专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

EP2114394B1 PLATINUM ANALOGS WITH BIS-NITRILE-CONTAINING LIGANDS 有权
标题翻译： PLATINUM类似物与二腈配体含
公开(公告)号：EP2114394B1
公开(公告)日：2012-08-15
申请号：EP07867308.4
申请日：2007-10-30
申请人： BIONUMERIK PHARMACEUTICALS, INC.
发明人： CHEN, Xinghai , PETLURU, Pavankumar, N.V. , HUANG, Qiuli , NARKUNAN, Kesavaram , HAUSHEER, Frederick, H.
IPC分类号： A61K31/275 , A61K31/382 , C07F15/00
CPC分类号： C07F15/0093
摘要： Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.

62. 发明公开

EP2249825A1 TREATMENT METHODS AND COMPOSITIONS FOR LUNG CANCER, ADENOCARCINOMA, AND OTHER MEDICAL CONDITIONS 有权转让
标题翻译：方法和组合物对肺癌的，腺癌及其他疾病病
公开(公告)号：EP2249825A1
公开(公告)日：2010-11-17
申请号：EP08726839.7
申请日：2008-03-14
申请人： BIONUMERIK PHARMACEUTICALS, INC.
发明人： HAUSHEER, Frederick, H.
IPC分类号： A61K31/255 , A61K31/095
CPC分类号： A61K31/095 , A61K31/255
摘要： The present invention discloses and claims: (i) compositions, methods, and kits which lead to an increase in patient survival time in cancer patients receiving chemotherapy; (ii) compositions and methods which cause cytotoxic or apoptotic potentiation of the anti-cancer activity of chemotherapeutic agents; (iii) compositions and methods for maintaining or stimulating hematological function in patients in need thereof, including those patients suffering from cancer; (iv) compositions and methods for maintaining or stimulating erythropoietin function or synthesis in patients in need thereof, including those patients suffering from cancer; (v) compositions and methods for mitigating or preventing anemia in patients in need thereof, including those patients suffering from cancer; (vi) compositions and methods for maintaining or stimulating pluripotent, multipotent, and unipotent normal stem cell function or synthesis in patients in need thereof, including those patients suffering from cancer; (vii) compositions and methods which promote the arrest or retardation of tumor progression in those cancer patients receiving chemotherapy; (viii) compositions and methods for increasing patient survival and/or delaying tumor progression while maintaining or improving the quality of life in a cancer patient receiving chemotherapy; (ix) novel methods of the administration of taxane and/or platinum medicaments and a Formula (I) compound of the present invention to a cancer patient; and (x) kits to achieve one or more of the aforementioned physiological effects in a patient in need thereof, including those patients suffering from cancer.

63. 发明公开

EP1896492A4 PLATINUM COMPLEXES WITH MONONITRILE-CONTAINING LIGANDS 有权
标题翻译：与MONONITRILHALTIGEN配体铂络合物
公开(公告)号：EP1896492A4
公开(公告)日：2010-09-22
申请号：EP06733954
申请日：2006-01-26
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： XIAO ZEJUN , HAUSHEER FREDERICK H , PETLURU PAVANKUMAR
IPC分类号： C07F15/00 , A61K31/28
CPC分类号： C07F15/0093

64. 发明公开

EP1694684A4 PROCESS FOR MAKING CAMPTOTHECIN DERIVATIVES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON CAMPTOTHECIN-DERIVATEN
公开(公告)号：EP1694684A4
公开(公告)日：2009-06-03
申请号：EP04800503
申请日：2004-11-01
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： WU YE , NARKUNAN KESAVARAM , WANG JIANYAN , KOCHAT HARRY
IPC分类号： C07F7/10 , C07D491/147 , C07D491/22
CPC分类号： C07F7/083 , C07D491/22
摘要： A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.
摘要翻译：一种合成喜树碱高亲脂性衍生物的方法。该方法包括在改进的Minisci型烷基化反应中使溶解的未衍生的喜树碱与甲硅烷基化的杂环化合物反应以产生喜树碱的7-取代衍生物。

65. 发明公开

EP2007386A2 CAMPTOTHECIN-ANALOG WITH A NOVEL, FLIPPED LACTONE-STABLE, E-RING AND METHODS FOR MAKING AND USING SAME 有权
标题翻译：用新颖的喜树碱类似物，翻转内酯稳定的E-RING及其制造方法和使用
公开(公告)号：EP2007386A2
公开(公告)日：2008-12-31
申请号：EP07755733.8
申请日：2007-04-19
申请人： BIONUMERIK PHARMACEUTICALS, INC.
发明人： HAUSHEER, Frederick H.
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： C07D491/22
摘要： The present invention discloses: (i) a novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (ii) methods of synthesis of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof; (iii) pharmaceutically-acceptable formulations comprising said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents; (iv) methods of administration of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof; and (v) devices for the administration of said novel, lactone-stable, “flipped” E-ring camptothecin, pharmaceutically-acceptable salts, and/or analogs thereof, and, optionally, one or more chemotherapeutic agents, to subjects in need thereof.

66. 发明公开

EP1991237A2 CHEMOPROTECTIVE METHODS AND COMPOSITIONS 有权转让
标题翻译：化学保护方法和组合物
公开(公告)号：EP1991237A2
公开(公告)日：2008-11-19
申请号：EP06848549.9
申请日：2006-12-13
申请人： BIONUMERIK PHARMACEUTICALS, INC.
发明人： HAUSHEER, Frederick, H.
IPC分类号： A61K31/66
CPC分类号： A61K31/185 , A61K31/255
摘要： Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of, for example, one or more chemotherapy-associated toxicities in a subject receiving one or more chemotherapeutic agents.

67. 发明公开

EP1796682A4 METHOD AND COMPOSITION FOR TREATING PATIENTS UNDERGOING KIDNEY DIALYSIS 有权
标题翻译：方法和组合物用于肾透析患者经历治疗
公开(公告)号：EP1796682A4
公开(公告)日：2008-06-04
申请号：EP05800321
申请日：2005-09-21
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： HAUSHEER FREDERICK H
IPC分类号： A61K31/185 , A61K31/66 , A61P13/12 , A61P39/06
CPC分类号： A61K31/185 , A61K31/66

68. 发明公开

EP1793831A4 METHOD OF TREATMENT FOR OR PROTECTION AGAINST LYMPHEDEMA 审中-公开
标题翻译：方法用于治疗或以防止淋巴水肿
公开(公告)号：EP1793831A4
公开(公告)日：2008-04-02
申请号：EP05811983
申请日：2005-09-21
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： HAUSHEER FREDERICK H
IPC分类号： A61K31/66 , A61K31/185 , A61P7/10
CPC分类号： A61K31/185 , A61K31/66

69. 发明公开

EP1694637A4 PROCESS FOR SYNTHESIZING DISULFIDES 审中-公开
标题翻译：方法合成二硫化物
公开(公告)号：EP1694637A4
公开(公告)日：2007-09-26
申请号：EP04818053
申请日：2004-12-17
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： KAWAMI KOH , TOKUDA OSAMU , NIIMOTO YOSHIHIDE
IPC分类号： C07C309/00 , C07C319/24 , C07C323/66 , C07C327/22
CPC分类号： C07C319/24 , C07C323/66
摘要： This invention relates to a process for producing a substantially pure disulfide compound of Formula (II) R5-S-S-R2 as disclosed herein, such as disodium 2,2'-dithiobis ethane sulfonate, by an efficient procedure from available, relatively inexpensive raw materials.

70. 发明公开

EP1554235A4 PROCESS FOR SYNTHESIZING L-Y-METHYLENE GLUTAMIC ACID AND ANALOGS 有权
标题翻译：法合成L的-YMETHYLENGLUTAMINSûURE及其类似物
公开(公告)号：EP1554235A4
公开(公告)日：2007-04-04
申请号：EP03781352
申请日：2003-10-22
申请人： BIONUMERIK PHARMACEUTICALS INC
发明人： KOCHAT HARRY , CHEN XINGHAI , WU YE , HUANG QIULI , WANG JIANYAN , GERUSZ VINCENT
IPC分类号： C07C227/22 , A61K20060101 , C07C53/00 , C07C207/00 , C07C229/00 , C07C229/24 , C07C229/30 , C07D209/46
CPC分类号： C07C227/22 , C07C229/30
摘要： A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L- -methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivative to form the desired end product.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式