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61. 发明公开

EP0812540A2 Method to overcome the antagonistic interactions of herbicides 失效
标题翻译： Verfahren und Zusammensetzungen zur Ueberwindung对象者Wechselwirkung von Herbiziden。
公开(公告)号：EP0812540A2
公开(公告)日：1997-12-17
申请号：EP97303975.3
申请日：1997-06-09
申请人： American Cyanamid Company
发明人： Whatley, Thomas L. , Krueger, Roger W. , Frazier, Todd Lyndon
IPC分类号： A01N43/50
CPC分类号： A01N43/50 , A01N43/88 , A01N43/70 , A01N39/04 , A01N37/40 , A01N2300/00
摘要： There is provided a method to overcome or decrease the antagonistic interaction caused by the application of an acetohydroxyacid synthase-inhibiting herbicide in combination with a non-acetohydroxyacid synthase-inhibiting herbicide such as dicamba, 2,4-D, bromoxynil, atrazine or bentazone, which comprises applying an effective amount of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid.
摘要翻译：提供了一种克服或减少由使用乙酰羟酸合成酶抑制性除草剂与非乙酰羟酸合成酶抑制性除草剂如麦草畏，2,4-D，溴苯腈，莠去津或苯达松等组合引起的拮抗相互作用的方法，其包括施用有效量的2-（4-异丙基-4-甲基-5-氧代-2-咪唑啉-2-基）烟酸。

62. 发明公开

EP0811008A1 BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS 失效
标题翻译：双环苯并吖庚因衍生物作为精氨酸加压素拮抗剂
公开(公告)号：EP0811008A1
公开(公告)日：1997-12-10
申请号：EP96903711.0
申请日：1996-01-16
申请人： American Cyanamid Company
发明人： ALBRIGHT, Jay, Donald , DELOS SANTOS, Efren, Guillermo
IPC分类号： C07D487 , A61K31 , A61P9 , A61P13 , A61P15 , C07D491 , C07D495 , C07D513
CPC分类号： C07D495/04
摘要： This invention relates to new bicyclic non-peptide vasopressin antagonists of formula (I) which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction.

63. 发明公开

EP0804125A1 ABSORBABLE BIOCOMPATIBLE SUTURE AND METHOD OF MANUFACTURE 失效
标题翻译：可吸收缝合线和BIOKOMPATIBELER
公开(公告)号：EP0804125A1
公开(公告)日：1997-11-05
申请号：EP95943967.0
申请日：1995-12-22
申请人： AMERICAN CYANAMID COMPANY
发明人： HUTTON, Jeffrey, D.
IPC分类号： A61L17 , D01F6 , D02J1 , D06M23 , A61B17
CPC分类号： D06M23/10 , A61B17/06166 , A61B2017/00004 , A61B2017/00831 , A61L17/12 , D01D5/12 , D01F6/625 , D02J1/08 , D06M7/00 , D06M2200/40
摘要： A process for producing an absorbable biocompatible medical suture yarn (21) includes the step of spin drawing a bioabsorbable polymer to form suture filaments (19). A spin finish using a non-aqueous based carrier is applied to the filaments (19) during processing, and an air entangling step is used after the filaments (19) are combined to form the suture yarn (21).

64. 发明公开

EP0792872A3 2,6-substituted pyridine derivatives, their preparation and their use as herbicidal agents 失效
标题翻译： 2,6-取代的吡啶衍生物，它们的制备和它们作为除草剂的用途
公开(公告)号：EP0792872A3
公开(公告)日：1997-10-15
申请号：EP97301091.1
申请日：1997-02-20
申请人： American Cyanamid Company
发明人： Kleemann, Axel , Baltruschat, Helmut Siegfried
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , A01N43/40 , A01N43/56
CPC分类号： C07D213/643 , A01N43/40 , A01N43/50 , A01N43/56 , C07D213/64 , C07D213/68 , C07D213/79 , C07D213/84 , C07D401/12 , C07D401/14
摘要： Substituted pyridine compounds having the structural formula I
Further provided are compositions containing these compounds, and a method of using same for the control of undesirable plant species.
摘要翻译：具有结构式I的取代的吡啶化合物进一步提供了含有这些化合物的组合物，以及使用它们来控制不希望的植物物种的方法。

65. 发明公开

EP0796101A1 COMPOSITIONS AND METHODS FOR INHIBITING FUNGAL CELL WALL FORMATION 失效
标题翻译：剂和一种抑制蘑菇细胞壁形成
公开(公告)号：EP0796101A1
公开(公告)日：1997-09-24
申请号：EP96906177.0
申请日：1996-01-02
申请人： AMERICAN CYANAMID COMPANY
发明人： KOLLAR, Roman , CABIB, Enrico , SILVERMAN, Sanford Jay , PETRAKOVA, Eva
IPC分类号： C12N9 , A61K31 , A61P31 , C07H5 , C07H7 , C07K14 , C12R1
CPC分类号： A61K36/07 , A61K31/70 , A61K31/7008 , A61K31/7016 , A61K31/702 , A61K36/06 , A61K36/062 , A61K36/064 , C12N9/1051 , A61K31/715 , A61K2300/00
摘要： Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked β(1→4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan β(1→4) transferase (CGβ(1→4)T) is disclosed along with methods for using this enzyme in an assay for antifungal agents. CGβ(1→4)T catalyses the formation of a β(1→4) linkage between the terminal reducing N-acetylglucosamine residue of chitin and the non-reducing glucose residue of β(1→3) linked glucans. Inhibitors of the enzyme, antifungals including such inhibitors, methods for the prevention and the treatment of fungal infections in animals and plants, and screening methods for identifying antifungals are also disclosed.

66. 发明公开

EP0795549A1 Bis-aryloxy(amino)-triazinyl-oxy(amino)aryl derivatives, their preparation and their use as antiviral agents 失效
标题翻译：双 - 芳氧基（氨基） - 三嗪基 - 氧基（氨基）芳基衍生物，deren Herstellung und deren Verwendung als anti-virale Mittel
公开(公告)号：EP0795549A1
公开(公告)日：1997-09-17
申请号：EP97300905.3
申请日：1997-02-12
申请人： American Cyanamid Company
发明人： Gluzman, Yakov , Larocque, James Paul , O'Hara, Bryan, Mark , Morin, John Edward , Ellestad, George Alfred , Mitsner, Boris , Ding, Wei-Dong , Raifeld, Yuri Efimovich , Nikitenko, Antonina Aristotelevna
IPC分类号： C07D251/54 , C07D251/68 , A61K31/53
CPC分类号： C07D401/14 , C07D251/44 , C07D251/50 , C07D251/52 , C07D251/70
摘要： This invention provides triazine ring containing compounds useful as pharmaceuticals, especially for treating viral infections, particularly infections by respiratory syncitial virus and pharmaceutical compositions containing these compounds. The compounds have the general structure:
wherein:
A is a moiety selected from the group consisting of
C' is selected from -SO 3 H, -OSO 3 H, -OH, or -COOH;
B' is -NH, -NR 1 or O;
R 1 is selected from H, (C 1 -C 6 ) lower alkyl, straight or branched, wherein the carbon atoms may be optionally substituted with C1, Br, F, OH or CN;
X is C1, F, or the moiety
U' is selected from the group of -SO 2 , -CO, -NC(O), or -NC(S);
W' is selected from the moieties:
Y is -(CH 2 ) n -;
n is 0 to 6;
m is 0 to 2;
Z is selected from H, CH 3 , CF 3 , -CH 2 -(halogen), where halogen is C1, Br, F or I, -CH 2 OH, -COOH, -COO(C 1 -C 6 ) lower alkyl straight or branched, -CONR 2 R 2 , CN or
and
R 2 , in each occurrence, is independently selected from H or (C 1 -C 6 ) lower alkyl; and the pharmaceutically acceptable salts and esters thereof.
摘要翻译：本发明提供了可用作药物的三嗪环化合物，特别是用于治疗病毒感染，特别是呼吸道合胞病毒感染和含有这些化合物的药物组合物。化合物具有以下通式：其中：A为选自-SO 3 H，-OSO 3 H，-OH或-COOH的选自下列的部分： B'是-NH，-NR 1或O; R 1选自H，（C 1 -C 6）低级烷基，直链或支链，其中碳原子可任选被C 1，Br，F，OH或CN取代; X是C1，F或部分 U'选自-SO 2，-CO，-NC（O）或-NC（S）; W'选自以下部分：CH 2 Y是 - （CH 2）n - ; n为0〜6; m为0〜2; Z选自H，CH 3，CF 3，-CH 2 - （卤素），其中卤素是C 1，Br，F或I，-CH 2 OH，-COOH，-COO（C 1 -C 6）低级烷基直链或支链， R 2，R 2，CN或和R 2各自独立地选自H或（C 1 -C 6）低级烷基; 及其药学上可接受的盐和酯。

67. 发明公开

EP0791603A2 Pure somatostatin antagonist and methods of use thereof 失效
标题翻译：生长抑素拮抗剂和dessen Verwendung
公开(公告)号：EP0791603A2
公开(公告)日：1997-08-27
申请号：EP97301092.9
申请日：1997-02-20
申请人： American Cyanamid Company
发明人： Bass, Roy Tyson , Buckwalter, Brian Lee , Hadcock, John Richard , Patel, Bomi Pilloo , Chiarello, John Francis
IPC分类号： C07K14/655 , A61K38/31
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method for decreasing the effect of somatostatin. A peptide of formula I which is a pure somatostatin antagonist, methods for increasing the release of growth hormone, insulin and glucagon in mammals, and a method for the enhancement of growth in mammals are also described.
摘要翻译：降低生长抑素作用的方法。还描述了作为纯生长抑素拮抗剂的式I肽，增加哺乳动物中生长激素，胰岛素和胰高血糖素释放的方法以及增强哺乳动物生长的方法。

68. 发明公开

EP0789712A1 GENES ENCODING A FAMILY OF POTASSIUM CHANNELS 失效
标题翻译：基因编码的钾通道家族
公开(公告)号：EP0789712A1
公开(公告)日：1997-08-20
申请号：EP95939781.0
申请日：1995-10-25
申请人： American Cyanamid Company
发明人： PAUSCH, Mark, Henry , PRICE, Laura, Alicia
IPC分类号： C12N15 , A01N63 , C07K14 , C12N1 , C12R1
CPC分类号： C07K14/705
摘要： This invention relates generally to the potassium channel gene family. More particularly, the present invention relates to the cloning and characterization of potassium channel genes from Drosophila melanogaster and Caenorhabditis elegans. Other aspects of the present invention include methods of assaying substances to determine effects on cell growth. Also presented are methods of controlling nematode and insect pests by inhibiting potassium channels substantially homologous to those encoded by nucleotide sequences as described herein.

69. 发明授权

EP0570682B1 Synthetic lipid A glycoconjugate antigens for use in vaccines 失效
标题翻译：合成脂质-A Clykoconjugate抗原及其在疫苗中使用
公开(公告)号：EP0570682B1
公开(公告)日：1997-07-23
申请号：EP93104369.9
申请日：1993-03-17
申请人： AMERICAN CYANAMID COMPANY
发明人： Porro, Massimo
IPC分类号： C07H13/04 , A61K39/05 , A61K39/08 , A61K47/48 , C07H15/18
CPC分类号： C07H11/04 , A61K39/02 , A61K39/385 , A61K47/646 , A61K2039/6037 , C07H13/04 , C07H15/18 , Y02A50/484
摘要： Synthetic glycoconjugate antigens of the formula: for use in vaccines for prophylaxis of septic shock caused by bacterial endotoxin and methods of preparing the glycoconjugates.

70. 发明授权

EP0657439B1 Process improvement in the synthesis of [R-(R*,R*)]-5-(3-chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolididone 失效
标题翻译：改进[R-（R *，R *）]的制备 - 5-（3-氯苯基）-3-（2-（3,4-二羟基苯基）-1-甲基乙基-2-恶唑烷酮
公开(公告)号：EP0657439B1
公开(公告)日：1997-07-16
申请号：EP94118198.4
申请日：1994-11-18
申请人： American Cyanamid Company
发明人： Cain, William Thomas , Cruz, Kelvin , McCoy, Kevin Michael , Mohan, Arthur G. , Blum, David Michael
IPC分类号： C07D263/20 , A61K31/42
CPC分类号： C07D263/20

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