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61. 发明公开

EP0983763A4 PREVENTIVES FOR RECONSTRICTION 失效
标题翻译： REKONSTRIKTIONSVORBEUGE MITTEL
公开(公告)号：EP0983763A4
公开(公告)日：2003-03-19
申请号：EP98911141
申请日：1998-03-31
申请人： TAISHO PHARMA CO LTD
发明人： ASAMI YUMIKO , AKIYOSHI KAZUHIKO , YAMAGISHI IZUMI , TOMOIKE HIDEKI
IPC分类号： A61K31/167 , A61K31/165
CPC分类号： A61K31/167
摘要： Preventives for reconstriction following coronary arterial intervention characterized by containing as the active ingredient a compound represented by formula (I). These drugs provide a novel use of preventing reconstriction after coronary arterial intervention of patients with anginal attack caused by coronary constriction of a high severity or patients with ischemic heart diseases for whom drug therapy is unapplicable.
摘要翻译：冠状动脉介入术后用于重建的预防剂，其特征在于含有式（I）代表的化合物作为活性成分。这些药物提供了一种新的用途，用于预防由冠状动脉狭窄严重的冠状动脉狭窄患者或缺血性心脏病患者接受冠状动脉介入治疗后的再狭窄，因为药物治疗不适用。

62. 发明公开

EP1083168A4 PROSTAGLANDIN DERIVATIVE 有权
标题翻译：前列腺素
公开(公告)号：EP1083168A4
公开(公告)日：2002-09-04
申请号：EP99921247
申请日：1999-05-25
申请人： TAISHO PHARMA CO LTD , SATO FUMIE
发明人： SATO FUMIE , TANAMI TOHRU , KAMEO KAZUYA , YAMADA KENJI , OKUYAMA SHIGERU , ONO NAOYA
IPC分类号： A61K31/00 , A61K31/557 , A61K31/5575 , A61P25/08 , C07C405/00
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/00 , Y10S514/923
摘要： A prostaglandin derivative represented by formula (I) wherein X represents a halogen atom, n is an integer of 1 to 5, R represents a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 alkyl group, a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, a C5-10 alkynyl group or a bridged cyclic hydrocarbon group, R represents a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl, or a pharmaceutically acceptable salt thereof.

63. 发明公开

EP0933080A4 REMEDY OR PREVENTIVE FOR HYPERLIPEMIA 失效
标题翻译：手段用于治疗或预防HYPERLIPÖMIE的
公开(公告)号：EP0933080A4
公开(公告)日：2002-02-27
申请号：EP96919989
申请日：1996-05-29
申请人： TAISHO PHARMA CO LTD
发明人： KITAJIMA HIDEAKI , TSUNODA KENJI , YANAGITA TERUYOSHI , MURAKAMI SHIGERU
IPC分类号： A61K31/455 , A61K31/185 , A61K31/195 , A61K31/575 , A61P3/06 , A61P9/10 , A61K31/215
CPC分类号： A61K31/575 , A61K2300/00
摘要： The object of the invention is to obtain a remedy or preventive for hyperlipemia which lowers the blood cholesterol and neutral fat levels and further ameliorates lipoprotein metabolism. Said remedy or preventive for hyperlipemia comprises taurine and η-orizanol as the active ingredients.

64. 发明公开

EP1082961A4 SLEEP INDUCING AGENT 有权
标题翻译： SCHLAFMITTEL
公开(公告)号：EP1082961A4
公开(公告)日：2001-07-11
申请号：EP99921249
申请日：1999-05-25
申请人： TAISHO PHARMA CO LTD , SATO FUMIE
发明人： SATO FUMIE , TANAMI TOHRU , KAMEO KAZUYA , YAMADA KENJI , OKUYAMA SHIGERU , ONO NAOYA
IPC分类号： A61K31/00 , A61K31/557 , A61K31/5575 , A61P25/08 , C07C405/00 , A61P25/20
CPC分类号： A61K31/5575 , A61K31/557 , C07C405/00 , Y10S514/923
摘要： A sleep inducing agent comprising, as an active component, a prostaglandin derivative represented by formula (1), wherein X represents a halogen atom, Y represents a group represented by (CH2)m, a cis-vinylene group or a phenylene group, Z represents an ethylene group, a trans-vinylene group, OCH2 or S(O)nCH2, R is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with a C1-4 alkyl group, a C4-13 cycloalkylalkyl group, a C5-10 alkyl group, a C5-10 alkenyl group, an C5-10 alkynyl group or a bridged cyclic hydrocarbon group, R represents a hydrogen atom, a C1-10 alkyl group or a C3-10 cycloalkyl, m is an integer of 1 to 3, and n is 0, 1 or 2, or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：一种睡眠诱导制剂，其包含作为有效成分的由下式表示的前列腺素衍生物：其中X是卤素原子，Y是由（CH 2）m表示的基团，顺式亚乙烯基或亚苯基， Z是亚乙基，反式亚乙烯基，OCH 2或S（O）n CH 2，R 1是C 3-10环烷基，被C 1-4烷基取代的C 3-10环烷基， C4-13环烷基烷基，C5-10烷基，C5-10烯基，C5-10炔基或桥连环烃基，R 2是氢原子，C1-10烷基或 C3-10环烷基，m为1〜3的整数，n为0,1或2，其药学上可接受的盐或其水合物。

65. 发明公开

EP1065205A4 HETEROAROMATIC DERIVATIVES 失效
标题翻译：杂芳族化合物
公开(公告)号：EP1065205A4
公开(公告)日：2001-04-25
申请号：EP98909749
申请日：1998-03-18
申请人： TAISHO PHARMA CO LTD , NIHON NOHYAKU CO LTD
发明人： NAKAZATO ATSURO , KUMAGAI TOSHIHITO , CHAKI SHIGEYUKI , TOMISAWA KAZUYUKI , NAGAMINE MASASHI , GOTOH MAKOTO , YOSHIDA MASANORI
IPC分类号： A61P25/14 , C07D231/12 , C07D401/06 , C07D417/06 , A61K31/445 , A61K31/505 , A61P25/18
CPC分类号： C07D231/12 , C07D401/06 , C07D417/06
摘要： Heteroaromatic derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein Z represents a group represented by general formula (II), (III), (IV) or (V) (wherein Ar1 represents phenyl optionally substituted by a halogen or C¿1-5? alkyl; R?2¿ represents a C¿1-5? alkyl; and Y represents hydrogen, mercapto, a C1-5 alkylthio, or amino optionally substituted by one or two C1-5 alkyls); Ar?2¿ represents phenyl optionally having one or two substituents selected among halogens, C¿1-5? alkyls, C1-5 alkoxys, hydroxy, and trifluoromethyl; B?1-B2¿ represents CH-CO or C=C(R1) (wherein R1 represents hydrogen or a C¿1-5? alkyl); and n is an integer of 1 to 4. The compounds are dopamine D4 receptor antagonists having a psychotropic action without causing extrapyramidal disorders.

66. 发明公开

EP1048655A4 1,2-DIHYDRO-2-OXOQUINOLINE DERIVATIVES 有权
标题翻译： 1,2-二氢-2- OXOCHINOLIN衍
公开(公告)号：EP1048655A4
公开(公告)日：2001-04-18
申请号：EP98957145
申请日：1998-12-03
申请人： TAISHO PHARMA CO LTD , NIHON NOHYAKU CO LTD
发明人： NAKAZATO ATSURO , OKUBO TAKETOSHI , KUMAGAI TOSHIHITO , CHAKI SHIGEYUKI , TOMISAWA KAZUYUKI , NAGAMINE MASASHI , GOTOH MAKOTO , YOSHIDA MASANORI
IPC分类号： C07D215/54 , C07D241/44 , C07D401/06 , C07D491/056 , A61K31/47 , A61K31/495 , C07D215/56
CPC分类号： C07D401/06 , C07D215/54 , C07D241/44
摘要： 1,2-Dihydro-2-oxoquinoline derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein Ar represents pyridyl or group represented by general formula (II) (wherein X?3 and X4¿ are the same or different and each represents hydrogen, halogeno, C¿1-5? alkyl, C1-5 alkoxy, hydroxy, or trifluoromethyl); Y represents nitrogen, CH, or C(OH); R?1 and R2¿ are the same or different and each represents hydrogen, C¿1-10? alkyl, C3-15 alkoxyalkyl, or C3-15 alkylaminoalkyl or R?1 and R2¿ form a cycloamino group together with the adjacent nitrogen atom; X?1 and X2¿ are the same or different and each represents hydrogen, C¿1-5? alkyl, C1-5 alkoxy, or halogeno or X?1 and X2¿ together represent alkylenedioxy; and n is an integer of 1 to 3.

67. 发明公开

EP0896815A4 SUSPENSION OF SPARINGLY WATER-SOLUBLE ACIDIC DRUG 失效
标题翻译：悬挂EINES WENIG WASSERLOESLICHEN SAUREN ARZENEISTOFFES
公开(公告)号：EP0896815A4
公开(公告)日：2000-02-09
申请号：EP97918348
申请日：1997-05-01
申请人： TAISHO PHARMA CO LTD
发明人： NAITO MAYUMI , NAKANO HIROSHI , HASEGAWA KAZUO , NAKAJIMA TOSHIAKI , OKUDAIRA ICHIRO , TSUNODA KENJI
IPC分类号： A61K9/107 , A61K9/00 , A61K31/19 , A61K47/34 , A61K47/10
CPC分类号： A61K9/0095
摘要： A suspension of a sparingly water-soluble acidic drug especially, a nonsteroidal anti-inflammatory analgetic agent, which is stable for a prolonged period of time and is highly dissolvable; and a process for simply and easily producing the suspension. This suspension has a pH value of 2 to 5 and comprises a sparingly water-soluble acidic drug whose average particle size ranges from 1 to 15 mu m, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water, optionally, together with an inorganic powder having an average particle size of 1 to 15 mu m. This process is characterized by carrying out pulverization and dispersion of sparingly water-soluble acid drug, a polyglycerol fatty acid ester, a water-soluble polyhydric alcohol and water by means of a pulverizer comprising a main shaft adapted to rotate in a casing and a plurality of layshafts adapted to revolve in relationship interlocked with the rotation of the main shaft, each of the layshafts being fitted with a multiplicity of annular grinding media.
摘要翻译：微溶于水的酸性药物尤其是非甾体抗炎镇痛药的悬浮液，其长时间稳定且高度溶解; 以及简单且容易地制造悬架的过程。该悬浮液的pH值为2〜5，含有平均粒径为1〜15μm的微水溶性酸性药物，聚甘油脂肪酸酯，水溶性多元醇和水，并任意地与平均粒径为1〜15μm的无机粉末。该方法的特征在于通过粉碎机对微水溶性酸药物，聚甘油脂肪酸酯，水溶性多元醇和水进行粉碎和分散，所述粉碎机包括适于在壳体中旋转的主轴和多个适于与主轴的旋转联动地旋转的中间轴，每个中间轴装配有多个环形研磨介质。

68. 发明公开

EP0717990A4 COMPOSITION FOR REMEDYING DRUG DEPENDENCE 失效
标题翻译：用于制备戒毒
公开(公告)号：EP0717990A4
公开(公告)日：1997-08-06
申请号：EP94925636
申请日：1994-09-06
申请人： TAISHO PHARMA CO LTD
发明人： OKUYAMA SHIGERU , IMAGAWA YASUKO , OGAWA SHINICHI , ARAKI HIROAKI , OTOMO SUSUMU
IPC分类号： A61K31/135 , A61K31/137
CPC分类号： A61K31/135 , A61K31/137
摘要： To provide a remedy for drug dependence which is lowly toxic and has an excellent effect. A composition for remedying drug dependence which contains a phenylalkylamine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein X represents halogen, hydroxy or C1-C5 alkoxy; X represents hydrogen, halogen or C1-C5 alkoxy; R and R represent each independently C1-C7 alkyl; R represents phenyl which may be substituted by halogen, hydroxy or C1-C5 alkoxy; and m and n represent each an integer of 2 to 5.

69. 发明公开

EP0695754A4 INDOLO 2,3-b]QUINOXALINE DERIVATIVE 失效
标题翻译：吲哚并[2,3-B] QUINOXALINDERIVATE
公开(公告)号：EP0695754A4
公开(公告)日：1997-06-11
申请号：EP94913803
申请日：1994-04-22
申请人： TAISHO PHARMA CO LTD
发明人： MATSUMOTO TARO , WADA HISAYA , MIGITA YOSHIHIRO , HATAYAMA KATSUO , SEKIGUCHI YOSHINORI
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： An indolo[2-3-b]quinoxaline derivative represented by general formula (I) (wherein one of R?1 and R2¿ represents hydrogen and the other represents -CH¿2?NHCCH3(CH2OH)2, etc.; and R?3¿ represents hydrogen, methyl, etc.) or a pharmaceutically acceptable salt thereof has an antitumor effect and therefore is useful as a drug.

70. 发明公开

EP0735047A4 STEROID DERIVATIVE 失效
标题翻译： STEROIDDERIVAT
公开(公告)号：EP0735047A4
公开(公告)日：1996-11-27
申请号：EP95902957
申请日：1994-12-14
申请人： TAISHO PHARMA CO LTD
发明人： YOKOO CHIHIRO , WADA HISAYA , MITOME HIDEMICHI , SANO TATSUHIKO , HATAYAMA KATSUO , YAMADA YASUJI
IPC分类号： C07J7/00 , C07J9/00 , C07J17/00 , C07J21/00 , A61K31/58
CPC分类号： C07J21/006 , C07J7/002 , C07J9/00 , C07J17/00
摘要： To provide a novel antitumor steroid compound which can be synthesized efficiently and stereoselectively by the technique of organic synthetic chemistry. A steroid derivative represented by general formula (I) or a salt thereof, wherein R represents C1-C13 alkyl; A represents hydroxyl or a group which can readily be hydrolyzed into a hydroxyl group; and X and Y represent in combination oxo or C2-C3 alkylenedioxy, or separately X represents hydroxyl, C1-C5 alkoxy or a group which can readily be hydrolyzed into a hydroxyl group, and Y represents hydrogen or C1-C5 alkoxy, provided Y represents hydrogen when X represents hydroxyl or a group which can readily be hydrolyzed into a hydroxyl group, while Y represents C1-C5 alkoxy when X represents C1-C5 alkoxy.

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