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51. 发明公开

EP0841931A1 PHARMACEUTICAL COMPOSITION 失效
标题翻译：药物组合物
公开(公告)号：EP0841931A1
公开(公告)日：1998-05-20
申请号：EP96925883.0
申请日：1996-07-31
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： FERGUSON, Mark, William, James , FREEMAN, Sally , MOORE, Sarah, Glenys
IPC分类号： C07H7 , A61K31 , A61P17 , C07H11
CPC分类号： A61K31/7024 , A61K31/70 , C07H11/04
摘要： The present invention concerns analogues of M6P for use in promoting the healing of wounds or fibrotic disorders with reduced scarring, together with methods for doing same.
摘要翻译：本发明涉及M6P类似物，其用于促进具有减少的瘢痕形成的伤口或纤维化病症的愈合，以及用于其的方法。

52. 发明公开

EP0839361A1 IMAGE ENHANCEMENT 失效
标题翻译：图像增强
公开(公告)号：EP0839361A1
公开(公告)日：1998-05-06
申请号：EP96924053.0
申请日：1996-07-12
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： OAKLEY, John, Peter
IPC分类号： G06T5 , G06T1
CPC分类号： G06K9/0063 , G06T5/20 , G06T5/50
摘要： An image of a scene partially obscured by atmospheric backscattered light is enhanced by taking account of variations in the mean backscattered flux component resulting from variations in the distance between the point from which the image is captured and points in the terrain contributing to the scene. A series of images of the scene is captured, and an averaged image is produced in which each pixel has a brightness which is an average of the brightness of those portions of the captured images that represent the same region of the scene as that pixel. A model is defined to represent the relationship between the brightness of a pixel of the averaged image and the distance between the point of view from which the image represents and the point in the scene represented by that pixel of the image. An estimate of the contribution of atmospheric backscattered light to the brightness of each pixel of the image is computed from the model. The estimated contribution for each pixel is then subtracted from the brightness of that pixel of the image to produce a modified brightness for that element. The image is reconstructed with each element of the reconstructed image having a brightness which is a function of the modified brightness of that element.
摘要翻译：通过考虑由捕获图像的点和对地形起作用的地形之间的距离变化引起的平均后向散射通量分量的变化，增强了被大气后向散射光部分遮挡的场景的图像。拍摄场景的一系列图像，并且产生平均图像，其中每个像素具有亮度，该亮度是表示与该像素相同的场景的相同区域的拍摄图像的那些部分的亮度的平均值。定义模型以表示平均图像的像素的亮度与图像表示的视点之间的距离与图像的该像素表示的场景中的点之间的距离之间的关系。根据该模型计算大气后向散射光对图像的每个像素的亮度的贡献的估计。然后从图像像素的亮度中减去每个像素的估计贡献，以产生该元素的修改后的亮度。用重构图像的每个元素重建图像，该重构图像的每个元素的亮度是该元素的修改亮度的函数。

53. 发明授权

EP0643120B1 Liquid crystal devices 失效
标题翻译：液晶装置
公开(公告)号：EP0643120B1
公开(公告)日：1997-05-07
申请号：EP94306441.0
申请日：1994-09-01
申请人： Dow Corning Limited , THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Coles, Harry James
IPC分类号： C09K19/40
CPC分类号： C09K19/408 , C09K19/406

54. 发明公开

EP0740703A1 DIAGNOSIS AND TREATMENT OF INFECTIONS DUE TO STREPTOCOCCI AND ENTEROCOCCI 失效
标题翻译：诊断和治疗链球菌感染或肠球菌的
公开(公告)号：EP0740703A1
公开(公告)日：1996-11-06
申请号：EP95907070.0
申请日：1995-01-30
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： BURNIE, James, Peter , MATTHEWS, Ruth, Christine
IPC分类号： G01N33 , A61K39 , A61P31 , C07H21 , C07K14 , C07K16 , C12N15 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C07K14/78 , A61K38/00 , C07K14/315 , C07K16/18 , C07K2319/00
摘要： The present invention provides a purified bacterial protein expressed during infection due to streptococci or enterococci and isolated from human sera, together with immunogenic fragments, analogs, inhibitors, antibodies and antigenic fragments specific thereto. Also provided is a DNA sequence coding for a bacterial protein or an immunogenic fragment or an analogue thereof expressed during infection due to Streptococci or Enterococci, together with homologues thereof, together with vectors, probes and inhibitors therefor. Also provided is fibronectin or an immunogenic fragment thereof or an analogue thereof or an antibody thereto or an antigen binding fragment thereof when used in a method of treatment or diagnosis of the human or animal body for infection due to Streptococci or Enterococci. Also provided are antibodies specific to HSP 90 or immunogenic fragments or analogues thereof for use in a method of diagnosis or treatment of the human or animal body of infection due to streptococci or enterococci due to any one of the group of S.oralis, S.gordonii, S.sanguis.

55. 发明公开

EP0672252A1 IMMUNOASSAY 失效
标题翻译：免疫分析
公开(公告)号：EP0672252A1
公开(公告)日：1995-09-20
申请号：EP94918229.0
申请日：1993-12-03
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： TRELOAR, Paul, Howard , KANE, John, William , VADGAMA, Pankaj, Maganlal
IPC分类号： G01N27 , G01N33
CPC分类号： G01N33/582 , G01N33/5438
摘要： Electrochemical immunoassay methods are disclosed. In one method, a membrane is provided between the sample and the detecting electrode. The membrane is such that it will allow passage therethrough of unbound labelled analyte (but not its complex with antibody). The unbound labelled analyte, which is electrochemically active, may then be detected at the electrode. In a further method, the electrochemical immunoassay uses a labelled analyte which is both fluorescent and electrochemically active. This allows optimisation of the electrochemical immunoassay.
摘要翻译：公开了电化学免疫测定方法。在一种方法中，在样品和检测电极之间提供膜。该膜使得它将允许未结合的标记分析物（而不是其与抗体的复合物）通过其中。然后可以在电极上检测到电化学活性的未结合的标记分析物。在另一种方法中，电化学免疫测定使用荧光和电化学活性的标记分析物。这允许优化电化学免疫测定。

56. 发明公开

EP0672167A1 ANALYTICAL METHOD AND APPARATUS 失效
标题翻译：分析方法和设备。
公开(公告)号：EP0672167A1
公开(公告)日：1995-09-20
申请号：EP93917910.0
申请日：1993-07-23
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： VADGAMA, Pankaj Madganlal , CHRISTIE, Ian McIntyre , LLOYD, Sheridan James
IPC分类号： C12Q1 , G01N27 , G01N33
CPC分类号： C12Q1/26
摘要： Method and electrodes (individual or composite) for detection and measurement of hydrogen peroxide by electrolytic analysis (especially amperometrically), in which the electrode has a surface coating of selective permeability formed by electrolytically oxidising a phenolic compound (especially phenol itself or dopamine). This is especially applicable to examination of biological samples, e.g. blood or serum. The electrode is preferably platinum, and during the coating procedure and/or use may be surrounded with a permeable membrane (e.g. polymer, and especially a polycarbonate 0.03 to 0.05 νm thick). The properties of the coating may be controlled, e.g. by the applied voltage for the oxidation, and is usually 0.1 νm or less in thickness. One form of assembly uses such a coated electrode as anode, with a surrounding cathode and a membrane retaining an electrolyte, preferably buffered. The hydrogen peroxide may be present as such or produced by an enzyme system.

57. 发明授权

EP0406029B1 Fungal stress proteins 有权转让
标题翻译：从真菌应激蛋白。
公开(公告)号：EP0406029B1
公开(公告)日：1995-03-29
申请号：EP90307236.1
申请日：1990-07-02
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Burnie, James Peter , Matthews, Ruth Christine
IPC分类号： C12N15/31 , A61K39/00 , C12P21/08 , G01N33/577 , G01N33/569 , C07K2/00 , C12N1/20
CPC分类号： C07K16/14 , A61K38/00 , C07K14/40 , C07K2317/34 , Y10S435/921 , Y10S435/922 , Y10S435/924 , Y10S436/815 , Y10S530/806 , Y10S530/823

58. 发明公开

EP0575412A1 SENSOR DEVICES 失效
标题翻译：传感器设备。
公开(公告)号：EP0575412A1
公开(公告)日：1993-12-29
申请号：EP92906395.0
申请日：1992-03-12
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： VADGAMA, Pankaj, Madganlal , ROSENBERG, Mark, Flanklyn , CHRISTIE, Ian, McIntyre
IPC分类号： C12M1 , C12Q1 , G01N27
CPC分类号： C12Q1/005
摘要： On décrit des dispositifs de détection analytique comportant un milieu permsélectif immobilisé comme barrière de phase liquide ou de gel continue entre l'échantillon et le détecteur. La barrière est électriquement isolante, imperméable aux espèces non lipophiles chargées, et sépare de façon sélective les espèces lipophiles qui se diffusent à travers ladite barrière, et sa sélectivité peut être contrôlée ou optimisée par des réglages du pH. Dans une forme de barrière préférée, le milieu permsélectif (par exemple un lipide ou un ester) est immobilisé par incorporation dans un polymère (surtout le PVC) pour servir de plastifiant. Le détecteur préféré est une électrode, surtout du type non potentiométrique. Le détecteur peut être utilisé pour détecter les constituants en tant que tels, ou indirectement en les laissant réagir pour produire d'autres matières auxquelles le détecteur réagit (par exemple, une espèce ionique ou un changement de concentration ou d'activité ionique), et peut être utile également pour détecter des espèces neutres ou de petites espèces hydrophiles non chargées, par exemple du peroxyde d'hydrogène, surtout une espèce formée par une activité enzymatique dans le détecteur ou le système qui l'incorpore.

59. 发明公开

EP0566368A2 Cosmetic conjugate 失效
标题翻译： Kosmetische Konjugate。
公开(公告)号：EP0566368A2
公开(公告)日：1993-10-20
申请号：EP93302870.6
申请日：1993-04-14
申请人： UNILEVER PLC , UNILEVER N.V. , THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Jones, Malcolm Norcliff , Lyle, Ian Gardner , Kaszuba, Michael
IPC分类号： A61K47/48 , A61K7/00
CPC分类号： A61Q17/005 , A61K8/14 , A61K8/347 , A61K8/64 , A61K8/645 , A61K8/65 , A61K9/127 , A61K9/1271 , A61K2800/57 , A61K2800/70 , A61K2800/94 , A61Q5/00 , A61Q15/00 , A61Q19/00 , B82Y5/00 , Y10S977/915 , Y10S977/926
摘要： A cosmetic composition for topical application to the skin and/or hair includes, optionally in a cosmetically or pharmaceutically acceptable vehicle, particles which enclose a cosmetically-effective benefit agent active at a target location accessible by application to the skin and/or hair, and which have means to bind to an organic surface at the target location. In particular, the particles are liposomes and have means for binding to microorganisms present on the skin and/or hair, for example those responsible for skin disorders, scalp irritation, and underarm and foot odour.
摘要翻译：用于局部施用于皮肤和/或头发的化妆品组合物任选地包括在化妆品或药学上可接受的载体中，其包含在通过施用于皮肤和/或毛发可获得的目标位置处活跃的美容效果有益剂的颗粒，以及其具有在目标位置处结合有机表面的手段。特别地，颗粒是脂质体，并且具有与存在于皮肤和/或头发上的微生物结合的方法，例如负责皮肤病症，头皮刺激和腋下和脚部气味的那些微生物。

60. 发明授权

EP0251461B1 Parallel free storage management method and device 失效
标题翻译：并行免费存储管理方法和设备
公开(公告)号：EP0251461B1
公开(公告)日：1993-03-03
申请号：EP87304321.0
申请日：1987-05-15
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER , MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Gurd John Richard , Kawakami Katsura
IPC分类号： G06F12/02
CPC分类号： G06F12/023 , Y10S707/99957

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