专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明公开

EP2529743A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR CROHN'S DISEASE COMPRISING ORGANIC ACID POLYMER AS ACTIVE INGREDIENT 有权
标题翻译：丙酮醇治疗剂GEGEN MORBUS CROHN MIT EINEM有机酸SURPROLYMER ALS WIRKSTOFF
公开(公告)号：EP2529743A1
公开(公告)日：2012-12-05
申请号：EP11737021.3
申请日：2011-01-26
申请人： Sanwa Kagaku Kenkyusho Co., Ltd
发明人： HASHIMOTO Hiroyuki , KUMAZAWA Toshihiko , TAKEDA Motohiro , JOMORI Takahito , HIBI Chihiro , MIZUNO Kuniharu
IPC分类号： A61K31/80 , A61P1/00
CPC分类号： A61K31/80
摘要： The present invention is to provide an agent for treating Crohn's disease that is of unknown cause and for which no radical therapeutic drug is present. Provided is an agent for preventing or treating Crohn's disease, comprising an organic acid polymer represented by the following formula: [(O 1/2 ) 3 Ge-A-CO 2 H] n , wherein n is 100-1,000, and A is a lower alkyl group. Preferably, A is a C1-C3 lower alkyl group and the degree of polymerization n is 200-900. The organic acid polymer according to the present invention is effective as an agent for treating Crohn's disease.
摘要翻译：本发明提供一种治疗克罗恩病的药物，其原因不明，并且没有基础治疗药物存在。本发明提供一种预防或治疗克罗恩病的药剂，其含有下式所示的有机酸聚合物：[（O 1/2）3 Ge-A-CO 2 H] n，其中n为100-1,000，A为低级烷基。优选A为C1-C3低级烷基，聚合度n为200-900。根据本发明的有机酸聚合物作为治疗克罗恩病的药剂是有效的。

62. 发明授权

EP1961420B1 AGENT FOR PREVENTION AND TREATMENT OF ACUTE RENAL FAILURE 有权
标题翻译：活跃的预防与处理急性肾功能衰竭
公开(公告)号：EP1961420B1
公开(公告)日：2012-07-25
申请号：EP06834797.0
申请日：2006-12-15
申请人： Sanwa Kagaku Kenkyusho Co., Ltd , Hirosaki University
发明人： YAGIHASHI, Soroku , OGASAWARA, Saori , HIBI, Chihiro , KATO, Noriaki
IPC分类号： A61K31/4188 , A61P13/12 , C07D491/107
CPC分类号： A61K31/4188 , C07D491/10
摘要： Disclosed is an agent for prevention and treatment of acute renal failure which contains a hydantoin derivative represented by the general formula below as an active ingredient. Among such compounds, (2S,4S)-6-fluoro-2’,5’-dioxospiro[chroman- 4,4’-imidazolidine]-2-carboxamide is particularly preferable. (formula) (In the formula, X represents a halogen atom or a hydrogen atom, and R1 and R2 independently represent a hydrogen atom or an optionally substituted C1-6 alkyl group or the like.)

63. 发明授权

EP1302304B1 METHOD OF PRODUCING A NUCLEATED MOLDED ARTICLE 有权
标题翻译：用于生产核状物体
公开(公告)号：EP1302304B1
公开(公告)日：2011-12-14
申请号：EP01941141.2
申请日：2001-06-20
申请人： SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： OZEKI, Yuichi Sanwa Kagaku Kenkyusho Co. Ltd , KONDO, Yoshiya Sanwa Kagaku Kenkyusho Co. Ltd. , WATANABE, Yukinao Sanwa Kagaku Kenkyusho Co. Ltd.
IPC分类号： B30B11/00 , A61J3/06 , B30B11/34 , B30B15/30 , A61K9/28 , A61J3/00
CPC分类号： A61K9/2054 , A61J3/06 , A61J3/10 , A61K9/2081 , A61K9/2095 , B30B11/02 , B30B11/08 , B30B11/34
摘要： A method of producing nucleated molded articles efficiently at a time from a molding material such as powder, by using a compression molding means comprising a mortar and upper and lower pestles, at least the upper pestle, preferably both upper and lower pestles, being of double construction consisting of a center pestle and an outer pestle surrounding the outer periphery of the center pestle, both the center pestle and the outer pestle being slidable and operable for compression. This production method comprises the steps of feeding both a nucleus-forming molding material and an outer layer-forming molding material, compression-molding the nucleus-forming molding material and/or outer layer-forming molding material, and compression molding the complete nucleated molded article. Also provided is a rotary type compression molding machine which is used to embody the method. Also provided are various characteristic nucleated molded articles produced by the method, including one containing lots of microcapsules or the like or having a plurality of nuclei, which is a nucleus-incomplete molded article.

64. 发明公开

EP2110141A1 PROTECTIVE AGENT FOR RETINAL NERVE OR OPTIC NERVE 有权
标题翻译： ACTIVE ON视网膜神经或视神经的保护
公开(公告)号：EP2110141A1
公开(公告)日：2009-10-21
申请号：EP08704120.8
申请日：2008-01-30
申请人： Sanwa Kagaku Kenkyusho Co., Ltd
发明人： CHUNG, Sookja, Kim , CHUNG, Stephen , HIBI, Chihiro
IPC分类号： A61K45/00 , A61K31/198 , A61K31/407 , A61K31/41 , A61K31/4166 , A61K31/4184 , A61K31/4188 , A61K31/425 , A61K31/50 , A61K31/501 , A61K31/517 , A61K31/5415 , A61P9/00 , A61P25/02 , A61P27/02 , A61P27/06 , A61P43/00 , C07D491/107
CPC分类号： C07D491/107 , A61K31/198 , A61K31/407 , A61K31/41 , A61K31/4166 , A61K31/4184 , A61K31/4188 , A61K31/425 , A61K31/50 , A61K31/501 , A61K31/517 , A61K31/5415
摘要： The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide:

wherein X represents a halogen atom or a hydrogen atom, R1 and R2 independently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R 1 and R 2 , together with a nitrogen atom bound thereto, or optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle.

65. 发明公开

EP2036887A1 NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF 审中-公开
标题翻译：近期6-5-BICYCLISCHES DERIVAT UND MEDISINISCHE VERWENDUNG DAVON
公开(公告)号：EP2036887A1
公开(公告)日：2009-03-18
申请号：EP07768337.3
申请日：2007-06-27
申请人： Sanwa Kagaku Kenkyusho Co., Ltd
发明人： ASANO, Yukiyasu , MAEDA, Koji , TSURUTA, Nobuaki , MURASE, Toru
IPC分类号： C07D209/08 , A61K31/404 , A61K31/416 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/14 , A61P5/16 , A61P9/04 , A61P9/06 , A61P17/00 , A61P17/02 , A61P17/14 , A61P19/10 , A61P25/24 , A61P27/06 , A61P35/00 , A61P43/00 , C07D209/12 , C07D231/56
CPC分类号： C07D209/12 , C07D231/56
摘要： An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof:

[wherein
[Chemical Formula 2] is a single bond or a double bond; A is -CH 2 - or -CO-; X, Y, and Z are each independently a nitrogen atom or a carbon atom; R 1 is a hydrogen atom or an aralkyl group; R 2 is an alkyl group or an aralkyl group, etc.; R 3 is a hydrogen atom or an alkyl group, etc.; R 4 is a hydrogen atom or an alkyl group; R 5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.; R 6 is a hydrogen atom or an alkyl group; R 7 is a hydrogen atom, etc.; R 8 is a hydrogen atom, or an alkyl group, etc.; and E is -NHCO-G-COR 12 , etc. (wherein G is a single bond or an alkylene group, and R 12 is a hydroxy group or an alkoxy group)].
摘要翻译：本发明的目的是提供一种药物作为甲状腺激素受体配体，其药物功效和安全性足够，作为药物具有优异的作用。本发明提供由以下通式（I）表示的化合物或其药学上可接受的盐：[其中[化学式2]为单键或双键; A是-CH 2 - 或-CO-; X，Y和Z各自独立地为氮原子或碳原子; R 1是氢原子或芳烷基; R 2是烷基或芳烷基等; R 3为氢原子或烷基等; R 4是氢原子或烷基; R 5为氢原子，烷基或卤代低级烷基等; R 6为氢原子或烷基; R 7是氢原子等; R 8是氢原子或烷基等; 和E是-NHCO-G-COR 12等（其中G是单键或亚烷基，R 12是羟基或烷氧基）]。

66. 发明公开

EP1782944A1 MALLET AND ROTARY COMPRESSION FORMING MACHINE USING THE SAME 有权
标题翻译： Drehformpressmaschine mit einem stem。
公开(公告)号：EP1782944A1
公开(公告)日：2007-05-09
申请号：EP05780912.1
申请日：2005-08-24
申请人： Kikusui Seisakusho Ltd. , SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： HARADA, Kenji , IKAI, Fumiharu , OZEKI, Yuichi, SANWA KAGAKU KENKYUSHO CO., LTD.
IPC分类号： B30B11/08 , B30B11/00
CPC分类号： B30B11/08 , B30B11/34 , B30B15/0023 , B30B15/065 , Y10T83/391 , Y10T83/395
摘要： This invention provides a punch comprising: a center punch and an outer punch surrounding the outer periphery of the center punch, both of which being slidable and capable of compressing; and relative position restriction means for restricting a relative position of the center and outer punches, the relative position restriction means being configured to restrict a first position in which a punch tip of the center punch is protruded from a punch tip of the outer punch and a second position in which the punch tip of the center punch is substantially coincident with the punch tip of the outer punch, and being configured to fail to restrict a third position in which the punch tip of the center punch is retracted in the punch tip of the outer punch, as well as a rotary compression molding machine provided with the double-structured punch.
摘要翻译：本发明提供了一种冲头，其包括：中心冲头和围绕中心冲头的外周的外冲头，两者均可滑动并能够压缩; 以及用于限制中心和外侧冲头的相对位置的相对位置限制装置，相对位置限制装置被构造成限制中心冲头的冲头顶端从外冲头的冲头顶端突出的第一位置和第二位置，其中中心冲头的冲头尖部与外冲头的冲头顶端基本一致，并且构造成不能限制第三位置，其中中心冲头的冲头尖端在其中的冲头顶端中缩回外冲头，以及设置有双结构冲头的旋转压缩成型机。

67. 发明公开

EP1609855A1 PROCESS FOR PRODUCING PLANT STORAGE ORGAN WITH HIGH PRODUCTION OF RECOMBINANT PROTEIN AND NOVEL RECOMBINANT PROTEIN 审中-公开
标题翻译：用于生产蔬菜MEMORY的机构，重组蛋白质和新的重组蛋白的高产
公开(公告)号：EP1609855A1
公开(公告)日：2005-12-28
申请号：EP04723838.1
申请日：2004-03-26
申请人： NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES , NIPPON PAPER INDUSTRIES CO., LTD. , SANWA KAGAKU KENKYUSHO CO., LTD.
发明人： SUGITA, Koichi, Nippon Paper Industries Co., Ltd. , KASAHARA, Saori, Nippon Paper Industries Co., Ltd. , EBINUMA, Hiroyasu, Nippon Paper Industries Co. Ltd , TAKAIWA, Humio , JOMORI, Takahito, Sanwa Kagaku Kenkyusho Co., Ltd. , HAYASHI, Yuji, c/o Sanwa Kagaku Kenkyusho Co., Ltd , TASHITA, Akira, c/o Sanwa Kagaku Kenkyusho Co. Ltd , KOBARA, Yukari, c/o Sanwa Kagaku Kenkyusho Co. Ltd
IPC分类号： C12N15/00 , A01H5/00 , C07K14/605
CPC分类号： C12N15/8257 , C07K14/605 , C12N15/8216
摘要： The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided.
摘要翻译：本发明提供了用于生产高度在贮藏器官的重组蛋白和植物GLP-1衍生物的方法。其中重组蛋白是高度产生的植物贮藏器官通过转化了包含重组蛋白基因，细胞分裂素相关基因，抗药性基因和一个可除去DNA因子，载体的获得，其中细胞分裂素 - 相关基因和抗药基因中的位置存在，因此thatthey可以与DNA元件一起表现，而在植物贮藏器官中过表达重组蛋白存在于位置所以没有它不会连同DNA表现元素。对GLP-1是通过使用该方法生产的，并进一步提供了具有针对酶促消化稳定的衍生物。

69. 发明公开

EP1506777A1 OBESITY PREVENTIVE OR AMELIORATOR CONTAINING METHYLIDENE HYDRAZIDE COMPOUND AS ACTIVE INGREDIENT 审中-公开
标题翻译：剂防止或减少肥胖症一个METHYLIDENHYDRAZID LINK为活动
公开(公告)号：EP1506777A1
公开(公告)日：2005-02-16
申请号：EP03728110.2
申请日：2003-05-20
申请人： Sanwa Kagaku Kenkyusho Co., Ltd.
发明人： TSUBAMOTO, Yoshiharu c/o SANWA KAGAKU KENKYUSHO CO , TASHITA, Akira c/o SANWA KAGAKU KENKYUSHO CO., LTD , KOBARA, Yukari c/o SANWA KAGAKU KENKYUSHO CO., LTD , KAKIGAMI, Takuji c/o SANWA KAGAKU KENKYUSHO CO.,
IPC分类号： A61K31/166 , A61K31/4045 , A61P3/04 , A61P43/00 , C07D209/08
CPC分类号： C07C243/38 , A61K31/166 , A61K31/4045 , C07D209/08 , C07D209/14 , C07D409/06
摘要： The present invention provides a low-molecular inhibitor of GIP functions and, further, an agent for preventing/ameliorating obesity based on inhibition of GIP functions, which comprises, as an active ingredient, a compound represented by the following general formula (I):
(wherein R 1 represents hydrogen, halogen, a nitro group or a cyano group, R 2 and R 3 each represent hydrogen or halogen, hydrogen or a methoxy group, or both R 2 and R 3 may form an optionally substituted benzene or pyrrole ring, and A represents nitrogen or C-R 4 whereupon R 4 represents hydrogen, an optionally substituted C1 to C6 alkyl group, -OR 7 , -NR 8 R 9 , -NHCO-R 10 or -SO 2 -R 11 or may, together with R 3 , form an optionally substituted benzene or pyrrole ring, R 7 , R 8 and R 9 each represent hydrogen or an optionally substituted C1 to C6 alkyl group, R 10 represents a C1 to C6 alkyl group or the like, and R 11 represents an optionally substituted morpholyl group or the like) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供的GIP功能的低分子抑制剂和，进一步，为了防止/基于抑制的GIP的功能，其包含作为活性成分，由下述通式（I）表示的化合物改善肥胖的药剂：（其中，R <1>表示氢，卤素，硝基或氰基，R <2>和R <3>各自表示氢或卤素，氢或甲氧基，或两个R <2>和 [R <3>可形成任选取代的苯环或吡咯环，和A darstellt氮或CR <4>其中一旦ř<4>氢darstellt到任选取代的C1〜C6烷基，-OR <7>，-NR <8 > - [R <9>，-NHCO - [R <10>或-SO 2 -R <11>或可以，其中R <3>，一起形成在OPTIONALLY substituiertem苯或吡咯环，R <7> - [R <8>和 [R <9>各自代表氢或在OPTIONALLY substituiertem C1〜C6烷基，R <10> darstellt C1〜C6的烷基或类似物，且R <11> darstellt到任选substituiertem吗啉基等）或PHA 其rmaceutically上可接受的盐。

70. 发明公开

EP1440790A1 DEVICE FOR PRODUCING MOLDED ARTICLES, AND A MOLDED ARTICLE THAT CAN BE PRODUCED BY SUCH DEVICE 审中-公开
标题翻译：器具，用于产生形体，并通过这样的设备可生产成型
公开(公告)号：EP1440790A1
公开(公告)日：2004-07-28
申请号：EP02760780.3
申请日：2002-08-28
申请人： Sanwa Kagaku Kenkyusho Co., Ltd.
发明人： OZEKI, Yuichi c/o Sanwa Kagaku Kenkyusho Co., Ltd
IPC分类号： B30B11/08 , A61J3/06 , A61J3/10
CPC分类号： A61J3/10 , A61J3/007 , A61J2205/20 , B29C43/36 , B29C2043/3618 , B29C2043/3626 , B30B11/02 , B30B11/06 , B30B11/085
摘要： The present invention provides a manufacturing apparatus which is a rotary press that allows mass production of a molded product consisting of a plurality of molded parts part of whose at least two molded parts faces outside of the molded product, wherein at least the upper punch and preferably both the upper and lower punches is/are split into a plurality of split punches, the rotary press comprising means for moving each of the plurality of split punches and means for allowing manipulation of the plurality of split punches for at least two of compression operations, a first molding material supply-charging unit for supplying and charging a first molding material into a space in the die formed above the tip portion of the lower punch or formed by the tip portions of the split punches of the lower punch, a second molding material supply-charging unit for supplying and charging a second molding material into a space formed above and/or around the first molding material in the die, a precompression molding unit for compression-molding at least one of the molding materials supplied and charged and a main compression molding unit for compression-molding the entire molded product, and as necessary, a residual molding material removal unit for removing residual molding material remaining on the lower punch and/or the temporary molded product. The present invention also provides a molded product whose characters and/or graphics can be externally identified by using molding materials of different colors in the manufacturing apparatus.
摘要翻译：本发明提供的制造装置的所有这是一种轮转印刷机做允许大量生产的模制产品由......组成谁的至少两个成型件的模制零件的一部分的多个的面向所述模制产品的外，worin至少使上冲头和优选上部和下冲头被/被分成分割冲头的复数，所述轮转印刷机包括用于移动每个分割冲头和装置的多个用于允许分割冲头的多个操纵用于至少两个压缩操作，第一成型材料供给充电单元用于供应和一个第一模制材料填充到下冲头的前端部的上方形成或形成在由下冲头的分割冲头的前端部在模具中的空间，一个第二模制材料供给充电单元进行充电和供给第二成型材料到空间的上方形成和/或围绕在模具中的第一模制材料，预对于压缩成型的成型材料提供的至少一个，并且充电和用于压缩成形的整个模制产品的主压缩成型机，并在必要时，用于除去残留在剩余的成型材料的残留成型材料去除单元压缩成型机下冲头和/或临时成型品。本发明因此提供了一模制的产品，其字符和/或图形可在外部IDENTIFIED通过使用不同颜色的模塑材料在制造装置。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式