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61. 发明公开

EP1507531A2 STABLE PHARMACEUTICAL COMPOSITIONS OF DESLORATADINE 无效
标题翻译：稳定的药物组合物氯雷他定
公开(公告)号：EP1507531A2
公开(公告)日：2005-02-23
申请号：EP04720451.6
申请日：2004-03-12
申请人： BIOGAL GYOGYSZERGYAR RT.
发明人： TOTH, Zoltan G. , GYOLLAI, Viktor , KOVACSNE-MEZEI, Adrienne , SZABO, Csaba , ARONHIME, Judith , SINGER, Claude
IPC分类号： A61K31/4545 , A61P37/06
CPC分类号： C07D401/04 , A61K31/4545
摘要： Provided is a stable pharmaceutical composition of desloratadine.

62. 发明公开

EP1468002A2 COORDINATION COMPLEX 有权
标题翻译：配合物
公开(公告)号：EP1468002A2
公开(公告)日：2004-10-20
申请号：EP03700887.7
申请日：2003-01-16
申请人： Imperial College Innovations Limited
发明人： MARSHALL, Edward , SEGAL, John , GIBSON, Vernon, Charles
IPC分类号： C07F3/00 , C07F3/02
CPC分类号： C07F3/02 , C07F3/003
摘要： The present invention provides a complex of formula (I) wherein M is Ca, Mg, Ba or Sr; L1 is selected from R1O, R2S, R3R4N, R5R6P, a substituted or unsubstituted cyclopentadienide, and a substituted or unsubstituted pyrazolyl group, where R1-6 are each independently H or hydrocarbyl; L2 is selected from R7R8O, R7R8S, R7R8R9N, R7R8C=NR9, PR7R8R9, and a substituted or unsubstituted heterocycle containing one or more O, N or S atoms, Where R7-9 are each independently H or a hydrocarbyl group; or L1 and L2 are linked to form a bidentate ligand; L3 is absent or is a solvent molecule, or a neutral ligand as defined for L2 , wherein L3 may be the same or different to L2; or L3 is linked to a further metal center ; or L1, L2 and L3 are linked to form a tridentate ligand; and X is an alkyl group , an aryl group, an aryloxide, an amide group, or an enolate group of formula R10 R11C=CR12O- , wherein R10-12 are each independently H or hydrocarbyl; with the proviso that when L1 and L2 are {HC(C(CH3 )=N-2,6-iPr2C6H3 )2} and M is magnesium , X is other than Me or tBu.

63. 发明公开

EP1465601A2 A STABLE PHARMACEUTICAL FORMULATION OF PAROXETINE HYDROCHLORIDE ANHYDROUS AND A PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：稳定的药物制剂PAROXETINHYDROCHLORIDANHYDRID和方法及其
公开(公告)号：EP1465601A2
公开(公告)日：2004-10-13
申请号：EP02794423.0
申请日：2002-12-27
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人： FOX, Michael , COHEN, Rakefet , BRAUNSTEIN, Anne , LEIBOVICI, Minutza
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： A61K9/2886 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/4525
摘要： Provided are formulations of a stable commercial paroxetine tablet comprising paroxetine hydrochloride anhydrous, povidone, copovidone or HPMC as a binder, and an HCI free/non-hygroscopic filler, prepared by the wet granulation method.

64. 发明公开

EP1373253A1 INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT 有权
标题翻译：细胞周期蛋白依赖性激酶为手段对抗癌症抑制剂
公开(公告)号：EP1373253A1
公开(公告)日：2004-01-02
申请号：EP02718319.3
申请日：2002-03-26
申请人： Cyclacel Limited
发明人： FISCHER, Peter, Martin , WANG, Shudong , WOOD, Gavin
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04
摘要： The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferation disorders such as cancer, leukaemia, psoriasis and the like.

65. 发明公开

EP1334779A1 Method for modifying surfaces with ultra thin films 失效
标题翻译：用超薄膜修饰表面的方法
公开(公告)号：EP1334779A1
公开(公告)日：2003-08-13
申请号：EP03004401.0
申请日：1997-11-21
申请人： nanoFILM, Ltd.
发明人： Singh, Brij P. , Arora, Pramod K.
IPC分类号： B05D1/18
CPC分类号： B82Y30/00 , B05D1/185 , B05D7/16 , B82Y40/00 , Y10T428/31663
摘要： A faster and more efficient method for applying ultra thin films to substrate surfaces is disclosed. The method comprises heating a film forming composition comprising amphiphilic molecules to a liquid state, immersing the substrate surface in the heated liquid composition to heat the surface, and washing away the excess composition. For surfaces that ordinarily have insufficient or no chemical moieties reactive with the amphiphilic molecules, the immersion in the heated composition causes the substrate to become porous and expose previously unavailable chemically reactive moieties in the surface matrix. The amphiphilic molecules then self-assemble, chemically bond to the surface matrix and self-polymerize with each other and with other surface matrix-bound and/or surface-bound molecules to form the ultra thin surface film. The method is also faster and more efficient for coating non porous and metal surfaces.
摘要翻译：公开了一种更快和更有效的将超薄膜应用于基材表面的方法。该方法包括将包含两亲分子的成膜组合物加热至液态，将该基底表面浸入加热的液体组合物中以加热该表面，并洗去过量的组合物。对于通常不具有足够或不具有与两亲性分子反应的化学部分的表面而言，浸入加热的组合物中导致基材变得多孔并且暴露表面基质中先前不可用的化学反应性部分。两亲分子然后自组装，化学键合到表面基质并且彼此自身聚合并与其他表面基质结合和/或表面结合分子自聚，形成超薄表面膜。该方法对于涂布无孔和金属表面也更快且更高效。

66. 发明公开

EP2895465A1 PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF 有权转让
标题翻译： PARASITIZIDE ZUSAMMENSETZUNGEN MIT BENZIMIDAZOLDERIVATEN，VERFAHREN UND VERWENDUNGEN DAVON
公开(公告)号：EP2895465A1
公开(公告)日：2015-07-22
申请号：EP13719345.4
申请日：2013-04-18
申请人： Merial Limited
发明人： MENG, Charles, Q.
IPC分类号： C07D235/10 , C07D235/18 , C07D235/28 , A01N43/52 , A61K31/4184
CPC分类号： C07D235/28 , A61K31/277 , A61K31/4184 , A61K45/06 , C07D235/08 , C07D235/10 , C07D235/18 , C07D405/04 , C07D405/10 , C07D409/04 , C07D409/10
摘要： The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.
摘要翻译：本发明涉及用于对抗哺乳动物中的肝吸虫寄生虫的口服，局部或可注射的组合物，其包含至少一种苯并咪唑衍生物活性剂。本发明还提供了用于消除和控制哺乳动物的肝吸虫寄生虫感染和侵染的改进方法，其包括将本发明的组合物施用于有需要的哺乳动物。

67. 发明授权

EP2459569B1 INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE 失效转让
标题翻译：杀虫剂4-氨基噻吩并[2,3-D] -PYRIMIDINVERBINDUNGEN AND其生产和使用
公开(公告)号：EP2459569B1
公开(公告)日：2015-07-22
申请号：EP10745045.4
申请日：2010-07-29
申请人： Merial, Inc.
发明人： SOLL, Mark, David , MENG, Charles, Q. , POHLMAN, Matthias , BAUMANN, Ernst , PAULINI, Ralph
IPC分类号： C07D495/04 , A01N43/90 , A01P7/00
CPC分类号： C07D495/04 , A01N43/90 , A01N47/02

69. 发明公开

EP2838915A1 SOLID PHASE PEPTIDE SYNTHESIS OF INSULIN USING SIDE CHAIN ANCHORED LYSINE 有权转让
标题翻译：蛋白酶抑制剂胰岛素去氧胆碱酯酶
公开(公告)号：EP2838915A1
公开(公告)日：2015-02-25
申请号：EP13726299.4
申请日：2013-04-19
申请人： Barlos, Kleomenis K.
发明人： Barlos, Kleomenis K.
IPC分类号： C07K14/62 , C07K1/04
CPC分类号： C07K14/62 , C07K1/042 , Y02P20/55
摘要： The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis.
摘要翻译：本申请公开了使用有效的固相和溶液相肽合成方法制备肽，包括胰岛素和胰岛素衍生物。

70. 发明公开

EP2794565A1 HEPATITIS B ANTIVIRAL AGENTS 失效
标题翻译：肝炎B-VIRUZIDE
公开(公告)号：EP2794565A1
公开(公告)日：2014-10-29
申请号：EP12859684.8
申请日：2012-12-21
申请人： Novira Therapeutics Inc.
发明人： HARTMAN, George D. , FLORES, Osvaldo A.
IPC分类号： C07D211/54 , C07D241/18 , A61K31/435 , A61P31/12
CPC分类号： C07D401/06 , A61K31/167 , A61K31/18 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/536 , A61K31/5375 , A61K31/551 , A61K31/675 , A61K31/7072 , A61K38/21 , A61K45/06 , C07C311/46 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/48 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/50 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/96 , C07D213/74 , C07D213/82 , C07D265/30 , C07D265/32 , C07D295/195 , C07D295/26 , C07D401/12 , A61K2300/00
摘要： The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

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