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51. 发明授权

EP2345419B8 MUCOSAL VACCINE USING CATIONIC NANOGEL 有权转让
标题翻译：使用阳离子纳米凝胶的粘膜疫苗
公开(公告)号：EP2345419B8
公开(公告)日：2017-04-26
申请号：EP09823688.8
申请日：2009-10-30
申请人： Intellectual Property Strategy Network, Inc.
发明人： AKIYOSHI Kazunari , KIYONO Hiroshi , YUKI Yoshikazu , NOCHI Tomonori
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/08 , A61K39/12 , A61K9/10 , A61K9/06 , A61K47/28 , A61K47/36 , A61K47/61 , A61K9/51 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/02 , A61K9/00
CPC分类号： A61K39/08 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/5161 , A61K39/39 , A61K47/36 , A61K47/554 , A61K47/61 , A61K47/6903 , A61K2039/541 , A61K2039/543 , A61K2039/55583 , A61K2039/6087

52. 发明公开

EP3035968A4 TELODENDRIMERS AND NANOCARRIERS AND METHODS OF USING SAME 有权
标题翻译： TELODENDRIMERE和纳米货船和方法及其使用
公开(公告)号：EP3035968A4
公开(公告)日：2017-04-19
申请号：EP14837242
申请日：2014-08-21
申请人： UNIV NEW YORK STATE RES FOUND
发明人： LUO JUNTAO , HUANG WENZHE , SHAO YU , SHI CHANGYING
IPC分类号： A61K47/50 , A61K9/51 , A61K45/06 , A61K47/28 , A61K49/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K47/551 , A61K47/554 , A61K49/0054
摘要： Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.

53. 发明公开

EP3148590A1 HIGHLY DRUG-LOADED POLY(ALKYL 2-CYANOACRYLATE) NANOCAPSULES 无效
标题翻译： POLY（ALKYL-2-CYANOACRYLAT）NANOKAPSELN MIT HOHER WIRKSTOFFLADUNG
公开(公告)号：EP3148590A1
公开(公告)日：2017-04-05
申请号：EP15727927.4
申请日：2015-05-29
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： CURIC, Anamarija , MÖSCHWITZER, Jan-Peter , REUL, Regina
IPC分类号： A61K47/28 , A61K9/51 , A61K31/496 , A61K31/513
CPC分类号： A61K9/5138 , A61K31/496 , A61K31/513 , A61K47/28
摘要： The present invention relates to nanocapsules which are stabilized by a bile acid or salt thereof. The nanocapsules comprise a polymeric shell formed by poly(alkyl cyanoacrylates) and/or alkoxy derivatives thereof, wherein the polymeric shell encapsulates a core comprising an active agent. The invention further relates to methods for preparing and compositions comprising such nanocapsules.
摘要翻译：本发明涉及由胆汁酸或其盐稳定的纳米胶囊。纳米胶囊包括由聚（氰基丙烯酸烷基酯）和/或其烷氧基衍生物形成的聚合物壳，其中聚合物壳包封包含活性剂的核心。本发明还涉及制备方法和包含这种纳米胶囊的组合物。

54. 发明公开

EP3138555A4 LIPOSOME COMPOSITION AND PRODUCTION METHOD THEREFOR 有权转让
标题翻译： LIPOSOMZUSAMMENSETZUNG UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP3138555A4
公开(公告)日：2017-03-08
申请号：EP15785362
申请日：2015-04-30
申请人： FUJIFILM CORP
发明人： ONO MAKOTO , ONO KOHEI , MATSUMOTO TAKESHI , MORI MIKINAGA
IPC分类号： A61K9/127 , A61K47/24 , A61K47/28 , B01J13/02 , B01J13/20
CPC分类号： A61K9/127 , A61K9/1278 , A61K31/7068 , A61K47/24 , A61K47/28 , B01J13/02 , B01J13/20
摘要： Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol% to 35 mol% with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.
摘要翻译：本发明提供一种脂质体组合物，其具有实用上所要求的长期保存稳定性，并且由于药物的释放性能够通过使内水发生适当控制而具有数十小时量级的药物释放速率相超渗透; 及其制造方法。根据本发明，可以提供一种脂质体组合物，其包含各自具有内部水相和构成外部水相的水溶液并且其中分散有脂质体的脂质体，其中胆固醇的含量为相对于脂质体组合物中的脂质成分总量为10摩尔％〜35摩尔％，并且各脂质体以溶解状态包封药物，内部水相的渗透压为2倍至8倍，相对于外部水相的渗透压而言是折叠的。

55. 发明授权

EP2788029B1 DRY POWDER FORMULATION OF AZOLE DERIVATIVE FOR INHALATION 有权
标题翻译： TROCKENPULVERFORMULIERUNG EINES AZOLDERIVATS ZUM INHALIEREN
公开(公告)号：EP2788029B1
公开(公告)日：2017-03-08
申请号：EP12797933.4
申请日：2012-12-07
申请人： Laboratoires SMB SA
发明人： VANDERBIST, Francis , SEBTI, Thami , DEBOECK, Arthur , DURET, Christophe , AMIGHI, Karim , BAUDIER, Philippe
IPC分类号： A61K47/14 , A61K47/26 , A61K47/28 , A61K9/00
CPC分类号： A61K31/496 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K9/1682 , A61K9/1688 , A61K9/1694 , A61K47/14 , A61K47/26 , A61K47/28 , A61K2300/00
摘要： A spray dried-powder composition for inhalation comprising particles (X) containing (a) between 5 and 50% by weight of at least one azole derivative in amorphous state but not in crystalline structure and (b) at least one matricial agent to the composition selected from a group consisting of polyol such as sorbitol, mannitol and xylitol; a monosaccharides such as glucose and arabinose; disaccharide such as lactose, maltose, saccharose and dextrose; cholesterol, and any mixture thereof, wherein the composition provides a dissolution rate of said azole derivative of at least, 5 % within 10 minutes, 10 % within 20 minutes and 40 % within 60 minutes when tested in the dissolution apparatus type 2 of the United States Pharmacopoeia at 50 rotation per minute, 37 °C in 900 milliters of an aqueous dissolution medium adjusted at pH 1.2 and containing 0.3 % of sodium laurylsulfate.
摘要翻译：一种用于吸入的喷雾干燥粉末组合物，其包含颗粒（X），其包含（a）5至50重量％的至少一种无定形态但不在结晶结构中的唑衍生物，和（b）至少一种组合物选自多元醇如山梨糖醇，甘露糖醇和木糖醇组成的组; 单糖如葡萄糖和阿拉伯糖; 二糖如乳糖，麦芽糖，蔗糖和右旋糖; 胆固醇及其任何混合物，其中组合物在10分钟内提供至少5％的溶解速率，20分钟内10％，60分钟内40％的溶出速率，国家药典以每分钟50转，37℃在900毫升调节pH为1.2的含水溶解介质中并含有0.3％十二烷基硫酸钠。

56. 发明授权

EP2345419B1 MUCOSAL VACCINE USING CATIONIC NANOGEL 有权转让
标题翻译：与阳离子NANOGEL粘膜疫苗
公开(公告)号：EP2345419B1
公开(公告)日：2017-02-22
申请号：EP09823688.8
申请日：2009-10-30
申请人： LSIP, LLC
发明人： AKIYOSHI Kazunari , KIYONO Hiroshi , YUKI Yoshikazu , NOCHI Tomonori
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/08 , A61K39/12 , A61K9/10 , A61K9/06 , A61K47/28 , A61K47/36 , A61K47/61 , A61K9/51 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/02 , A61K9/00
CPC分类号： A61K39/08 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/5161 , A61K39/39 , A61K47/36 , A61K47/554 , A61K47/61 , A61K47/6903 , A61K2039/541 , A61K2039/543 , A61K2039/55583 , A61K2039/6087

57. 发明授权

EP2123274B1 MEDICINAL COMPOSITION FOR TRANSDERMAL ABSORPTION, MEDICINAL COMPOSITION STORING UNIT AND TRANSDERMAL ABSORPTION PREPARATION USING THE SAME 有权
标题翻译：的经皮吸收，存储单元医疗组成药物组合物和本二手经皮吸收制剂
公开(公告)号：EP2123274B1
公开(公告)日：2016-08-24
申请号：EP08721045.6
申请日：2008-02-29
申请人： Teika Pharmaceutical Co., Ltd.
发明人： KIMURA, Takahito , ORIHASHI, Masahiro , FUJISHITA, Shigeto , TAKABATAKE, Koichi , KATO, Tatsuhisa , SHIOTA, Satoshi , SHIMA, Yuichiro
IPC分类号： A61K31/485 , A61K9/00 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/34 , A61K47/38 , A61P25/04 , A61K47/28 , A61K9/10 , A61K9/70
CPC分类号： A61K31/485 , A61K9/0014 , A61K9/10 , A61K9/7084 , A61K47/10 , A61K47/12 , A61K47/28

59. 发明公开

EP2861256A4 COMPOSITIONS FOR TREATING CANCER AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：癌症和方法的处理组合物及其制造
公开(公告)号：EP2861256A4
公开(公告)日：2016-06-01
申请号：EP13805073
申请日：2013-06-14
申请人： BRIGHAM & WOMENS HOSPITAL
发明人： SENGUPTA SHILADITYA , KULKARNI ASHISH , RAO POORNIMA , ROY BHASKAR
IPC分类号： A61K47/28 , A61K31/015 , A61K31/337 , A61K31/355 , A61K31/519 , A61K45/06 , A61K45/08 , A61K47/48 , A61P35/00
CPC分类号： A61K47/554 , A61K45/06 , A61K47/48123
摘要： Described herein are compositions and methods relating to chemotherapeutic agent conjugates and the treatment of cancer.

60. 发明公开

EP2889302A4 BORON CLUSTER-MODIFIED PEG LIPID DERIVATIVE, AND MOLECULAR ASSEMBLY USING SAME 有权
标题翻译： BORCLUSTERMODIFIZIERTES PEG脂类衍生物与分子安排，
公开(公告)号：EP2889302A4
公开(公告)日：2016-05-18
申请号：EP13831030
申请日：2013-08-22
申请人： UNIV TSUKUBA
发明人： MATSUMURA AKIRA , NAKAI KEI , SHIRAKAWA MAKOTO
IPC分类号： A61K41/00 , A61K9/127 , A61K31/69 , A61K47/24 , A61K47/28 , A61K47/34 , C07F5/05 , C07F9/09 , C07F19/00 , C08G65/328
CPC分类号： A61K47/48215 , A61K9/1271 , A61K31/69 , A61K33/22 , A61K41/0095 , A61K47/544 , A61K47/554 , A61K47/6911 , C07F9/106 , C07F9/5721 , C08G65/3322 , C08G65/33324 , C08G65/3353 , C08G65/337

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