专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明公开

EP1426756A1 Free-standing nanowire sensor and method for detecting an analyte in a fluid 有权
标题翻译：传感器微波炉
公开(公告)号：EP1426756A1
公开(公告)日：2004-06-09
申请号：EP03257364.4
申请日：2003-11-21
申请人： Hewlett-Packard Development Company, L.P.
发明人： Stasiak, James , McClelland, Paul H. , Hackleman, David E. , Pease, Grant , Williams, R. Stanley , Peters, Kevin
IPC分类号： G01N27/22 , G01N27/00 , B82B1/00 , C01B31/02
CPC分类号： G01N27/3278 , Y10T436/114998
摘要： A sensor device and method for detecting the presence of an analyte (22) in a fluid solution are disclosed. The sensor device system (10) can include a substrate (12) and an array of free-standing nanowires (16) attached to the substrate. The array can include individual free-standing nanowires wherein each of the individual free-standing nanowires have a first end (24) and a second end (26). The first end is attached to the substrate and the second end unattached to the substrate. Such individual free-standing nanowires are configured for electrical communication with other individual free-standing nanowires through the first end. A signal measurement apparatus (38) such as a chip, computer, or coupon, can be electrically coupled to the array of free-standing nanowires for receiving electrical information from the array of free-standing nanowires. In some embodiments a power source (38) can be used to send electrical current through the nanowire array.
摘要翻译：公开了一种用于检测流体溶液中分析物（22）的存在的传感器装置和方法。传感器装置系统（10）可以包括衬底（12）和附着到衬底的独立的纳米线阵列（16）。阵列可以包括单独的独立的纳米线，其中每个独立的纳米线具有第一端（24）和第二端（26）。第一端连接到基板，第二端连接到基板。这种单独的独立的纳米线被配置为通过第一端与其他单独的独立的纳米线电连通。诸如芯片，计算机或优惠券的信号测量装置（38）可以电耦合到独立的纳米线阵列，用于从独立的纳米线阵列接收电信息。在一些实施例中，电源（38）可以用于通过纳米线阵列发送电流。

52. 发明公开

EP1376128A1 Methode und Vorrichtung zum impedimetrischen Nachweis eines oder meherer Analyten in einer Probe 审中-公开
标题翻译： Methode und Vorrichtung zum阻抗测量仪Nachweis eines oder meherer在einer Probe中分析
公开(公告)号：EP1376128A1
公开(公告)日：2004-01-02
申请号：EP03013220.3
申请日：2003-06-12
申请人： Bayer Aktiengesellschaft
发明人： Diessel, Edgar, Dr. , Hoheisel, Werner, Dr. , Merker, Udo, Dr. , Burmeister, Jens, Dr. , Köhler, Burkhard, Dr.
IPC分类号： G01N33/543 , C12Q1/00 , G01N27/02
CPC分类号： G01N33/5438 , G01N27/3278
摘要： Die Erfindung betrifft ein Verfahren zum Nachweis eines oder mehrerer Analyten durch eine Erkennungsreaktion, mit den Schritten

Bereitstellung einer Vorrichtung mit

einer Messelektrode mit biofunktioneller Oberfläche, wobei die biofunktionelle Oberfläche Erkennungselemente für die Analyten aufweist,
einer oder mehreren Gegenelektroden,
einem flüssigen Elektrolyten zwischen Messelektrode und Gegenelektroden,

in Kontaktbringen von mit elektrisch aktiven Markierungseinheiten markierten Analyten mit der biofunktionellen Oberfläche, wobei die elektrisch aktiven Markierungseinheiten entweder vor dem Kontakt der Analyten mit der biofunktionellen Oberfläche an die Analyten gebunden worden sind oder nach dem Kontakt der Analyten mit der biofunktionellen Oberfläche an die Analyten gebunden werden,
Anlegen einer a) zeitlich veränderlichen Spannung oder b) eines zeitlich veränderlichen Stroms zwischen der ersten Gegenelektrode und der Messelektrode, und
entweder im Fall a) Messung des Stroms oder im Fall b) Messung der Spannung zwischen erster Gegenelektrode und Messelektrode, oder
im Fall a) Messung des Stroms oder im Fall b) Messung der Spannung Messung des Stroms zwischen zweiter oder weiterer Gegenelektrode und der Messelektrode.

Die Erfindung betrifft weiterhin eine Vorrichtung mit der das erfindungsgemäße Verfahren durchgeführt werden kann.
摘要翻译：用于通过识别反应检测至少一种分析物（I）的方法，该装置（A）具有：（a）具有包括用于（I）的识别元件（RE）的生物功能表面的测量电极（ME）; （b）至少一个对电极（CE）; 和（c）ME和CE之间的液体电解质。用于通过识别反应检测至少一种分析物（I）的方法，该装置（A）具有：（a）具有包括用于（I）的识别元件（RE）的生物功能表面的测量电极（ME）; （b）至少一个对电极（CE）; 和（c）ME和CE之间的液体电解质。在与表面反应之前或之后，将表面与具有电活性标记（M）的标记分析物（Ia）接触，并且在第一CE和第一CE之间施加时间上变化的电压或电流 ME，并且相应地测量这些电极（或ME和一些其它CE之间）之间的电流或电压。还包括如上所述的包括ME，CE和电解质，加上标记的分析物和电压或电流源的装置的独立权利要求。

53. 发明公开

EP0948744A1 MICROSYSTEME POUR ANALYSES BIOLOGIQUES ET SON PROCEDE DE FABRICATION 失效
标题翻译：微系统生物分析和HERSTELLUNSGVERFAHREN
公开(公告)号：EP0948744A1
公开(公告)日：1999-10-13
申请号：EP97953963.0
申请日：1997-12-29
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE
发明人： CLERC, Jean-Frédéric , MASSIT, Claude
IPC分类号： C12Q1 , G01N27 , G01N33 , H05K3
CPC分类号： G01N33/5438 , G01N27/3278 , H05K3/4007
摘要： The invention concerns a micro system for biological analysis for detecting analytes, for example antigens, in a sample. The micro system comprises: an isolating substrate (1) coated with a first conductor (3) forming a first electrode, and a second conductor (7) bearing a plurality of conductive elements (7) extending above the first conductor so as to form a second coplanar electrode arranged at a distance d from the first conductor; and means (13, 15) for polarising the first and second conductors. The electrode(s) are covered with a specific ligand. After a sample has been introduced on the substrate, the presence of analyte in the sample can be detected by measuring the impedance between electrodes 3 and 7, which will indicate the formation or not of an analyte-ligand layer on the electrode(s).

54. 发明公开

EP3320340A1 METHODS FOR GENERATING pH/IONIC CONCENTRATION GRADIENT NEAR ELECTRODE SURFACES FOR MODULATING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：在电极表面产生调节生物分子相互作用的pH /离子浓度梯度的方法
公开(公告)号：EP3320340A1
公开(公告)日：2018-05-16
申请号：EP16735628.6
申请日：2016-07-01
申请人： Robert Bosch GmbH
发明人： GANGADHARAN, Rajan , VERMA, Piyush , JOHNSON, Christopher , KAVUSI, Sam , LAU, Aldrich
IPC分类号： G01N33/53 , G01N27/327 , G01N33/543
CPC分类号： G01N33/5306 , G01N27/3274 , G01N27/3277 , G01N27/3278 , G01N33/5438
摘要： Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the p H or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the p H of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

55. 发明公开

EP3315461A1 MICRO-POROUS ELECTRODE AND METHOD FOR ANALYSIS OF CHEMICAL SUBSTANCES 有权
标题翻译：微孔电极和用于分析化学物质的方法
公开(公告)号：EP3315461A1
公开(公告)日：2018-05-02
申请号：EP16813709.9
申请日：2016-06-23
申请人： BGI Shenzhen , BGI Shenzhen Co., Limited
发明人： LI, Handong , LIN, Jianxun , YUN, Quanxin , XIANG, Shaohua , DRMANAC, Radoje , DRMANAC, Snezana , ZHANG, Yongwei
IPC分类号： B81B7/02 , C12Q1/68
CPC分类号： G01N27/3276 , B81B7/02 , C12Q1/68 , C12Q1/6869 , G01N27/3277 , G01N27/3278
摘要： Provided is a microwell electrode, comprising one or more first electrodes (301); one or more second electrodes (303) each arranged opposite to one first electrode (301), wherein a channel (601) is provided between each first electrode and the second electrode opposite thereto, and the channel (601) has at least one end in communication with a chamber; and one or more guiding electrodes (501) located in the chamber (401). The microwell electrode electrode can sensitively detect a signal and improve the read length of a sequencer greatly. The invention further relates to a method for manufacturing the micro-porous electrode, a microwell electrode array, a sensor chip, a sequencing system, and a method for analysis of a chemical substance and a nucleic acid molecule based on the microwell electrode.
摘要翻译：提供了一种微孔电极，包括一个或多个第一电极（301）; 一个或多个第二电极（303），每个第二电极与一个第一电极（301）相对布置，其中在每个第一电极和与其相对的第二电极之间提供沟道（601），并且沟道（601）至少具有一端与商会沟通; 以及位于腔室（401）中的一个或多个引导电极（501）。微孔电极可以灵敏地检测信号，大大提高了测序仪的读数长度。本发明还涉及用于制造微孔电极的方法，微孔电极阵列，传感器芯片，测序系统以及基于微孔电极的用于分析化学物质和核酸分子的方法。

56. 发明授权

EP2005148B1 DIELECTRIC SENSING METHOD AND SYSTEM 有权
标题翻译：介电检测方法和系统
公开(公告)号：EP2005148B1
公开(公告)日：2018-03-07
申请号：EP07710757.1
申请日：2007-03-16
申请人： Universal Nanosensor Technologies Inc.
发明人： Dhirani, Al-Amin , Suganuma, Yoshinori
IPC分类号： G01N27/22 , G01N27/447 , G01N30/64 , G01R27/26
CPC分类号： G01N30/64 , G01N27/3278 , G01N2030/645
摘要： Sensing device and method for detecting presence and concentration of generic target analytes of interest. The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest. Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and/or biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device. Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically. The changes are used to detect the presence of the target analytes of interest and to characterize their presence.

57. 发明授权

EP2780702B1 MOLECULAR JUNCTION PLATFORM AND METHOD OF FABRICATING SUCH A PLATFORM 失效转让
标题翻译：分子连接平台和制造这种平台的方法
公开(公告)号：EP2780702B1
公开(公告)日：2018-02-14
申请号：EP12849801.1
申请日：2012-11-19
申请人： Leifer, Klaus
发明人： Leifer, Klaus , Jafri, S. Hassan M.
IPC分类号： G01N33/483 , B82Y15/00 , B82Y40/00 , G01N27/327
CPC分类号： B82Y15/00 , G01N27/3278
摘要： A molecular junction platform, a gas sensor comprising such a platform and a method of fabrication are disclosed.The platform comprises two nanoelectrodes separated by a nanogap, at least one nanoparticle situated between the nanoelectrodes and at least two molecules connecting the nanoparticle to the nano- electrodes.The method of fabrication comprises preparation of at least one nanoparticle functionalised with a first set of molecules, trapping of the at least one functionalised nanoparticle in a nanogap between two nanoelectrodes on a substrate, and at least one place exchange reaction replacing the first set of molecules by a second set of molecules, so that the second set of molecules creates a network connecting the nanoelectrodes and the at least one nanoparticle.

58. 发明公开

EP3273233A1 DEVICE FOR DETECTING CHEMICAL/PHYSICAL PHENOMENON 有权转让
标题翻译：用于检测化学/物理现象的装置
公开(公告)号：EP3273233A1
公开(公告)日：2018-01-24
申请号：EP16764628.0
申请日：2016-02-19
申请人： National University Corporation Toyohashi University of Technology
发明人： DASAI, Fumihiro , SAWADA, Kazuaki
IPC分类号： G01N27/414 , G01N27/00 , G01N27/416
CPC分类号： G01N27/3278 , G01N21/00 , G01N27/414 , G01N27/4145 , G01N27/4148 , G01N33/5438 , H01L21/76883 , H01L23/53238 , H01L23/53295 , H01L29/78
摘要： Proposed is a device for detecting a chemical/physical phenomenon, in which, via a novel scheme, charges are accumulated in a charge accumulation region. An amount of charges thus accumulated reflects the potential of a sensing region and the potential corresponds to an external environment (chemical phenomenon or physical phenomenon) to be detected. A charge accumulation region 5 includes a first potential well region FD1 that is continuous with a sensing region 3, the boundary potential of the charges held in the first potential well region FD1 being made equal to the potential of the sensing region 3, whereby the potential of the sensing region 3 is made to be reflected in the amount of charges held in the first potential well region FD1.
摘要翻译：提出了一种用于检测化学/物理现象的装置，其中通过新颖的方案在电荷积累区域中积累电荷。这样累积的电荷量反映了感测区域的电位，并且该电位对应于待检测的外部环境（化学现象或物理现象）。电荷蓄积区域5包括与感测区域3连续的第一电位阱区域FD1，使得保持在第一电位阱区域FD1中的电荷的边界电位等于感测区域3的电位，使得感测区3的电荷量反映在第一电位阱区FD1中保持的电荷量中。

59. 发明公开

EP3080596A4 HIGHLY SELECTIVE COATED-ELECTRODE NANOGAP TRANSDUCERS FOR THE DETECTION OF REDOX MOLOCULES 有权
标题翻译： HOCHSELEKTIVE NANOGAP-WANDLER麻省理工学院BESCHICHTETER ELEKTRODEFÜRDEN NACHWEIS VON REDOX-MOLEKÜLEN
公开(公告)号：EP3080596A4
公开(公告)日：2017-08-02
申请号：EP14870407
申请日：2014-10-14
申请人： INTEL CORP
发明人： TAYEBI NOUREDDINE , SU XING , LI HANDONG
IPC分类号： G01N27/30 , G01N27/327 , G01N33/48
CPC分类号： G01N27/3278 , C23C16/00
摘要： Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
摘要翻译：描述了用于检测氧化还原分子的高选择性涂覆电极纳米间隙换能器。在一个示例中，分析物检测系统包括具有用于分析物检测的表面的一个或多个换能器电极。该表面包括涂层以抑制分析物与一个或多个换能器电极的表面直接接触。

60. 发明授权

EP2785868B1 SYSTEMS AND METHODS FOR HIGH EFFICIENCY ELECTRONIC SEQUENCING AND DETECTION 失效转让
标题翻译：系统和高效率的电子测序和证明方法
公开(公告)号：EP2785868B1
公开(公告)日：2017-04-12
申请号：EP12852490.7
申请日：2012-12-03
申请人： Genapsys Inc.
发明人： Esfandyarpour, Hesaam
IPC分类号： G01N33/551 , C12Q1/68
CPC分类号： C12Q1/6874 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2400/0415 , B01L2400/043 , B01L2400/086 , B03C1/286 , B03C1/288 , B03C5/005 , B03C5/02 , B03C5/022 , B03C5/026 , B03C2201/26 , C12Q1/6825 , C12Q1/6844 , C12Q1/6869 , G01N27/3278 , C12Q2565/629 , C12Q2535/122 , C12Q2563/116 , C12Q2565/607

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式