOHNS HOPKINS
发明人： VAN EYK JENNIFER E , GUNDRY REBEKAH LYNN , COTTER ROBERT J
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/6848 , G01N2333/76 , G01N2800/00 , G01N2800/324

69. 发明公开

EP2051080A1 D/P CREATININE MARKER, METHOD OF DETERMINING D/P CREATININE AND USE OF THE SAME 审中-公开
标题翻译： D / P-KREATINMARKER，VERFAHREN ZUM BESTIMMEN VON D / P-KREATIN UND VERWENDUNG DAVON
公开(公告)号：EP2051080A1
公开(公告)日：2009-04-22
申请号：EP07807873.0
申请日：2007-09-26
申请人： JMS Co., Ltd.
发明人： HIRAI, Satoshi , KARINO, Tomokazu
IPC分类号： G01N33/70
CPC分类号： G01N33/70 , G01N2333/76
摘要： A method of indirectly determining D/P creatinine for easily judging a peritoneal function is provided that does not require blood sampling or multiple recoveries of dialysis effluent. The method includes preparing a dialysis effluent obtained by peritoneal dialysis, measuring at least one protein marker selected from the group consisting of prealbumin, haptoglobin, alpha 1-microglobulin, C4, and total protein that are contained in the dialysis effluent, and determining D/P creatinine indirectly from the correlation equation that represents the relationship between the marker concentration and the D/P creatinine value that has been prepared beforehand. Furthermore, the PET category is determined indirectly from the D/P creatinine, which has been determined indirectly, based on the known reference value.
摘要翻译：提供间接测定D / P肌酐以容易判断腹膜功能的方法，其不需要血液取样或多次回收透析流出物。该方法包括制备通过腹膜透析获得的透析流出物，测量至少一种选自透析流出物中包含的前白蛋白，触珠蛋白，α1-微球蛋白，C4和总蛋白质的蛋白质标记物，并测定D / P肌酸酐间接地代表了事先准备的标记浓度与D / P肌酐值之间关系的相关方程。此外，PET类别是根据已知参考值间接测定的D / P肌酸酐间接测定的。

70. 发明授权

EP1776587B1 USE OF C3A AND DERIVATIVES THEREOF AS BIOMARKER FOR COLORECTAL ADENOMA AND/OR CARCINOMA ; DIAGNOSIS METHODS AND ASSAYS USING THE SAME 有权
标题翻译：使用C3A以及由此派生的生物标志物KOLOREKTALADENOM和/或-KARZINOM的; 检测方法和测试系统，
公开(公告)号：EP1776587B1
公开(公告)日：2008-12-31
申请号：EP05772471.8
申请日：2005-08-11
申请人： Indivumed GmbH
发明人： JUHL, Hartmut , DAVID, Kerstin , FENTZ, Anne-Kristin
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/57488 , G01N33/78 , G01N2333/76 , G01N2800/52
摘要： The present invention is directed to a method for detecting colorectal adenoma and/o( colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of C3a or a derivative thereof in said isolated sample material, c) comparing the determined level of C3a or a derivative thereof with one or more reference values. The invention is further directed to a method for discriminating between colorectal adenoma and colorectal carcinoma as well as to a method for monitoring the course of colorectal adenoma and/or colorectal carcinoma and/or the treatment of colorectal adenoma and/or' colorectal carcinoma. Moreover, the invention is directed to a test system and an array for use in these methods. Furthermore, the invention is directed to the use of C3a as a biomarker for a detection of colorectal adenoma and/or colorectal carcinoma in an individual. Further, the invention is directed to method for determining whether a compound is effective in the treatment colorectal adenoma and/or colorectal carcinoma.

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