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51. 发明公开

EP2145949A1 TEMPERATURE CONTROL DEVICE, AND TEMPERATURE CONTROL METHOD 审中-公开
标题翻译：温度范围：温度范围
公开(公告)号：EP2145949A1
公开(公告)日：2010-01-20
申请号：EP08739991.1
申请日：2008-04-07
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68
CPC分类号： B01L7/525 , B01L3/021 , B01L3/0275 , B01L7/52 , B01L2200/0684 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844 , B01L2300/1888 , B01L2400/0478 , B01L2400/0487 , G01N2035/00346 , G01N2035/103 , G01N2035/1039 , G01N2035/1062 , Y10T137/0329 , Y10T137/6552
摘要： The present invention relates to a temperature controlling apparatus and the temperature controlling method which can arrest foaming and inflation of the air contained in a liquid, and can perform temperature controlling of a liquid of high reliance, and the present invention is constructed to have one or a plurality of sets of nozzles which can suck and discharge a liquid through a tip, and can retain the sucked liquid, a suction and discharge mechanism which can suck and discharge a gas via the each nozzle, a temperature regulator which can maintain one or two or more set predetermined temperatures for a predetermined time regarding one or two or more predetermined temperature controlling regions set in the each nozzle, a movement mechanism which allows relative movement between one or two or more containers which can accommodate a liquid and a nozzle, and a controlling part which instructs the movement mechanism, the suction and discharge mechanism or the temperature regulator to adjust a liquid to be sucked into the nozzle and a liquid amount thereof, a position of the sucked liquid in the nozzle, and temperature controlling of the liquid.
摘要翻译：本发明涉及一种温度控制装置和温度控制方法，其可以阻止液体中包含的空气的起泡和膨胀，并且可以执行高依赖性的液体的温度控制，并且本发明构造成具有一个或多个能够通过尖端吸取和排出液体并能够保持被吸入的液体的喷嘴组，能够通过各个喷嘴吸入和排出气体的吸引和排出机构，能够保持一个或两个的温度调节器或更多地对预定时间设定关于设置在每个喷嘴中的一个或两个或更多个预定温度控制区域的预定温度;允许一个或两个或更多个可容纳液体和喷嘴的容器之间的相对运动的移动机构，以及控制部分，指示移动机构，吸入和排出机构或温度调节器仅吸入喷嘴的液体及其液体量，吸入液体在喷嘴中的位置，以及液体的温度控制。

52. 发明公开

EP1553176A4 APPARATUS FOR INTRODUCING BIOLOGICAL MATERIAL, METHOD OF INTRODUCING BIOLOGICAL MATERIAL AND MAGNETIC SUPPORT FOR INTRODUCING BIOLOGICAL MATERIAL 审中-公开
标题翻译：设备引入生物材料，方法生物材料和磁支持为生物材料的介绍引进
公开(公告)号：EP1553176A4
公开(公告)日：2008-10-01
申请号：EP03756654
申请日：2003-10-16
申请人： UNIVERSAL BIO RESEARCH CO LTD , OKAMI YOSHIRO
发明人： OKAMI YOSHIRO , TAJIMA HIDEJI
IPC分类号： C12N15/00 , A61K48/00 , A61P35/00 , C12M1/00 , C12M3/00 , C12N1/00 , C12N15/09 , C12N15/87
CPC分类号： C12N15/64 , C12M35/02 , C12N13/00 , C12N15/87 , C12N15/895 , Y10T428/2982
摘要： It is intended to provide an apparatus for introducing biological material, a method of introducing a biological material and a magnetic support for introducing a biological material by which a biological material can be efficiently introduced into a host. The apparatus as described above has a constitution comprising one or more packing units in which a mixture solution containing a large number of magnetic supports carrying a biological material to be introduced into a host (cells, etc.) upon using together with a large number of the hosts in a liquid is pooled, and an introduction treatment unit in which the magnetic force within the packing unit is controlled so that the magnetic supports are driven relatively to the hosts and the biological material is thus introduced into the hosts.

53. 发明公开

EP1882951A1 METHOD OF DETECTING DISPENSED QUANTITY, AND LIQUID SUCTION MONITORING DISPENSING APPARATUS 有权
标题翻译：方法发出的数量和输送设备来监测吸液体的检测
公开(公告)号：EP1882951A1
公开(公告)日：2008-01-30
申请号：EP06756360.1
申请日：2006-05-19
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji , KOIZUKA, Michinori , SUZUKI, Hiroshi , KIMURA, Susumu
IPC分类号： G01N35/10
CPC分类号： G01N35/1016 , G01N2035/1025
摘要： There are provided a method of detecting dispensed quantity in which without the need of detecting a surface of liquid accommodated in a container, a liquid quantity can be detected only by measuring pressure change; and a relevant liquid suction monitoring dispensing apparatus. There is provided a method of detecting dispensed quantity for detection of the quantity of liquid suctioned and discharged by a dispensing apparatus including a pipette tip, a liquid suctioning/discharging mechanism for the pipette tip, a pressure sensor capable of detecting the pressure within the pipette tip, and a lifting and lowering mechanism for the pipette tip, which method comprises: an insertion step for inserting a distal end of the pipette tip down to the deepest zone of a container accommodating liquid to be measured; a suction pressure measuring step for without moving of the pipette tip, while suctioning the liquid into the pipette tip at a predetermined suctioning rate, measuring any pressure change during the suctioning; and a suction detecting step for on the basis of pressure change measured, determining the state of suction. Further, there is provided a liquid suction monitoring dispensing apparatus capable of practicing this method.

54. 发明公开

EP1882524A1 FILTER PROCESSING METHOD, FILTER ENCAPSULATION CHIP, AND FILTER PROCESSING DEVICE 审中-公开
标题翻译： FILTERVERARBEITUNGSVERFAHREN，FILTERVERKAPSELUNGSCHIP UND FILTERVERARBEITUNGSVORRICHTUNG
公开(公告)号：EP1882524A1
公开(公告)日：2008-01-30
申请号：EP06746518.7
申请日：2006-05-17
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji, PRECISION SYSTEM SCIENCE Co., Ltd. , HATANO, T., PRECISION SYSTEM SCIENCE Co., Ltd. , FUMOTO, M., PRECISION SYSTEM SCIENCE Co., Ltd. , KOH, Yoshinor, PRECISION SYSTEM SCIENCE Co., Ltd. , SAEGUSA, Tomomi, PRECISION SYSTEM SCIENCE Co., Ltd
IPC分类号： B01L3/02 , B01D35/02 , B01D61/14 , B01D63/08 , C07K1/14
CPC分类号： B01L3/0275 , B01D61/145 , B01L2300/0681 , G01N2035/1053
摘要： The present invention relates to a filtration method, a filter-incorporated tip and a filtration device, and its object is to perform efficient and swift isolation of a target substance. The filtration method therefore comprises: a liquid introducing step to introduce a liquid into a filter-incorporated tip through a guide opening portion thereof, wherein the filter-incorporated tip has a nozzle-tipped container and a filter, the nozzle-tipped container has a guide opening portion that can be directly or indirectly fitted to an air nozzle capable of ejecting a gas and a front nozzle portion capable of delivering the liquid by the ejection of the gas from the air nozzle, and the filter is locked in the nozzle-tipped container to partition the interior of the nozzle-tipped container into the guide opening portion side and the front nozzle portion side and is adapted to temporarily hold the liquid and isolate a predetermined substance as the liquid passes through the filter, with the nozzle-tipped container coupled to the air nozzle on the guide opening portion side; a coupling step to directly or indirectly couple the filter-incorporated tip containing the liquid to the air nozzle; and a pressure application step to eject the gas from the air nozzle into the coupled filter-incorporated tip.
摘要翻译：本发明涉及一种过滤方法，一种过滤嘴装置和一种过滤装置，其目的是对靶物质进行高效快速的分离。因此，过滤方法包括：液体引入步骤，通过其引导开口部分将液体引入到过滤器引入的尖端中，其中过滤器引入的尖端具有喷嘴顶端的容器和过滤器，喷嘴端的容器具有导向开口部分，其可以直接或间接地装配到能够喷射气体的空气喷嘴和能够通过从空气喷嘴喷射气体而输送液体的前喷嘴部分，并且过滤器被锁定在喷嘴尖端容器将喷嘴头容器的内部分隔成导向开口部分侧和前部喷嘴部分侧，并且当液体通过过滤器时，适于临时保持液体并隔离预定物质，喷嘴头容器与导向开口部侧的空气喷嘴连接; 将包含液体的过滤器引入的尖端直接或间接地耦合到空气喷嘴的耦合步骤; 以及压力施加步骤，用于将气体从空气喷嘴喷射到耦合的过滤器引入的尖端中。

55. 发明公开

EP1637881A4 SAMPLE ARRAYING/ASSEMBLING DEVICE, ITS METHOD, AND APPARATUS USING SAMPLE ASSEMBLY 有权
标题翻译：设备技术取样阵列和样品收集，处理和使样品的成分中使用的设备
公开(公告)号：EP1637881A4
公开(公告)日：2007-10-17
申请号：EP04746522
申请日：2004-06-21
申请人： UNIVERSAL BIO RESEARCH CO LTD
发明人： TAJIMA HIDEJI , MIYASHITA YUKIKO , SEGAWA OSAMU
IPC分类号： G01N33/53 , B01L3/00 , B01L3/02 , C12M1/00 , C12M1/32 , C12N15/00 , C12Q1/68 , G01N33/543 , G01N35/02 , G01N35/10 , G01N37/00
CPC分类号： B01L3/0241 , B01J2219/0081 , B01L3/5025 , B01L2300/0829 , B01L2300/0845 , B01L2400/0409
摘要： A sample arraying/assembling device adapted to any type of microplate conforming to the International Standards and capable of arraying/assembling any of various types of samples quickly with high efficiency. Its method and an apparatus using a sample assembly are also disclosed. The device comprises a distributing section and a wound body. The distributing portion can hold solutions each containing a sample to be distributed and has holding ends arranged in a predetermined matrix. The wound body includes a plane around which string-like or thread-like oblong basic members are so wound as to be parallel arrayed at column intervals and line intervals in such a way that the samples can come into contact with the holding ends. The samples are distributed at the column or line intervals.

56. 发明公开

EP1835020A1 CARRIER ENCLOSING CHIP, CARRIER TREATING APPARATUS AND METHOD OF CARRIER TREATMENT 审中-公开
标题翻译：载波封装芯片，载波处理装置和载波处理方法
公开(公告)号：EP1835020A1
公开(公告)日：2007-09-19
申请号：EP06702044.6
申请日：2006-01-06
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji
IPC分类号： C12M1/00 , C07K1/16 , C12M1/38 , B01D15/00
CPC分类号： B01L3/00 , B01D15/22 , B01J2220/64 , B01L3/0275 , B01L2200/0631 , B01L2300/0681 , B01L2300/1827 , C07K1/16 , C07K1/22 , G01N1/405 , G01N30/6091
摘要： The invention relates to a carrier enclosing tip, a carrier treating apparatus, and a method of carrier treatment. An object is to perform separation/purification more efficiently and rapidly as compared with treatments using conventional liquid chromatography or filters. There is provided a carrier enclosing tip comprising: a tip-like container having a fitting opening which is fittable to a nozzle for use in gas suction and discharge, or a member to be fitted to a nozzle, and a port through which fluid inflow and outflow can be effected by the gas suction and discharge; and a carrier which is enclosed in the tip-like container, and is capable of adsorbing a biosubstance in the fluid or is capable of reacting with or binding to the biosubstance.
摘要翻译：载体封闭尖端，载体处理装置以及载体处理方法技术领域本发明涉及一种载体封闭尖端，目标是与使用常规液相色谱或过滤器的处理相比，更有效和迅速地进行分离/纯化。本发明提供一种载体封入用吸头，其特征在于，具备：具有能够与吸气吐出用喷嘴或者与喷嘴嵌合的部件嵌合的嵌合口的尖端状容器;以及流体流入口排气可以通过吸气和排气来实现; 以及封入尖端状容器中并能够吸附流体中的生物物质或能够与生物物质反应或结合的载体。

57. 发明公开

EP1548440A4 PARTICLE COMPOSITE AND PROCESS FOR PRODUCING PARTICLE COMPOSITE 审中-公开
标题翻译：颗粒组成及其制造方法颗粒组成
公开(公告)号：EP1548440A4
公开(公告)日：2007-04-04
申请号：EP03797639
申请日：2003-09-17
申请人： UNIVERSAL BIO RESEARCH CO LTD
发明人： TAJIMA HIDEJI , STIMPSON DONALD I
IPC分类号： G01N33/543 , G01N33/53 , G01N33/553 , G01N33/58
CPC分类号： G01N33/54313 , G01N33/54326 , G01N33/585 , Y10T436/10
摘要： A particle composite comprising a first particle having a reactant capable of reacting with a target substance fixed to a surface thereof and a second particle labeled with a marker substance, the particle composite dispersible in a liquid sample containing a target substance, wherein the second particle provides such a steric hindrance as to effectively prevent the lowering of efficiency of reaction between the target substance and the reactant. In particular, a particle composite characterized in that a first particle having a reactant capable of reacting with a target substance fixed to a surface thereof and a second particle labeled with a marker substance are immobilized on a surface of solid support dispersible in a liquid sample containing a target substance.

58. 发明公开

EP1637881A1 SAMPLE ARRAYING/ASSEMBLING DEVICE, ITS METHOD, AND APPARATUS USING SAMPLE ASSEMBLY 有权
标题翻译：设备技术取样阵列和样品收集，处理和使样品的成分中使用的设备
公开(公告)号：EP1637881A1
公开(公告)日：2006-03-22
申请号：EP04746522.4
申请日：2004-06-21
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji , MIYASHITA, Yukiko , SEGAWA, Osamu
IPC分类号： G01N33/53 , G01N33/543 , G01N35/02 , G01N37/00 , C12N15/00 , C12Q1/68 , C12M1/00
CPC分类号： B01L3/0241 , B01J2219/0081 , B01L3/5025 , B01L2300/0829 , B01L2300/0845 , B01L2400/0409
摘要： The present invention relates to a sample arraying/assembling device, its method, and an apparatus using a sample assembly, and has an object of providing a sample arraying/assembling device which is adapted to various microplates of International Standards, and is capable of efficiently and quickly arraying and assembling various samples; its method; and an apparatus using a sample assembly.
The present invention is constituted to comprise: a distributing section which is capable of holding respective solutions containing samples to be distributed, and which has a plurality of holding ends arranged in a predetermined matrix; and a wound body which has a plane surface wound with a string-like or thread-like slender foundation member on which samples are to be distributed at distribution intervals of column or line of the matrix, which is arranged in parallel at the winding intervals of the line or column on the plane surface, so that the respective holding ends can come into contact therewith.

10 ··· sample arraying/assembling device
11 ··· sample distributing device
18 ··· container
19 ··· wound body
21 ··· distributing section
38, 120 ··· core
50 ··· sample assembling device
82 ··· sample assembly
122 ··· pipette tip
127 ··· controller
摘要翻译：本发明涉及一种样品整序/组装装置，其方法以及装置使用样品组件，并且具有提供样品整序/装配装置所有这些是angepasst各种微孔板国际标准的到对象，并能够有效地迅速和排列及组装各种样本; 其方法; 和设备使用样品组件。本发明被构成为包括：分配部，其全部能够保持含样品respectivement解决方案是分布式的，并且其具有保持在预定的矩阵排列端部的多元性; 和一个卷绕体具有带有在其上采样的绳状或线状细长基础构件的平面表面伤口将被在柱或基体的线的分布区间在卷绕的间隔分布，所有这一切都在平行地布置的平面表面上的线或列，所以DASS模具respectivement保持端部可以接触到那里。 10 ...样品整序/组装装置11 ...样品分配装置18 ... ... ...容器19卷绕体21 ...分配部38，120 ... ... ...芯部50的样品组装装置82·· ·样品组件122···移液管尖端127 ...控制器

59. 发明公开

EP1589332A1 CONTINUOUS OPTICAL MEASURING APPARATUS AND CONTINUOUS OPTICAL MEASURING METHOD 审中-公开
标题翻译： VORRICHTUNG UND VERFAHREN ZUR KONTINUIERLICHEN OPTISCHEN MESSUNG
公开(公告)号：EP1589332A1
公开(公告)日：2005-10-26
申请号：EP04707306.9
申请日：2004-02-02
申请人： Universal Bio Research Co., Ltd.
发明人： TAJIMA, Hideji, c/o Universal Bio Research Co. Ltd
IPC分类号： G01N21/64 , G01N21/78
CPC分类号： G01N21/6452 , G01N21/6428 , G01N35/10 , G01N2035/1062
摘要： An inexpensive continuous optical measuring apparatus with high cost/performance ratio capable of obtaining the emission of light at respective fixed positions arranged on a foundation member, by a simple device or a control, and a continuous optical measuring method.
The apparatus comprises: at least one transparent or semi-translucent storage part capable of storing the foundation member having a plurality of types of predetermined detection substances fixed thereto along an arrangement line at predetermined intervals, with the detection substances and their fixed positions associated; at least one light receiving part installed at a predetermined position outside of the storage part, and receiving light from the fixed positions, and receiving light from an area having a light receiving width narrower than the width of the arrangement line; and a continuous moving part which is continuously moved relatively between the light receiving part and the storage part so as to scan the fixed positions on the foundation member along a spiral moving line having the light receiving width.
摘要翻译：通过简单的装置或控制，能够获得在配置在基础构件上的各固定位置处的光的发光的成本/性能比高的廉价的连续光学测量装置和连续的光学测量方法。该装置包括：至少一个透明或半透明的存储部件，其能够以预定间隔沿着布置线将具有固定在其上的多种类型的预定检测物质的基础部件与检测物质及其固定相关职位至少一个光接收部分，安装在所述存储部分外部的预定位置处，并且从所述固定位置接收光，并接收来自具有比所述布置线宽度窄的光接收宽度的区域的光; 以及连续移动部件，其相对地在光接收部分和存储部分之间相对移动，以沿着具有光接收宽度的螺旋移动线扫描基础部件上的固定位置。

60. 发明公开

EP1491893A1 SUPPORT FOR AMINATED SUBSTANCE FIXING 审中-公开
标题翻译： TRÄGERZUR FIXIERUNG AMINIERTER SUBSTANZEN
公开(公告)号：EP1491893A1
公开(公告)日：2004-12-29
申请号：EP03708627.9
申请日：2003-03-14
申请人： Universal Bio Research Co., Ltd.
发明人： Tajima, Hideji , Stimpson, Donald I., Bio-Strand, Inc.
IPC分类号： G01N33/545 , G01N33/53 , G01N33/547 , C12N15/09 , C12M1/00
CPC分类号： G01N33/54353 , Y10T428/249942
摘要： An object of the present invention is to provide a carrier for fixing a material containing an amino group, which has a shape to be wound on a spindle member, and on the surface of which the material can be immobilized via covalent bonding; and in order to achieve this object, the carrier of the present invention is a carrier which has a shape to be wound on a spindle member, and has a carboxyl group or an amino group, or derivative groups thereof formed by cleaving an amide bond in the main chain of a polyamide on its surface.
摘要翻译：用于固定胺化物质的载体，其包括能够缠绕在轴构件上的构造，其特征在于，其表面上存在羧基或氨基或其衍生物通过在聚酰胺的主链中断裂而产生，是新的。还包括用于固定胺化物质的方法的独立权利要求：（a）支持物的水解以在其表面上切割暴露的聚酰胺的酰胺键以提供羧基和氨基或其衍生物; 和（b）使胺化物质与羧基或其衍生物反应以在表面上形成酰胺键用于固定。

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