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51. 发明公开

EP0888053A1 METHOD FOR TREATMENT OF CANCER AND INFECTIOUS DISEASES AND COMPOSITIONS USEFUL IN SAME 失效
标题翻译：方法癌症和传染病的治疗和。确保合适的组合物
公开(公告)号：EP0888053A1
公开(公告)日：1999-01-07
申请号：EP96930521.0
申请日：1996-08-16
申请人： Sloan-Kettering Institute For Cancer Research
发明人： ROTHMAN, James E., Apartment 10B , HARTL, F., Ulrich , HOE, Mee, H. , HOUGHTON, Alan , TAKEUCHI, Yoshizumi , MAYHEW, Mark
IPC分类号： C12N15 , A61K9 , A61K38 , A61K39 , A61K47 , A61K48 , C07K7 , C07K14 , C07K16 , C07K19 , C12N1 , C12N5 , C12P21
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/6901 , A61K48/00 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/6043 , A61K2039/622 , A61K2039/625 , C07K7/08 , C07K14/47 , C12N2710/20034 , Y10S530/828
摘要： Administration of expressible polynucleotides encoding eukaryotic heat shock proteins to mammalian cells leads to the stimulation of an immune response to antigens present in those cells. This makes it possible to stimulate an immune response to target antigens, including target tumor antigens or antigens associated with an infectious disease, without having to isolate a unique antigen or antigen-associated heat shock protein for each target antigen by administering to a mammalian subject or to a group of mammalian cells containing the antigen, an expressible polynucleotide encoding a heat shock protein. The expressed heat shock protein may have the same structure as native heat shock proteins, or may be a modified form adapted to control the trafficking of the expressed heat shock protein within the cells.

52. 发明授权

EP0594577B1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHOD OF USE THEREOF 失效转让
标题翻译：新的高效电感终末分化及使用方法
公开(公告)号：EP0594577B1
公开(公告)日：1998-12-30
申请号：EP91901442.3
申请日：1990-11-14
申请人： Sloan-Kettering Institute For Cancer Research , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： MARKS, Paul, A. , RIFKIND, Richard, A. , BRESLOW, Ronald , JURSIC, Branko
IPC分类号： C07C69/34 , C07C229/24 , C07C233/04 , C07C235/20 , A61K31/22
CPC分类号： C07C233/36 , C07C233/05 , C07C233/07 , C07C243/28 , C07C259/06 , C07C259/08 , C07D231/32 , C07D239/62 , C07D243/08
摘要： The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effective to selectively induce terminal differentiation. Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.

53. 发明授权

EP0473721B1 ANTI-IDIOTYPIC ANTIBODY WHICH INDUCES AN IMMUNE RESPONSE AGAINST A GLYCOSPHINGOLIPID AND USE THEREOF 有权
标题翻译：抗独特型抗体的免疫应答抗脑糖脂和需求
公开(公告)号：EP0473721B1
公开(公告)日：1998-12-23
申请号：EP90909554.9
申请日：1990-05-25
申请人： Sloan-Kettering Institute For Cancer Research
发明人： CHAPMAN, Paul, B. , HOUGHTON, Alan, N.
IPC分类号： A61K39/395 , C07K16/42
CPC分类号： C07K16/4266 , A61K39/00 , A61K47/6873 , A61K2039/505 , C07K16/30
摘要： The present invention provides an anti-idiotypic monoclonal antibody which specifically induces an immune response against a glycosphingolipid. Additionally, this invention provides a method of producing the anti-idiotypic monoclonal antibody. Finally, this invention provides a composition of matter comprising an effective amount of a cytokine and a melanoma ganglioside-specific antibody attached to a carrier.

54. 发明公开

EP0877615A1 COMBINATION THERAPY METHOD FOR TREATING CANCER USING EDATREXATE AND A TAXANE DERIVATIVE, E.G. PACLITAXEL 失效
标题翻译：联合治疗方法中用于癌症USING依达曲沙的治疗和紫杉烷例如紫杉醇
公开(公告)号：EP0877615A1
公开(公告)日：1998-11-18
申请号：EP97904831.0
申请日：1997-01-29
申请人： Sloan-Kettering Institute For Cancer Research
发明人： FENNELLY, David, W. , SIROTNAK, Francis, M.
IPC分类号： A61K31 , A61P35
CPC分类号： A61K31/519 , A61K31/505 , A61K31/335 , A61K2300/00
摘要： This invention provides combination therapy methods, pharmaceutical combinations and compositions for inducing tumor cell regression in cancer patients, particularly metastatic breast cancer patients. The combination methods, combinations and compositions employ both edatrexate and a taxane (e.g. Paclitaxel) which are administered simultaneously or sequentially. The combination therapy described here permits the administration of unusually high doses of edatrexate.

55. 发明公开

EP0812356A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF 失效
标题翻译：前列腺特异性抗原滤膜及其应用
公开(公告)号：EP0812356A1
公开(公告)日：1997-12-17
申请号：EP96908504.0
申请日：1996-02-23
申请人： Sloan-Kettering Institute For Cancer Research
发明人： ISRAELI, Ron, S. , HESTON, Warren, D., W. , FAIR, William, R.
IPC分类号： A01K67 , A61K39 , A61K45 , A61K48 , A61K51 , A61P35 , A61P43 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1
CPC分类号： C07K14/705 , C12Q1/6886 , C12Q2600/112
摘要： This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM') antigen. This invention provides an isolated nucleic acid molecule encoding a prostate-specific membrane antigen promoter. This invention provides a method of detecting hematogenous micrometastic tumor cells of a subject, and determining prostate cancer progression in a subject.

56. 发明公开

EP0760657A1 NOVEL POTENT INDUCERS OF TERMINAL DIFFERENTIATION AND METHODS OF USE THEREOF 失效
标题翻译：终末分化和新的强电感它们的使用方法
公开(公告)号：EP0760657A1
公开(公告)日：1997-03-12
申请号：EP95921378.0
申请日：1995-05-19
申请人： Sloan-Kettering Institute For Cancer Research , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： BRESLOW, Ronald , MARKS, Paul A. , RIFKIND, Richard A.
IPC分类号： C07D295 , A61K31 , A61P35 , A61P43 , C07C229 , C07C233 , C07C237 , C07C255 , C07C259 , C07C271 , C07C275 , C07D211 , C07D213 , C07D277 , C07D487 , C07D519
CPC分类号： C07D295/185 , A61K31/16 , A61K31/164 , A61K31/197 , A61K31/221 , A61K31/277 , A61K31/427 , A61K31/4453 , C07C233/05 , C07C233/06 , C07C233/07 , C07C233/15 , C07C233/25 , C07C233/36 , C07C233/43 , C07C233/54 , C07C233/92 , C07C237/42 , C07C255/42 , C07C255/44 , C07C255/60 , C07C259/06 , C07C259/08 , C07C259/10 , C07C275/28 , C07C2601/14 , C07D211/32 , C07D213/75 , C07D277/46
摘要： The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiazoleamino group; when R1 and R2 are different, R1 = R3-N-R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

57. 发明公开

EP0749442A1 ISOLATED p27 PROTEIN AND ITS ENCODING NUCLEIC ACID MOLECULES 失效
标题翻译：隔离P27蛋白质和核酸。确保CODING
公开(公告)号：EP0749442A1
公开(公告)日：1996-12-27
申请号：EP95906793.0
申请日：1995-01-09
申请人： Sloan-Kettering Institute For Cancer Research , Fred Hutchinson Cancer Research Center
发明人： MASSAGUE, Joah , ROBERTS, James M. , KOFF, Andrew , POLYAK, Kornelia
IPC分类号： G01N33 , A61K35 , A61K38 , A61K48 , A61P1 , A61P35 , A61P43 , C07H21 , C07K14 , C12N1 , C12N5 , C12N15 , C12P21
CPC分类号： C07K14/4738 , A61K38/00
摘要： The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject invention also provides the nucleic acid encoding the p27 protein, vectors, and host cells for producing the recombinant form of the p27 protein. The subject invention further provides methods for identifying agents capable of modulating the ability of p27 to inhibit the activation of the cyclin E-Cdk2 complex. Finally, the subject invention provides methods for treating subjects diagnosed with hypoproliferative disorders using said agents.

58. 发明授权

EP0208902B1 Monoclonal antibody specific for a pigmentation associated antigen 失效
标题翻译：用于染色相关抗原的单克隆抗体特异性
公开(公告)号：EP0208902B1
公开(公告)日：1993-01-13
申请号：EP86107788.1
申请日：1986-06-07
申请人： Sloan-Kettering Institute For Cancer Research
发明人： Thomson, Timothy M. , Mattes, Jules M. , Old, Lloyd J. , Lloyd, Kenneth O. , Roux, Linda
IPC分类号： C12N5/18 , C07K15/00 , C12P21/00 , G01N33/577 , G01N33/574
CPC分类号： C07K16/18 , Y10S436/813 , Y10S530/808

59. 发明公开

EP0212465A3 Method for enhancement of growth of human cells in culture 失效
标题翻译：提高文化人体细胞生长的方法
公开(公告)号：EP0212465A3
公开(公告)日：1989-03-01
申请号：EP86110915.5
申请日：1986-08-07
申请人： Sloan-Kettering Institute For Cancer Research
发明人： Eisinger, Magdalena , Ogata, Shun-Ichiro , Marko, Olga , Old, Lloyd J.
IPC分类号： C07K15/06 , C12N5/00 , C12Q1/00 , C07K3/02
CPC分类号： G01N33/5017 , C07K14/475 , C12N5/0626 , C12P1/00 , C12R1/91
摘要： Physiologically active growth factors produced by melanoma and astrocytoma cell lines support continued proliferation of slow-growing cells such as melanocytes in the absence of other added compounds. WI-38, a fibroblast cell line derived from human embryonic lung, was the most active source of melanocyte growth factors. No melanocyte growth promoting activity was found in extracts of cultured neuroblastoma, renal cancer, normal keratinocytes or renal epithelium. Nerve growth factor, epidermal growth factor, melanocyte stimulating hormone, transforming growth factor - Beta, and platelet-derived growth factor lacked growth promoting activity for melanocytes. The presence of melanocyte growth factors and TPA together resulted in the strongest mitogenic activity for slow-growing cells such as melanocytes, permitting the recovery (at 20 days) of 4 to 20 times more cells than in factor or TPA alone. A synergistic or augmented effect is seen with TPA plus melanocyte growth factor.
摘要翻译：由黑素瘤和星形细胞瘤细胞系产生的生理活性生长因子在不存在其他添加化合物的情况下支持慢生长细胞如黑素细胞的持续增殖。来自人类胚胎肺的成纤维细胞系WI-38是黑素细胞生长因子中最活跃的来源。在培养的神经母细胞瘤，肾癌，正常角质形成细胞或肾上皮的提取物中未发现黑素细胞生长促进活性。神经生长因子，表皮生长因子，黑素细胞刺激激素，转化生长因子-β和血小板衍生生长因子对黑素细胞缺乏生长促进活性。黑素细胞生长因子和TPA的存在一起导致对于慢生长细胞如黑素细胞的最强有丝分裂活性，允许恢复（在20天）比单独因子或TPA高4至20倍的细胞。 TPA加黑素细胞生长因子可以看到协同或增强的作用。

60. 发明授权

EP0092163B1 Purification of interleukin 2 有权
标题翻译：白细胞介素2的纯化
公开(公告)号：EP0092163B1
公开(公告)日：1988-09-28
申请号：EP83103582.9
申请日：1983-04-14
申请人： Sloan-Kettering Institute For Cancer Research
发明人： Mertelsmann, Roland , Welte, Karl , Venuta, Salvatore
IPC分类号： C12P21/00 , C07K15/00 , A61K37/02
CPC分类号： C07K14/55 , A61K38/00

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