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51. 发明授权

EP1046037B1 PARTICULES MAGNETIQUES PERFECTIONNEES, LEURS PROCEDES D'OBTENTION ET LEURS UTILISATIONS DANS LA SEPARATION DE MOLECULES 有权
标题翻译：完善磁性颗粒的制备方法及其应用用于分离分子
公开(公告)号：EP1046037B1
公开(公告)日：2005-05-11
申请号：EP99900498.9
申请日：1999-01-06
申请人： BIO MERIEUX
发明人： ELAISSARI, Abdelhamid , PICHOT, Christian , MANDRAND, Bernard
IPC分类号： G01N33/543 , H01F1/11 , B03C1/01
CPC分类号： H01F1/111 , B03C1/01 , G01N33/5434 , G01N2446/20 , G01N2446/86 , Y10S428/90 , Y10T428/2991 , Y10T428/2998

52. 发明授权

EP1179091B1 PROCEDE D'ANALYSE DE LA PREDISPOSITION GENETIQUE D'UN PATIENT A AU MOINS UNE MALADIE ET AMPLIFICATION ADAPTEE A UN TEL PROCEDE 有权
标题翻译：分析方法确定易感性ENES患者至少一种疾病和放大适合这样的一种方法
公开(公告)号：EP1179091B1
公开(公告)日：2004-10-13
申请号：EP00929650.0
申请日：2000-05-19
申请人： BIO MERIEUX
发明人： MOUGIN, Bruno , TIERCY, Jean-Marie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16
摘要： The invention concerns a method for analysing a patient's genetic predisposition to at least one disease. It also concerns an amplification process adapted to said method. The method consists in bringing a liquid sample containing at least one type of amplicons, derived from the amplification of at least one polymorphous region of interest related to the searched disease(s), in the presence of probes selected as follows: at least one specific typing probe, said to be low-resolution, capable of being hybridized on the polymorphous region of interest of at least one gene or one group of alleles of said gene borne by the amplicon and associated with at least said disease(s); and at least a specific subtyping probe, said to be high-resolution, capable of being hybridized on said polymorphous region of interest of the allele or group of alleles of the specific typing probe, said to be low-resolution, the high-resolution probe(s) enabling to discriminate the allele(s) associated with the susceptibility and/or the allele(s) associated with resistance to said disease(s), on the basis of their hybridization or non-hybridization. The invention is particularly applicable in the field of diagnosis.

53. 发明授权

EP1140963B1 COMPOSE FONCTIONNALISE, POLYNUCLEOTIDE EVENTUELLEMENT MARQUE ET PROCEDE DE DETECTION D'UN ACIDE NUCLEIQUE CIBLE 有权
标题翻译：功能化的连接，如果需要标记的多核苷酸和检测方法的靶核酸的
公开(公告)号：EP1140963B1
公开(公告)日：2004-09-22
申请号：EP00900527.3
申请日：2000-01-05
申请人： BIO MERIEUX
发明人： DEFRANC, Eric , LAAYOUN, Ali , LHOMME, Jean , TREVISIOL, Emmanuelle
IPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/68 , C12P19/34
CPC分类号： C07H21/00 , C12P19/34 , C12Q1/68
摘要： The invention concerns a functionalised compound of general formula (I) wherein: W represents a nucleotide analog; L represents a binding group comprising at least four atoms; R1 represents a linear or branched alkyl chain. The invention also concerns one said functionalised polynucleotide, one marked polynucleotide, including at least a functionalised compound corresponding to formula (I'). The invention further concerns a method for detecting a target nucleic acid using one said compound.

54. 发明授权

EP1198295B1 DISPOSITIF D'ANALYSE AVEC UNE BIOPUCE 有权
标题翻译：与生物芯片分析装置
公开(公告)号：EP1198295B1
公开(公告)日：2003-09-03
申请号：EP00953265.6
申请日：2000-07-19
申请人： BIO MERIEUX
发明人： GUERITAULT, Thomas , ODIET, Maxime , PRELAZ, Jean-Claude
IPC分类号： B01L3/00 , H01L21/58 , B01J19/00
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/00529 , B01J2219/00608 , B01J2219/0061 , B01J2219/00659 , B01J2219/00707 , B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , G01N2035/00158 , H01L24/29 , H01L24/32 , H01L24/83 , H01L2224/2919 , H01L2224/8319 , H01L2224/8385 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01039 , H01L2924/01058 , H01L2924/01074 , H01L2924/01082 , H01L2924/01087 , H01L2924/014 , H01L2924/0665 , H01L2924/07802 , H01L2924/09701 , H01L2924/00
摘要： The invention concerns a device (1) for analysing at least an analyte, comprising a container (8) and a biochip (2) defining together at least a section (10), attached to the container by fixing means (5), said biochip comprising a support (9), for example polyhedral, comprising an active face (3) including an active surface (31), whereon are distributed and bound a plurality of ligands (4) to be analysed, at least a face opposite (6) to the active face (3) and a peripheral transverse strip (7) linking the active (3) and opposite (6) faces, comprising for example several edges (71 to 74). The invention is characterised in that the means fixing (5) the biochip (2) to the container (8) links, on one side the transverse strip (7) of the biochip, practically excluding any other part, face or surface of the biochip, and on the other side the container (8), and on either side of the active face (3) of the biochip (2), and the fixing means (5) completely expose the peripheral zone (32) of the active face (3) of the biochip (2).

55. 发明授权

EP0549776B9 SYSTEME DE SONDES PERMETTANT D'EFFECTUER LE TYPAGE HLA DR, ET PROCEDE DE TYPAGE UTILISANT LESDITES SONDES 失效
标题翻译：为HLA-DR表征和使用的表征方法探测系统
公开(公告)号：EP0549776B9
公开(公告)日：2003-03-12
申请号：EP92916146.1
申请日：1992-07-17
申请人： BIO MERIEUX, Société anonyme
发明人： ALLIBERT, Patrice, André , CROS, Philippe , MACH, Bernard, François , MANDRAND, Bernard, Fabien , TIERCY, Jean-Marie
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6881 , C12Q2600/156

56. 发明授权

EP0920626B1 PROCEDE DE MISE EN EVIDENCE D'UN MATERIEL BIOLOGIQUE CIBLE, PHASE DE CAPTURE, PHASE DE DETECTION ET REACTIF LES CONTENANT 失效
标题翻译：检测方法的生物材料，输入相位检测相和含试剂
公开(公告)号：EP0920626B1
公开(公告)日：2003-02-26
申请号：EP98932247.4
申请日：1998-06-19
申请人： BIO MERIEUX
发明人： MALLET, François , DELAIR, Thierry , LADAVIERE, Catherine , NOVELLI-ROUSSEAU, Armelle , CHARLES, Marie-Hélène
IPC分类号： G01N33/543 , C07K17/00 , G01N33/532
CPC分类号： G01N33/54393 , C12N15/62 , C12N15/87
摘要： The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a reactive function and at least a protein material capable of recognising or binding, specifically and directly or indirectly, with the target biological material, said protein material having a specific covalent binding site with the organic molecule reactive function, consisting of at least a tag comprising at least six contiguous lysine, or lysine derivative residues; the method consists in contacting said target biological material with at least the capture phase; and detecting the target biological material fixed on the capture phase: The invention also concerns the capture and detection phases, and a reagent containing them.

57. 发明授权

EP0882233B1 PROCEDE ET DISPOSITIF DE TRAITEMENT PAR COMPLEXATION D'UN MILIEU LIQUIDE 失效
标题翻译：方法和一种用于治疗络合潮湿的环境
公开(公告)号：EP0882233B1
公开(公告)日：2003-02-26
申请号：EP97944930.3
申请日：1997-10-06
申请人： BIO MERIEUX
发明人： GINOT, Frédéric
IPC分类号： G01N33/543
CPC分类号： C12Q1/6874 , G01N33/543
摘要： The invention concerns a method and device for treatment by complexing of a liquid medium containing one or several constituents determining the presence in said liquid medium of a plurality of ligands, which consists in: a) providing a support for plural complexing, on which are distributed a plurality of coupling sites, in which are immobilised a plurality of anti-ligands respectively different; b) contacting said liquid medium with said complexing support, whereby said ligands are paired with said anti-ligands. The invention is characterised in that the stability of each ligand/anti-ligand complex being dependent of at least one exogenous parameter, called reference parameter, conditioning said support, the coupling sites on the support are differentiated, depending on said exogenous reference parameter, having respectively different values in said sites, and the anti-ligands are distributed among the different coupling sites, depending on the predetermined optimum values of the exogenous reference parameter, determining the stability of the different ligand/anti-ligand complexes respectively. The invention is useful for sequencing nucleic acids by hybridisation.

58. 发明公开

EP1260597A2 Procédé de marquage d'un acide ribonucléique avec purification et fragments d'ARN marqués ainsi obtenus 有权
标题翻译：一种用于标记的核糖核酸，用清洗方法
公开(公告)号：EP1260597A2
公开(公告)日：2002-11-27
申请号：EP02018001.4
申请日：1999-06-17
申请人： BIO MERIEUX
发明人： Laayoun, Ali
IPC分类号： C12Q1/68
CPC分类号： C07H21/00
摘要： La présente invention concerne un procédé de marquage d'un acide ribonucléique (ARN) de synthèse ou naturel. Elle concerne également des fragments d'ARN marqués selon le procédé, ainsi que leur utilisation.
Le procédé consiste :

à fragmenter l'ARN de manière non spécifique pour générer une pluralité de fragments d'ARN, et
à marquer une pluralité de fragments d'ARN au niveau du phosphate terminal situé à l'extrémité 3' et /ou 5', ledit phosphate terminal ayant été libéré lors de la fragmentation, et
à purifier l'échantillon biologique traité.

L'invention trouve une application préférentielle dans le domaine du diagnostic médical.

59. 发明公开

EP1201305A3 Système microfluidique de réactions et de transferts 审中-公开
标题翻译：微流体反应和输送系统
公开(公告)号：EP1201305A3
公开(公告)日：2002-11-13
申请号：EP01204802.1
申请日：1999-09-08
申请人： BIO MERIEUX
发明人： Colin, Bruno , Paris,Cécile , Dachaud, Jacques , Imbaud, Pierre
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2400/0605 , B01L2400/0638 , F16K99/0015 , F16K99/0023 , F16K2099/0071
摘要： Dispositif (1), permettant de conduire une réaction ou au moins deux réactions en parallèle ou en série en son sein, qui est constitué par : une surface supérieure et une surface inférieure reliées l'une à l'autre par un bord, au moins un canal (5) dans lequel un flux fluidique peut être créé par des moyens de transfert pour permettre le transfert d'au moins un échantillon à traiter et/ou à analyser, et au moins une vanne (38) incorporée à chaque canal (5) permettant l'orientation de chaque échantillon et donc le contrôle des transferts, des réactions et des analyses dans le dispositif (1), chaque vanne (38) est constituée de deux moyens (39 et 40, 50, 60 ou 70) solidaires du dispositif (1), le premier moyen (39) étant mobile entre une position de repos où le transfert de fluide est possible et une position active où ledit transfert est impossible, et le second moyen (40, 50, 60 ou 70) étant mobile entre une position de repos où il (40, 50, 60 ou 70) n'est pas en contact avec ledit premier moyen (39) et une position active où il déforme le premier moyen (39), pour que le transfert soit impossible, ledit second moyen (40, 50, 60 ou 70) est activé par un actionneur extérieur au dispositif (1), qui agit uniquement lors du maintien du second moyen (50, 60 ou 70) dans sa position de repos ou lors du maintien du second moyen dans sa position active.

60. 发明公开

EP1248679A2 PROCEDE D'ISOLEMENT DE PROTEINES OU D'ASSOCIATIONS DE PROTEINES ET D'ACIDES NUCLEIQUES ET COMPLEXES DE PARTICULES ET DE PROTEINES AINSI FORMES 有权
标题翻译：方法在蛋白质或混合物蛋白质和核酸的清洁和这样生成ZUSAMMESETZUNGEN粒子和蛋白质
公开(公告)号：EP1248679A2
公开(公告)日：2002-10-16
申请号：EP01907667.8
申请日：2001-01-22
申请人： BIO MERIEUX
发明人： ELAISSARI, Abdelhamid , MANDRAND, Bernard , DELAIR, Thierry , SPENCER, Doran , ARKIS, Ahmed
IPC分类号： B03C1/01 , G01N33/543 , C07K1/22 , C12N15/10
CPC分类号： C12N15/1013 , C07K1/22 , G01N33/5434
摘要： The invention concerns a method for isolating proteins and/or protein and nucleic acid associations in a sample, comprising steps which consist in: contacting said sample and magnetic colloidal particles comprising a core and a coat wherein: the core is magnetic and is coated with at least a polymer comprising functional groups X selected among amine, hydroxyl, thiol, aldehyde, ester, anhydride, acid chloride, carbonate, carbamate, isocyanate and isothiocyanate groups or mixtures thereof, whereof at least one fraction has reacted with other functional groups of the coat, and the coat consists of a polymer bearing functional groups Z and Z', capable of ionisation, identical or different, selected among amine, carboxylic acid, ester, anhydride, aldehyde, thiol, disulphide, α-halogenocarbonyl, sulphonic acid, maleimide, isocyanate and isothiocyanate groups to form a mixture; incubating said mixture in predetermined conditions; and separating from the mixture the protein and/or protein and nucleic acid associations complexed on the colloidal particles by applying a magnetic field. The invention also concerns a complex consisting of colloidal particles and proteins, a reagent comprising such a complex or colloidal particles.

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