专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明公开

EP2877465A1 LFA-1 INHIBITOR AND POLYMORPH THEREOF 审中-公开
标题翻译： LFA-1抑制剂和晶型物
公开(公告)号：EP2877465A1
公开(公告)日：2015-06-03
申请号：EP13823367.1
申请日：2013-07-25
申请人： SARcode Bioscience Inc.
发明人： ZELLER, James, Robert , VENKATRAMAN, Sripathy , BROT, Elisabeth, C.A. , IYER, Subashree , HALL, Michael
IPC分类号： C07D405/00 , C07D405/02 , C07D405/10
CPC分类号： C07D407/06 , C07B2200/13 , C07D405/06
摘要： Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed.

53. 发明授权

EP2005497B1 QUINOID SYSTEMS AS ORGANIC SEMICONDUCTORS 有权转让
标题翻译： CHINOIDSYSTEME有机半导体
公开(公告)号：EP2005497B1
公开(公告)日：2014-10-08
申请号：EP07727784.6
申请日：2007-04-04
申请人： BASF SE
发明人： BERENS, Ulrich , STASSEN, Arno , SCHMIDHALTER, Beat , KALB, Wolfgang , BIENEWALD, Frank
IPC分类号： H01L51/30 , C07D405/00
CPC分类号： H01L51/0074 , C07D493/04 , C07D493/22 , C07D495/04 , H01L51/0055 , H01L51/0073 , H01L51/0529 , H01L51/0533 , H01L51/0545 , Y02E10/549

56. 发明公开

EP2476667A3 Aminoheteroaryl compounds as protein kinase inhibitors 有权
标题翻译：氨基杂芳基化合物作为蛋白激酶抑制剂
公开(公告)号：EP2476667A3
公开(公告)日：2013-01-02
申请号：EP12163855.5
申请日：2004-02-26
申请人： Sugen, Inc.
发明人： Cui, Jingjong, Jean , Johnson, Joanne , Kolodziej, Stephen, A. , Kung, Pei-Pei , Li, Xiaoyuan (Sharon) , Lin, Jason (Qishen) , Meng, Jerry Jialun , Nambu, Mitchell David , Nelson, Christopher G. , Pairish, Mason Alan , Shen, Hong , Zhang, Jennifer , Tran-Dube, Michelle , Walter, Allison , Zhang, Fang-Jie , Hanau, Cathleen Elizabeth , Bhumralkar, Dilip , Botrous, Iriny , Chu, Ji Yu , Funk, Lee A. , Harris Jr., G. Davis , Jia, Lei
IPC分类号： C07D213/73 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D211/72 , A61P35/00
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

57. 发明公开

EP2301930A1 Thrombin receptor antagonists 有权
标题翻译：用于治疗，其它自身免疫性或炎性疾病中的Hexahydrobezofuranon合适的衍生物
公开(公告)号：EP2301930A1
公开(公告)日：2011-03-30
申请号：EP10185528.6
申请日：2001-06-13
申请人： Schering Corporation
发明人： Cackalamannil, Samuel , Chelliah, Marriappan , Xia, Yan
IPC分类号： C07D405/00 , C07D405/08 , C07D409/08 , C07D417/08 , A61K31/343 , A61P13/12
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D405/06 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Heterocyclic-substituted compounds of formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein: Z is - (CH2)n-; (a); (b), wherein R 10 is absent; or, (c) wherein R 3 is absent; the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Het is an optionally substituted mono-, bi- or tri-cyclic heteroaromatic group; B is -(CH 2 ) n3 -. wherein n 3 is 0-5, -CH 2 -O-, -CH 2 S-, -CH 2 -NR 6 -, -C(O)NR 6 -. -NR 6 C(O)-, (d), optionally substituted alkenyl or optionally substituted alkynyl; X is -O- or -NR 6 - when the double dotted line represents a single bond, or X is H, -OH or -NHR 20 when the bond is absent; Y is =O, =S, (H, H), (H, OH) or (H, C 1 -C 6 alkoxy) when the double dotted line represents a single bond or when the bond is absent, Y is =O, =NOR 17 (H, H). (H, OH), (H, SH), (H, C 1 -C 6 alkoxy) or (H, substituted-amino); R 22 and R 23 are independently -OH, -OC(O)R 30 , OC(O)NR 30 R 31 , or optionally substituted alkyl, alkenyl, alkynyl, heterocycloalkyl, aryl, cycloalkyl, cycloalkenyl, carbonyl, amino, alkoxy, alkenyloxy, alkynyloxy, heterocycloalkyloxy, cycloalkyloxy, or cycloalkenyloxy; or R 22 and R 10 , or R 23 and R 11 , can form a carbocyclic or heterocyclic ring; and the remaining variables are as described in the specification, Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and blinders to cannabinoid receptors.
摘要翻译：（I）或其药学上可接受的盐，式杂环取代的化合物是游离缺失光盘，worin：Z是 - （CH 2）N; （A）; （B），worin R 10为不存在; 或者，（c）其中R 3为不存在; 任选的双键的单虚线darstellt; 可选单键的双点划线darstellt; n为0-2; Het是任选substituiertem单环，双环或三环杂芳族基团; B是 - （CH 2）N3 - 。 worin n 3为0-5，-CH 2 -O-，-CH 2 S - ， - CH 2 -NR 6 - ， - C（O）NR 6 - 。 -NR 6 C（O） - ，（d）中，任选取代的链烯基或任选取代的炔基; X是-O-或-NR 6 - 时，双点划线代表单键，或X为H，-OH或-NHR 20当键不存在; Y是= O，= S，（H，H），（H，OH）或（H，C 1 -C 6烷氧基）当双虚线表示单键或darstellt当键不存在，Y是= O ，= NOR 17（H，H）。（H，OH），（H，SH），（H，C 1 -C 6烷氧基）或（H，substituiertem - 氨基）; R 22和R 23独立地是-OH，-OC（O）R 30，OC（O）NR 30 R 31，或任选取代的烷基，烯基，炔基，杂环烷基，芳基，环烷基，环烯基，羰基，氨基，烷氧基，烯氧基，炔氧基，杂环烷基氧基，环烷基氧基，环烯氧基或; 或R 22和R 10，或R 23和R 11，可以形成碳环或杂环; 并且剩余的变量如说明书中所描述的，所以盘游离缺失是含有所述化合物和它们作为凝血酶受体拮抗剂和大麻素受体眼罩到药物组合物。

58. 发明公开

EP2285376A1 6-AMINONICOTINAMIDE DERIVATIVES AS POTENT AND SELECTIVE HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译： 6-氨基十二酰亚胺衍生物作为有效且选择性的半胱氨酸脱乙酰酶抑制剂
公开(公告)号：EP2285376A1
公开(公告)日：2011-02-23
申请号：EP09747249.2
申请日：2009-05-08
申请人： Chipscreen Biosciences Ltd.
发明人： LU, Xian-Ping , LI, Zhi-Bin , ZHI-QIANG, Ning
IPC分类号： A61K31/44 , C07D401/00 , C07D405/00
CPC分类号： C07D213/82 , C07D405/12 , C07D409/12
摘要： The present invention relates to certain 6-aminonicotinamide derivatives which are capable of inhibiting histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal histone deacetylase activities. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing these compounds are also disclosed.
摘要翻译：本发明涉及能够抑制组蛋白脱乙酰酶的某些6-氨基烟酰胺衍生物。因此本发明化合物可用于治疗与组蛋白脱乙酰酶活性异常有关的疾病。还公开了包含这些化合物的药物组合物，利用包含这些化合物的药物组合物治疗疾病的方法以及制备这些化合物的方法。

59. 发明公开

EP2191006A1 METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY 有权
标题翻译：检验方法的酶活性ALPHA-L-艾杜糖苷酸酶的
公开(公告)号：EP2191006A1
公开(公告)日：2010-06-02
申请号：EP08827775.1
申请日：2008-08-18
申请人： University of Washington
发明人： GELB, Michael , BLANCHARD, Sophie
IPC分类号： C12Q1/34 , G01N33/49 , G01N33/50 , G01N33/58 , C07D311/00 , C07D405/00
CPC分类号： C12Q1/34 , C07D311/16 , C07D311/18 , C12Y302/01076 , G01N2333/924 , G01N2800/04 , G01N2800/042
摘要： Methods for assaying α-L-iduronidase enzymatic activity and methods for screening newborns for Mucopolysaccharidosis Type-I.

60. 发明公开

EP1725535A4 HIV INTEGRASE INHIBITORS 审中-公开
公开(公告)号：EP1725535A4
公开(公告)日：2009-11-25
申请号：EP05724616
申请日：2005-03-04
申请人： MERCK & CO INC
发明人： MORRISSETTE MATTHEW M , WILLIAMS PETER D , WAI JOHN S , FISHER THORSTEN E , LYLE TERRY A
IPC分类号： C07D221/18 , C07D211/08 , C07D211/68 , C07D211/80 , C07D231/02 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00 , C07D471/04 , C07D471/10
CPC分类号： C07D471/04 , C07D471/10

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式