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61. 发明授权

EP1390524B1 MILIEUX DE DETECTION SPECIFIQUE DE STAPHYLOCOCCUS AUREUS ET PROCEDES D'IDENTIFICATION ET/OU DE DENOMBREMENT UTILISANT DE TELS MILIEUX 有权
标题翻译：具体的检测介质金黄色葡萄球菌和鉴定和/或使用所述计数法检测MEDIA
公开(公告)号：EP1390524B1
公开(公告)日：2006-10-11
申请号：EP02757748.5
申请日：2002-03-29
申请人： Biomerieux S.A.
发明人： COTTE, Christine , ORENGA, Sylvain , RE, Andréa , ROBICHON, Denis
IPC分类号： C12Q1/14 , C12Q1/34
CPC分类号： C12Q1/34 , C12Q1/045 , G01N2333/31 , G01N2333/924
摘要： The invention concerns a medium for specific detection of Staphylococcus aureus - and/or discrimination between positive-coagulase Staphylococcus and negative-coagulase enabling Staphylococcus to isolate bacteria of the genus staphylococcus and identify the Staphylococcus aureus species, which use at least an enzymatic substrate, preferably a chromogenic or fluorescent agent, and still more preferably consisting of an indoxyl or naphthol base. The invention also concerns a method for identifying, and optionally counting, Staphylococcus aureus using such a medium. It consists of a Staphylococcus aureus culture medium and at least an enzymatic substrate enabling testing of an alpha -glucosidase activity. The invention is particularly applicable in the field of diagnosis.

62. 发明授权

EP1295125B1 TEST IMMUNOLOGIQUE ET KIT DE DIAGNOSTIC D'UN ADENOCARCINOME DE LA PROSTATE 有权
标题翻译：于诊断PROSTATADENOKARZINOM的免疫分析试剂盒
公开(公告)号：EP1295125B1
公开(公告)日：2006-05-17
申请号：EP01945401.6
申请日：2001-06-12
申请人： Biomerieux S.A.
发明人： CHARRIER, Jean-Philippe
IPC分类号： G01N33/574
CPC分类号： G01N33/57434
摘要： The invention concerns an analysis method for diagnosing a prostate adenocarcinoma or a benign prostatic hypertrophy in a male patient, not involving prostate biopsy, using the combination of at least a tissue marker (PSA) and at least an inflammation marker (ACT) for the diagnosis. The invention also concerns a process using said method, an immunological test for implementing such a method and a diagnostic kit. The invention is applicable to the diagnosis of prostatic adenocarcinoma or benign prostatic hypertrophy.

63. 发明授权

EP1483374B1 UTILISATION DE L-ALPHA-LYSOPHOSPHATIDYLCHOLINE POUR OBTENIR LA DIFFERENCIATION DE MONOCYTES EN CELLULES DENDRITIQUES MATURES IN VITRO 有权
标题翻译： L-ALPHA LIPOPHOSPHATIDYLCHOLINE用于体外轮胎中树突状细胞分化的单核细胞USE
公开(公告)号：EP1483374B1
公开(公告)日：2006-05-10
申请号：EP03725275.6
申请日：2003-03-07
申请人： BIOMERIEUX , Institut National de la Santé et de la Recherche Médicale
发明人： LOTTEAU, Vincent , ANDRE, Patrice
IPC分类号： C12N5/08 , C12N5/02 , A61K39/00 , A61K31/66 , A61P31/00 , A61P35/00 , A61P29/00
CPC分类号： A61K31/4439 , A61K9/0019 , A61K47/10 , A61K47/24
摘要： The invention relates to a method for in vivo differentiation of monocytes in mature dendritic cells, wherein a) monocytes are provided in an appropriate culture medium, b) the monocytes are differentiated in dendritic cells in the presence of a differentiation factor, c) L-α-lysophosphatidylcholine is added to the medium and mature dendritric cells are obtained. The invention also relates to the use of at least one inhibitor of L-α-lysophosphatidylcholine in the production of a medicament for the prevention of an inflammation and/or in order to combat an inflammatory disease and/or autoimmune disease.

64. 发明公开

EP1637139A2 Nouvelle utilisation de composés inhibiteurs de la protéase du VIH 审中-公开
标题翻译：抑制HIV蛋白酶的化合物的新用途
公开(公告)号：EP1637139A2
公开(公告)日：2006-03-22
申请号：EP05028334.0
申请日：1999-06-11
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , BIOMERIEUX
发明人： Andre, Patrice , Lotteau, Vincent , Zinkernagel, Rolf , Klenerman, Paul , Groettrup, Marcus
IPC分类号： A61K31/427 , A61K31/4725 , A61P43/00 , A61P37/06 , A61P31/12
CPC分类号： A61K31/427 , A61K31/4725
摘要： Cette invention concerne l'utilisation d'au moins un composé inhibiteur de la protéase du virus de l'immunodéficience humaine (VIH) choisi parmi le ritonavir, le saquinavir, ou un de leurs sels pharmaceutiquement acceptables, en association avec un véhicule pharmaceutiquement acceptable, pour la fabrication d'un médicament destiné à moduler le protéasome.
摘要翻译：本发明涉及从利托那韦，沙奎那韦选择的使用HIV（艾滋病毒）中的至少一种化合物蛋白酶抑制剂，或其药学上可接受的盐，与药学上可接受的载体结合，用于制造调节蛋白酶体的药物。

65. 发明授权

EP1404817B1 UTILISATION DE LIPOPROTEINES OXYDEES POUR OBTENIR LA DIFFERENCIATION DE CELLULES PRECURSEUR EN CELLULES DENDRITIQUES MATURES 有权
标题翻译：使用氧化脂蛋白易制毒化学细胞在成熟树突状细胞分化
公开(公告)号：EP1404817B1
公开(公告)日：2006-03-22
申请号：EP02784858.9
申请日：2002-07-08
申请人： BIOMERIEUX , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： LOTTEAU, Vincent , ANDRE, Patrice
IPC分类号： C12N5/08 , A61K39/00 , A61P31/00 , A61P35/00
CPC分类号： C12N5/0639 , A61K2039/5154 , C12N2500/36
摘要： The invention concerns the use of at least a fraction of oxidised (VLDL oxidised and/or IDL oxidised and/or LDL oxidised) lipoproteins for differentiating precursor cells into mature dendritic cells. The precursor cells are preferably monocytes. The invention also concerns a method for differentiating precursor cells into mature dendritic cells which consists in placing the precursor cells in a medium suitable for their differentiation and adding to said medium, in a predetermined amount, at least a fraction of oxidised lipoproteins selected among VLDL oxidised and/or IDL oxidised n and/or LDL oxidised lipoproteins. The precursor cells are preferably monocytes.

66. 发明公开

EP1627233A1 SYSTEME DE CONTROLE DE LA TEMPERATURE AU SEIN D'UN AUTOMATE D'ANALYSE BIOLOGIQUE 有权
标题翻译：系统在温度控制在生物分析仪的
公开(公告)号：EP1627233A1
公开(公告)日：2006-02-22
申请号：EP04742872.7
申请日：2004-05-19
申请人： BIOMERIEUX
发明人： BIANCALANI, Maurizio , ALUNNI, Giovanni , RICCI, Gabriele
IPC分类号： G01N35/02
CPC分类号： G01N21/03 , G01N21/76 , G01N35/0098 , G01N35/025 , G01N35/026 , G01N2035/00435
摘要： The invention relates to a system for temperature control within an automatic biological analyser, the automatic machine essentially comprising: support, guidance and step-by-step transport means for reaction cuvettes on a path comprising a pre-determined number of positions, a support turntable for analyte samples, a support turntable for reactants, means for taking fixed quantities of samples and reactants and injection of the same into reaction cuvettes, means for washing cuvettes, means for optical reading of dosing results and a computer control system which permits carrying out pre-programmed analysis cycles. The invention consists in the association of the temperature control system with the lower part of the support turntable for the analyte samples, said system comprising therein, at least one inlet air deflector (2), at least one outlet air deflector (3), a circular air transfer path (4) positioned between the inlet deflector (2) and the outlet deflector (3) and means for generating circulating air in the circular path (4), which permits a reduction in the thermal variation between the temperatures of the inlet air and the outlet air within the temperature control system. The invention preferably is applied in the diagnostics field.

67. 发明公开

EP1621890A1 Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods 审中-公开
标题翻译：装置和用于分离，混合和浓缩的磁性粒子与液体的方法，以及它们在清洁方法的使用
公开(公告)号：EP1621890A1
公开(公告)日：2006-02-01
申请号：EP04077153.7
申请日：2004-07-26
申请人： bioMerieux B.V.
发明人： Kreuwel, Hermannus Johannes Maria , Verwimp, Emiel Gerebern Maria , Beerling, Bernardus Jozef Maria , Spee, Franciscus Gerardus
IPC分类号： G01N35/00 , B01L3/00 , C12Q1/68
CPC分类号： B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2300/0858 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N35/0098
摘要： The present invention is related to a process for manipulating magnetic particles that are suspended in a fluid, possibly containing a biological entity of interest, the magnetic particles being able to bind the entity of interest, the fluid being contained in a reaction vessel constituted by a large upper compartment with a funnel shape, an elongate lower compartment with a substantially constant cross-section and a closed base.
The process consists of:

a) subjecting the magnetic particles to two magnetic fields applied simultaneously to separate all said magnetic particles present in at least the upper compartment of the vessel from the fluid,
b) transferring the separated magnetic particles from the upper compartment to the elongated lower compartment,
c) removing the fluid from the vessel,
d) adding a washing liquid to the lower compartment),
e) subjecting the rest of the fluid to at least two magnetic fields applied successively with different and changing directions to wash all the magnetic particles present in the lower compartment, and

concentrating said magnetic particles in said lower compartment.
The according to the present invention are especially useful in methods for the extraction of nucleic acid to enable them for further processing.
摘要翻译：本发明涉及一种处理用于操纵磁性颗粒没有悬浮在流体，可能含有感兴趣的生物实体，能够对感兴趣的实体结合磁性颗粒，流体被包含在由构成的反应容器有漏斗形状大上部隔室到细长下部隔室具有基本上恒定的横截面和一个封闭的底部。该方法的besteht：a）使磁性粒子以同时应用的两个磁场来分离所有的所述磁性粒子的至少从流体，B）传递环存在于容器的上隔室从上部隔室的分离的磁性粒子细长的下部隔室，c）从容器中移除流体，d）将洗涤液到下隔室）中，e）使流体的剩余部分的至少两个磁场依次用不同和变化的方向施加到洗所有的存在于所述下部隔室的磁性粒子，和€ƒ€ƒ€ƒ浓缩所述在所述磁性颗粒下部隔室。所述gemäß到本发明是在用于核酸的提取，以使它们进行进一步的处理方法的爱特别有用。

68. 发明公开

EP1621530A1 Procédés, compositions et substrats enzymatiques pour la détection de pseudomonas aeruginosa 审中-公开
标题翻译： Verfahren，Zusammensetzungen und Enzymsubstraten zum Nachweis von Pseudomonas Aeruginosa
公开(公告)号：EP1621530A1
公开(公告)日：2006-02-01
申请号：EP05020919.6
申请日：2000-12-06
申请人： BIOMERIEUX SA
发明人： Desmonceaux, Mireille , Monget, Daniel
IPC分类号： C07C237/20 , C12Q1/37 , C12Q1/04
CPC分类号： C12Q1/04 , C07C237/04 , C07D209/40 , C07D311/16 , C12Q1/37 , C12Q2326/90 , C12Q2337/10 , C12Q2337/12 , C12Q2337/22 , C12Q2337/30
摘要： La présente invention concerne un substrat enzymatique constitué d'une partie cible et d'une partie marqueur, l'hydrolyse du substrat permettant la séparation de la partie cible et de la partie marqueur, ladite partie cible caractérisant l'activité enzymatique recherchée. Elle concerne également une composition contenant au moins un tel substrat, ainsi qu'un procédé de détection de l'espèce bactérienne Pseudomonas aeruginosa .
La partie cible du substrat permet de révéler une activité enzymatique β-alanine aminopeptidase et la partie marqueur est une molécule révélant la réaction d'hydrolyse.
L'invention trouve une application préférentielle dans le domaine du diagnostic.
摘要翻译：一种酶底物（I），其包含：（a）指示至少一种绿脓假单胞菌的β-丙氨酸氨肽酶（bAAP）活性的目标部分（Ia）;和（b）指示水解发生的标记物（Ib）是新的。还包括以下独立权利要求：（1）用于检测至少一种（I）和培养基的至少一种菌株和/或微生物种类的组合物; （2）检测（M1）铜绿假单胞菌，使用至少一种可检测bAPP活性的底物和检测任何有色和/或荧光反应产物的培养试验样品。

70. 发明公开

EP1616168A1 BIOPUCE A ZONES DE RECONNAISSANCE ET FORMAT OPTIQUE INDEPENDANTS ET SA LECTURE FLOTTANTE 有权
标题翻译：与独立的承认领域和光学格式和浮扫描生物芯片THEREOF
公开(公告)号：EP1616168A1
公开(公告)日：2006-01-18
申请号：EP04742848.7
申请日：2004-04-21
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , BIOMERIEUX SA
发明人： POUTEAU, Patrick , BEC, Daniel , LE BRUN, Stéphane
IPC分类号： G01N21/25 , G01N21/64 , B01L3/00
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456
摘要： The invention concerns a biochip comprising a plurality of molecular recognition areas distributed in a specific arrangement to constitute a format of molecular recognition areas and means for optically localizing the positioning of each molecular recognition area, distributed in a specific arrangement to constitute an optical format. The optical format and the format of the recognition areas are formats provided independently of each other, means for determining the relative position of the two formats being provided on the biochip. The invention also concerns a device for scanning such a biochip.

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