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    • 61. 发明公开
    • REDUCING FRICTION OF A VISCOUS FLUID FLOW IN A CONDUIT
    • EINER LEITUNG的VERMINDERUNG DER REIBUNG EINER VISKOSENFLÜSSIGKEIT
    • EP2812625A1
    • 2014-12-17
    • EP13747268.4
    • 2013-02-07
    • Commonwealth Scientific and Industrial Research Organisation
    • WU, JieGRAHAM, LachlanSHORT, Gregory MarkHARRIS, Dean William
    • F17D1/16
    • F17D1/17F15D1/008F15D1/06F17D1/16Y10T137/0391Y10T137/2076Y10T137/2082
    • A device for reducing friction of a viscous fluid flow in a conduit is disclosed. The device comprises a body positionable to define at least a segment of a flow path for the viscous fluid in or contiguous with the conduit, a cavity in the body for retaining lubricating fluid, and at least one port in the body for delivering lubricating fluid to the cavity. A fluid outlet arrangement from said cavity delivers lubricating fluid to the flow path to form a downstream lubricating film at the conduit surface. The fluid outlet arrangement comprises a substantially continuous opening or ring of close spaced openings, effective collectively to reduce the pressure variation and therefore velocity variation of the delivered lubricating fluid along said outlet arrangement.
    • 用于减少导管中的粘性流体流的摩擦的装置包括主体(10,110),其可定位成限定用于粘性流体或与导管邻接的粘性流体的流路的至少一段,所述主体中的空腔(40,140)用于 保持润滑流体,以及至少一个端口(42,142),用于将润滑流体输送到腔体。 来自空腔的流体出口装置(48,148)将润滑流体输送到流动路径,以在其中流动的粘性流体形成下游润滑膜。 流体出口装置包括围绕流动路径的基本上连续的开口或环的紧密间隔的开口。 空腔包括主体中的一组通道,其包括多个细长通道(55,155),所述多个细长通道围绕流动路径延伸,共同有效地降低压力变化并因此减小输送的润滑流体沿出口装置的速度变化。 还公开了相应的方法。
    • 64. 发明公开
    • Detection method for characterising the anatomical origin of a cell
    • Nachweisverfahren
    • EP2767595A1
    • 2014-08-20
    • EP13161597.3
    • 2007-05-22
    • Clinical Genomics Pty LtdCommonwealth Scientific and Industrial Research Organisation
    • Lapointe, LawrenceDunne, Robert
    • C12Q1/68G01N33/48G01N33/574G06F19/00
    • C12Q1/6881C12Q1/6886C12Q2600/158G06F19/20G06F19/24
    • The present invention relates generally to an array of nucleic acid molecules, the expression profiles of which characterise the anatomical origin of a cell or population of cells within the large intestine. More particularly, the present invention relates to an array of nucleic acid molecules, the expression profiles of which characterise the proximal or distal origin of a cell or population of cells within the large intestine. The expression profiles of the present invention are useful in a range of applications including, but not limited to determining the anatomical origin of a cell or population of cells which have been derived from the large intestine. Still further, since the progression of a normal cell towards a neoplastic state is often characterised by phenotypic de-differentiation, the method of the present invention also provides a means of identifying a cellular abnormality based on the expression of an incorrect expression profile relative to that which should be expressed by the subject cells when considered in light of their anatomical location within the colon. Accordingly, this aspect of the invention provides a valuable means of identifying the existence of large intestine colon cells, these being indicative of an abnormality within the large intestine such as the onset or predisposition to the onset of a condition such as colorectal neoplasm.
    • 本发明一般涉及核酸分子阵列,其表达谱表征大肠细胞或细胞群在大肠内的解剖起源。 更具体地,本发明涉及一种核酸分子阵列,其表达谱表征大肠内的细胞或细胞群的近端或远端起源。 本发明的表达谱在一系列应用中是有用的,包括但不限于确定从大肠衍生的细胞或细胞群的解剖起源。 此外,由于正常细胞朝向肿瘤状态的进展通常以表型去分化为特征,本发明的方法还提供了一种鉴别细胞异常的方法,该方法基于相对于 当考虑到它们在结肠内的解剖位置时,其应该由受试者细胞表达。 因此,本发明的这个方面提供了鉴定大肠结肠细胞存在的有价值的手段,这些细胞指示大肠内的异常,例如诸如结肠直肠肿瘤的病症的发病或倾向。
    • 65. 发明公开
    • Moisture monitor system for diapers and alike
    • FeeltigkeitssensorfürWindeln und dergleichen
    • EP2754429A1
    • 2014-07-16
    • EP14164504.4
    • 2007-01-31
    • Commonwealth Scientific and Industrial Research Organisation
    • Helmer, Richard James NeilMestrovic, Michael AnthonyPetersen, Pamela Margaret
    • A61F13/42G08B21/00
    • A61F13/42
    • The invention relates to a moisture monitoring system suitable for monitoring liquid leakage of a wearer and, in turn, for monitoring wetting of a diaper, nappy, incontinence pad or alike sanitary product, the system including: i) two or more than two electrodes each being supported in a spaced apart relationship; and ii) a liquid permeable substrate between the electrodes, the liquid permeable substrate lacking or having a low capacity for holding or storing liquid, whereby in the event of initial liquid leakage, an electrical bridge connecting the electrodes can extend, at least in part, through the permeable substrate by liquid located on or in the permeable substrate, and subsequently liquid can drain from the permeable substrate so as to electrically disconnect the electrodes, and upon further liquid leakage, electrical connection between the electrodes can be reformed.
    • 本发明涉及一种适用于监测穿用者的液体泄漏并且又用于监测尿布,尿布,失禁垫或类似卫生产品的润湿的水分监测系统,该系统包括:i)两个或多于两个电极 以间隔的关系支持; 以及ii)电极之间的液体可渗透的基底,液体可渗透的基底缺乏或具有低的容纳液体的容量,由此在初始液体泄漏的情况下,连接电极的电桥可以至少部分地延伸, 通过位于可渗透基底上或液体中的液体通过可渗透基底,随后液体可以从可渗透基底排出,从而电绝缘电极,并且在进一步的液体泄漏时,可以改变电极之间的电连接。
    • 69. 发明授权
    • NUCLEIC ACID AMPLIFICATION
    • 核酸扩增
    • EP2207896B1
    • 2014-01-29
    • EP08800110.2
    • 2008-10-03
    • Commonwealth Scientific and Industrial Research Organisation
    • RAND, Keith Norman
    • C12Q1/68
    • C12Q1/6848C12Q1/686C12Q2525/186
    • Provided herein is a method for the selective amplification of a target nucleotide sequence located within a nucleic acid molecule, the method comprising contacting the nucleic acid molecule ("template" molecule) with (i) at least one facilitator oligonucleotide, wherein the facilitator oligonucleotide includes at least one modification at or near its 3' terminus such that 3' extension from the facilitator oligonucleotide is blocked, and (ii) two or more oligonucleotide primers, at least one of which is an initiator primer modified such that the presence of the modification prematurely terminates complementary strand synthesis, wherein the facilitator oligonucleotide and the initiator primer bind to substantially the same or adjacent regions of the template nucleic acid molecule and the facilitator oligonucleotide further comprises sequences complementary to the target sequence 3' to the binding location of the initiator primer; and carrying out thermocyclic, enzymatic amplification such that the specific target sequence is selectively amplified.
    • 本文提供了用于选择性扩增位于核酸分子内的靶核苷酸序列的方法,所述方法包括使所述核酸分子(“模板”分子)与(i)至少一种促进剂寡核苷酸接触,其中所述促进剂寡核苷酸包括 在其3'末端或其附近的至少一个修饰,使得来自辅酶寡核苷酸的3'延伸被阻断,和(ii)两个或更多个寡核苷酸引物,其中至少一个是经修饰的启动子引物,使得修饰 过早地终止互补链合成,其中协助寡核苷酸和起始引物结合到模板核酸分子的基本上相同或相邻的区域,并且协助寡核苷酸进一步包含与靶标序列3'互补的序列与起始引物的结合位置互补的序列 ; 并进行热循环酶促扩增,使得特定靶序列被选择性扩增。