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61. 发明授权

EP0837641B1 CONTAINER FOR HYPERPOLARIZED NOBLE GASES HAVING A SURFACE COATED WITH A MODIFIED POLYMER 失效
标题翻译：容器超极化稀有气体与改性聚合物涂在表面
公开(公告)号：EP0837641B1
公开(公告)日：2007-11-14
申请号：EP96918293.0
申请日：1996-06-07
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： DRIEHUYS, Bastiaan , HAPPER, William , CATES, Gordon, D., Jr.
IPC分类号： C08G77/12 , C08L83/04 , C09D183/04 , A47G19/22 , B32B1/08 , B32B9/00 , B32B17/06 , B05D3/00
CPC分类号： G01R33/282 , A61K49/1815 , B65D25/14 , C01B23/00 , F17C1/16 , F17C2203/0607 , F17C2221/07 , F17C2270/0536 , Y10T428/1321 , Y10T428/31612
摘要： The invention provides a method of inhibiting surface-induced nuclear spin relaxation and surface trapping of a hyperpolarized noble gas, most preferably Xe, by polymercoated surfaces. The method includes inhibiting the amount of interaction of the noble gas with a polymeric coating on the surface of apparatus which contacts the noble gas. Preferably, the method includes inhibiting noble gas nuclear spin relaxation by replacing at least some of the protons in the polymer with substituents which have non-zero nuclear spin and/or reduced polymer permeability. A preferred substituent having non-zero spin is deuterium. A preferred modification which reduces permeability includes introducing into the polymer a substituent such as a halogen, more preferably fluorine. The method also provides containers having surfaces which have been coated with a polymer which inhibits noble gas trapping and nuclear spin relaxation. Furthermore, the invention provides methods for enhancing the production and storage of a hyperpolarized noble gas by decreasing the relaxation of nuclear spin and limiting the trapping of the noble gas in a polymeric coating of apparatus containing the noble gas.

62. 发明公开

EP1816423A2 High volume hyperpolarizer for spin-polarized noble gas 失效
标题翻译：超声波发生器，旋转波纹管Edelgas Durchsatzfürspinpolarisiertes Edelgas
公开(公告)号：EP1816423A2
公开(公告)日：2007-08-08
申请号：EP07008501.4
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Cates, Gordan D., Jr. , Driehuys, Bastiaan , Happer, William , Saam, Brian , Walter, Daniel , Middleton, Hunter , Miron, Eli
IPC分类号： F25J1/00 , A61K49/00 , A61K49/18
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subject through magnetic resonance imaging (MRI) techniques.
摘要翻译：一种用于超极化129 Xe的方法，包括：靶极气中的超极化129 Xe，其特征在于，所述气体包括：a）荧光猝灭气体，用于淬灭碱金属荧光; b）缓冲气体，用于对碱金属原子的光吸收光谱，以及c）至少含有同位素丰度的129 Xe的氙; 在足以通过与碱金属原子的自旋交换诱导所述129Xe的超极化的条件下，由此提供超极化的129Xe。

63. 发明公开

EP1697968A2 TWO-COMPONENT, RECTIFYING-JUNCTION MEMORY ELEMENT 审中-公开
标题翻译：由两个部分组成同一方向上的屏障存储器元件
公开(公告)号：EP1697968A2
公开(公告)日：2006-09-06
申请号：EP04812301.2
申请日：2004-11-26
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： SMITH, Shawn , FORREST, Stephen, R.
IPC分类号： H01L21/00
CPC分类号： H01L51/0587 , B82Y10/00 , G11C13/0009 , G11C13/0014 , G11C13/0016 , G11C17/16 , G11C2213/72 , G11C2216/26 , H01L27/285 , H01L51/0037
摘要： Embodiments of the present invention are directed to low complexity, efficient, two-component memory elements for use in low-cost, robust, and reliable WORM memories. The memory element of one embodiment is an organic-on-inorganic heterojunction diode comprising an organic-polymer layer joined to a doped, inorganic semiconductor layer. The organic polymer layer serves both as one later of a two-later, semiconductor-based diode, as well as a fuse. Application of a voltage greater than a threshold WRITE voltage for a period of time greater than a threshold time interval for a WRITE-voltage pulse irreversibly and dramatically increases the resistivity of the organic polymer layer. The memory element that represents one embodiment of the present invention is more easily manufactured than previously described, separate-fuse-and-diode memory elements, and has the desirable characteristics of being switchable at lower voltages and with significantly shorter-duration WRITE-voltage pulses than the previously described memory elements.

64. 发明公开

EP1692788A2 ALL-OPTICAL, 3R REGENERATION USING THE SAGNAC AND MACH-ZEHNDER VERSIONS OF THE TERAHERTZ OPTICAL ASYMMETRIC DEMULTIPLEXER (TOAD) 审中-公开
标题翻译：一贯OPTICAL 3R再生USING OPTICAL ASYMMETRIC太赫兹解复用器萨格纳克及马赫 - 曾德尔的版本（TOAD）
公开(公告)号：EP1692788A2
公开(公告)日：2006-08-23
申请号：EP04813760.8
申请日：2004-12-09
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： PRUCNAL, Paul, R. , WANG, Bing, C.
IPC分类号： H04B10/02 , H04B10/12 , H04B10/16 , H04B10/20
CPC分类号： H04B10/299
摘要： A system and method for regenerating optical signals comprising a clock recovery circuit coupled to a transmission line, a first optical gating device having an input port coupled to the transmission line and a clock port coupled to the clock recovery circuit, and a second optical gating device having an input port coupled to a continuous wave (CW) laser and a clock port coupled to the output of the first optical gating device, wherein the optical gating devices may be terahertz optical asymmetric demultiplexers (TOADs).

65. 发明公开

EP1665481A2 ALL-OPTICAL WAVELENGTH CONVERTER BASED ON SAGNAC INTERFEROMETER WITH AN SOA AT ASYMMETRIC POSITION 审中-公开
标题翻译： PURE光波长转换器基于WITH A SOA在不对称位置的萨格纳克干涉仪
公开(公告)号：EP1665481A2
公开(公告)日：2006-06-07
申请号：EP04788559.5
申请日：2004-09-02
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： PRUCNAL, Paul, R. , GLESK, Ivan , XU, Lei , BABY, Varghese
IPC分类号： H01S1/00
CPC分类号： G02F1/3519 , G02B6/2861
摘要： According to at least one embodiment, a system comprises a Sagnac interferometric loop and a semiconductor optical amplifier (SOA) located at an asymmetric position on that loop, wherein the Sagnac interferometric loop and the SOA are operable to perform signal conversion on an input signal.

66. 发明公开

EP1636023A1 CARRIER APPLIED COATING LAYERS 审中-公开
标题翻译：载体应用涂层
公开(公告)号：EP1636023A1
公开(公告)日：2006-03-22
申请号：EP04756014.9
申请日：2004-06-23
申请人： PRINCETON UNIVERSITY
发明人： SCHWARTZ, Jeffrey , ALVATRONI, Michael, J. , DANAHY, Michael, P. , SILVERMAN, Brett, M.
IPC分类号： B32B15/04 , B32B18/00 , B05D3/02
CPC分类号： C23C22/48 , B05D1/28 , B05D3/02 , B05D2201/00 , B05D2202/35 , B05D2350/63 , C03C17/001 , C03C17/23 , C23C22/02
摘要： The present invention provides a process for providing on the surface of a substrate an adherent phosphorous acid-based coating layer, the method comprising contacting said surface with a carrier conveying a coating composition comprising an acid selected from the group consisting of phosphoroic acids, organo-phosphoric acids, phosphonic acids, and mixtures thereof, at a sufficient temperature and for a sufficient time to bond at least a portion of the acid in the composition to the oxide surface.
摘要翻译：本发明提供了一种在基材表面上提供粘附性亚磷酸基涂层的方法，所述方法包括使所述表面与载体接触，所述载体传送包含选自磷酸，有机 - 磷酸，膦酸及其混合物在足够的温度下和足够的时间将组合物中的酸的至少一部分结合到氧化物表面。

67. 发明公开

EP1587636A4 CONDUCTIVE-POLYMER ELECTRONIC SWITCH 审中-公开
标题翻译：导电性高分子电子开关
公开(公告)号：EP1587636A4
公开(公告)日：2006-03-15
申请号：EP04706562
申请日：2004-01-29
申请人： PRINCETON UNIVERSITY OFFICE OF
发明人： MOELLER SVEN , FORREST STEPHEN
IPC分类号： G11C13/02 , H01L27/28 , H01L51/00 , H01L51/30
CPC分类号： G11C13/0014 , B82Y10/00 , G11C13/0016 , H01L27/28 , H01L51/0037 , Y10T428/31504 , Y10T428/31678 , Y10T428/31855
摘要： A switch, used as an electronic-memory element, comprising a conductive organic polymer layer (819) sandwiched between, and in contact with, two metallic conductive elements (802-806 and 810-813). In an initial post-fabrication state, the organic polymer layer is relatively highly conductive, the post-fabrication constituting a first stable state of the memory element that can serve to represent a binary bit “1” or “0,” depending on which of two possible encoding conventions is employed. A relatively high voltage pulse can be passed between the two metal conductive elements, resulting in a market decrease in the current-carrying capacity of the organic polymer layer sandwiched between the two conductive elements. This change in conductivity of the organic polymer layer is generally irreversible, and constitutes a second stable state of the memory element that may be used to encode a binary bit '0' or '1'. Organic-polymer-based memory elements, modified to include an additional diode-acting layer (818), may be fabricated in dense, two-dimensional arrays.

68. 发明公开

EP1607481A1 Engineered protein kinases which can utilize modified nucleotide triphosphate substrates 失效
标题翻译： VeränderteProteinkinasen，die modifizierte nukleotidtriphosphat Substrate verwendenkönnen
公开(公告)号：EP1607481A1
公开(公告)日：2005-12-21
申请号：EP04076255.1
申请日：1998-02-09
申请人： PRINCETON UNIVERSITY
发明人： Shokat, Kevan M.
IPC分类号： C12N15/52 , C12N9/12 , G01N33/50 , A61K38/45
CPC分类号： C12N9/1205 , A61K38/00 , C12Q1/48 , C12Q1/485 , G01N33/573
摘要： Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified substrates to identify which protein substrates the kinases act upon, to measure the extent of such action, and to determine if test compounds can modulate such action. Also engineered forms of multi-substrate enzymes which covalently attach part or all of at least one (donor) substrate to at least one other (recipient) substrate, which engineered forms will accept modified substrates that are not as readily utilized by the wild-type forms of those enzymes. Methods for making and using such engineered enzymes. Modified substrates and methods of making and using them. Methods for using such engineered enzymes and such modified substrates to identify the recipient substrates the enzymes act upon, to measure the extent of such action, and to measure whether test compounds modulate such action.
摘要翻译：可利用不被野生型形式的这些酶所容易利用的修饰的三磷酸核苷酸底物的工程化蛋白激酶，以及制备和使用它们的方法。修饰的三磷酸核苷底物及其制备和使用方法。使用这种工程化激酶和这种修饰的底物以鉴别激酶作用于哪种蛋白质底物的方法，以测量这种作用的程度，以及确定测试化合物是否可以调节这种作用。还将工程化形式的多底物酶共价连接至少一种（供体）底物的部分或全部至少一种其它（受体）底物，其工程化形式将接受未被野生型使用的修饰底物这些酶的形式。制备和使用这些工程化酶的方法。改性底物及其制备和使用方法。使用这些工程化酶和这种修饰的底物以鉴定酶作用于受体底物的方法，以测量这种作用的程度，以及测量测试化合物是否调节这种作用。

69. 发明授权

EP1025430B1 OPTICAL RESONATOR FOR CAVITY RING-DOWN SPECTROSCOPY WITH PRISM RETROREFLECTORS 有权
标题翻译：光学谐振腔与PRISM复古反射器的腔降光谱法
公开(公告)号：EP1025430B1
公开(公告)日：2005-02-02
申请号：EP98948539.6
申请日：1998-09-25
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： LEHMANN, Kevin, K. , RABINOWITZ, Paul
IPC分类号： G01N21/39 , G01N21/03 , G02B5/04
CPC分类号： G01J3/42 , G02B5/04 , G02B5/12

70. 发明公开

EP1495294A1 METHOD AND APPARATUS FOR ENHANCED EVANESCENT FIELD EXPOSURE IN AN OPTICAL FIBER RESONATOR FOR SPECTROSCOPIC MEASUREMENT OF TRACE SPECIES 审中-公开
标题翻译：的方法和设备具有增强的渐逝波围绕光纤谐振器微量元素的光谱测量。
公开(公告)号：EP1495294A1
公开(公告)日：2005-01-12
申请号：EP02799337.7
申请日：2002-12-30
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： LEHMANN, Kevin K. , TARSA, Peter B. , RABINOWITZ, Paul
IPC分类号： G01J3/42 , G01N21/55
CPC分类号： G01N21/39 , G01J3/42 , G01N21/552 , G01N2021/391 , G01N2021/7789
摘要： An apparatus for detection and measurement of trace species in a gas or liquid sample. A sensor of a ring down cell formed from an optical fiber is exposed to the sample gas or liquid. A coherent source emits radiation into the optical fiber loop, which in turn is received at an output coupler. The fiber optic ring is coupled to a sensor which has a portion thereof, between the input and output, exposed to the sample gas or sample liquid. The sensor has an enhanced evanescent region. A processor is coupled to the receiver and determines the level of trace species in the gas or liquid sample based on the rate of decay of the radiation within the fiber optic ring.

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