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    • 62. 发明公开
    • NON-INVASIVE METHOD TO MONITOR MICROCIRCULATION
    • 无创的用于监控微循环
    • EP1737339A1
    • 2007-01-03
    • EP05733811.3
    • 2005-04-18
    • Wheelsbridge AB
    • NILSSON, GertSJÖBERG, Folke
    • A61B5/026
    • A61B5/0261
    • This invention relates to the non-invasive determination of the degree of vasoactivity in the microcirculation in a tissue caused by a drug, disease, injury normal or pathological regulation. More specifically, the invention relates to a method of determining the influence on microcirculation in living tissue from an irritative agent, drugs, disease, injuries normal or pathological regulation including, illuminating a tissue surface with polarized light, collecting the backscattered light through a polarizing filter, detecting the backscattered and polarized light by a photo-sensitive array, transferring the collected information in digital form to a computing device, separating the collected information into at least two data matrixes, each representing a specific wavelength range and generating an output data matrix by processing corresponding values in at least two data matrixes by an algorithm, wherein each value in said output data matrix represents the amount of influence on the microcirculation in a source point of the tissue. Thereby a representation of the tissue microcirculation is obtained.
    • 63. 发明公开
    • ASSAY DEVICE AND METHOD
    • 测定装置和方法
    • EP1732690A2
    • 2006-12-20
    • EP05722264.8
    • 2005-03-23
    • Amic AB
    • BERGMAN, DavidMENDEL-HARTVIG, IbUHRBERG, Simon
    • B01L3/00
    • B01L3/50273B01J20/28014B01L3/502746B01L3/502753B01L3/502761B01L2200/0668B01L2300/0681B01L2300/0825B01L2300/087B01L2300/161B01L2400/0406B01L2400/0439B01L2400/086G01N33/54386
    • A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.
    • 一种用于在检测所述样品中的分析物之前分离液体样品中的组分的装置和方法,其中样品被添加到基板上的接收区域,所述基板进一步可选地包括反应区域,运输或 培养区分别连接接收区和反应区,在基底上形成流动路径,其中所述基底是无孔基底,并且所述流动路径的至少一部分由基本上垂直于所述表面的突起区域构成,并且具有 (H),直径(D)和倒数间距(t1,t2),以便实现所述液体样品在所述区域中的侧向毛细管流动,并且其中在用于接收样品的区域附近提供用于分离的装置。 所述用于分离的装置选自过滤装置,任选地通过亲和结合和/或聚集增强; 磁性手段,也可选地通过亲和力结合和/或聚集增强; 和声学手段。