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61. 发明公开

EP0706836A1 Sifter frame for powder particle sifter 失效
标题翻译：筛粉机框架用于粉末筛分机
公开(公告)号：EP0706836A1
公开(公告)日：1996-04-17
申请号：EP94308333.7
申请日：1994-11-11
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Hosokoshi, Yasunobu, 1-3-12-1106 , Maruo, Toshio, c/o Nisshin Flour M. Co., LTD , Sakata, Yasuaki, c/o Nisshin Flour M. Co., LTD , Morita, Katsumasa, c/o Nisshin Flour M. Co., LTD , Ibori, Takefumi, c/o Nisshin Flour M. Co., LTD , Kubota, Harumi, c/o Nisshin Flour M. Co., LTD , Yoshizawa, Yukio, c/o Nisshin Flour M. Co., LTD , Douzono, Toshio, c/o Nisshin Flour M. Co., LTD , Nakagawa, Kanemitsu, c/o Nisshin Flour M. Co., LTD , Sugihara, Kunio, c/o Nisshin Flour M. Co., LTD , Aritome, Yoshiaki, c/o Nisshin Flour M. Co., LTD , Yamanaka, Akishige, c/o Nisshin Flour M. Co., LTD
IPC分类号： B07B1/46 , B07B1/38
CPC分类号： B07B1/4618 , B07B1/38 , B07B1/46
摘要： A sifter frame comprises an outer frame (6) and an inner frame (5). The outer frame (6) is formed from frame members (62 - 64) having the same height and includes a pair of fine powder dropping ports (75), a rough powder dropping port (69) and a rectangular fine powder receiving plate (67) disposed in a region surrounded by these openings and one of the outer block frame members (62). The inner frame (5) is fitted within the space above the receiving plate (67). The two outer frame members (54, 55) of the inner frame (5) in contact with the fine powder dropping ports (65) project towards the rough powder dropping port and beyond the outer block frame member (52) of the inner frame (5) in contact with the rough powder dropping port (69) to form horn portions. The outer frame (6) includes complementary receiving portions (82) for receiving and engaging the horn portions of the inner frame (5).
The engaging surfaces of the horn portions and the receiving portions are formed with mutual sealing surfaces having an arcuate shape, so that a vertical compression force applied to the engaging surfaces via the upper stage sifter provides a sealing effect.
The Specification discloses further embodiments of stacking type sifter frame in which mixing of rough (i.e. unsifted) powder with fine (i.e. sifted) powder can be securely prevented while reducing the size or complexity of the interchangeable or replaceable sifter component.
摘要翻译：筛框包括外框（6）和内框（5）。外框（6）由高度相同的框架构件（62-64）形成，并包括一对细粉末滴落口（75），粗粉末滴落口（69）和矩形细粉末接收板（67））布置在由这些开口和外部块状框架构件（62）中的一个围绕的区域中。内框架（5）安装在接收板（67）上方的空间内。内框架5的与细粉末落下口65接触的两个外框架构件54,55朝向粗粉末落下口突出并超出内框架的外框块构件52 5）与粗粉落下口（69）接触以形成喇叭部分。外框架（6）包括用于接收和接合内框架（5）的喇叭部分的互补接收部分（82）。喇叭部分和接收部分的接合表面形成有具有弓形形状的相互密封表面，使得通过上级筛件施加到接合表面的竖直压缩力提供密封效果。该说明书公开了堆叠式筛分机框架的进一步实施例，其中可以可靠地防止粗糙（即未筛分的）粉末与精细（即筛分过的）粉末的混合，同时减小可互换或可替换筛分机部件的尺寸或复杂性。

62. 发明授权

EP0372523B1 Process of preparing alpha-amylase inhibiting substances from wheat 失效
标题翻译：用于抑制从小麦物质的生产α-淀粉酶的方法
公开(公告)号：EP0372523B1
公开(公告)日：1996-03-20
申请号：EP89122480.0
申请日：1989-12-06
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Maeda, Koji , Satoh, Yoshitaka
IPC分类号： A61K35/78 , A61K38/55
CPC分类号： A61K38/005 , A61K36/899

63. 发明授权

EP0398179B1 Rhodanine derivatives and pharmaceutical compositions 有权
标题翻译：绕丹宁衍生物和药物组合物
公开(公告)号：EP0398179B1
公开(公告)日：1996-01-17
申请号：EP90108915.1
申请日：1990-05-11
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Inoue, Hitoshi, Masuda Dai-ichi Heights 504 , Kato, Hiroki , Sueda, Noriyoshi , Tahara, Yoshiyuki , Kinoshita, Nobuhiro
IPC分类号： C07D277/36
CPC分类号： C07D417/06 , C07D277/36 , C07D417/12

64. 发明公开

EP0663456A1 METHOD OF PRODUCING COATED PARTICLES 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG BESCHICHTETER TEILCHEN。
公开(公告)号：EP0663456A1
公开(公告)日：1995-07-19
申请号：EP94922370.5
申请日：1994-08-12
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： YAMADA, Yukiyoshi , FUYUKI, Tadashi , AKIYAMA, Satoshi , HAMADA, Yoshiaki , KURODA, Eisuke
IPC分类号： C23C14/00
CPC分类号： C23C14/223 , B22F1/025 , C23C14/22 , C23C16/4417
摘要： When producing coated particles by charging core particles into a coating space and vacuum-evaporating coating material on the core particles, or by bringing gaseous coating material into contact with the core particles, the core particles having a mean particle size of not larger than 10µm and having a powder distribution [D M /5, 5D M ] ≧ 90% are so dispersed that the degree of dispersion β is greater than 70%. The core particles can be coated with the coating material even though the particles consist only of very small particles or consist mainly of very small particles. The resultant coated particles are uniformly coated with the coating material and do not contain uncoated particles or partially coated particles due to aggregation. The method imparts an extremely great merit to the industrial production.
摘要翻译：当通过将核心颗粒充填到包覆空间中并在芯颗粒上真空蒸发涂层材料或通过使气态涂层材料与芯颗粒接触来制造涂覆颗粒时，芯颗粒的平均粒度不大于10微米 m且具有粉末分布[DM / 5DM]> / = 90％的分散度使得分散度β大于70％。即使颗粒仅由非常小的颗粒组成或主要由非常小的颗粒组成，核心颗粒可以涂覆涂层材料。所得到的涂覆颗粒均匀地涂覆有涂层材料，并且由于聚集而不包含未涂覆的颗粒或部分涂覆的颗粒。该方法给工业生产带来极大的优点。

65. 发明授权

EP0389995B1 Isoquinoline derivatives for the treatment of glaucoma or ocular hypertension 失效
标题翻译：异喹啉衍生物用于治疗青光眼或高眼压症的治疗。
公开(公告)号：EP0389995B1
公开(公告)日：1995-05-31
申请号：EP90105606.9
申请日：1990-03-24
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Tadokoro, Toyohiro , Sato, Kiyoshi , Hatakeyama, Shigeki , Kawase, Shigeo , Ueno, Masao
IPC分类号： A61K31/47 , A61K31/05 , A61K31/08
CPC分类号： A61K31/47

66. 发明公开

EP0637592A1 Processes of producing amylase inhibitors 失效
标题翻译： HerstellungsverfahrenfürAmylaseinhibitoren。
公开(公告)号：EP0637592A1
公开(公告)日：1995-02-08
申请号：EP94305769.5
申请日：1994-08-03
申请人： NISSHIN FLOUR MILLING CO., LTD. , NAGATA SANGYO CO., Ltd.
发明人： Miyazaki, Toshiyuki, c/o Nisshin Flour M. Co.Ltd. , Morimoto, Toshihisa, c/o Nisshin Flour M. Co.Ltd. , Murayama,Ryuji, 40-1 , Mitani ,
IPC分类号： C07K14/415 , C07K1/14 , A23L1/307 , A23L1/03 , A23J1/12
CPC分类号： C07K14/415 , A23J1/16 , A23J3/18 , A23L29/03 , A23L33/20
摘要： A process of producing an amylase inhibitor from an amylase inhibitor-containing solution extracted from wheat flour, etc with water, a dilute acid, a dilute alkali or from an amylase inhibitor-containing starch waste solution, by utilization of an adsorption of the amylase inhibitor on a calcium phosphate gel, while removing impure proteins contained in the solution.
The process can produce in economy and high yields the amylase inhibitor having a very high amylase inhibitory activity but no or very little trypsin inhibitory activity.
摘要翻译：通过利用淀粉酶抑制剂的吸附从含有淀粉酶抑制剂的小麦粉等中用水，稀酸，稀碱或含淀粉酶抑制剂的淀粉废液中提取淀粉酶抑制剂的方法在磷酸钙凝胶上，同时去除溶液中包含的不纯蛋白质。该方法可以经济地生产并且高产率的淀粉酶抑制剂具有非常高的淀粉酶抑制活性，但没有或很少的胰蛋白酶抑制活性。

67. 发明授权

EP0385351B1 Nicotinic acid derivatives and pharmaceutical compositions comprising same 有权
标题翻译：烟酸衍生物及含有它们的药物组合物。
公开(公告)号：EP0385351B1
公开(公告)日：1995-01-11
申请号：EP90103704.4
申请日：1990-02-26
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Miura, Katsutoshi , Koyama, Hiroyasu , Sugai, Toshiji , Yamada, Hiroaki , Sakurai, Einosuke
IPC分类号： C07D213/80 , C07D401/14 , C07D405/14 , A61K31/495 , A61K31/55 , A61K31/535
CPC分类号： C07D213/80 , C07D401/04 , C07D401/06 , C07D405/12 , C07D413/04 , C07D413/06

68. 发明授权

EP0385350B1 Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same 失效
标题翻译：吡啶羧酸酰胺衍生物和含有它们的药物组合物。
公开(公告)号：EP0385350B1
公开(公告)日：1994-11-30
申请号：EP90103703.6
申请日：1990-02-26
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Miura, Katsutoshi , Koyama, Hiroyasu , Sugai, Toshiji , Yamada, Hiroaki , Sakurai, Einosuke , Horigome, Masato
IPC分类号： C07D213/82 , C07D401/06 , A61K31/495 , A61K31/55
CPC分类号： C07D213/81 , C07D213/82 , C07D401/04 , C07D401/06 , C07D401/14

69. 发明公开

EP0623621A1 Oxazabicyclo derivatives and their use as 5-HT4 receptor agonists 失效
标题翻译： Oxazabicycloderivate und ihre Verwendung als 5-HT4 Rezeptor-Agonisten。
公开(公告)号：EP0623621A1
公开(公告)日：1994-11-09
申请号：EP94303063.5
申请日：1994-04-21
申请人： NISSHIN FLOUR MILLING CO., LTD.
发明人： Kikuchi, Haruhiko, c/o Nisshin Flour , Satoh, Hiroaki, c/o Nisshin Flour , Fukutomi, Ruta, c/o Nisshin Flour , Inomata, Kohei, c/o Nisshin Flour , Suzuki, Masashi, c/o Nisshin Flour , Ueno, Masahiro, c/o Nisshin Flour , Hagihara, Koichiro, c/o Nisshin Flour , Arai, Takeo, c/o Nisshin Flour , Eguchi, Haruko, c/o Nisshin Flour , Noguchi, Yumiko, c/o Nisshin Flour
IPC分类号： C07D498/08 , A61K31/535
CPC分类号： C07D498/08
摘要： Oxazabicyclo derivatives of formula (I):

wherein the variable groups are as defined in the specification, which are useful as 5-HT₄ receptor agonist for the treatment of digestive tract diseases.
摘要翻译：式（I）的恶唑烷二环衍生物：其中可变基团如本说明书中所定义，其可用作治疗消化道疾病的5-HT 4受体激动剂。

70. 发明公开

EP0618229A1 Amylase inhibitors 失效
标题翻译：淀粉酶抑制剂
公开(公告)号：EP0618229A1
公开(公告)日：1994-10-05
申请号：EP94302148.5
申请日：1994-03-24
申请人： NISSHIN FLOUR MILLING CO., LTD. , NAGATA SANGYO CO., Ltd.
发明人： Miyazaki, Toshiyuki , Morimoto, Toshihisa , Murayama, Ryuji , Matsubara, Hiroshi
IPC分类号： C07K15/00 , A23L1/03 , A61K35/78 , A61K37/64
CPC分类号： C07K14/415 , A23J1/12 , A23J3/18 , A61K38/00
摘要： An amylase inhibitor consisting essentially of a protein constructed of 248 amino acid residues having two subunits, each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis. The amylase inhibitor is useful as an agent for inhibiting increase of blood glucose level, controlling insulin secretion or suppressing appetite, and as a food additive. For the same use, the amylase inhibitor is used in combination with a protein composed of two subunits, each identified as SEQ ID NO:2, the total content of both proteins being not less than 20% by weight.
摘要翻译：淀粉酶抑制剂基本上由具有248个氨基酸残基构成的蛋白质组成，其具有两个亚基，每个被鉴定为SEQ ID NO：1，其中通过聚丙烯酰胺凝胶电泳以0.26的迁移率观察到单个条带。淀粉酶抑制剂可用作抑制血糖水平升高，抑制胰岛素分泌或抑制食欲的药剂，作为食品添加剂。对于相同的用途，淀粉酶抑制剂与由两个亚基组成的蛋白质组合使用，每个亚基各自鉴定为SEQ ID NO：2，两种蛋白质的总含量不小于20重量％。

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