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61. 发明公开

EP0986750A4 NOVEL POLYMERIZED CRYSTALLINE COLLOIDAL ARRAY SENSORS 失效
标题翻译：新型聚合晶体胶体阵列传感器
公开(公告)号：EP0986750A4
公开(公告)日：2002-05-08
申请号：EP98909054
申请日：1998-03-09
申请人： UNIV PITTSBURGH
发明人： ASHER SANFORD A , HOLTZ JOHN H
IPC分类号： G01N21/41 , B01J13/00 , C08F2/00 , C08F2/16 , C08F2/48 , C08F220/56 , G01J3/18 , G01N21/47 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/00 , G01N33/48 , G02B26/00
CPC分类号： B01J13/00 , B01J13/0065 , G01J3/18 , G01N21/4788 , G01N21/77 , G01N31/222 , G01N2021/772 , G01N2021/7723 , G02B26/002 , Y10S436/805 , Y10S436/811 , Y10T436/144444 , Y10T436/204998 , Y10T436/205831 , Y10T436/207497 , Y10T436/209163
摘要： Novel sensor devices composed of a crystalline colloidal array (CCA) polymerized in a hydrogel are disclosed. The hydrogels are characterized as being capable of shrinking and swelling in response to specific stimuli applied thereto. As the hydrogels shrink or swell, the lattice structure of the CCA embedded therein changes, thereby changing the wavelength of light diffracted by the CCA. Thus by monitoring the change in diffracted wavelength, the concentration of a stimulus is determined. The gels can be modified to sense numerous different stimuli. The sensor devices are specific in that they are modified to react with only one species or family of species. These sensors have various applications in areas including, for example, environmental and chemical systems, chemomechanical systems, sensor devices and medical diagnostic tools. Various methods for making and using these devices are also disclosed.

62. 发明公开

EP1012657A4 THERMALLY SWITCHABLE OPTICAL DEVICES 失效
标题翻译：热切换光学材料
公开(公告)号：EP1012657A4
公开(公告)日：2001-09-12
申请号：EP97941487
申请日：1997-09-09
申请人： UNIV PITTSBURGH
发明人： ASHER SANFORD A , WEISSMAN JESSE M , SUNKARA HARI B
IPC分类号： G02F1/061 , G01K11/06 , G01K11/12 , G01L11/02 , G02F1/01 , G02F1/17 , B01D69/02 , B01D69/14 , G02B5/20 , G02B5/24
CPC分类号： G01L11/02 , G01K11/06 , G01K11/12 , G02F1/0147 , G02F1/172 , G02F2201/346 , G02F2202/022
摘要： Devices that comprise novel, mesoscopically periodic materials that combine crystalline colloidal array (CCA) self assembly with the temperature induced volume phase transistions of various, materials, preferably poly (N-isopropylacrylamide) (PNIPAM) are disclosed. In one embodiment, a PNIPAMCCA is formed in an aqueous media (14) and contained within cell means (16). In another embodiment, a CCA of charged particles (12) is formed and polymerized in a PNIPAM hydrogel. Methods for making these devices are also disclosed. The devices of the present invention are useful in many applications including, for example, optical switches, optical limiters, optical filters, display devices and processing elements. The devices are further useful as membrane filters. All of these devices have the feature of being tunable in response to temperature. Devices that change diffracted wavelength in response to pressure are also disclosed.

63. 发明公开

EP0910385A4 SENSITIZATION OF CELLS TO RADIATION AND CHEMOTHERAPY 失效
标题翻译： SENSIBILISIERUNG VON ZELLEN ZUR STRAHLEN- UND CHEMOTHERAPIE
公开(公告)号：EP0910385A4
公开(公告)日：1999-12-22
申请号：EP97918662
申请日：1997-04-15
申请人： UNIV PENNSYLVANIA , UNIV PITTSBURGH
发明人： MCKENNA W GILLES , MUSCHEL RUTH J , BERNHARD ERIC J , SEBTI SAID M , HAMILTON ANDREW D
IPC分类号： A61K45/00 , A61K31/00 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/70 , A61K31/7088 , A61K31/7105 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/43 , A61K41/00 , A61P35/00 , A61P43/00 , G01N33/573 , G01N33/574 , A01N43/04 , A61K38/00 , A61K39/00 , A61K51/00 , A61M36/14 , C12Q1/00
CPC分类号： G01N33/57407 , A61K31/198 , A61K31/216 , A61K41/0038 , G01N33/573 , G01N33/5748
摘要： The invention relates to a method of conferring radiation sensitivity on a tumor cell comprising administering to the cell an inhibitor of a protein product which participates in the ras signalling pathway, whereby inhibition of the protein product confers radiation sensitivity on the cell.
摘要翻译：本发明涉及赋予肿瘤细胞辐射敏感性的方法，其包括向细胞施用参与ras信号传导途径的蛋白质产物的抑制剂，由此抑制蛋白质产物赋予细胞辐射敏感性。

64. 发明公开

EP0724650A4 SELECTION AND USE OF ANTIVIRAL PEPTIDES 失效
标题翻译： VERWENDUNG ANTIVIRALER PEPTIDE
公开(公告)号：EP0724650A4
公开(公告)日：1998-12-02
申请号：EP94923428
申请日：1994-07-08
申请人： UNIV PITTSBURGH
发明人： DELUCA NEAL A
IPC分类号： C12N15/09 , C12P21/02 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/569
CPC分类号： G01N33/56994
摘要： The present invention relates to the screening and selection of potential antiviral compounds or peptides. Potential antiviral compounds or peptides are chosen by their ability to interact and interfere with an essential function of a wild type viral protein subsequent to host infection. Potential antiviral compounds or peptides or pools thereof are screened in an in vitro reconstitution assay comprising a wild type viral protein, host cellular trans-acting factors and an appropriate DNA promoter fragment. A potential antiviral agent possesses the ability to form a unique protein:protein or DNA:protein complex in comparison to interactions involving the wild type viral protein in the absence of the antiviral agent.
摘要翻译：本发明涉及潜在的抗病毒化合物或肽的筛选和选择。潜在的抗病毒化合物或肽通过其在宿主感染后相互作用并干扰野生型病毒蛋白的基本功能的能力来选择。在包含野生型病毒蛋白，宿主细胞反式作用因子和合适的DNA启动子片段的体外重建测定中筛选潜在的抗病毒化合物或其肽或其库。与不存在抗病毒剂的野生型病毒蛋白相互作用相比，潜在的抗病毒剂具有形成独特蛋白质的能力：蛋白质或DNA：蛋白质复合物。

65. 发明公开

EP0690673A4 SYSTEMIC GENE TREATMENT OF CONNECTIVE TISSUE DISEASES 失效
标题翻译：遗传性疾病结缔组织全身治疗
公开(公告)号：EP0690673A4
公开(公告)日：1996-05-29
申请号：EP95906631
申请日：1994-12-12
申请人： UNIV PITTSBURGH
发明人： EVANS CHRISTOPHER H , ROBBINS PAUL D
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K38/17 , A61K38/18 , A61K38/20 , A61K38/30 , A61K38/48 , A61K48/00 , A61P29/00 , A61P43/00 , C07H21/04 , C07K14/47 , C12N5/00 , C12N5/10 , C12R1/91 , A01N43/04 , A01N63/00 , C07H17/00 , C12N5/06 , C12N7/00 , C12N15/00
CPC分类号： A61K38/20 , A61K48/00 , C07K14/47 , C12N2799/027

66. 发明公开

EP0556182A4 DNA CAPABLE OF SITE-SPECIFIC INTEGRATION INTO MYCOBACTERIA 失效
标题翻译：能够将基因特异性整合置于MYCOBACTERIA中的DNA
公开(公告)号：EP0556182A4
公开(公告)日：1995-03-01
申请号：EP91914084
申请日：1991-07-09
申请人： EINSTEIN COLL MED , UNIV PITTSBURGH
发明人： JACOBS WILLIAM R , HATFULL GRAHAM
IPC分类号： A61K39/04 , A61K38/00 , A61K39/00 , A61P31/04 , C07K14/16 , C12N1/21 , C12N15/09 , C12N15/74 , C12N15/90 , C12P21/02 , C12R1/32 , C12N15/00 , C12N15/11
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N15/74 , C12N15/90 , C12N2740/16222
摘要： A DNA for integrating DNA into a mycobacterium chromosome portion which includes a first DNA sequence which is a phage DNA portion encoding bacteriophage integration into a mycobacterium chromosome, and a second DNA sequence encoding a protein or polypeptide heterologous to the mycobacterium in which the DNA is to be integrated. Such DNA may be integrated into mycobacteria, which may then be administered as a vaccine and/or therapeutic agent.

67. 发明公开

EP0563239A4 A TRUNCATED INTERLEUKIN-1 RECEPTOR GENE FOR THE TREATMENT OF ARTHRITIS. 失效
标题翻译：残缺的白细胞介素-1受体基因治疗关节炎。
公开(公告)号：EP0563239A4
公开(公告)日：1994-10-12
申请号：EP92902630
申请日：1991-12-09
申请人： UNIV PITTSBURGH
发明人： GLORIOSO JOSEPH C , EVANS CHRISTOPHER H , ROBBINS PAUL D , BANDARA GEETHANI
IPC分类号： A61K35/24 , A61K35/76 , A61K38/00 , A61K48/00 , A61P29/00 , C07K14/715 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/867 , C12N15/00 , A61K31/70 , C07H15/12
CPC分类号： C12N15/86 , A61K38/00 , C07K14/715 , C12N2740/13043 , C12N2740/13045

68. 发明公开

EP2968478A4 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA 有权
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VONCARBOXYHÄMOGLOBINÄMIE
公开(公告)号：EP2968478A4
公开(公告)日：2016-09-07
申请号：EP14769521
申请日：2014-03-11
申请人： UNIV PITTSBURGH
发明人： GLADWIN MARK T , TEJERO BRAVO JESUS
IPC分类号： A61K38/41 , A61P39/02 , C07K14/795
CPC分类号： C07K14/795 , A61K9/0019 , A61K38/00 , A61K38/41
摘要： Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.
摘要翻译：本文描述了一种用于从血红蛋白（包括脑，心脏和红细胞血红蛋白）快速消除一氧化碳的新的解毒剂。所公开的治疗涉及使用修饰的人球蛋白，特别是在残基64处修饰的神经球蛋白和在残基81修饰的细胞球蛋白，其以非常高的亲和力结合一氧化碳。单体突变体珠蛋白注入血液，其中它们迅速和不可逆地螯合一氧化碳，从而限制一氧化碳对细胞呼吸和氧气运输和利用的毒性作用。

69. 发明公开

EP2925382A4 EXTRACORPOREAL AMBULATOR ASSIST LUNG 审中-公开
标题翻译： EXTRAKORPORALE AMBULATORISCHEUNTERSTÜTZUNGSLUNGE
公开(公告)号：EP2925382A4
公开(公告)日：2016-07-06
申请号：EP13859515
申请日：2013-11-27
申请人： UNIV PITTSBURGH , UNIV CARNEGIE MELLON
发明人： FEDERSPIEL WILLIAM J , FRANKOWSKI BRIAN JOSEPH , ANTAKI JAMES F , BERMUDEZ CHRISTIAN ANDRES , JEFFRIES RICHARD GARRETT , WAGNER WILLIAM R
IPC分类号： A61M1/14 , A61M1/10 , A61M1/26 , A61M37/00
CPC分类号： A61M1/3667 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1029 , A61M1/1036 , A61M1/1698 , A61M1/262 , A61M1/267 , A61M1/32 , A61M2205/7536 , A61M2206/20
摘要： A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing.
摘要翻译：用于肺辅助的体外系统包括壳体，与壳体流体连接的血流入口; 与所述壳体流体连接的血流出口; 多个中空透气纤维，其适于允许血液和中空透气纤维内部之间的气体扩散，多个中空透气纤维位于血流入口和血流出口之间，使得血液流过当从血流入口流到血流出口时，多个中空透气纤维; 与所述壳体流体连接并与所述多个中空透气纤维的入口流体连接的气体入口; 与所述壳体流体连接并与所述多个中空透气纤维的出口流体连接的气体出口; 以及至少一个移动元件以在与多个中空透气纤维接触的血液流中产生速度场。多个中空透气纤维可以大致垂直于血液通过壳体的大量流动方向延伸。

70. 发明公开

EP2841147A4 TIP-LOADED MICRONEEDLE ARRAYS FOR TRANSDERMAL INSERTION 审中-公开
标题翻译：顶部加载微针安排引入透皮
公开(公告)号：EP2841147A4
公开(公告)日：2016-04-13
申请号：EP13784192
申请日：2013-05-01
申请人： UNIV PITTSBURGH , UNIV CARNEGIE MELLON
发明人： FALO LOUIS D JR , ERDOS GEZA , OZDOGANLAR O BURAK
IPC分类号： A61M37/00 , A61B17/00 , A61B17/20 , A61K9/00 , A61L31/00 , A61L31/04 , A61L31/16 , A61M5/158 , B23C3/00 , B29C67/00 , B29L31/00 , B81C1/00
CPC分类号： B29C67/00 , A61B2017/00526 , A61K9/0021 , A61L31/042 , A61L31/16 , A61L2300/802 , A61L2400/18 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B23C3/20 , B29L2031/7544
摘要： A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.

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